| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammed Auwal Ibrahim, Murtala Bindawa Isah, Mayen David Inim, Aliyu Dantani Abdullahi, Auwal Adam. The connections of sialic acids and diabetes mellitus: therapeutic or diagnostic value? Glycobiology. 2024-07-23. PMID:39041707. |
additionally, sialic acids are also profoundly associated with glucose transport and insulin resistance in human-based studies while animal-based studies revealed that the increased desialylation of insulin receptors by sialidases, especially neu1, might be the causal link. |
2024-07-23 |
2024-07-25 |
Not clear |
| Samuel Turvey, Stephen P Muench, Tarik Issad, Colin W G Fishwick, Mark T Kearney, Katie J Simmon. Using site-directed mutagenesis to further the understanding of insulin receptor-insulin like growth factor-1 receptor heterodimer structure. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 77. 2024-07-21. PMID:39033666. |
the key hubs of these signalling cascades - the insulin receptor (ir) and insulin-like growth factor 1 receptor (igf1r) - are known to form functional ir-igf1r hybrid receptors which are insulin resistant. |
2024-07-21 |
2024-07-24 |
Not clear |
| František Hubálek, Christian N Cramer, Hans Helleberg, Eva Johansson, Erica Nishimura, Gerd Schluckebier, Dorte Bjerre Steensgaard, Jeppe Sturis, Thomas B Kjeldse. Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec. Nature communications. vol 15. issue 1. 2024-07-20. PMID:39033137. |
the insulin icodec molecule was developed based on the hypothesis that lowering insulin receptor affinity and introducing a strong albumin-binding moiety would result in a long insulin half-life, provided that non-receptor-mediated clearance is diminished. |
2024-07-20 |
2024-07-24 |
Not clear |
| Elizabeth M Rhea, William A Bank. Insulin and the blood-brain barrier. Vitamins and hormones. vol 126. 2024-07-19. PMID:39029972. |
the bbb is also an important site of insulin binding and mediator of insulin receptor (insr) signaling. |
2024-07-19 |
2024-07-22 |
Not clear |
| Vukasin M Jovanovic, Narisu Narisu, Lori L Bonnycastle, Ravi Tharakan, Kendall T Mesch, Hannah J Glover, Tingfen Yan, Neelam Sinha, Chaitali Sen, David Castellano, Shu Yang, Dvir Blivis, Seungmi Ryu, Daniel F Bennett, Giovanni Rosales-Soto, Jason Inman, Pinar Ormanoglu, Christopher A LeClair, Menghang Xia, Martin Schneider, Erick O Hernandez-Ochoa, Michael R Erdos, Anton Simeonov, Shuibing Chen, Ilyas Singeç, Francis S Collins, Claudia A Doege, Carlos A Trista. Scalable Hypothalamic Arcuate Neuron Differentiation from Human Pluripotent Stem Cells Suitable for Modeling Metabolic and Reproductive Disorders. bioRxiv : the preprint server for biology. 2024-07-15. PMID:39005353. |
in addition, differential glucose and insulin treatments uncovered adaptability within the generated arc neurons in the dynamic regulation of pomc and insulin receptors. |
2024-07-15 |
2024-07-18 |
human |
| Masaji Sakaguch. The role of insulin signaling with FOXO and FOXK transcription factors. Endocrine journal. 2024-07-10. PMID:38987195. |
the insulin receptor depends on the tyrosine phosphatase feedback of insulin signaling to maintain adipocyte insulin responsiveness. |
2024-07-10 |
2024-07-13 |
mouse |
| Wenfeng Gong, Wenzhe Chen, Jianjun Dong, Lin Lia. Rabson-Mendenhall Syndrome: Analysis of the Clinical Characteristics and Gene Mutations in 42 Patients. Journal of the Endocrine Society. vol 8. issue 8. 2024-07-03. PMID:38957655. |
