| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong-In Park, Seung-Youn Jung, Kyung-Hee Song, Dong-Hyeon Lee, Jiyeon Ahn, Sang-Gu Hwang, In-Su Jung, Dae-Seog Lim, Jie-Young Son. Predictive DNA damage signaling for low‑dose ionizing radiation. International journal of molecular medicine. vol 53. issue 6. 2024-05-02. PMID:38695243. |
notably, the activation of ataxia telangiectasia mutated (atm), checkpoint kinase 2 (chk2), p53 and h2a histone family member x (h2ax) significantly increased in a concentration‑dependent manner, which was also observed in human peripheral blood mononuclear cells. |
2024-05-02 |
2024-05-04 |
human |
| Adeline Clergé, Jérémie Le Goff, Emilie Brotin, Edwige Abeillard, Isabelle Vaudorne, Christophe Denoyelle, Ludovic Le Hegarat, Raphaël Delépé. In vitro genotoxicity potential investigation of 7 oxy-PAHs. Environmental and molecular mutagenesis. 2023-02-09. PMID:36757094. |
in this paper, a prospective study on seven oxy-pahs selected in terms of occurrence in the environment was conducted on mutagenicity, genotoxicity, and cytotoxicity potentials using in vitro assays including ames test on 5 strains, kinetic analysis of cytotoxicity and apoptosis, phosphorylation of histone h2ax, and p53 induction assays on human lung cell line beas-2b. |
2023-02-09 |
2023-08-14 |
human |
| Elena G Novoselova, Mars G Sharapov, Sergey M Lunin, Svetlana B Parfenyuk, Maxim O Khrenov, Elvira K Mubarakshina, Anna A Kuzekova, Tatyana V Novoselova, Ruslan G Goncharov, Olga V Glushkov. Peroxiredoxin 6 Applied after Exposure Attenuates Damaging Effects of X-ray Radiation in 3T3 Mouse Fibroblasts. Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34943054. |
our results suggested that prdx6 treatment normalized p53 and nf-κb/p65 expression, p21 levels, dna repair-associated genes (xrcc4, xrcc5, h2ax, apex1), tlr expression, cytokine production (tnf-α and il-6), and apoptosis, as evidenced by decreased caspase 3 level in irradiated 3t3 cells. |
2021-12-24 |
2023-08-13 |
mouse |
| Wangdong Jin, Li Zhou, Bo Yan, Li Yan, Fucun Liu, Peijian Tong, Wenhua Yu, Xiaoqiao Dong, Li Xie, Jin Zhang, Yiqiao Xu, Chunqi Li, Qiang Yuan, Letian Shan, Thomas Effert. Theabrownin triggers DNA damage to suppress human osteosarcoma U2OS cells by activating p53 signalling pathway. Journal of cellular and molecular medicine. vol 22. issue 9. 2019-10-29. PMID:29993186. |
the cellular data confirmed that tb-triggered dna damage and induced apoptosis of u2os cells by regulation of mki67, parp, caspase 3 and h2ax, and western blot assay showed an activation of p53 signalling pathway. |
2019-10-29 |
2023-08-13 |
human |
| Chengshan Xu, Ling Zhang, Lianning Duan, Chengrong L. MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUMA. Oncotarget. vol 7. issue 47. 2018-02-22. PMID:27780918. |
microrna-3196 (mir-3196) was identified as a target of h2ax and shown to inhibit apoptosis in lung cancer cells by targeting p53 upregulated modulator of apoptosis (puma). |
2018-02-22 |
2023-08-13 |
Not clear |
| Mohamed Hassan, Abdelouahid El Khattouti, Ahmed Ejaeidi, Tangeng Ma, William A Day, Ingrid Espinoza, Srinivasan Vijayakumar, Christian R Gome. Elevated Expression of Hepatoma Up-Regulated Protein Inhibits γ-Irradiation-Induced Apoptosis of Prostate Cancer Cells. Journal of cellular biochemistry. vol 117. issue 6. 2016-12-13. PMID:26505164. |
γ-irradiation-induced apoptosis of pca cells is associated with expression of e2f1, p53, p21 proteins together with the phosphorylation of apoptosis signal-regulating kinase1 (ask1), c-jun-n-terminal kinase (jnk) and ataxia-telangiectasia mutated (atm) and histone family member x (h2ax). |
2016-12-13 |
2023-08-13 |
Not clear |
| Eva Martini, Nadine Wittkopf, Claudia Günther, Moritz Leppkes, Hitoshi Okada, Alastair J Watson, Eva Podstawa, Ingo Backert, Kerstin Amann, Markus F Neurath, Christoph Becke. Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis. Cell reports. vol 14. issue 5. 2016-11-01. PMID:26832409. |
