| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akihiro Nakamura, Sungsin Jo, Sayaka Nakamura, Mansi K Aparnathi, Shaghayegh Foroozan Boroojeni, Mariia Korshko, Ye-Soo Park, Himanshi Gupta, Sandra Vijayan, Jason S Rockel, Mohit Kapoor, Igor Jurisica, Tae-Hwan Kim, Nigil Haroo. HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model. Cellular & molecular immunology. 2024-06-05. PMID:38839914. |
herein, we identified hypoxia-inducible factor-1 alpha (hif1a) as an interacting partner molecule of mif that drives spa pathologies, including inflammation and nbf. |
2024-06-05 |
2024-06-08 |
mouse |
| Dandan Feng, Jie Gao, Ruiqiong Liu, Wei Liu, Tianyang Gao, Yunkai Yang, Die Zhang, Tianshu Yang, Xin Yin, Hefen Yu, Wei Huang, Yan Wan. CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A. Protein & cell. 2024-03-13. PMID:38476024. |
genome-wide analysis of carm1 showed that carm1 is recruited by hypoxia-inducible factor 1 subunit alpha (hif1a) and occupy the promoters of cdk4, cyclin d1, β-catenin, hif1a, malat1, and six1 critically involved in cell cycle, hif-1 signaling pathway, wnt signaling pathway, vegf signaling pathway, thereby modulating the proliferation and invasion of tnbc cells. |
2024-03-13 |
2024-03-15 |
Not clear |
| José M Delgado, Christopher J Shoemake. An unexpected journey for BNIP3. Autophagy. 2024-03-07. PMID:38449384. |
historically, bnip3 regulation was thought to be primarily transcriptional through hif1a (hypoxia inducible factor 1 subunit alpha). |
2024-03-07 |
2024-03-09 |
Not clear |
| Taylor E Murphy, Jasmine C Harris, Bernard B Ree. Hypoxia-inducible factor 1 alpha protein increases without changes in mRNA during acute hypoxic exposure of the Gulf killifish, Fundulus grandis. Biology open. 2023-12-20. PMID:38116983. |
while the hypoxia-responsiveness of hif1 is generally attributed to the stabilization of the alpha protein subunit (hif1α) at low oxygen, several studies on fish report increased tissue levels of hif1a mrna during hypoxia, suggesting transcriptional regulation. |
2023-12-20 |
2023-12-23 |
Not clear |
| Ying Wang, Xueying Chen, Yan Wang, Hong Zhong, Liqin Liu, Yang Y. Network pharmacology integrated with molecular docking technology to reveal the potential mechanism of Shuganfang against drug-induced liver injury. Medicine. vol 102. issue 48. 2023-12-05. PMID:38050247. |
the core targets implicated in the study were il6, estrogen receptor 1 (esr1), hypoxia-inducible factor alpha subunit 1 (hif1a), myc and vascular endothelial growth factor a (vegfa). |
2023-12-05 |
2023-12-10 |
Not clear |
| Nicholas Downes, Henri Niskanen, Vanesa Tomas Bosch, Mari Taipale, Mehvash Godiwala, Mari-Anna Väänänen, Tiia A Turunen, Einari Aavik, Nihay Laham-Karam, Seppo Ylä-Herttuala, Minna U Kaikkone. Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription. The Journal of biological chemistry. vol 299. issue 11. 2023-10-28. PMID:37748649. |
notably, we identify a novel antisense long noncoding rna that convergently overlaps the majority of the hypoxia inducible factor 1 alpha (hif1a) locus, which is expressed across several cell types and elevated in atherosclerotic lesions. |
2023-10-28 |
2023-11-08 |
Not clear |
| Xi-Ying Tan, Jing Tao, Yu Zhang, Ru-Xin G. [Mechanism of Astragali Radix-Curcumae Rhizoma in treating gastric cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802848. |
the cell experiments demonstrated that hqez significantly downregulated the expression of atp-binding cassette subfamily b member 1(abcb1), epidermal growth factor receptor(egfr), phosphorylated serine/threonine kinase(p-akt), hypoxia inducible factor 1 subunit alpha(hif1a), b-cell lymphoma 2(bcl2), breast cancer susceptibility protein 1(brca1), dna polymerase theta(polh), ribonucleotide reductase m1(rrm1), and excision repair cross-complementation group 1(ercc1), and upregulated the expression of tumor protein p53(tp53) and cysteinyl aspartate-specific proteinase(caps3). |
