| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Domenico Accili, Zhaobing Deng, Qingli Li. Insulin resistance in type 2 diabetes mellitus. Nature reviews. Endocrinology. 2025-04-17. PMID:40247011. |
while recognizing the heterogeneity of the elusive fundamental disruptions that cause insulin resistance, we endorse the view that effector mechanisms impinge on insulin receptor signalling and its relationship with plasma levels of insulin. |
2025-04-17 |
2025-04-20 |
Not clear |
| Creaminar D Shira, Kanmoni Malakar, Bidyadhar Da. Unravelling the Role of Insulin-Like Peptide Genes in Bombyx mori: Potential Key Regulators of Insect Metabolism. Archives of insect biochemistry and physiology. vol 118. issue 4. 2025-04-16. PMID:40235296. |
insulin suppressed bmx (-0.25-fold) and bmz (-0.91-fold) mrna expression levels in food-deprived larvae in the fat body, whereas 20e consistently downregulated bmx, bmz, and bminr (insulin receptor) mrna expression levels in all the conditions. |
2025-04-16 |
2025-04-18 |
cattle |
| Maria Mirabelli, Eusebio Chiefari, Biagio Arcidiacono, Alessandro Salatino, Angelo Pascarella, Maurizio Morelli, Sara C Credendino, Francesco S Brunetti, Anna Di Vito, Adelaide Greco, Vincent Huin, Ferdinando Nicoletti, Giovanna M Pierantoni, Monica Fedele, Umberto Aguglia, Daniela P Foti, Antonio Brunett. HMGA1 deficiency: a pathogenic link between tau pathology and insulin resistance. EBioMedicine. vol 115. 2025-04-15. PMID:40233659. |
our previous research identified hmga1 as crucial for insulin receptor (insr) expression, with defects in the hmga1 gene associated with insulin resistance and t2d. |
2025-04-15 |
2025-04-18 |
Not clear |
| Ran Wang, Xiangjing Li, Li Long, Min Li, Huijing Chen, Han Zhang, Wei Ruan, Hong Zhang, Pengwu Zheng, Shan X. Novel ALK inhibitors containing DAAP fragments: Rational drug design and anti-tumor activity research. Bioorganic chemistry. vol 160. 2025-04-10. PMID:40209355. |
anaplastic lymphoma kinase (alk) is a receptor tyrosine kinase belonging to the insulin receptor subfamily, involved in cellular signaling pathways associated with insulin. |
2025-04-10 |
2025-04-14 |
human |
| Gufeng Gao, Ai Chen, Yan Yan, Mohammad Ismail Hajary Sagor, Weijun Lin, Huakan Lin, Guili Lian, Liangdi Xie, Li Lu. Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension. Frontiers in cardiovascular medicine. vol 12. 2025-04-08. PMID:40196172. |
the insulin receptor substrate-1 (irs-1) plays a crucial role in the insulin signaling pathway; however, its function in pah is still not fully understood. |
2025-04-08 |
2025-04-10 |
rat |
| Correction to: "Insulin Signaling Through the Insulin Receptor Increases Linear Growth Through Effects on Bone and the GH-IGF-1 Axis". The Journal of clinical endocrinology and metabolism. 2025-04-03. PMID:40178627. |
correction to: "insulin signaling through the insulin receptor increases linear growth through effects on bone and the gh-igf-1 axis". |
2025-04-03 |
2025-04-04 |
Not clear |
| Xiao Wang, Minghui Xu, Xue Kong, Shaofeng Zhong, Jeremiah Joe Kabissa, Dandan Li, Zhiwei Kang, Yongyu Xu, Zhenzhen Che. The role of insulin receptor InR in photoperiod-regulated reproductive diapause of Chrysoperla nipponensis. Insect biochemistry and molecular biology. 2025-03-30. PMID:40158640. |
injecting bovine insulin promoted ovarian development and egg formation in diapause females, while injecting insulin receptor induced diapause-like traits in reproductive females. |
2025-03-30 |
2025-04-03 |
cattle |
| Suélen Santos Alves, Letícia Rossi, Jose Antonio Cortes de Oliveira, Gabriel Servilha-Menezes, Mariana Grigorio-de-Sant'Ana, Rodrigo Focosi Mazzei, Sebastião Sousa Almeida, Adriano Sebollela, Rui Milton Patrício da Silva Junior, Norberto Garcia-Cairasc. Metformin Improves Spatial Memory and Reduces Seizure Severity in a Rat Model of Epilepsy and Alzheimer's Disease comorbidity via PI3K/Akt Signaling Pathway. Molecular neurobiology. 2025-03-24. PMID:40126600. |
these results suggest that chronic met treatment alleviates behaviors related to both ad and epilepsy in wars and modulates insulin signaling independently of insulin receptor activation. |
2025-03-24 |
2025-03-26 |
rat |
| Mirna Ezzat Sedrak Sorial, Ragwa Mansour Abdelghany, Nesrine Salah El Dine El Saye. Modulation of the cognitive impairment associated with Alzheimer's disease by valproic acid: possible drug repurposing. Inflammopharmacology. 2025-03-20. PMID:40108007. |
insulin receptor desensitization in the brain is hypothesized to cause inhibition of insulin signaling pathway that ultimately causes cognitive deficits seen in sad. |
2025-03-20 |
2025-03-22 |
mouse |
| Huseyin Demirbilek, Maria Melikyan, Violeta Iotova, Sonya Galcheva, Mehmet Nuri Ozbek, Antonia Dastamani, Nino Kheladze, Kineret Mazor-Aronovitch, Maria Clemente, Susann Empting, Klaus Mohnike, Henrik Thybo Christesen, Paul S Thornton, Diva D De Leon, Davelyn Hood, Erin O'Boyle, Brian K Robert. Global, multi-center, repeat-dose, phase 2 study of RZ358 (ersodetug), an insulin receptor antibody, for congenital hyperinsulinism. Med (New York, N.Y.). 2025-03-19. PMID:40107271. |
