| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we found that tph2, htr1a and slc6a4 mrna expression were increased in subregions of the dorsal raphe nucleus in the hfd, relative to control diet. |
2024-05-05 |
2024-05-08 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
here we conducted a nine-week hfd protocol in male rats, followed by an analysis of the gut microbiome diversity and community composition, brainstem serotonergic gene expression (tph2, htr1a, and slc6a4), and anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Fei Wang, Defan Luo, Jianxiang Chen, Cuiqing Pan, Zhongyao Wang, Housheng Fu, Jianbing Xu, Meng Yang, Shaowei Mo, Liying Zhuang, Weifu Wan. Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population. BMC urology. vol 23. issue 1. 2023-05-10. PMID:37161455. |
influence of tph2 and htr1a polymorphisms on lifelong premature ejaculation risk among the chinese han population. |
2023-05-10 |
2023-08-14 |
Not clear |
| Fei Wang, Defan Luo, Jianxiang Chen, Cuiqing Pan, Zhongyao Wang, Housheng Fu, Jianbing Xu, Meng Yang, Shaowei Mo, Liying Zhuang, Weifu Wan. Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population. BMC urology. vol 23. issue 1. 2023-05-10. PMID:37161455. |
the serotonin (5-ht) synthesis rate-limiting enzyme (tph2) and receptor (htr1a) in the 5-ht regulatory system may play a key role in the pathogenesis of lpe. |
2023-05-10 |
2023-08-14 |
Not clear |
| Tomasz Pawlowski, Krzysztof Malyszczak, Dariusz Pawlak, Małgorzata Inglot, Małgorzata Zalewska, Anna Grzywacz, Marek Radkowski, Tomasz Laskus, Justyna Janocha-Litwin, Dorota Frydeck. HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV). Cells. vol 12. issue 6. 2023-03-29. PMID:36980311. |
seeing that there are no data about associations between serotonin gene polymorphism and tryptophan catabolite concentration during peg-ifn-α2a treatment, the aim of the current study is to examine (a) the associations between polymorphisms within the htr1a, tph2, and 5-htt genes and the severity of depression symptoms and (b) the relationships among rs6295, rs4570625, and 5-httlpr rs25531polymorphisms and indoleamine 2,3-dioxygenase (ido) activity, as well as kynurenine (kyn), tryptophan (trp), kynurenic acid (ka), and anthranilic acid (aa) concentrations. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
the shh ligand activates two main transcriptional factors known as foxa2 and nkx2.2, which again activates another transcriptional factor, gata (gata2 and gata3), in post mitotic precursor cells of serotonergic neurons-following increased expression of pet-1 and lmx1b after gata regulates the expression of many serotonergic enzymes such as tph2, sert, vmat, slc6a4, htr1a, htr1b (serotonin receptor enzymes), and mao that regulate and control the release of serotonin and maintain their neuronal identity after their maturation. |
2022-10-22 |
2023-08-14 |
Not clear |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
abbreviation: foxa2: forkhead box; gata: globin transcription factor; lmx1b: lim homeobox transcription factor 1 beta; tph2: tryptophan hydroxylase 2; htr1a: serotonin receptor 1a; htr1b: serotonin receptor 1b; sert: serotonin transporter; vmat: vesicular monoamine transporter; mao: monoamine oxidase. |
2022-10-22 |
2023-08-14 |
Not clear |
| Jiabin Hong, Xiaoxun Lu, Jieyu Wang, Mengzhu Jiang, Qian Liu, Juntong Lin, Wenjing Sun, Jing Zhang, Yanwei Shi, Xiaoshan Li. Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavior abnormal in male offspring. Ecotoxicology and environmental safety. vol 243. 2022-08-25. PMID:36007322. |
