| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas Downes, Henri Niskanen, Vanesa Tomas Bosch, Mari Taipale, Mehvash Godiwala, Mari-Anna V\\xc3\\xa4\\xc3\\xa4n\\xc3\\xa4nen, Tiia A Turunen, Einari Aavik, Nihay Laham-Karam, Seppo Yl\\xc3\\xa4-Herttuala, Minna U Kaikkone. Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription. The Journal of biological chemistry. vol 299. issue 11. 2023-10-28. PMID:37748649. |
notably, we identify a novel antisense long noncoding rna that convergently overlaps the majority of the hypoxia inducible factor 1 alpha (hif1a) locus, which is expressed across several cell types and elevated in atherosclerotic lesions. |
2023-10-28 |
2023-11-08 |
Not clear |
| Xi-Ying Tan, Jing Tao, Yu Zhang, Ru-Xin G. [Mechanism of Astragali Radix-Curcumae Rhizoma in treating gastric cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802848. |
the cell experiments demonstrated that hqez significantly downregulated the expression of atp-binding cassette subfamily b member 1(abcb1), epidermal growth factor receptor(egfr), phosphorylated serine/threonine kinase(p-akt), hypoxia inducible factor 1 subunit alpha(hif1a), b-cell lymphoma 2(bcl2), breast cancer susceptibility protein 1(brca1), dna polymerase theta(polh), ribonucleotide reductase m1(rrm1), and excision repair cross-complementation group 1(ercc1), and upregulated the expression of tumor protein p53(tp53) and cysteinyl aspartate-specific proteinase(caps3). |
2023-10-06 |
2023-10-15 |
Not clear |
| Yan Meng, Kai-Wen Kong, Yong-Qing Chang, Xiao-Ming Deng, Tao Yan. Histone methyltransferase SETD2 inhibits M1 macrophage polarization and glycolysis by suppressing HIF-1\\xce\\xb1 in sepsis-induced acute lung injury. Medical microbiology and immunology. 2023-09-01. PMID:37658121. |
luciferase reporter assay and chromatin immunoprecipitation assay were conducted to detect the binding of setd2 or h3k36me3 with the hypoxia-inducible factor 1, alpha subunit (hif1a) gene. |
2023-09-01 |
2023-09-07 |
mouse |
| Shufang Wang, Xihua Chen, Shige Guo, Fang Zhou, Xin Zhang, Cong Lu, Xuqing Yang, Qianxing Wang, Bin He, Jiedong Wang, Hanbi Wang, Xiangbo X. CXCR4, regulated by HIF1A, promotes endometrial breakdown via CD45 Reproductive biology. vol 23. issue 3. 2023-07-01. PMID:37392490. |
this study aimed to clarify the role of cxcr4 in endometrial breakdown and its regulation by hypoxia-inducible factor-1 alpha (hif1a). |
2023-07-01 |
2023-08-14 |
mouse |
| Chengyi Dai, Yuhang Li. Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis. Scientific reports. vol 13. issue 1. 2023-05-26. PMID:37237021. |
we combined cross-validation results from multiple databases to predict that hcg17-hsa-mir-424-5p-hif1a, a competitive endogenous rna (cerna) network, may regulate hypoxia inducible factor 1 subunit alpha (hif1a) expression. |
2023-05-26 |
2023-08-14 |
mouse |
| Bingtan Kong, Jie Zhou, Hao Wang, Yinan Li, Yuancan Pan, Hui Zhu, Qing Zhang, Qingsheng Fan, Xiaomin Wang, Ganlin Zhan. Histopathological growth pattern evolution of tumor in VX2 liver cancer model. Pathology, research and practice. vol 244. 2023-03-11. PMID:36905696. |
additionally, fibrin deposition and neovascularization were evaluated by masson staining and immunohistochemical analysis of cd31, hypoxia-inducible factor-1 alpha (hif1a) and vascular endothelial growth factor (vegf). |
2023-03-11 |
2023-08-14 |
Not clear |
| Ning Zhang, Da Huang, Xiaohao Ruan, Ada Tsui-Lin Ng, James Hok-Leung Tsu, Guangliang Jiang, Jingyi Huang, Yongle Zhan, Rong N. CRISPR screening reveals gleason score and castration resistance related oncodriver ring finger protein 19 A (RNF19A) in prostate cancer. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 67. 2023-01-09. PMID:36623445. |