rabson-mendenhall syndrome (rms) is a rare autosomal, recessive disorder characterized by severe insulin resistance due to mutations in the insulin receptor (insr) gene. |
2024-07-03 |
2024-07-06 |
Not clear |
| Chen Chongyang, Zhao Yangting, Li Kai, Lv Xiaoyu, Wang Yawen, Zhen Donghu, Fu Songbo, Ma Lihua, Zhou Liyuan, Liu Jingfan. Hereditary Severe Insulin-resistance Syndrome and Acanthosis Nigricans Caused by Novel Mutations in the Journal of clinical research in pediatric endocrinology. 2024-07-02. PMID:38952179. |
hereditary severe insulin-resistance syndrome and acanthosis nigricans caused by novel mutations in the most cases associated with hereditary severe insulin resistance syndrome (h-sirs) are linked to mutations in the insulin receptor ( |
2024-07-02 |
2024-07-04 |
Not clear |
| Lixia Song, Yong Li, Meihong X. Exogenous Nucleotides Ameliorate Insulin Resistance Induced by Palmitic Acid in HepG2 Cells through the IRS-1/AKT/FOXO1 Pathways. Nutrients. vol 16. issue 12. 2024-06-27. PMID:38931156. |
moreover, exogenous nt intervention orchestrates insulin signaling pathway (insulin receptor substrate-1, protein kinase b, and forkhead box protein o1) and amp-activated protein kinase (ampk) activity in hepg2 cells. |
2024-06-27 |
2024-06-29 |
Not clear |
| Ankita B Jaykumar, Derk Binns, Clinton A Taylor, Anthony Anselmo, Shari G Birnbaum, Kimberly M Huber, Melanie H Cob. WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling. bioRxiv : the preprint server for biology. 2024-06-25. PMID:38915673. |
certain areas of the brain involved in episodic memory and behavior, such as the hippocampus, express high levels of insulin receptors and glucose transporter-4 (glut4) and are responsive to insulin. |
2024-06-25 |
2024-06-27 |
mouse |
| Liwei Sun, Hailong Bing, Chenxi Zhang, Lin Lin, Hongkai Lian, Qinjun Chu, Xiaogao Ji. Short-Term Preconditioning with Insulin and Glucose Efficiently Protected the Kidney Against Ischemia-Reperfusion Injury via the P-AKT-Bax-Caspase-3 Signaling Pathway in Mice. Drug design, development and therapy. vol 18. 2024-06-25. PMID:38915866. |
insulin attaches insulin receptor to activate the pi3-kinase/akt signaling to maintain glucose homeostasis and inhibit apoptosis. |
2024-06-25 |
2024-06-27 |
mouse |
| Rady E El-Araby, Qisheng Tu, Ying Xie, Tarek Aboushousha, Zhongyu Li, Xiaoyang Xu, Zoe X Zhu, Lily Q Dong, Jake Che. Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes. Aging and disease. 2024-06-25. PMID:38916734. |
this resulted in reactivation of insulin receptors in insulin target tissues and stimulation of insulin secretion from pancreatic beta cells. |
2024-06-25 |
2024-06-27 |
mouse |
| Hooman Hatami, Vahid Reza Askari, Vafa Baradaran Rahimi, Md Saquib Hasnain, Amit Kumar Naya. The Dilemma of Insulin Delivery into the Brain: A Comprehensive Review. Current drug delivery. 2024-06-24. PMID:38910469. |
the ubiquitous distribution of insulin receptors on various brain cells, such as neurons, microglia, astrocytes, and oligodendrocytes, and their differential localization across various brain regions, including the hippocampus, hypothalamus, and olfactory bulb, collectively underscore the crucial involvement of insulin in the modulation of cerebral functions. |
2024-06-24 |
2024-06-26 |
human |
| Lorenzo Del Moro, Elenamaria Pirovano, Eugenia Rot. Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance. Aging and disease. 2024-06-24. PMID:38913047. |
