| Andrea Fortova, Andrey V Barkhash, Martina Pychova, Lenka Krbkova, Martin Palus, Jiri Salat, Daniel Ruze. Genetic polymorphisms in innate immunity genes influence predisposition to tick-borne encephalitis. Journal of neurovirology. 2023-10-29. PMID:37898570.
||more specifically, we investigated a possible association between snps rs304478 and rs303212 in the gene interferon induced protein with tetratricopeptide repeats 1 (ifit1), rs7070001 and rs4934470 in the gene interferon induced protein with tetratricopeptide repeats 2 (ifit2), and rig-i (retinoic acid-inducible gene i) encoding gene ddx58 rs311795343, rs10813831, rs17217280 and rs3739674 snps with predisposition to tbe in population of the czech republic, where tbev is highly endemic.
| Serena Martire, Nicole D Navone, Francesca Montarolo, Simona Perga, Antonio Bertolott. A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients. Journal of neuroimmunology. vol 292. 2016-07-12. PMID:26943956.
||we studied the baseline expression level of 25 interferon-regulated genes (mxa, gpr3, il17rc, isg15, trail, oasl, ifit1, ifit2, rsad2, oas3, ifi44l, trim22, il10, cxcl10, stat1, oas1, oas2, ifnar1, ifnar2, ifn\xce\xb2, isg20, ifi6, pkr, irf7, usp18), recurrently proposed in the literature as predictive biomarkers of interferon-beta treatment response, in whole blood of 10 "responders" and 10 "non-responders" multiple sclerosis relapsing-remitting patients, retrospectively selected on the basis of stringent clinical criteria after a five years follow-up.
| J Lee, L Li, N Gretz, J Gebert, S Dihlman. Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers. Oncogene. vol 31. issue 10. 2012-04-24. PMID:21804607.
||among the upregulated genes that were validated by quantitative pcr and western blotting we recognized several interferon-stimulated genes (isgs: ifit1, ifit2, ifit3, ifi6, irf7, isg15, hla-dra, hla-drb, tlr3 and ciita), as well as genes involved in intercellular adhesion and matrix remodeling.