moreover, survivin-deficient animals showed induced phosphorylation of p53 and h2ax and increased levels of cell-intrinsic apoptosis in iecs. |
2016-11-01 |
2023-08-13 |
Not clear |
| Yinhui Dong, Shutao Yin, Xinhua Song, Yazhen Huo, Lihong Fan, Min Ye, Hongbo H. Involvement of ROS-p38-H2AX axis in novel curcumin analogues-induced apoptosis in breast cancer cells. Molecular carcinogenesis. vol 55. issue 4. 2016-07-20. PMID:25647442. |
inhibition of p38/h2ax led to a significant reduction of apoptosis, whereas inactivation of p53 caused a dramatically enhanced h2ax phosphorylation and apoptosis induction, suggesting activation of p38/h2ax contributed to apoptosis induction by t1, whereas p53 activation protected novel curcumins-induced apoptosis via suppression of h2ax activation. |
2016-07-20 |
2023-08-13 |
Not clear |
| Laureen C Colis, Denise C Hegan, Miho Kaneko, Peter M Glazer, Seth B Herzo. Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines. Journal of the American Chemical Society. vol 137. issue 17. 2016-03-14. PMID:25849366. |
both 1 and 3 induce ataxia telangiectasia mutated- (atm-) and dna-dependent protein kinase- (dna-pk-) dependent production of phospho-ser139-histone h2ax (γh2ax) and generation of p53 binding protein 1 (53bp1) foci in k562 cells within 1 h of exposure, which is indicative of activation of nonhomologous end joining (nhej) and homologous recombination (hr) repair. |
2016-03-14 |
2023-08-13 |
human |
| Priyadharsini Nagarajan, Kathleen L Tober, Judith A Riggenbach, Donna F Kusewitt, Amy M Lehman, Thais Sielecki, James Pruitt, Abhay R Satoskar, Tatiana M Oberyszy. MIF antagonist (CPSI-1306) protects against UVB-induced squamous cell carcinoma. Molecular cancer research : MCR. vol 12. issue 9. 2015-06-05. PMID:24850900. |
in addition to decreasing skin thickness and myeloperoxidase (mpo) activity, cpsi-1306 pretreatment increased keratinocyte apoptosis and p53 expression, decreased proliferation and phosphohistone variant h2ax (γ-h2ax), and enhanced repair of cyclobutane pyrimidine dimers. |
2015-06-05 |
2023-08-13 |
mouse |
| Maarja Laos, Tommi Anttonen, Anna Kirjavainen, Taija af Hällström, Marikki Laiho, Ulla Pirvol. DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells. Aging. vol 6. issue 6. 2015-02-23. PMID:25063730. |
phosphorylated form of histone h2ax (γh2ax) and p53 binding protein 1 (53bp1) were induced in a foci-like pattern in scs of both ages as an indication of dna double-strand break formation and activated dna damage response. |
2015-02-23 |
2023-08-13 |
mouse |
| Bilge Debelec-Butuner, Nursah Ertunc, Kemal Sami Korkma. Inflammation contributes to NKX3.1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression. Journal of inflammation (London, England). vol 12. 2015-02-23. PMID:25705129. |
oxidative stress-induced dna damage resulted in increased h2ax((s139)) phosphorylation (a hallmark of dna damage), along with the degradation of the androgen receptor (ar), p53 and nkx3.1, upon treatment with conditioned medium (cm) obtained from activated macrophages or h2o2. |
2015-02-23 |
2023-08-13 |
Not clear |
| Aderbal R T Silva, Ana Cecília Feio Santos, Jose M Farfel, Lea T Grinberg, Renata E L Ferretti, Antonio Hugo Jose Froes Marques Campos, Isabela Werneck Cunha, Maria Dirlei Begnami, Rafael M Rocha, Dirce M Carraro, Carlos Alberto de Bragança Pereira, Wilson Jacob-Filho, Helena Brentan. Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease. PloS one. vol 9. issue 6. 2015-02-12. PMID:24936870. |
we evaluated markers of oxidative dna damage (8-ohdg, h2ax), dna repair (p53, brca1, pten), and cell-cycle (cdk1, cdk4, cdk5, cyclin b1, cyclin d1, p27kip1, phospho-rb and e2f1) through immunohistochemistry and cell death through tunel in autopsy hippocampal tissue samples arrayed in a tissue microarray (tma) composed of three groups: i) "clinical-pathological ad" (cp-ad)--subjects with neuropathological ad (braak ≥ iv and cerad = b or c) and clinical dementia (cdr ≥ 2, iqcode>3.8); ii) "pathological ad" (p-ad)--subjects with neuropathological ad (braak ≥ iv and cerad = b or c) and without cognitive impairment (cdr 0, iqcode<3.2); and iii) "normal aging" (n)--subjects without neuropathological ad (braak ≤ ii and cerad 0 or a) and with normal cognitive function (cdr 0, iqcode<3.2). |
