| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ke Zhao, Yinchao Li, Huanling Lai, Ruili Niu, Huifeng Li, Shipei He, Zhengwei Su, Yue Gui, Lijie Ren, Xiaofeng Yang, Liemin Zho. Alterations in HCN1 expression and distribution during epileptogenesis in rats. Epilepsy research. vol 202. 2024-03-31. PMID:38555654. |
the hyperpolarization-activated cyclic nucleotide-gated cation channel (hcn1) is predominantly located in key regions associated with epilepsy, such as the neocortex and hippocampus. |
2024-03-31 |
2024-04-03 |
rat |
| Ke Zhao, Yinchao Li, Xiaofeng Yang, Liemin Zho. The Impact of Altered HCN1 Expression on Brain Function and Its Relationship with Epileptogenesis. Current neuropharmacology. 2023-06-27. PMID:37366350. |
hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (hcn1) is predominantly expressed in neurons from the neocortex and hippocampus, two important regions related to epilepsy. |
2023-06-27 |
2023-08-14 |
Not clear |
| Zhi He, Chao Chen, Lin Huang, Shenghong Liu, Lianjun Gu. WITHDRAWN: Decreased HCN1 mRNA in hippocampal area CA1 and neocortex after chronic cerebral hypoperfusion. European journal of pharmacology. 2019-11-20. PMID:19073170. |
withdrawn: decreased hcn1 mrna in hippocampal area ca1 and neocortex after chronic cerebral hypoperfusion. |
2019-11-20 |
2023-08-12 |
Not clear |
| Mattia Bonzanni, Jacopo C DiFrancesco, Raffaella Milanesi, Giulia Campostrini, Barbara Castellotti, Annalisa Bucchi, Mirko Baruscotti, Carlo Ferrarese, Silvana Franceschetti, Laura Canafoglia, Francesca Ragona, Elena Freri, Angelo Labate, Antonio Gambardella, Cinzia Costa, Ilaria Rivolta, Cinzia Gellera, Tiziana Granata, Andrea Barbuti, Dario DiFrancesc. A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability. Neurobiology of disease. vol 118. 2019-09-09. PMID:29936235. |
among the four known isoforms, hcn1 is the most expressed in the neocortex and hippocampus and de novo hcn1 point mutations have been recently associated with early infantile epileptic encephalopathy. |
2019-09-09 |
2023-08-13 |
human |
| Wiebke Wilkars, Jessica Wollberg, Evita Mohr, Mieri Han, Dane M Chetkovich, Robert Bähring, Roland A Bende. Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 5. 2014-06-16. PMID:24451387. |
we identified a py motif (l/ppxy), the characteristic binding motif for nedd4-2 in the c terminus of the hcn1 subunit, and showed that hcn1 and nedd4-2 interacted both in vivo (rat hippocampus, neocortex, and cerebellum) and in vitro [human embryonic kidney 293 (hek293) cells], resulting in increased hcn1 ubiquitination. |
2014-06-16 |
2023-08-12 |
human |
| S Li, Z He, L Guo, L Huang, J Wang, W H. Behavioral alterations associated with a down regulation of HCN1 mRNA in hippocampal cornus ammon 1 region and neocortex after chronic incomplete global cerebral ischemia in rats. Neuroscience. vol 165. issue 3. 2010-03-08. PMID:19892002. |
in the in situ hybridization cytochemistry experiment, hcn1 mrna declined to 52.00% and 46.00% of the control values in the cornus ammon 1 (ca1) regions of hippocampus and neocortex separately after chronic cerebral ischemia. |
2010-03-08 |
2023-08-12 |
rat |
| S Li, Z He, L Guo, L Huang, J Wang, W H. Behavioral alterations associated with a down regulation of HCN1 mRNA in hippocampal cornus ammon 1 region and neocortex after chronic incomplete global cerebral ischemia in rats. Neuroscience. vol 165. issue 3. 2010-03-08. PMID:19892002. |
behavioral alterations associated with a down regulation of hcn1 mrna in hippocampal cornus ammon 1 region and neocortex after chronic incomplete global cerebral ischemia in rats. |
2010-03-08 |
2023-08-12 |
rat |
| S Li, Z He, L Guo, L Huang, J Wang, W H. Behavioral alterations associated with a down regulation of HCN1 mRNA in hippocampal cornus ammon 1 region and neocortex after chronic incomplete global cerebral ischemia in rats. Neuroscience. vol 165. issue 3. 2010-03-08. PMID:19892002. |
hcn1 mrna in the hippocampal ca1 region and neocortex was markedly down regulated by ischemia, reaching 48.90% and 45.80% of the control values respectively in the semi-quantitative rt-pcr experiment. |
2010-03-08 |
2023-08-12 |
rat |
| Ulf Strauss, Maarten H P Kole, Anja U Bräuer, Jens Pahnke, Rika Bajorat, Arndt Rolfs, Robert Nitsch, Rudolf A Deis. An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy. The European journal of neuroscience. vol 19. issue 11. 2004-08-02. PMID:15182313. |
the results showing decreases in currents corresponded to a 34% reduction in hcn1 protein in the wag/rij compared to the wistar neocortex, but hcn1 mrna showed stable expression. |
2004-08-02 |
2023-08-12 |
rat |
| Takuya Notomi, Ryuichi Shigemot. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. The Journal of comparative neurology. vol 471. issue 3. 2004-05-03. PMID:14991560. |
at the electron microscopic level, immunogold particles for hcn1 and hcn2 had similar distribution patterns along plasma membrane of dendritic shafts in layer i of the neocortex and stratum lacunosum moleculare of the hippocampal ca1 area, suggesting that these subunits could form heteromeric channels. |
2004-05-03 |
2023-08-12 |
rat |
| Takuya Notomi, Ryuichi Shigemot. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. The Journal of comparative neurology. vol 471. issue 3. 2004-05-03. PMID:14991560. |
immunoreactivity for hcn1 showed predominantly cortical distribution, being intense in the neocortex, hippocampus, superior colliculus, and cerebellum, whereas those for hcn3 and hcn4 exhibited subcortical distribution mainly concentrated in the hypothalamus and thalamus, respectively. |
2004-05-03 |
2023-08-12 |
rat |
| Takuya Notomi, Ryuichi Shigemot. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. The Journal of comparative neurology. vol 471. issue 3. 2004-05-03. PMID:14991560. |
double immunofluorescence revealed colocalization of immunoreactivity for hcn1 and hcn2 in distal dendrites of pyramidal cells in the hippocampus and neocortex. |
2004-05-03 |
2023-08-12 |
rat |
| S Chen, J Wang, S A Siegelbau. Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. The Journal of general physiology. vol 117. issue 5. 2001-07-19. PMID:11331358. |
here, we report that hcn1 and hcn2, isoforms coexpressed in neocortex and hippocampus that differ markedly in their biophysical properties, coassemble to generate heteromultimeric channels with novel properties. |
2001-07-19 |
2023-08-12 |
xenopus_laevis |