| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rohani, Ellin Febrina, Indah Suasani Wahyuni, Jutti Levit. Pharmacological and Clinical Studies of Medicinal Plants That Inhibit Dipeptidyl Peptidase-IV. Drug design, development and therapy. vol 17. 2023-12-01. PMID:38024536. |
this, in turn, leads to an extension of glp-1's duration of action, prolongs gastric emptying, enhances insulin sensitivity, and ultimately results in the reduction of blood glucose levels. |
2023-11-29 |
2023-12-07 |
human |
| Rikke Viggers, Nicklas Højgaard-Hessellund Rasmussen, Peter Vestergaar. Effects of Incretin Therapy on Skeletal Health in Type 2 Diabetes-A Systematic Review. JBMR plus. vol 7. issue 11. 2023-12-01. PMID:38025038. |
the group of hormones known as incretins, which includes gastric inhibitory peptide (gip) and glucagon-like peptide 1 (glp-1), play a role in regulating bowel function and insulin secretion during feeding. |
2023-11-29 |
2023-12-07 |
human |
| Xiaodi Zhao, Dohee Ahn, Gibeom Nam, Jihee Kwon, Songyi Song, Min Ji Kang, Hyejin Ahn, Sang J Chun. Identification of Crocetin as a Dual Agonist of GPR40 and GPR120 Responsible for the Antidiabetic Effect of Saffron. Nutrients. vol 15. issue 22. 2023-11-25. PMID:38004168. |
this compound notably enhanced insulin and glp-1 secretion from pancreatic β-cells and intestinal neuroendocrine cells, respectively, presenting a dual mechanism of action in glucose-lowering effects. |
2023-11-25 |
2023-11-28 |
Not clear |
| Julia Herrou, Guillaume Mabilleau, Jean-Michel Lecerf, Thierry Thomas, Emmanuel Biver, Julien Pacco. Narrative Review of Effects of Glucagon-Like Peptide-1 Receptor Agonists on Bone Health in People Living with Obesity. Calcified tissue international. 2023-11-24. PMID:37999750. |
further studies are needed to investigate the bone impact of glp-1ra, dual- and triple-receptor agonists for glp-1, glucose-dependent insulin releasing polypeptide (gip), and glucagon in pwo. |
2023-11-24 |
2023-11-29 |
Not clear |
| Andrea I d'Aquino, Caitlin L Maikawa, Leslee T Nguyen, Katie Lu, Ian A Hall, Carolyn K Jons, Catherine M Kasse, Jerry Yan, Alexander N Prossnitz, Enmian Chang, Sam W Baker, Lars Hovgaard, Dorte B Steensgaard, Hanne B Andersen, Lotte Simonsen, Eric A Appe. Use of a biomimetic hydrogel depot technology for sustained delivery of GLP-1 receptor agonists reduces burden of diabetes management. Cell reports. Medicine. vol 4. issue 11. 2023-11-22. PMID:37992687. |
glucagon-like peptide-1 (glp-1) is an incretin hormone and neurotransmitter secreted from intestinal l cells in response to nutrients to stimulate insulin and block glucagon secretion in a glucose-dependent manner. |
2023-11-22 |
2023-11-29 |
rat |
| Ye Zhu, Jun Tian, Xiali Wei, Shaohui Jia, Qing Sh. Electroacupuncture Alleviates Obesity and Insulin Resistance via the GLP-1-VTA DA Reward Circuit. Neuroendocrinology. 2023-11-21. PMID:37989106. |
we investigated the effects of electroacupuncture (ea) on improving obesity and insulin resistance (ir) in high-fat-diet-induced (hfdi) obese rats by modulating the nucleus tractus solitarius (nts) glucagon-like peptide-1 (glp-1)-ventral tegmental area (vta) dopamine (da) neural reward circuit, thereby uncovering a possible central mechanism underlying ea's actions in improving obesity and ir. |
2023-11-21 |
2023-11-29 |
rat |
| Soumia Majait, Emma C E Meessen, Frederic Maxime Vaz, E Marleen Kemper, Samuel van Nierop, Steven W Olde Damink, Frank G Schaap, Johannes A Romijn, Max Nieuwdorp, Aad Verrips, Filip Krag Knop, Maarten R Soeter. Characterization of Postprandial Bile Acid Profiles and Glucose Metabolism in Cerebrotendinous Xanthomatosis. Nutrients. vol 15. issue 21. 2023-11-14. PMID:37960277. |
