| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minhaz Zabin Saif, Nusrat Jahan Ikbal Esha, Syeda Tasnim Quayum, Shofiur Rahman, Mahmoud A Al-Gawati, Ghadah Alsowygh, Hamad Albrithen, Abdullah N Alodhayb, Raymond A Poirier, Kabir M Uddi. Investigating the potential of 6-substituted 3-formyl chromone derivatives as anti-diabetic agents using in silico methods. Scientific reports. vol 14. issue 1. 2024-06-08. PMID:38851807. |
pass prediction revealed that 3-formyl chromone derivatives are potent aldehyde oxidase inhibitors, insulin inhibitors, hif1a expression inhibitors, and histidine kinase. |
2024-06-08 |
2024-06-11 |
Not clear |
| Huiping Liu, Yongnian Zhou, Yike Li, Zhihua Gon. Important roles of Hif1a in maternal or adult BPA exposure induced pancreatic injuries. Scientific reports. vol 13. issue 1. 2023-07-17. PMID:37460698. |
seventeen insulin secretion-related degs (stxbp5l, fam3d, mia3, igf1, hif1a, aqp1, kif5b, tiam1, map4k4, cyp51, pde1c, rab3c, arntl, clock, edn3, kcnb1, and krt20) in the bpa group were identified, and 15 regulator degs (zfp830, 4931431b13rik, egr1, ddit4l, cep55, g530011o06rik, hspa1b, hspa1a, cox6a2, ibtk, banf1, slc35b2, golt1b, lrp8, and pttg1) with opposite expression trends and a regulator gene cerkl with the similar expression trend in the control and bpa groups were identified. |
2023-07-17 |
2023-08-14 |
human |
| Zhijue Xu, Peng Qiu, Yihong Jiang, Jiateng Hu, Zhaoyu Wu, Jiahao Lei, Hongji Pu, Qun Huang, Xin Wang, Bo Li, Kaichuang Ye, Xinwu Lu, Guang Li. m6A Modification Mediates Endothelial Cell Responses to Oxidative Stress in Vascular Aging Induced by Low Fluid Shear Stress. Oxidative medicine and cellular longevity. vol 2023. 2023-02-06. PMID:36743697. |
functional annotations enriched by the hypermethylated and hypomethylated genes at low fss revealed that the m6a modifications were clustered in the aging-related signaling pathways of mtor, pi3k-akt, insulin, and errb and in the oxidative stress-related transcriptional factors, such as hif1a, nfat5, and nfe2l2. |
2023-02-06 |
2023-08-14 |
Not clear |
| Woobeen Jo, Min Kim, Jiyoung Oh, Chu-Sook Kim, Chanho Park, Sora Yoon, Changhu Lee, Sahee Kim, Dougu Nam, Jiyoung Par. MicroRNA-29 Ameliorates Fibro-Inflammation and Insulin Resistance in HIF1α-Deficient Obese Adipose Tissue by Inhibiting Endotrophin Generation. Diabetes. 2022-02-15. PMID:35167651. |
adipocyte-specific hif1a knock-out (apn-hif1αko) mice fed a chronic high-fat diet exhibited the significant amelioration of both local fibro-inflammation in at and systemic insulin resistance compared to the control littermates, partly through the inhibition of endotrophin generation. |
2022-02-15 |
2023-08-13 |
mouse |
| Karima Drareni, Raphaëlle Ballaire, Serena Barilla, Mano J Mathew, Amine Toubal, Rongrong Fan, Ning Liang, Catherine Chollet, Zhiqiang Huang, Maria Kondili, Fabienne Foufelle, Antoine Soprani, Ronan Roussel, Jean-François Gautier, Fawaz Alzaid, Eckardt Treuter, Nicolas Ventecle. GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation. Cell reports. vol 24. issue 11. 2019-12-02. PMID:30208320. |
correlation analysis of gene expression in human adipose tissue reveals a negative relationship between gps2 and hif1a, adipocyte hypertrophy, and insulin resistance. |
2019-12-02 |
2023-08-13 |
mouse |
| Lorna W Harries, Alexander D Fellows, Luke C Pilling, Dena Hernandez, Andrew Singleton, Stefania Bandinelli, Jack Guralnik, Jonathan Powell, Luigi Ferrucci, David Melze. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mechanisms of ageing and development. vol 133. issue 8. 2012-12-31. PMID:22813852. |
genes involved in insulin signaling (pten, pi3k, pdk1), ribosomal biogenesis (s6k), lipid metabolism (srebf1), cellular apoptosis (sgk1), angiogenesis (vegfb), insulin production and sensitivity (foxo), cellular stress response (hif1a) and cytoskeletal remodeling (pkc) were inversely correlated with age, whereas genes relating to inhibition of ribosomal components (4ebp1) and inflammatory mediators (stat3) were positively associated with age in one or both datasets. |
2012-12-31 |
2023-08-12 |
human |