the expression of serotonergic neuron gene markers including tph2, htr1a, htr2a, pet1 and lmx1b in the hippocampus of treatment group was significantly decreased. |
2022-08-25 |
2023-08-14 |
mouse |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
serotonergic genes studied included tph2, the high-affinity, low-capacity, sodium-dependent serotonin transporter (slc6a4), the serotonin type 1a receptor (htr1a), and the corticosterone-sensitive, low-affinity, high-capacity sodium-independent serotonin transporter, organic cation transporter 3 (slc22a3). |
2020-09-14 |
2023-08-13 |
mouse |
| James E Hassell, James H Fox, Mathew R Arnold, Philip H Siebler, Margaret W Lieb, Dominic Schmidt, Emma J Spratt, Tessa M Smith, Kadi T Nguyen, Chloé A Gates, Kaley S Holmes, K'loni S Schnabel, Kelsey M Loupy, Maike Erber, Christopher A Lowr. Treatment with a heat-killed preparation of Mycobacterium vaccae after fear conditioning enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31175996. |
rats were euthanized on day 21 and brain tissue was sectioned for analysis of tph2, htr1a, slc6a4, slc22a3, and crhr2 mrna expression throughout the brainstem dorsal and median raphe nuclei. |
2020-08-04 |
2023-08-13 |
rat |
| Afërdita Goçi Uka, Ferid Agani, Afrim Blyta, Blerina Hoxha, Shpend Haxhibeqiri, Valdete Haxhibeqiri, Emina Sabic Dzananovic, Sabina Kucukalic, Alma Bravo Mehmedbasic, Abdulah Kucukalic, Alma Dzubur-Kulenovic, Elma Feric Bojic, Damir Marjanovic, Nermina Kravic, Esmina Avdibegovic, Mirnesa Muminovic Umihanic, Nenad Jaksic, Ana Cima Franc, Dusko Rudan, Miro Jakovljevic, Romana Babic, Marko Pavlovic, Dragan Babic, Branka Aukst Margetic, Nada Bozina, Osman Sinanovic, Christiane Ziegler, Bodo Warrings, Katharina Domschke, Jürgen Deckert, Christiane Wol. Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD. Psychiatria Danubina. vol 31. issue 2. 2019-09-16. PMID:31291234. |
the aim of this study was to investigate the potential role of single nucleotide polymorphisms (snps) of the two serotonergic candidate genes 5-hydroxytryptamine receptor 1a (htr1a) and tryptophan hydroxylase 2 (tph2) in the pathogenesis of ptsd and comorbid psychopathology. |
2019-09-16 |
2023-08-13 |
Not clear |
| Afërdita Goçi Uka, Ferid Agani, Afrim Blyta, Blerina Hoxha, Shpend Haxhibeqiri, Valdete Haxhibeqiri, Emina Sabic Dzananovic, Sabina Kucukalic, Alma Bravo Mehmedbasic, Abdulah Kucukalic, Alma Dzubur-Kulenovic, Elma Feric Bojic, Damir Marjanovic, Nermina Kravic, Esmina Avdibegovic, Mirnesa Muminovic Umihanic, Nenad Jaksic, Ana Cima Franc, Dusko Rudan, Miro Jakovljevic, Romana Babic, Marko Pavlovic, Dragan Babic, Branka Aukst Margetic, Nada Bozina, Osman Sinanovic, Christiane Ziegler, Bodo Warrings, Katharina Domschke, Jürgen Deckert, Christiane Wol. Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD. Psychiatria Danubina. vol 31. issue 2. 2019-09-16. PMID:31291234. |
role of the allelic variation in the 5-hydroxytryptamine receptor 1a (htr1a) and the tryptophan hydroxylase 2 (tph2) genes in the development of ptsd. |
2019-09-16 |
2023-08-13 |
Not clear |
| A G Galyamina, I L Kovalenko, D A Smagin, N N Kudryavtsev. [Altered Expression of Neurotransmitters Systems' Genes in the Ventral Tegmental Area of Depressive Male Mice: Data of RNA-Seq]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 67. issue 1. 2019-02-19. PMID:30695556. |
'we found that genes, related with serotonin (tph2, maob, sic6a4, htr4, htr1a) were upregulated but expression of htr3a gene was downregulated in the ventral tegmental area of depressive mice in comparison with the control. |
