| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rolien Bosch, Marcella Petrone, Rosalin Arends, Paolo Vicini, Eric J G Sijbrands, Sven Hoefman, Nelleke Snelde. Characterisation of cotadutide's dual GLP-1/glucagon receptor agonistic effects on glycaemic control using an in vivo human glucose regulation quantitative systems pharmacology model. British journal of pharmacology. 2024-02-25. PMID:38403793. |
we characterised the effects of cotadutide on glucose, insulin, glp-1, gip, and glucagon over time in a quantitative manner using our glucose dynamics systems model (4gi systems model), in combination with clinical data from a multiple ascending dose/phase 2a (mad/ph2a) study in overweight and obese subjects with a history of type 2 diabetes mellitus (nct02548585). |
2024-02-25 |
2024-02-28 |
human |
| Yoko Yamashit. Physiological functions of poorly absorbed polyphenols via the glucagon-like peptide 1. Bioscience, biotechnology, and biochemistry. 2024-02-21. PMID:38378922. |
this review focuses on the health beneficial effects of polyphenols mediated by intestinal hormones, particularly related to the systemic functions through the secretion of glucagon-like peptide 1 (glp-1), an enteric hormone that stimulates postprandial insulin secretion. |
2024-02-21 |
2024-02-23 |
Not clear |
| Yurong Gao, Hanguk Ryu, Hyejin Lee, Young-Joon Kim, Ji-Hye Lee, Jaemin Le. ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets. Molecules and cells. vol 47. issue 1. 2024-02-20. PMID:38376482. |
incretin hormones, such as glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide, also stimulate insulin secretion. |
2024-02-20 |
2024-02-22 |
mouse |
| Henri Honka, Jashdeep Bhattacharjee, Mansour Zadeh, Rohit Kohli, Amalia Gastaldelli, Marzieh Saleh. Vagal activation alters prandial bile acid composition and glycemia in patients with hypoglycemia after Roux-en-Y gastric bypass surgery. Neurogastroenterology and motility. 2024-02-11. PMID:38342974. |
increased contribution of glucagon-like peptide 1 (glp-1) to prandial insulin secretion plays a key role in developing hypoglycemia after rygb, but the role of nonhormonal gut factors remains unknown. |
2024-02-11 |
2024-02-14 |
human |
| Tingting Liu, Min Zhao, Yumeng Zhang, Ruixiang Xu, Zixuan Fu, Tong Jin, Jiaxi Song, Yihe Huang, Miao Wang, Chunjie Zha. Polysaccharides from Phellinus linteus attenuate type 2 diabetes mellitus in rats via modulation of gut microbiota and bile acid metabolism. International journal of biological macromolecules. 2024-02-10. PMID:38340923. |
in conclusion, this study demonstrated that plp can regulate gut microbiota and bas metabolism to promote glp-1 secretion, thereby increasing insulin release, decreasing blood glucose and attenuating t2dm. |
2024-02-10 |
2024-02-14 |
rat |
| Jiudan Zhang, Dominik Sonnenburg, Domenico Tricò, Stefan Kabisch, Andrea Mari, Stephan Theis, Margrit Kemper, Olga Pivovarova-Ramich, Sascha Rohn, Andreas F H Pfeiffe. Isomaltulose Enhances GLP-1 and PYY Secretion to a Mixed Meal in People With or Without Type 2 Diabetes as Compared to Saccharose. Molecular nutrition & food research. 2024-02-09. PMID:38332571. |
secretion of the gut hormones glucagon-like peptide (glp-1) and peptide yy (pyy) are induced by nutrients reaching the lower small intestine which regulate insulin and glucagon release, inhibit appetite, and may improve β-cell regeneration. |
2024-02-09 |
2024-02-11 |
human |
| Snehasish Nag, Samanwita Mandal, Oindrila Mukherjee, Tanmay Majumdar, Satinath Mukhopadhyay, Rakesh Kund. Vildagliptin inhibits high fat and fetuin-A mediated DPP-4 expression, intracellular lipid accumulation and improves insulin secretory defects in pancreatic beta cells. Biochimica et biophysica acta. Molecular basis of disease. vol 1870. issue 3. 2024-02-03. PMID:38296116. |
