| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we show that hfd intake decreased alpha diversity and altered the community composition of the gut microbiome in association with obesity, increased brainstem tph2, htr1a and slc6a4 mrna expression, including in the caudal part of the dorsomedial dorsal raphe nucleus (cdrd), a subregion previously associated with stress- and anxiety-related behavioral responses, and, finally, increased anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
we found that tph2, htr1a and slc6a4 mrna expression were increased in subregions of the dorsal raphe nucleus in the hfd, relative to control diet. |
2024-05-05 |
2024-05-08 |
rat |
| Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. |
here we conducted a nine-week hfd protocol in male rats, followed by an analysis of the gut microbiome diversity and community composition, brainstem serotonergic gene expression (tph2, htr1a, and slc6a4), and anxiety-related defensive behavioral responses. |
2024-05-05 |
2024-05-08 |
rat |
| Yéssica P López-Echeverri, Kelly J Cardona-Londoño, Jhonny F Garcia-Aguirre, Mary Orrego-Cardoz. Effects of serotonin transporter and receptor polymorphisms on depression. Revista Colombiana de psiquiatria (English ed.). 2023-07-15. PMID:37453823. |
serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-htt, slc6a4) and the serotonin receptor genes (htr1a, htr1b, htr2a) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics. |
2023-07-15 |
2023-08-14 |
Not clear |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
the shh ligand activates two main transcriptional factors known as foxa2 and nkx2.2, which again activates another transcriptional factor, gata (gata2 and gata3), in post mitotic precursor cells of serotonergic neurons-following increased expression of pet-1 and lmx1b after gata regulates the expression of many serotonergic enzymes such as tph2, sert, vmat, slc6a4, htr1a, htr1b (serotonin receptor enzymes), and mao that regulate and control the release of serotonin and maintain their neuronal identity after their maturation. |
2022-10-22 |
2023-08-14 |
Not clear |
| Yéssica P López-Echeverri, Kelly J Cardona-Londoño, Jhonny F Garcia-Aguirre, Mary Orrego-Cardoz. Effects of Serotonin Transporter and Receptor Polymorphisms on Depression. Revista Colombiana de psiquiatria (English ed.). 2021-10-07. PMID:34493397. |
serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-htt, slc6a4) and the serotonin receptor genes (htr1a, htr1b, htr2a) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics. |
2021-10-07 |
2023-08-13 |
Not clear |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
serotonergic genes studied included tph2, the high-affinity, low-capacity, sodium-dependent serotonin transporter (slc6a4), the serotonin type 1a receptor (htr1a), and the corticosterone-sensitive, low-affinity, high-capacity sodium-independent serotonin transporter, organic cation transporter 3 (slc22a3). |
2020-09-14 |
2023-08-13 |
mouse |
| James E Hassell, James H Fox, Mathew R Arnold, Philip H Siebler, Margaret W Lieb, Dominic Schmidt, Emma J Spratt, Tessa M Smith, Kadi T Nguyen, Chloé A Gates, Kaley S Holmes, K'loni S Schnabel, Kelsey M Loupy, Maike Erber, Christopher A Lowr. Treatment with a heat-killed preparation of Mycobacterium vaccae after fear conditioning enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31175996. |
rats were euthanized on day 21 and brain tissue was sectioned for analysis of tph2, htr1a, slc6a4, slc22a3, and crhr2 mrna expression throughout the brainstem dorsal and median raphe nuclei. |
2020-08-04 |
2023-08-13 |
rat |
| Nicky Staes, Chet C Sherwood, Hani Freeman, Sarah F Brosnan, Steven J Schapiro, William D Hopkins, Brenda J Bradle. Serotonin Receptor 1A Variation Is Associated with Anxiety and Agonistic Behavior in Chimpanzees. Molecular biology and evolution. vol 36. issue 7. 2020-01-30. PMID:31045220. |
polymorphisms in genes coding for the serotonin receptor subtype 1a (htr1a), the serotonin transporter (slc6a4), and the serotonin degrading enzyme monoamine oxidase a (maoa) are associated with anxiety, impulsivity, and neurotic personality in humans. |
2020-01-30 |
2023-08-13 |
Not clear |
| Christina Schlecker, Alfred Ultsch, Gerd Geisslinger, Jörn Lötsc. The pharmacogenetic background of hepatitis C treatment. Mutation research. Reviews in mutation research. vol 751. issue 1. 2019-11-20. PMID:22409946. |
however, a search in pubmed identified 41 genes reportedly modulating the individual therapy response, e.g., genes coding for major histocompatibility complex (hla), the tumor necrosis factor (tnf), interleukin 10 (il10), other interferon coding genes than il28b (e.g., ifnar1, ifnar2, ifng), several components of downstream interferon signaling as well as genes modulating side effects of current anti-hcv therapeutics (e.g., slc28a3, itpa involved in ribavirin associated hemolytic effects or slc6a4 and htr1a involved in serotonin associated psychiatric side effects). |
2019-11-20 |
2023-08-12 |
Not clear |
| James H Fox, James E Hassell, Philip H Siebler, Mathew R Arnold, Andrew K Lamb, David G Smith, Heidi E W Day, Tessa M Smith, Emma M Simmerman, Alexander A Outzen, Kaley S Holmes, Christopher J Brazell, Christopher A Lowr. Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28888667. |