mechanistically, transcriptomics, quantitative and ubiquitination proteomic analysis showed that rnf19a ubiquitylated thyroid hormone receptor interactor 13 (trip13) and was transcriptionally activated by androgen receptor (ar) and hypoxia inducible factor 1 subunit alpha (hif1a). |
2023-01-09 |
2023-08-14 |
Not clear |
| Ruipeng Wang, Xiaoye Qiao, Xiaobin Wan. Exploring the mechanisms of Gui Zhi Fu Ling Wan on varicocele via network pharmacology and molecular docking. Andrologia. 2022-11-13. PMID:36372090. |
the main targets of the active components on vc were tumour protein p53 (tp53), tumour necrosis factor (tnf), hypoxia inducible factor 1 subunit alpha (hif1a), interleukin-6 (il-6), caspase 3 (casp3), catalase (cat), prostaglandin-endoperoxide synthase 2 (ptgs2), vascular endothelial growth factor a (vegfa). |
2022-11-13 |
2023-08-14 |
cat |
| Yuxiang Zhang, Saidi Wang, Haiyan Hu, Xiaoman L. A systematic study of HIF1A cofactors in hypoxic cancer cells. Scientific reports. vol 12. issue 1. 2022-11-08. PMID:36347941. |
hypoxia inducible factor 1 alpha (hif1a) is a transcription factor (tf) that forms highly structural and functional protein-protein interactions with other tfs to promote gene expression in hypoxic cancer cells. |
2022-11-08 |
2023-08-14 |
Not clear |
| Ujjaldeep Jaggi, Harry H Matundan, Dhong Hyun Lee, Homayon Ghias. Blocking Autophagy in M1 Macrophages Enhances Virus Replication and Eye Disease in Ocularly Infected Transgenic Mice. Journal of virology. 2022-10-26. PMID:36286481. |
analysis of 62 autophagy genes and 32 cytokines/chemokines from infected bone marrow-derived macrophages from m1-\xce\xb334.5, m2-\xce\xb334.5, and wt mice suggested that upregulation of autophagy-blocking genes (i.e., hif1a, mtmr14, mtor, mtmr3, stk11, and ulk2) and the inflammatory tumor necrosis factor alpha (tnf-\xce\xb1) gene in m1-\xce\xb334.5 transgenic mice correlated with increased pathogenicity, while upregulation of proautophagy genes (nrbf2 and rb1cc1) in m2-\xce\xb334.5 macrophages correlated with reduced pathogenicity. |
2022-10-26 |
2023-08-14 |
mouse |
| Nattawan Suwannakul, Napat Armartmuntree, Raynoo Thanan, Kaoru Midorikawa, Tetsuo Kon, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murat. Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma. Genes & diseases. vol 9. issue 6. 2022-09-26. PMID:36157482. |
furthermore, in the metabolic pathways of fructolysis-warburg effect, the expression levels of relative downstream genes, including ketohexokinase (khk), aldolase b (aldob), lactate dehydrogenase a (ldha), and monocarboxylate transporter 4 (mct4), as well as hypoxia-inducible factor 1 alpha (hif1a), were altered in a glut5 expression-dependent manner. |
2022-09-26 |
2023-08-14 |
mouse |
| Zuoxiang Wang, Zhisong He, Qinkao Xuan, Yue Zhang, Jialiang Xu, Jia Lin, Hongxia Li, Weixiang Chen, Tingbo Jian. Analysis of the potential ferroptosis mechanism and multitemporal expression change of central ferroptosis-related genes in cardiac ischemia-reperfusion injury. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091399. |
a total of 43 defrgs and 7 hub genes (tumor protein p53 [tp53], tumor necrosis factor [tnf], hypoxia-inducible factor 1 subunit alpha [hif1a], interleukin 6 [il6], heme oxygenase 1 [hmox1], x-box binding protein 1 [xbp1], and caspase 8 [casp8]) were screened based on bioinformatics analysis. |
2022-09-12 |
2023-08-14 |
rat |
| Xueling Zhang, Jini Qiu, Feifei Huang, Peizhen Han, Kun Shan, Chaoran Zhan. Construction and verification of a hypoxia-related nine-gene prognostic model in uveal melanoma based on integrated single-cell and bulk RNA sequencing analyses. Experimental eye research. 2022-08-18. PMID:35981602. |
it is reported that the increased expression of hypoxia inducible factor 1 alpha subunit (hif1a), a hypoxia-related molecule, is associated with worse prognoses of um patients. |
2022-08-18 |
2023-08-14 |
Not clear |