in this paper, we examined postprandial bile acid, glucose, insulin, glp-1 and fibroblast growth factor 19 (fgf19) plasma profiles in patients with ctx and matched healthy controls. |
2023-11-14 |
2023-11-20 |
human |
| Soumia Majait, Emma C E Meessen, Frederic Maxime Vaz, E Marleen Kemper, Samuel van Nierop, Steven W Olde Damink, Frank G Schaap, Johannes A Romijn, Max Nieuwdorp, Aad Verrips, Filip Krag Knop, Maarten R Soeter. Characterization of Postprandial Bile Acid Profiles and Glucose Metabolism in Cerebrotendinous Xanthomatosis. Nutrients. vol 15. issue 21. 2023-11-14. PMID:37960277. |
this novel characterization of ctx patients reveals very low circulating bile acid levels and fgf19 levels, aberrant postprandial glucose and insulin profiles, and elevated postprandial glp-1 responses. |
2023-11-14 |
2023-11-20 |
human |
| Gabriela Brenta, Fernando Di Ferm. Thyroid cancer and insulin resistance. Reviews in endocrine & metabolic disorders. 2023-11-13. PMID:37957487. |
in contrast, the evidence for an association between glucagon-like peptide-1 receptor agonists (glp-1 ra) and increased thyroid cancer findings is limited.in conclusion, the association between thyroid cancer and diabetes may be explained by insulin resistance, as shown in observational studies. |
2023-11-13 |
2023-11-20 |
Not clear |
| Sara Becerril, Javier A Cienfuegos, Amaia Rodríguez, Victoria Catalán, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Xabier Unamuno, Javier Gómez-Ambrosi, Gema Frühbec. Single anastomosis duodeno-ileal bypass with sleeve gastrectomy generates sustained improvement of glycemic control compared with sleeve gastrectomy in the diet-induced obese rat model. Journal of physiology and biochemistry. 2023-11-07. PMID:37935948. |
body weight and food intake were weekly monitored, and 6 weeks after interventions, fasting plasma glucose, oral glucose and insulin tolerance tests, plasma insulin, adiponectin, gip, glp-1, and ghrelin levels were determined.the body weight of sadi-s rats was significantly (p < 0.001) lower as compared to the sham-operated, sg, and pair-fed groups. |
2023-11-07 |
2023-11-20 |
rat |
| Rawayh Albaghlany, Mohammad Bagher Shahsavani, Masaru Hoshino, Ali Akbar Moosavi-Movahedi, Younes Ghasemi, Reza Yousef. Optimizing expression, purification, structural and functional assessments of a novel dimeric incretin (GLP-1cpGLP-1). Biochimie. 2023-11-06. PMID:37931794. |
glucagon-like peptide-1 (glp-1) is an incretin hormone that reduces postprandial glycemic excursions by enhancing insulin secretion. |
2023-11-06 |
2023-11-08 |
mouse |
| Rawayh Albaghlany, Mohammad Bagher Shahsavani, Masaru Hoshino, Ali Akbar Moosavi-Movahedi, Younes Ghasemi, Reza Yousef. Optimizing expression, purification, structural and functional assessments of a novel dimeric incretin (GLP-1cpGLP-1). Biochimie. 2023-11-06. PMID:37931794. |
in this study, a new dimeric glp-1 analogue (glp-1cpglp-1) was designed by inserting human insulin c-peptide (cp) in the middle of a dimer of [gly8] glp-1 (7-36). |
2023-11-06 |
2023-11-08 |
mouse |
| Binish A Ahmad, Isha M Sanghani, Rithika Sayabugari, Hannah Biju, Akshaya Siddegowda, Minnu Ittiachen Kinattingal, Sai Goutham Reddy Yartha, Prajyoth M Gaonkar, Syed Shireen Andrabi, Yogeshkumar K Vaghamashi, Arunika Korwa. Beyond Blood Sugar: Investigating the Cardiovascular Effects of Antidiabetic Drugs. Cureus. vol 15. issue 10. 2023-11-03. PMID:37920618. |
some drugs, such as glucagon-like peptide 1 (glp-1) agonists and sodium-glucose cotransporter 2 (sglt-2) inhibitors, are cardioprotective, whereas others, such as insulin, have deleterious effects on the cardiovascular system. |
2023-11-03 |
2023-11-08 |
Not clear |
| Swapnali Vasant Birajdar, Farhan Mazahir, Md Imtiyaz Alam, Amit Kumar, Awesh K Yada. Repurposing and clinical attributes of antidiabetic drugs for the treatment of neurodegenerative disorders. European journal of pharmacology. 2023-10-31. PMID:37907134. |