dipeptidyl peptidase-4 (dpp-4), a ubiquitous proteolytic enzyme, inhibits insulin secretion from pancreatic beta cells by inactivating circulating incretin hormones glp-1 and gip. |
2024-02-03 |
2024-02-06 |
mouse |
| Trang Thi Bich Le, Le Huu Nhat Minh, Pooja Devi, Nabila Islam, Issac Sachmech. A Case Report of Systemic Allergic Reaction to the Dual Glucose-Dependent Insulinotropic Polypeptide/Glucagon-Like Peptide-1 Receptor Agonist Tirzepatide. Cureus. vol 16. issue 1. 2024-02-01. PMID:38298324. |
a 67-year-old woman, previously treated with basal insulin, metformin, and semaglutide (a glp-1 agonist), experienced severe disseminated pruritus and a generalized urticarial rash after her first dose of tirzepatide. |
2024-02-01 |
2024-02-03 |
Not clear |
| Mark M Smits, Katrine D Galsgaard, Sara Lind Jepsen, Nicolai Wewer Albrechtsen, Bolette Hartmann, Jens J Hols. In vivo inhibition of dipeptidyl peptidase 4 allows measurement of GLP-1 secretion in mice. Diabetes. 2024-01-31. PMID:38295385. |
the described approach allows improved estimates of glp-1 secretion for future studies, although it is a limitation that these inhibitors additionally influence levels of insulin and glucagon. |
2024-01-31 |
2024-02-03 |
mouse |
| Olusegun A Olanrewaju, Fnu Sheeba, Avinash Kumar, Saad Ahmad, Narendar Blank, Reema Kumari, Komal Kumari, Tamara Salame, Ayesha Khalid, Nazdar Yousef, Giustino Varrassi, Mahima Khatri, Satish Kumar, Tamam Mohama. Novel Therapies in Diabetes: A Comprehensive Narrative Review of GLP-1 Receptor Agonists, SGLT2 Inhibitors, and Beyond. Cureus. vol 15. issue 12. 2024-01-29. PMID:38283440. |
glp-1 receptor agonists replicate the effects of natural glucagon-like peptide-1, leading to insulin production that is reliant on glucose levels, reducing the release of glucagon, and providing cardiovascular advantages that go beyond controlling blood sugar levels. |
2024-01-29 |
2024-01-31 |
Not clear |
| Micaela Morettini, Maria Concetta Palumbo, Alessandro Bottiglione, Andrea Danieli, Simone Del Giudice, Laura Burattini, Andrea Tur. Glucagon-like peptide-1 and interleukin-6 interaction in response to physical exercise: An in-silico model in the framework of immunometabolism. Computer methods and programs in biomedicine. vol 245. 2024-01-23. PMID:38262127. |
glucagon-like peptide 1 (glp-1) is classically identified as an incretin hormone, secreted in response to nutrient ingestion and able to enhance glucose-stimulated insulin secretion. |
2024-01-23 |
2024-01-26 |
Not clear |
| Yifei Wang, Yupeng Shi, Xueyuan Peng, Tongtong Li, Chenglin Liang, Wenhao Wang, Mengyang Zhou, Jiali Yang, Jingliang Cheng, Zhenzhong Zhang, Lin Ho. Biochemotaxis-Oriented Engineering Bacteria Expressing GLP-1 Enhance Diabetes Therapy by Regulating The Balance of Immune. Advanced healthcare materials. 2024-01-22. PMID:38253022. |
glucagon like peptide-1 (glp-1) is an effective hypoglycemic drug that can repair the pancreas β cells and promote insulin secretion. |
2024-01-22 |
2024-01-25 |
mouse |
| Yifei Wang, Yupeng Shi, Xueyuan Peng, Tongtong Li, Chenglin Liang, Wenhao Wang, Mengyang Zhou, Jiali Yang, Jingliang Cheng, Zhenzhong Zhang, Lin Ho. Biochemotaxis-Oriented Engineering Bacteria Expressing GLP-1 Enhance Diabetes Therapy by Regulating The Balance of Immune. Advanced healthcare materials. 2024-01-22. PMID:38253022. |
