| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
here we conducted a nine-week hfd protocol in male rats, followed by an analysis of the gut microbiome diversity and community composition, brainstem serotonergic gene expression (tph2, htr1a, and slc6a4), and anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Maria Jose Ortuno, Marc Schneeberger, Anoj Ilanges, François Marchildon, Kyle Pellegrino, Jeffrey M Friedman, Patricia Duc. Melanocortin 4 receptor stimulation prevents anti-depressant-associated weight gain in mice caused by long-term fluoxetine exposure. The Journal of clinical investigation. 2021-10-21. PMID:34673574. |
within hours, flx decreased the activity of a subset of brainstem serotonergic neurons by triggering autoinhibitory signaling through the htr1a receptor. |
2021-10-21 |
2023-08-13 |
mouse |
| James E Hassell, James H Fox, Mathew R Arnold, Philip H Siebler, Margaret W Lieb, Dominic Schmidt, Emma J Spratt, Tessa M Smith, Kadi T Nguyen, Chloé A Gates, Kaley S Holmes, K'loni S Schnabel, Kelsey M Loupy, Maike Erber, Christopher A Lowr. Treatment with a heat-killed preparation of Mycobacterium vaccae after fear conditioning enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31175996. |
rats were euthanized on day 21 and brain tissue was sectioned for analysis of tph2, htr1a, slc6a4, slc22a3, and crhr2 mrna expression throughout the brainstem dorsal and median raphe nuclei. |
2020-08-04 |
2023-08-13 |
rat |
| James H Fox, James E Hassell, Philip H Siebler, Mathew R Arnold, Andrew K Lamb, David G Smith, Heidi E W Day, Tessa M Smith, Emma M Simmerman, Alexander A Outzen, Kaley S Holmes, Christopher J Brazell, Christopher A Lowr. Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28888667. |
rats were euthanized on day 11 and brain tissue was sectioned for analysis of mrna expression for genes important in control of brain serotonergic signaling, including tph2, htr1a, slc6a4, and slc22a3, throughout the brainstem dorsal and median raphe nuclei. |
2018-06-06 |
2023-08-13 |
mouse |
| Lukasz Piszczek, Agnieszka Piszczek, Joanna Kuczmanska, Enrica Audero, Cornelius T Gros. Modulation of anxiety by cortical serotonin 1A receptors. Frontiers in behavioral neuroscience. vol 9. 2015-03-11. PMID:25759645. |
in particular, cell-type specific rescue and suppression of htr1a expression in either forebrain principal neurons or brainstem serotonin neurons reached opposite conclusions about the role of the two populations in the anxiety phenotype of the knockout. |
2015-03-11 |
2023-08-13 |
mouse |