Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Samantha J Thomas, Biswarup Ghosh, Zhicheng Wang, Mengxi Yang, Jia Nong, Jenna Severa, Megan C Wright, Yinghui Zhong, Angelo C Lepor. Hepatocyte growth factor delivery to injured cervical spinal cord using an engineered biomaterial protects respiratory neural circuitry and preserves functional diaphragm innervation. Journal of neurotrauma. 2024-07-30. PMID:39078323. |
hgf hydrogel also preserved phmn innervation of the diaphragm, as assessed by both retrograde phmn tracing and detailed neuromuscular junction morphological analysis. |
2024-07-30 |
2024-08-02 |
rat |
Samantha J Thomas, Biswarup Ghosh, Zhicheng Wang, Mengxi Yang, Jia Nong, Jenna Severa, Megan C Wright, Yinghui Zhong, Angelo C Lepor. Hepatocyte growth factor delivery to injured cervical spinal cord using an engineered biomaterial protects respiratory neural circuitry and preserves functional diaphragm innervation. Journal of neurotrauma. 2024-07-30. PMID:39078323. |
our findings demonstrate that local biomaterial-based delivery of hgf hydrogel to injured cervical spinal cord is an effective strategy for preserving respiratory circuitry and diaphragm function. |
2024-07-30 |
2024-08-02 |
rat |
Samantha J Thomas, Biswarup Ghosh, Zhicheng Wang, Mengxi Yang, Jia Nong, Jenna Severa, Megan C Wright, Yinghui Zhong, Angelo C Lepor. Hepatocyte growth factor delivery to injured cervical spinal cord using an engineered biomaterial protects respiratory neural circuitry and preserves functional diaphragm innervation. Journal of neurotrauma. 2024-07-30. PMID:39078323. |
implantation of hgf hydrogel after unilateral c5 contusion-type sci in rats preserved diaphragm function, as assessed by in vivo recordings of both compound muscle action potentials and inspiratory electromyography amplitudes. |
2024-07-30 |
2024-08-02 |
rat |
Elizabeth M Sefton, Mirialys Gallardo, Claire E Tobin, Brittany C Collins, Mary P Colasanto, Allyson J Merrell, Gabrielle Kardo. Fibroblast-derived eLife. vol 11. 2022-09-26. PMID:36154712. |
ppf-derived hgf is directly required for recruitment of met+ muscle progenitors to the diaphragm and indirectly (via its effect on muscle development) required for phrenic nerve primary branching. |
2022-09-26 |
2023-08-14 |
mouse |
Elizabeth M Sefton, Mirialys Gallardo, Claire E Tobin, Brittany C Collins, Mary P Colasanto, Allyson J Merrell, Gabrielle Kardo. Fibroblast-derived eLife. vol 11. 2022-09-26. PMID:36154712. |
hgf/met signaling is required for diaphragm muscularization, but the source of hgf and the specific functions of this pathway in muscle progenitors and effects on phrenic nerve have not been explicitly tested. |
2022-09-26 |
2023-08-14 |
mouse |
Elizabeth M Sefton, Mirialys Gallardo, Claire E Tobin, Brittany C Collins, Mary P Colasanto, Allyson J Merrell, Gabrielle Kardo. Fibroblast-derived eLife. vol 11. 2022-09-26. PMID:36154712. |
localization of hgf at the diaphragm's leading edges directs dorsal and ventral expansion of muscle and regulates its overall size and shape. |
2022-09-26 |
2023-08-14 |
mouse |
Elizabeth M Sefton, Mirialys Gallardo, Claire E Tobin, Brittany C Collins, Mary P Colasanto, Allyson J Merrell, Gabrielle Kardo. Fibroblast-derived eLife. vol 11. 2022-09-26. PMID:36154712. |
using conditional mutagenesis in mice and pharmacological inhibition of met, we demonstrate that the pleuroperitoneal folds (ppfs), transient embryonic structures that give rise to the connective tissue in the diaphragm, are the source of hgf critical for diaphragm muscularization. |
2022-09-26 |
2023-08-14 |
mouse |
Ashish K Solanki, Ehtesham Arif, Pankaj Srivastava, Christopher M Furcht, Bushra Rahman, Pei Wen, Avinash Singh, Lawrence B Holzman, Wayne R Fitzgibbon, Milos N Budisavljevic, Glenn P Lobo, Sang-Ho Kwon, Zhe Han, Matthew J Lazzara, Joshua H Lipschutz, Deepak Nihalan. Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair. The Journal of biological chemistry. vol 297. issue 3. 2021-11-17. PMID:34391780. |
phosphorylation of slit diaphragm proteins nephrin and neph1 upon binding of hgf promotes podocyte repair. |
2021-11-17 |
2023-08-13 |
drosophila_melanogaster |
Toshiaki Takahashi, Florian Friedmacher, Julia Zimmer, Prem Pur. Decreased expression of hepatocyte growth factor in the nitrofen model of congenital diaphragmatic hernia. Pediatric surgery international. vol 32. issue 10. 2017-03-27. PMID:27480986. |
hepatocyte growth factor (hgf), which is secreted in ppfs, plays a crucial role in the formation of the muscular diaphragmatic components by regulating the migration of myogenic progenitor cells into the primordial diaphragm. |
2017-03-27 |
2023-08-13 |
rat |
J D Proto, Y Tang, A Lu, W C W Chen, E Stahl, M Poddar, S A Beckman, P D Robbins, L J Nidernhofer, K Imbrogno, T Hannigan, W M Mars, B Wang, J Huar. NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair. Cell death & disease. vol 6. 2016-02-23. PMID:25906153. |
hgf silencing resulted in increased inflammation and extensive necrosis of the diaphragm muscle. |
2016-02-23 |
2023-08-13 |
mouse |