the repurposing of existing antidiabetic drugs such as metformin, dpp-4 inhibitors, thiazolidinediones, glucagon-like peptides (glp-1), sodium-glucose co-transport-2 (sgct-2) inhibitors, and insulin could be an alternative and effective strategy to treat neurodegeneration via modulating insulin signaling, insulin resistance, ide activity, oxidative stress, mitochondrial dysfunction, serum lipid profile and neuroinflammation in the brain. |
2023-10-31 |
2023-11-08 |
mouse |
| Mohammad Mukul Hossain, Juscelino Tovar, Lieselotte Cloetens, Anne Nilsso. Inclusion of Oat Polar Lipids in a Solid Breakfast Improves Glucose Tolerance, Triglyceridemia, and Gut Hormone Responses Postprandially and after a Standardized Second Meal: A Randomized Crossover Study in Healthy Subjects. Nutrients. vol 15. issue 20. 2023-10-30. PMID:37892464. |
test variables (blood glucose, serum insulin, triglyceride (tg), free fatty acids (ffa), ghrelin, glp-1, pyy, and gip) were measured at fasting and repeatedly during the 5.5 h after ingestion of the breakfast. |
2023-10-30 |
2023-11-08 |
human |
| Yingxiao Li, Kai-Chun Cheng, I-Min Liu, Juei-Tang Chen. Identification of Andrographolide as an Agonist of Bile Acid TGR5 Receptor in a Cell Line to Demonstrate the Reduction in Hyperglycemia in Type-1 Diabetic Rats. Pharmaceuticals (Basel, Switzerland). vol 16. issue 10. 2023-10-30. PMID:37895888. |
the current study revealed a novel finding suggesting that adg may activate tgr5 in diabetic rats in a way that results in enhanced insulin and glp-1 production, which may be helpful for future research and therapies. |
2023-10-30 |
2023-11-08 |
human |
| Yu Zhao, Wenjun Jing, Liping Li, Shi Zhao, Masayuki Yamasak. Dynamical modeling the effect of glucagon-like peptide on glucose-insulin regulatory system based on mice experimental observation. Mathematical biosciences. vol 366. 2023-10-28. PMID:37890522. |
specifically, we develop a mathematical model of glp-1 dynamics as part of the interaction model of β-cell, insulin, and glucose dynamics. |
2023-10-28 |
2023-11-08 |
mouse |
| Yu Zhao, Wenjun Jing, Liping Li, Shi Zhao, Masayuki Yamasak. Dynamical modeling the effect of glucagon-like peptide on glucose-insulin regulatory system based on mice experimental observation. Mathematical biosciences. vol 366. 2023-10-28. PMID:37890522. |
model analyses reveal that the high fat or high cholesterol diet stimulated glp-1 plays an important role in the dynamics of glucose, insulin and β cells in short-term. |
2023-10-28 |
2023-11-08 |
mouse |
| Yu Zhao, Wenjun Jing, Liping Li, Shi Zhao, Masayuki Yamasak. Dynamical modeling the effect of glucagon-like peptide on glucose-insulin regulatory system based on mice experimental observation. Mathematical biosciences. vol 366. 2023-10-28. PMID:37890522. |
these results show that enhanced glp-1 may mitigate the dysregulation of glucose-insulin regulatory system via promoting the β cells function and stimulating secretion of insulin, which offers an in-depth insights into the mechanistic of hyperglycemia from dynamical approach and provide the theoretical basis for glp-1 served as a potential clinical targeted drug for treatment of t2dm. |
2023-10-28 |
2023-11-08 |
mouse |
| Shiying Li, Hongbing Zhu, Jiande D Z Che. Intestinal Electrical Stimulation Synchronized With Intestinal Slow Wave Ameliorates Glucagon-Induced Hyperglycemia in Rats. Neuromodulation : journal of the International Neuromodulation Society. 2023-10-28. PMID:37897473. |
we hypothesized that sies is more potent in suppressing postprandial blood glucose by enhancing the release of glucagon-like peptide-1 (glp-1) and insulin. |
2023-10-28 |
2023-11-08 |
rat |