| Danfei Liu, Xiangyuan Luo, Meng Xie, Tongyue Zhang, Xiaoping Chen, Bixiang Zhang, Mengyu Sun, Yijun Wang, Yangyang Feng, Xiaoyu Ji, Yiwei Li, Bifeng Liu, Wenjie Huang, Limin Xi. HNRNPC downregulation inhibits IL-6/STAT3-mediated HCC metastasis by decreasing HIF1A expression. Cancer science. 2022-07-18. PMID:35848884. |
the decreased expression of hypoxia inducible factor 1 subunit alpha (hif1a) was identified as the molecular mechanism underlying hnrnpc downregulation inhibited hcc metastasis by rna sequencing. |
2022-07-18 |
2023-08-14 |
human |
| Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Ada. Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape. Journal of hematology & oncology. vol 15. issue 1. 2022-06-06. PMID:35659268. |
studies have demonstrated that hypoxia and hypoxia-inducible factors (hifs) 1 and 2 alpha (hif1a and hif2a) are involved in tumor immune escape. |
2022-06-06 |
2023-08-14 |
Not clear |
| Wenjing Xiao, Wei Geng, Mei Zhou, Juanjuan Xu, Sufei Wang, Qi Huang, Yice Sun, Yumei Li, Guanghai Yang, Yang Ji. POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway. Cell death & disease. vol 13. issue 5. 2022-05-03. PMID:35504868. |
mechanistically, pou6f1 bound and stabilized retinoid-related orphan receptor alpha (rora) to exert the transcriptional inhibition of hypoxia-inducible factor 1-alpha (hif1a) and alter the expression of hif1a signaling pathway-associated genes, including eno1, pdk1, and prkcb, thereby leading to the suppression of luad cells. |
2022-05-03 |
2023-08-13 |
mouse |
| Vidhi M Shah, Craig Dorrell, Adel Al-Fatease, Brittany L Allen-Petersen, Yeonhee Woo, Yuliya Bortnyak, Rohi Gheewala, Brett C Sheppard, Rosalie C Sears, Adam Wg Alan. Microfluidics Formulated Liposomes of Hypoxia Activated Prodrug for Treatment of Pancreatic Cancer. Pharmaceutics. vol 14. issue 4. 2022-04-23. PMID:35456547. |
in patient-derived 3d organoids, cpd100li exhibited higher cell inhibition in the organoids that displayed higher expression of hypoxia-inducible factor 1 alpha (hif1a) compared to cpd100. |
2022-04-23 |
2023-08-13 |
Not clear |
| Tomas Novotny, Adam Eckhardt, Martina Doubkova, Jarmila Knitlova, David Vondrasek, Eliska Vanaskova, Martin Ostadal, Jiri Uhlik, Lucie Bacakova, Jana Musilkov. The possible role of hypoxia in the affected tissue of relapsed clubfoot. Scientific reports. vol 12. issue 1. 2022-03-16. PMID:35292718. |
we found a significant increase in the levels of smooth muscle actin, transforming growth factor-beta, hypoxia-inducible factor 1 alpha, lysyl oxidase, lysyl oxidase-like 2, tenascin c, matrix metalloproteinase-2, matrix metalloproteinase-9, fibronectin, collagen types iii and vi, hemoglobin subunit alpha and hemoglobin subunit beta, and an overexpression of acta2, fn1, tgfb1, hif1a and mmp2 genes in the contracted medial side tissue of clubfoot. |
2022-03-16 |
2023-08-13 |
Not clear |
| Magdalena Szymanska, Sarah Manthe, Ketan Shrestha, Eliezer Girsh, Avi Harlev, Tatiana Kisliouk, Rina Meida. Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible factor 1 alpha and epigenetic modifications\\xe2\\x80\\xa0. Biology of reproduction. vol 104. issue 2. 2021-11-26. PMID:33112382. |
endothelin-2 (edn2) expression in granulosa cells was previously shown to be highly dependent on the hypoxic mediator, hypoxia inducible factor 1 alpha (hif1a). |
2021-11-26 |
2023-08-13 |
human |
| Astrid De Roover, Ana Escribano N\\xc3\\xba\\xc3\\xb1ez, Frederique Mf Cornelis, Chahrazad Cherifi, Leire Casas-Fraile, An Sermon, Frederic Cailotto, Rik J Lories, Silvia Monteagud. Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis. JCI insight. 2021-11-02. PMID:34727094. |
we provide unprecedented evidence that hypoxia enhances dot1l expression and h3k79 methylation via hypoxia-inducible factor-1 alpha (hif1a). |
2021-11-02 |
2023-08-13 |
mouse |