| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongjiang Wu, Yanfei Wang, Yunchi Lu, Junguo Yan, Hongjun Zhao, Riyun Yang, Jingying Pa. Research advances in huntingtin-associated protein 1 and its application prospects in diseases. Frontiers in neuroscience. vol 18. 2024-07-08. PMID:38975245. |
besides brain, hap1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. |
2024-07-08 |
2024-07-11 |
Not clear |
| JingYing Pan, YaYu Zhao, Rui Sang, RiYun Yang, JingYin Bao, YongJiang Wu, Ying Fei, Jian Wu, Gang Che. HAP1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation. Pain. 2022-12-12. PMID:36508175. |
here, we discovered that hap1 level was greatly increased in the dorsal horn and drg under acute and chronic pain conditions. |
2022-12-12 |
2023-08-14 |
mouse |
| JingYing Pan, YaYu Zhao, Rui Sang, RiYun Yang, JingYin Bao, YongJiang Wu, Ying Fei, Jian Wu, Gang Che. HAP1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation. Pain. 2022-12-12. PMID:36508175. |
as a crucial huntington-associated protein, hap1 is enriched in normal spinal dorsal horn and dorsal root ganglia (drg) where are regarded as "primary sensory center", indicating its potential functions in pain process. |
2022-12-12 |
2023-08-14 |
mouse |
| JingYing Pan, YaYu Zhao, Rui Sang, RiYun Yang, JingYin Bao, YongJiang Wu, Ying Fei, Jian Wu, Gang Che. HAP1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation. Pain. 2022-12-12. PMID:36508175. |
collectively, our results suggest that hap1 in dorsal horn and drg neurons regulates cav1.2 surface expression, which in turn reduces neuronal excitability, bdnf secretion and inflammatory responses and ultimately influences neuropathic pain progression. |
2022-12-12 |
2023-08-14 |
mouse |
| Md Nabiul Islam, Naoki Maeda, Emi Miyasato, Mir Rubayet Jahan, Abu Md Mamun Tarif, Taiga Ishino, Kanako Nozaki, Koh-Hei Masumoto, Akie Yanai, Koh Shinod. Expression of huntingtin-associated protein 1 in adult mouse dorsal root ganglia and its neurochemical characterization in reference to sensory neuron subpopulations. IBRO reports. vol 9. 2020-10-23. PMID:33089002. |
in this study, the expression of hap1 in cervical, thoracic, lumbar and sacral drg in adult male mice and its relationships with different chemical markers for sensory neurons were examined using western blot and immunohistochemistry. |
2020-10-23 |
2023-08-13 |
mouse |
| Md Nabiul Islam, Naoki Maeda, Emi Miyasato, Mir Rubayet Jahan, Abu Md Mamun Tarif, Taiga Ishino, Kanako Nozaki, Koh-Hei Masumoto, Akie Yanai, Koh Shinod. Expression of huntingtin-associated protein 1 in adult mouse dorsal root ganglia and its neurochemical characterization in reference to sensory neuron subpopulations. IBRO reports. vol 9. 2020-10-23. PMID:33089002. |
nevertheless, to date hap1 expression in drg remains unreported. |
2020-10-23 |
2023-08-13 |
mouse |