more interestingly, leg not only continuously produces glp-1 to restore pancreatic islet β cell function and secrete insulin to control blood sugar levels, but also regulates the intestinal flora and increases the richness and diversity of probiotics. |
2024-01-22 |
2024-01-25 |
mouse |
| Marta Santos Hernandez, Frank Reimann, Fiona M Gribbl. Cellular mechanisms of incretin hormone secretion. Journal of molecular endocrinology. 2024-01-19. PMID:38240302. |
the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are involved in the regulation of insulin secretion, appetite, food intake and body weight after their nutrient-induced secretion from the gut. |
2024-01-19 |
2024-01-21 |
Not clear |
| Xiangchen Kong, Chao Lin, Chenxi Yang, Xin Wang, Bingfeng Li, Dan Yan, Yanhui Yang, Anyi Hu, Yanyin Chen, Xiaohui Xu, Xiaosong M. GLP-1 signaling-regulated SNAP25 is involved in improved insulin secretion in diabetic GK rats after Roux-en-Y gastric bypass surgery. Molecular biology reports. vol 51. issue 1. 2024-01-16. PMID:38227062. |
glp-1 signaling-regulated snap25 is involved in improved insulin secretion in diabetic gk rats after roux-en-y gastric bypass surgery. |
2024-01-16 |
2024-01-18 |
rat |
| H Huber, A Schieren, Jens J Holst, M-C Simo. Dietary impact on fasting and stimulated GLP-1 secretion in different metabolic conditions - a narrative review. The American journal of clinical nutrition. 2024-01-13. PMID:38218319. |
because of the actions of glp-1 on stimulating insulin secretion and promoting weight loss, glp-1 and its analogs are used in pharmacological preparations for the treatment of t2dm. |
2024-01-13 |
2024-01-16 |
Not clear |
| Landon S Deru, Elizabeth Z Gipson, Katelynn E Hales, Benjamin T Bikman, Lance E Davidson, Benjamin D Horne, James D LeCheminant, Larry A Tucker, Bruce W Baile. The Effects of a High-Carbohydrate versus a High-Fat Shake on Biomarkers of Metabolism and Glycemic Control When Used to Interrupt a 38-h Fast: A Randomized Crossover Study. Nutrients. vol 16. issue 1. 2024-01-11. PMID:38201992. |
this study aimed to determine the impact of various fast-interrupting shakes on markers of glycemic control including glucose, β-hydroxybutyrate (bhb), insulin, glucagon, glp-1, and gip. |
2024-01-11 |
2024-01-13 |
Not clear |
| Liping Qiao, Cindy Lu, Tianyi Zang, Brianna Dzyuba, Jianhua Sha. Maternal GLP-1 Receptor Activation Inhibits Fetal Growth. American journal of physiology. Endocrinology and metabolism. 2024-01-10. PMID:38197791. |
glucagon-like peptide 1 (glp-1) regulates food intake, insulin production, and metabolism. |
2024-01-10 |
2024-01-13 |
mouse |
| Liping Qiao, Cindy Lu, Tianyi Zang, Brianna Dzyuba, Jianhua Sha. Maternal GLP-1 Receptor Activation Inhibits Fetal Growth. American journal of physiology. Endocrinology and metabolism. 2024-01-10. PMID:38197791. |
our recent studydemonstrated that pancreatic α-cells-secreted (intraislet) glp-1 effectively promotes maternal insulin secretion and metabolic adaptation during pregnancy. |
2024-01-10 |
2024-01-13 |
mouse |
| Liyang Yuan, Juan Zhao, Yanjun Liu, Jialiang Zhao, Chen Guang Olnood, Yong-Jiang Xu, Yuanfa Li. Multiomics analysis revealed the mechanism of the anti-diabetic effect of Salecan. Carbohydrate polymers. vol 327. 2024-01-03. PMID:38171651. |
multiomics analysis indicated that lactobacillus johnsonii, muribaculaceae, and lachnoclostridium were highly associated with fatty acid esters of hydroxy fatty acids (fahfa) levels in the colon, accordingly enhancing arachidonic acid and linoleic acid in serum, and promoting glp-1 release in the intestine and insulin secretion in the pancreas, thus relieving insulin resistance and exhibiting hypoglycemic effects. |
2024-01-03 |
2024-01-06 |
mouse |