| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael L Fragner, Manish A Parikh, Kaedrea A Jackson, Michal Laniado Schwartzman, William H Frishman, Stephen J Peterso. GPR75: A Newly Identified Receptor for Targeted Intervention in the Treatment of Obesity and Metabolic Syndrome. Cardiology in review. 2024-05-02. PMID:38695569. |
gpr75 and its association with its ligand, 20-hydroxyeicosatetraenoic acid, have been shown to promote hypertension, inflammation, obesity, and insulin resistance. |
2024-05-02 |
2024-05-04 |
Not clear |
| Mohammad Reza Dashti, Fatemeh Gorbanzadeh, Davoud Jafari-Gharabaghlou, Mahdi Farhoudi Sefidan Jadid, Nosratollah Zargham. G Protein-Coupled Receptor 75 (GPR75) As a Novel Molecule for Targeted Therapy of Cancer and Metabolic Syndrome. Asian Pacific journal of cancer prevention : APJCP. vol 24. issue 5. 2023-05-30. PMID:37247305. |
the findings indicate that inhibiting gpr75 in humans leads to an increase in insulin sensitivity and glucose tolerance, as well as a reduction in body fat storage. |
2023-05-30 |
2023-08-14 |
Not clear |
| Andrew Speidell, Sofia Walton, Lee A Campbell, Francesco Tomassoni-Ardori, Lino Tessarollo, Claudia Corbo, Francesca Taraballi, Italo Mocchett. Mice deficient for G-protein coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall. Journal of neurochemistry. 2023-03-29. PMID:36978267. |
recent reports suggest that gpr75 may play a role in regulating insulin secretion and obesity. |
2023-03-29 |
2023-08-14 |
mouse |
| Sakib Hossain, Ankit Gilani, Jonathan Pascale, Elizabeth Villegas, Danielle Diegisser, Kevin Agostinucci, Melissa-Maria Kulaprathazhe, Ercument Dirice, Victor Garcia, Michal Laniado Schwartzma. Gpr75-deficient mice are protected from high-fat diet-induced obesity. Obesity (Silver Spring, Md.). 2023-03-01. PMID:36854900. |
g-protein coupled receptor 75 (gpr75) has been identified as the high-affinity receptor of 20-hydroxyeicosatetraenoic acid (20-hete), a vasoactive and proinflammatory lipid, and mice overproducing 20-hete have been shown to develop insulin resistance when fed a high-fat diet (hfd), which was prevented by a 20-hete receptor blocker. |
2023-03-01 |
2023-08-14 |
mouse |
| Sakib Hossain, Ankit Gilani, Elizabeth Villegas, Kevin Agostinucci, Danielle Diegisser, Ercument Dirice, Victor Garcia, Michal Schwartzma. GPR75 Deficiency Protects Against High-Fat Diet Induced Obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554247. |
based on these findings, we hypothesized that global deletion of gpr75 protects against diet-induced obesity (dio) and insulin resistance. |
2022-05-13 |
2023-08-13 |
mouse |
| Ankit Gilani, Kevin Agostinucci, Sakib Hossain, Jonathan V Pascale, Victor Garcia, Adeniyi Michael Adebesin, John R Falck, Michal Laniado Schwartzma. 20-HETE interferes with insulin signaling and contributes to obesity-driven insulin resistance. Prostaglandins & other lipid mediators. vol 152. 2021-10-29. PMID:33011364. |
additional studies in 3t3-1 differentiated adipocytes confirmed that 20-hete impairs insulin signaling and that its effect may require activation of its receptor gpr75. |
2021-10-29 |
2023-08-13 |
mouse |
| Bo Liu, Zoheb Hassan, Stefan Amisten, Aileen J King, James E Bowe, Guo Cai Huang, Peter M Jones, Shanta J Persau. The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis. Diabetologia. vol 56. issue 11. 2014-05-14. PMID:23979485. |
gpr75 is coupled to gq to elevate intracellular calcium, so we investigated whether islets express this receptor and whether its activation by ccl5 increases beta cell calcium levels and insulin secretion. |
2014-05-14 |
2023-08-12 |
Not clear |