2023-10-06 |
2023-10-15 |
Not clear |
| Yan Meng, Kai-Wen Kong, Yong-Qing Chang, Xiao-Ming Deng, Tao Yan. Histone methyltransferase SETD2 inhibits M1 macrophage polarization and glycolysis by suppressing HIF-1α in sepsis-induced acute lung injury. Medical microbiology and immunology. 2023-09-01. PMID:37658121. |
luciferase reporter assay and chromatin immunoprecipitation assay were conducted to detect the binding of setd2 or h3k36me3 with the hypoxia-inducible factor 1, alpha subunit (hif1a) gene. |
2023-09-01 |
2023-09-07 |
mouse |
| Shufang Wang, Xihua Chen, Shige Guo, Fang Zhou, Xin Zhang, Cong Lu, Xuqing Yang, Qianxing Wang, Bin He, Jiedong Wang, Hanbi Wang, Xiangbo X. CXCR4, regulated by HIF1A, promotes endometrial breakdown via CD45 Reproductive biology. vol 23. issue 3. 2023-07-01. PMID:37392490. |
this study aimed to clarify the role of cxcr4 in endometrial breakdown and its regulation by hypoxia-inducible factor-1 alpha (hif1a). |
2023-07-01 |
2023-08-14 |
mouse |
| Chengyi Dai, Yuhang Li. Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis. Scientific reports. vol 13. issue 1. 2023-05-26. PMID:37237021. |
we combined cross-validation results from multiple databases to predict that hcg17-hsa-mir-424-5p-hif1a, a competitive endogenous rna (cerna) network, may regulate hypoxia inducible factor 1 subunit alpha (hif1a) expression. |
2023-05-26 |
2023-08-14 |
mouse |
| Bingtan Kong, Jie Zhou, Hao Wang, Yinan Li, Yuancan Pan, Hui Zhu, Qing Zhang, Qingsheng Fan, Xiaomin Wang, Ganlin Zhan. Histopathological growth pattern evolution of tumor in VX2 liver cancer model. Pathology, research and practice. vol 244. 2023-03-11. PMID:36905696. |
additionally, fibrin deposition and neovascularization were evaluated by masson staining and immunohistochemical analysis of cd31, hypoxia-inducible factor-1 alpha (hif1a) and vascular endothelial growth factor (vegf). |
2023-03-11 |
2023-08-14 |
Not clear |
| Ning Zhang, Da Huang, Xiaohao Ruan, Ada Tsui-Lin Ng, James Hok-Leung Tsu, Guangliang Jiang, Jingyi Huang, Yongle Zhan, Rong N. CRISPR screening reveals gleason score and castration resistance related oncodriver ring finger protein 19 A (RNF19A) in prostate cancer. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 67. 2023-01-09. PMID:36623445. |
mechanistically, transcriptomics, quantitative and ubiquitination proteomic analysis showed that rnf19a ubiquitylated thyroid hormone receptor interactor 13 (trip13) and was transcriptionally activated by androgen receptor (ar) and hypoxia inducible factor 1 subunit alpha (hif1a). |
2023-01-09 |
2023-08-14 |
Not clear |
| Ruipeng Wang, Xiaoye Qiao, Xiaobin Wan. Exploring the mechanisms of Gui Zhi Fu Ling Wan on varicocele via network pharmacology and molecular docking. Andrologia. 2022-11-13. PMID:36372090. |
the main targets of the active components on vc were tumour protein p53 (tp53), tumour necrosis factor (tnf), hypoxia inducible factor 1 subunit alpha (hif1a), interleukin-6 (il-6), caspase 3 (casp3), catalase (cat), prostaglandin-endoperoxide synthase 2 (ptgs2), vascular endothelial growth factor a (vegfa). |
2022-11-13 |
2023-08-14 |
cat |
| Yuxiang Zhang, Saidi Wang, Haiyan Hu, Xiaoman L. A systematic study of HIF1A cofactors in hypoxic cancer cells. Scientific reports. vol 12. issue 1. 2022-11-08. PMID:36347941. |