the safety, pharmacokinetics, and glycemic efficacy of ersodetug, a fully human monoclonal antibody that allosterically and reversibly binds the insulin receptor (insr) and reduces excess insulin action, are being evaluated for the treatment of chi-related hypoglycemia. |
2025-03-19 |
2025-03-22 |
human |
| Henrietta Philippa Seaward Brain, Christiana Georgiou, Helen D Mason, Suman Ric. The effect of Vitamin D (1,25-(OH)2-D3) on human theca and granulosa cell function. Reproduction (Cambridge, England). 2025-03-18. PMID:40100123. |
we also demonstrated that deficient levels of 1,25-(oh)2-d3 down-regulated insulin receptor expression, potentially reducing insulin sensitivity. |
2025-03-18 |
2025-03-21 |
human |
| Rahul Mittal, Karan Prasad, Joana R N Lemos, Giuliana Arevalo, Khemraj Hiran. Unveiling Gestational Diabetes: An Overview of Pathophysiology and Management. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076938. |
excessive gestational weight gain exacerbates insulin resistance through hyperleptinemia, which downregulates insulin receptor expression via jak/stat signaling. |
2025-03-13 |
2025-03-15 |
human |
| Keahi M Horowitz, Alyrene Dorey, B Zane Horowit. Severe hypoglycemia and hypothermia in massive metformin overdose. Clinical toxicology (Philadelphia, Pa.). 2025-03-06. PMID:40047521. |
it does not induce insulin release or act via insulin receptors, so it is not considered a common cause of hypoglycemia, even in overdose. |
2025-03-06 |
2025-03-08 |
Not clear |
| Y J Li, G Q Yang, L Zang, Y Pei, K Chen, J Du, Z H Ly. [Analysis of novel mutations in the insulin receptor gene of a family with type A insulin resistance syndrome]. Zhonghua nei ke za zhi. vol 64. issue 3. 2025-03-06. PMID:40050092. |
[analysis of novel mutations in the insulin receptor gene of a family with type a insulin resistance syndrome]. |
2025-03-06 |
2025-03-09 |
human |
| Y J Li, G Q Yang, L Zang, Y Pei, K Chen, J Du, Z H Ly. [Analysis of novel mutations in the insulin receptor gene of a family with type A insulin resistance syndrome]. Zhonghua nei ke za zhi. vol 64. issue 3. 2025-03-06. PMID:40050092. |
this study aimed to identify mutations in the human insulin receptor gene (insr) and investigate their role in the pathogenesis of severe insulin resistance syndrome. |
2025-03-06 |
2025-03-09 |
human |
| Farah Ali ALQuraishi, Mohammed Ibrahim Rasoo. Impact of INSR (rs2229429) G>A genetic polymorphism on response to exogenous insulin in type 1 diabetic Iraqi patients. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 78. issue 1. 2025-03-02. PMID:40023858. |
aim: to examine prevalence of genotypic distribution, particularly assessing how genetic polymorphisms in insulin receptor gene influence effectiveness of insulin therapy in a sample of iraqi population. |
2025-03-02 |
2025-03-05 |
Not clear |
| Wang-Hsin Lee, Evelyn A Bates, Zachary A Kipp, Sally N Pauss, Genesee J Martinez, Cheavar A Blair, Terry D Hind. Insulin receptor responsiveness governs TGFβ-induced hepatic stellate cell activation: Insulin resistance instigates liver fibrosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 39. issue 5. 2025-03-01. PMID:40022609. |
insulin receptor responsiveness governs tgfβ-induced hepatic stellate cell activation: insulin resistance instigates liver fibrosis. |
2025-03-01 |
2025-03-04 |
human |
| Tucker Hopkins, Cole Ragsdale, Jin Se. Elevated ambient temperature reduces fat storage through the FoxO-mediated insulin signaling pathway. PloS one. vol 20. issue 2. 2025-02-26. PMID:40009607. |
at elevated temperatures, direct targets of foxo, such as insulin receptor (inr), thor (drosophila eukaryotic initiation factor 4e binding protein), and foxo itself, are significantly upregulated, which indicates an inhibition of insulin signaling. |
2025-02-26 |
2025-03-01 |
drosophila_melanogaster |
| Olivia Tyso. Obesity induces systemic insulin resistance via endothelium-specific insulin receptor inhibition. Nature reviews. Endocrinology. 2025-02-26. PMID:40011750. |
obesity induces systemic insulin resistance via endothelium-specific insulin receptor inhibition. |
2025-02-26 |
2025-03-01 |
Not clear |
| Fusun Gundogan, Ming Tong, Suzanne M de la Mont. Association between dietary soy prevention of fetal alcohol spectrum disorder and normalization of placental insulin and insulin-like growth factor signaling networks and downstream effector molecule expression. Gene & protein in disease. vol 3. issue 2. 2025-02-10. PMID:39925675. |
chronic gestational ethanol exposure in rats fed diets containing casein significantly reduced the expression of insulin, insulin receptor, |
2025-02-10 |
2025-02-13 |
rat |