2015-02-12 |
2023-08-13 |
human |
| Bo S Kim, Leonid Serebreni, Omar Hamdan, Lan Wang, Ahmad Parniani, Thomas Sussan, R Scott Stephens, Laurent Boyer, Mahendra Damarla, Paul M Hassoun, Rachel Damic. Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis. Free radical biology & medicine. vol 60. 2013-11-01. PMID:23380026. |
furthermore, we show that xor activation results in dna double-strand breaks that activate the enzyme ataxia telangiectasia mutated, which phosphorylates histone h2ax and upregulates p53. |
2013-11-01 |
2023-08-12 |
mouse |
| Ramya Kumareswaran, Olga Ludkovski, Alice Meng, Jenna Sykes, Melania Pintilie, Robert G Bristo. Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability. Journal of cell science. vol 125. issue Pt 1. 2013-06-03. PMID:22266907. |
the response of phosphorylated histone h2ax (γ-h2ax), phosphorylated ataxia telangiectasia mutated [atm(ser1981)], and the p53 binding protein 1 (53bp1) was quantified by intranuclear dna repair foci and western blotting. |
2013-06-03 |
2023-08-12 |
human |
| Yohei Tanaka, Naoto Tatewaki, Hiroshi Nishida, Takahiro Eitsuka, Nobuo Ikekawa, Jun Nakayam. Non-thermal DNA damage of cancer cells using near-infrared irradiation. Cancer science. vol 103. issue 8. 2013-05-07. PMID:22515193. |
moreover, near-infrared treatment increased the phosphorylation of ataxia-telangiectasia mutated (atm) at ser(1981), h2ax at ser(139), chk1 at ser(317), structural maintenance of chromosome (smc) 1 at ser(966), and p53 at ser(15) in a549 cells compared with control. |
2013-05-07 |
2023-08-12 |
mouse |
| Z Korwek, T Sewastianik, A Bielak-Zmijewska, G Mosieniak, O Alster, M Moreno-Villanueva, M Moreno-Villaneuva, A Burkle, E Sikor. Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells. DNA repair. vol 11. issue 11. 2013-03-27. PMID:23058634. |
pretreatment of resting t cells with ku 55933 blocked phosphorylation of atm, h2ax and p53, which, in turn, prevented puma expression, caspase activation and apoptosis. |
2013-03-27 |
2023-08-12 |
human |
| b' Alena Rajnochov\\xc3\\xa1 Svobodov\\xc3\\xa1, Ad\\xc3\\xa9la Galand\\xc3\\xa1kov\\xc3\\xa1, Jarmila Siansk\\xc3\\xa1, Dalibor Dole\\xc5\\xbeal, Radka Lichnovsk\\xc3\\xa1, Jitka Ulrichov\\xc3\\xa1, Jitka Vost\\xc3\\xa1lov\\xc3\\xa. DNA damage after acute exposure of mice skin to physiological doses of UVB and UVA light. Archives of dermatological research. vol 304. issue 5. 2012-12-21. PMID:22271212.' |
the number of dna single-strand breaks (ssb) in lymphocytes, amount of phosphorylated histone h2ax (gamma-h2ax) and apoptosis or dna fragmentation (tunel-positive cells) in skin sections and level of gamma-h2ax, activated caspase-3 and phosphorylated p53 in skin were evaluated after 4 and 24 h. ssb analyzed by alkaline comet assay were found to be 4 and 24 h following uvb and uva treatment, respectively. |
2012-12-21 |
2023-08-12 |
mouse |
| Jifeng Wang, Baobing Zhao, Yuting Yi, Wei Zhang, Xuan Wu, Lianru Zhang, Yuemao She. Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-κB pathways. Biochemical pharmacology. vol 84. issue 7. 2012-11-01. PMID:22796259. |
the present results show that med induces dna damage through the production of reactive oxygen species (ros), which resulted in the phosphorylation of h2ax and the activation of the ataxia telangiectasia mutated kinase (atm) and p53 signaling pathways. |
2012-11-01 |
2023-08-12 |
Not clear |
| D Muthna, J Vavrova, E Lukasova, A Tichy, J Knizek, R Kohlerova, N Mazankova, M Rezacov. Valproic acid decreases the reparation capacity of irradiated MOLT-4 cells. Molekuliarnaia biologiia. vol 46. issue 1. 2012-07-31. PMID:22642109. |
two-millimolar va increased apoptosis induction after irradiation as well as phosphorylation of h2ax and provokes an increase in the level of p53 and its phosphorylation at ser392 in 4 h post-irradiation. |
2012-07-31 |
2023-08-12 |
Not clear |