hypoxia inducible factor 1 alpha (hif1a) is a transcription factor (tf) that forms highly structural and functional protein-protein interactions with other tfs to promote gene expression in hypoxic cancer cells. |
2022-11-08 |
2023-08-14 |
Not clear |
| Ujjaldeep Jaggi, Harry H Matundan, Dhong Hyun Lee, Homayon Ghias. Blocking Autophagy in M1 Macrophages Enhances Virus Replication and Eye Disease in Ocularly Infected Transgenic Mice. Journal of virology. 2022-10-26. PMID:36286481. |
analysis of 62 autophagy genes and 32 cytokines/chemokines from infected bone marrow-derived macrophages from m1-γ34.5, m2-γ34.5, and wt mice suggested that upregulation of autophagy-blocking genes (i.e., hif1a, mtmr14, mtor, mtmr3, stk11, and ulk2) and the inflammatory tumor necrosis factor alpha (tnf-α) gene in m1-γ34.5 transgenic mice correlated with increased pathogenicity, while upregulation of proautophagy genes (nrbf2 and rb1cc1) in m2-γ34.5 macrophages correlated with reduced pathogenicity. |
2022-10-26 |
2023-08-14 |
mouse |
| Nattawan Suwannakul, Napat Armartmuntree, Raynoo Thanan, Kaoru Midorikawa, Tetsuo Kon, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murat. Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma. Genes & diseases. vol 9. issue 6. 2022-09-26. PMID:36157482. |
furthermore, in the metabolic pathways of fructolysis-warburg effect, the expression levels of relative downstream genes, including ketohexokinase (khk), aldolase b (aldob), lactate dehydrogenase a (ldha), and monocarboxylate transporter 4 (mct4), as well as hypoxia-inducible factor 1 alpha (hif1a), were altered in a glut5 expression-dependent manner. |
2022-09-26 |
2023-08-14 |
mouse |
| Zuoxiang Wang, Zhisong He, Qinkao Xuan, Yue Zhang, Jialiang Xu, Jia Lin, Hongxia Li, Weixiang Chen, Tingbo Jian. Analysis of the potential ferroptosis mechanism and multitemporal expression change of central ferroptosis-related genes in cardiac ischemia-reperfusion injury. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091399. |
a total of 43 defrgs and 7 hub genes (tumor protein p53 [tp53], tumor necrosis factor [tnf], hypoxia-inducible factor 1 subunit alpha [hif1a], interleukin 6 [il6], heme oxygenase 1 [hmox1], x-box binding protein 1 [xbp1], and caspase 8 [casp8]) were screened based on bioinformatics analysis. |
2022-09-12 |
2023-08-14 |
rat |
| Xueling Zhang, Jini Qiu, Feifei Huang, Peizhen Han, Kun Shan, Chaoran Zhan. Construction and verification of a hypoxia-related nine-gene prognostic model in uveal melanoma based on integrated single-cell and bulk RNA sequencing analyses. Experimental eye research. 2022-08-18. PMID:35981602. |
it is reported that the increased expression of hypoxia inducible factor 1 alpha subunit (hif1a), a hypoxia-related molecule, is associated with worse prognoses of um patients. |
2022-08-18 |
2023-08-14 |
Not clear |
| Danfei Liu, Xiangyuan Luo, Meng Xie, Tongyue Zhang, Xiaoping Chen, Bixiang Zhang, Mengyu Sun, Yijun Wang, Yangyang Feng, Xiaoyu Ji, Yiwei Li, Bifeng Liu, Wenjie Huang, Limin Xi. HNRNPC downregulation inhibits IL-6/STAT3-mediated HCC metastasis by decreasing HIF1A expression. Cancer science. 2022-07-18. PMID:35848884. |
the decreased expression of hypoxia inducible factor 1 subunit alpha (hif1a) was identified as the molecular mechanism underlying hnrnpc downregulation inhibited hcc metastasis by rna sequencing. |
2022-07-18 |
2023-08-14 |
human |
| Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Ada. Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape. Journal of hematology & oncology. vol 15. issue 1. 2022-06-06. PMID:35659268. |
studies have demonstrated that hypoxia and hypoxia-inducible factors (hifs) 1 and 2 alpha (hif1a and hif2a) are involved in tumor immune escape. |
2022-06-06 |
2023-08-14 |
Not clear |