2019-02-19 |
2023-08-13 |
mouse |
| J H Piel, T A Lett, C Wackerhagen, M M Plichta, S Mohnke, O Grimm, N Romanczuk-Seiferth, F Degenhardt, H Tost, S Witt, M Nöthen, M Rietschel, A Heinz, A Meyer-Lindenberg, H Walter, S Er. The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 3. 2019-01-29. PMID:29358097. |
while effects of 5-httlpr and of a serotonergic multi-marker score (5-httlpr, tph1(rs1800532), tph2(rs4570625), htr1a(rs6295) and htr2a(rs6311)) on amygdala activation did not withstand correction for multiple regions of interest, we observed a strong correlation of the multi-marker score and habituation in the amygdala, dlpfc, and acc. |
2019-01-29 |
2023-08-13 |
human |
| James H Fox, James E Hassell, Philip H Siebler, Mathew R Arnold, Andrew K Lamb, David G Smith, Heidi E W Day, Tessa M Smith, Emma M Simmerman, Alexander A Outzen, Kaley S Holmes, Christopher J Brazell, Christopher A Lowr. Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28888667. |
rats were euthanized on day 11 and brain tissue was sectioned for analysis of mrna expression for genes important in control of brain serotonergic signaling, including tph2, htr1a, slc6a4, and slc22a3, throughout the brainstem dorsal and median raphe nuclei. |
2018-06-06 |
2023-08-13 |
mouse |
| Victoria S Marshe, Malgorzata Maciukiewicz, Soham Rej, Arun K Tiwari, Etienne Sibille, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Charles F Reynolds, James L Kennedy, Benoit H Mulsant, Daniel J Mülle. Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults. The American journal of psychiatry. vol 174. issue 5. 2017-06-19. PMID:28068779. |
a secondary objective was to analyze 17 other variants in serotonergic system genes (htr1a, htr2a, htr1b, htr2c, tph1, tph2) potentially involved in the mechanism of action of venlafaxine. |
2017-06-19 |
2023-08-13 |
Not clear |
| Suzanne Vrshek-Schallhorn, Catherine B Stroud, Susan Mineka, Richard E Zinbarg, Emma K Adam, Eva E Redei, Constance Hammen, Michelle G Crask. Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression. Journal of abnormal psychology. vol 124. issue 4. 2016-12-13. PMID:26595467. |
in a first demonstration of this approach in a g×e predicting depression, we created an additive multilocus profile score from 5 serotonin system polymorphisms (1 each in the genes htr1a, htr2a, htr2c, and 2 in tph2). |
2016-12-13 |
2023-08-13 |
Not clear |
| Marta Sadkowski, Brittany Dennis, Robert C Clayden, Wala Elsheikh, Sumathy Rangarajan, Jane Dejesus, Zainab Samaa. The role of the serotonergic system in suicidal behavior. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24235834. |
these genes - tph1, tph2, slc6a4, slc18a2, htr1a, htr1b, htr2a, ddc, maoa, and maob - encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-htt; the vesicular transporter vmat2; the htr1a, htr1b, and htr2a receptors; the l-amino acid decarboxylase; and the monoamine oxidases. |
2014-06-24 |
2023-08-12 |
Not clear |
| Niki Antypa, Alessandro Serretti, Dan Rujesc. Serotonergic genes and suicide: a systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23742855. |
in this paper, we review evidence from studies examining the association between various serotonergic genes (tryptophan hydroxylase genes: tph1; tph2, serotonin transporter gene: 5-httlpr in slc6a4, serotonin receptor genes: htr1a, htr2a, htr1b, htr2c and monoamine oxidase a gene: maoa) and suicidal behavior. |
2014-04-24 |
2023-08-12 |
Not clear |