rats were euthanized on day 11 and brain tissue was sectioned for analysis of mrna expression for genes important in control of brain serotonergic signaling, including tph2, htr1a, slc6a4, and slc22a3, throughout the brainstem dorsal and median raphe nuclei. |
2018-06-06 |
2023-08-13 |
mouse |
| Huali Lin, Ying Lei, Bo Zhang, Zunxiao Dai, Xiaoyun L. Common variants of HTR1A and SLC6A4 confer the increasing risk of Schizophrenia susceptibility: A population-based association and epistasis analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168. issue 8. 2016-09-08. PMID:26408209. |
common variants of htr1a and slc6a4 confer the increasing risk of schizophrenia susceptibility: a population-based association and epistasis analysis. |
2016-09-08 |
2023-08-13 |
human |
| Huali Lin, Ying Lei, Bo Zhang, Zunxiao Dai, Xiaoyun L. Common variants of HTR1A and SLC6A4 confer the increasing risk of Schizophrenia susceptibility: A population-based association and epistasis analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168. issue 8. 2016-09-08. PMID:26408209. |
recent studies evaluating the association between sz and genetic polymorphisms in a serotonin transporter (encoded by slc6a4) and serotonin receptor 1a (encoded by htr1a) show conflicting results. |
2016-09-08 |
2023-08-13 |
human |
| Marta Sadkowski, Brittany Dennis, Robert C Clayden, Wala Elsheikh, Sumathy Rangarajan, Jane Dejesus, Zainab Samaa. The role of the serotonergic system in suicidal behavior. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24235834. |
these genes - tph1, tph2, slc6a4, slc18a2, htr1a, htr1b, htr2a, ddc, maoa, and maob - encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-htt; the vesicular transporter vmat2; the htr1a, htr1b, and htr2a receptors; the l-amino acid decarboxylase; and the monoamine oxidases. |
2014-06-24 |
2023-08-12 |
Not clear |
| Niki Antypa, Alessandro Serretti, Dan Rujesc. Serotonergic genes and suicide: a systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23742855. |
in this paper, we review evidence from studies examining the association between various serotonergic genes (tryptophan hydroxylase genes: tph1; tph2, serotonin transporter gene: 5-httlpr in slc6a4, serotonin receptor genes: htr1a, htr2a, htr1b, htr2c and monoamine oxidase a gene: maoa) and suicidal behavior. |
2014-04-24 |
2023-08-12 |
Not clear |
| Jae-Won Kim, Hyo-Sang Ahn, Ja-Hyun Baik, Bong-June Yoo. Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice. Journal of psychopharmacology (Oxford, England). vol 27. issue 2. 2013-09-30. PMID:22992375. |
an analysis of the expression of serotonergic genes after exposure to social defeat stress revealed small but significant changes in the expression of 5-ht1a receptor gene (htr1a) and 5-htt gene (slc6a4) in the mice treated with clomipramine compared with the mice injected with saline. |
2013-09-30 |
2023-08-12 |
mouse |
| Gabor Varga, Anna Szekely, Peter Antal, Peter Sarkozy, Zsofia Nemoda, Zsolt Demetrovics, Maria Sasvari-Szekel. Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 3. 2012-10-05. PMID:22259185. |
here we report an association study of both dopaminergic (comt rs4680, drd4 48 bp vntr, drd2/ankk1 rs1800497) and serotonergic (htr1a rs6925, htr1b rs13212041, slc6a4 5-httlpr) gene polymorphisms and trait impulsivity assessed with the barratt impulsiveness scale (bis-11) in a sample of 687 caucasian young adults. |
2012-10-05 |
2023-08-12 |
Not clear |
| Yuka Abe, Takeshi Suganuma, Masakazu Ishii, Gou Yamamoto, Tomohiko Gunji, Glenn T Clark, Tetsuhiko Tachikawa, Yuji Kiuchi, Yoshimasa Igarashi, Kazuyoshi Bab. Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population. Journal of sleep research. vol 21. issue 3. 2012-10-04. PMID:22545912. |
in addition, 13 polymorphisms in four genes related to serotonergic neurotransmission (slc6a4, htr1a, htr2a and htr2c) were genotyped. |
2012-10-04 |
2023-08-12 |
human |
| Ulrich Rabl, Christian Scharinger, Markus Müller, Lukas Pezawa. Imaging genetics: implications for research on variable antidepressant drug response. Expert review of clinical pharmacology. vol 3. issue 4. 2012-10-02. PMID:22111678. |
genetic variation of slc6a4, htr1a, maoa, comt and bdnf has been associated with depression, variable antidepressant drug responses as well as impacts on brain regions of emotion processing that are modulated by antidepressants. |
2012-10-02 |
2023-08-12 |
Not clear |
| Melinda Bence, Julia Koller, Maria Sasvari-Szekely, Gergely Keszle. Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 1. 2012-05-07. PMID:21785940. |
to this end, short-term parallel cultures of sk-nf-i neuroblastoma cells were treated with tsa either alone or in combination with hypoxia, and mrna levels of dopamine receptor d3 (drd3) and d4 (drd4), dopamine transporter (dat), dopamine hydroxylase (dbh), dopamine receptor regulating factor (drrf), catechol-o-methyltransferase (comt), serotonin receptor 1a (htr1a), monoamino oxidase a (mao-a), serotonin transporter (slc6a4) and tryptophan hydroxylase 2 (tph2) were determined by quantitative pcr. |
2012-05-07 |
2023-08-12 |
human |