brain insulin resistance has recently been described as a metabolic abnormality of brain glucose homeostasis that has been proven to downregulate insulin receptors, both in astrocytes and neurons, triggering a reduction in glucose uptake and glycogen synthesis. |
2024-06-24 |
2024-06-26 |
Not clear |
| Hengshuo Zhang, Ziyu Wang, Qinghui Li, Congcong Cao, Yongyuan Guo, Yunzhen Che. IRTKS promotes osteogenic differentiation by inhibiting PTEN phosphorylation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908202. |
insulin receptor tyrosine kinase substrate (irtks) is involved in insulin signaling as an adapter for insulin receptors (ir). |
2024-06-22 |
2024-06-25 |
Not clear |
| Pamela Mattar, Andressa Reginato, Christian Lavados, Debajyoti Das, Manu Kalyani, Nuria Martinez-Lopez, Mridul Sharma, Grethe Skovbjerg, Jacob Lercke Skytte, Urmas Roostalu, Rajasekaran Subbarayan, Elodie Picarda, Xingxing Zang, Jinghang Zhang, Chandan Guha, Gary Schwartz, Prashant Rajbhandari, Rajat Sing. Insulin and leptin oscillations license food-entrained browning and metabolic flexibility. Cell reports. vol 43. issue 7. 2024-06-20. PMID:38900636. |
single-cell rna-sequencing (scrna-seq) analyses and flow cytometry demonstrate a role for insulin and leptin surges in innate lymphoid type 2 (ilc2) cell recruitment and swat browning, since swat depot denervation or loss of leptin or insulin receptor signaling or ilc2 recruitment each dampens tan feeding-induced swat remodeling and energy expenditure. |
2024-06-20 |
2024-06-23 |
Not clear |
| Noha M Elemam, Hassan Youssef Hotait, Mohamed A Saleh, Waseem El-Huneidi, Iman M Talaa. Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities. Frontiers in endocrinology. vol 15. 2024-06-14. PMID:38872970. |
the mammalian insulin-like growth factor (igf) family is made up of three ligands (igf-i, igf-ii, and insulin), three receptors (igf-i receptor (igf-1r), insulin receptor (ir), and igf-ii receptor (igf-2r)), and six igf-binding proteins (igfbps). |
2024-06-14 |
2024-06-16 |
Not clear |
| Peter Thomas, Manon Leclerc, Kira Evitts, Caitlin Brown, Wyatt Miller, Angela J Hanson, William A Banks, Laura Gibbons, Kimiko Domoto-Reilly, Suman Jayadev, Ge Li, Elaine Peskind, Jessica E Young, Frederic Calon, Elizabeth M Rhe. Cerebrospinal fluid soluble insulin receptor levels in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 16. issue 2. 2024-05-27. PMID:38800123. |
insulin resistance can be mediated by the surface expression of the insulin receptor (ir). |
2024-05-27 |
2024-05-31 |
Not clear |
| Joseph A M J L Jansse. Overnutrition, Hyperinsulinemia and Ectopic Fat: It Is Time for A Paradigm Shift in the Management of Type 2 Diabetes. International journal of molecular sciences. vol 25. issue 10. 2024-05-25. PMID:38791525. |
the personal fat threshold hypothesis proposes that in susceptible individuals, excessive ectopic fat accumulation may eventually lead to hepatic insulin receptor resistance, the loss of pancreatic insulin secretion, hyperglycemia and the development of frank type 2 diabetes. |
2024-05-25 |
2024-05-27 |
Not clear |
| J M Gladding, Z N Rafiei, C S Mitchell, D P Beg. Excision of the endothelial blood-brain barrier insulin receptor does not alter spatial cognition in mice fed either a chow or high-fat diet. Neurobiology of learning and memory. 2024-05-21. PMID:38772444. |
to target bbb insulin function, we used cre-loxp genetic excision of the insulin receptor (insr) from endothelial cells in adult male mice. |
2024-05-21 |
2024-05-27 |
mouse |