| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prawej Ansari, Sara S Islam, Samia Akther, Joyeeta T Khan, Jaber A Shihab, Yasser H A Abdel-Waha. Insulin secretory actions of ethanolic extract of Acacia arabica bark in high fat-fed-diet induced obese type 2 diabetic rats. Bioscience reports. 2023-05-03. PMID:37133312. |
in hff rats, eeaa (250 mg/5 ml/kg) improved glucose tolerance, plasma insulin, and glp-1 levels, and lowered dpp-iv enzyme activity. |
2023-05-03 |
2023-08-14 |
mouse |
| Qing Wang, Haixin Guo, Wenwei Mao, Xiuping Qian, Yangang Li. The Oral Delivery System of Modified GLP-1 by Probiotics for T2DM. Pharmaceutics. vol 15. issue 4. 2023-04-28. PMID:37111687. |
the glucagon-like peptide-1 (glp-1) is a peptide with incretin activity and plays an important role in glycemic control as well as the improvement of insulin resistance in type 2 diabetes mellitus (t2dm). |
2023-04-28 |
2023-08-14 |
Not clear |
| Logan K Townsend, Gregory R Steinber. AMPK and the Endocrine Control of Metabolism. Endocrine reviews. 2023-04-28. PMID:37115289. |
these include hormones altered by fasting and refeeding including insulin, glucagon, glp-1 (glucagon like peptide-1), catecholamines, ghrelin and fgf21 (fibroblast growth factor 21); adipokines such as leptin and adiponectin; cell stress-induced cytokines like tnfα (tumor necrosis factor alpha) and gdf15 (growth differentiating factor 15), and lastly exerkines such as il-6 (interleukin-6) and irisin. |
2023-04-28 |
2023-08-14 |
Not clear |
| Jinhua Zhang, Hongjiang Xu, Jianguang Lu, Yuanzhen Dong, Jun Fen. Design, synthesis, and biological evaluation of a potential long-acting glucagon-like peptide-1 (GLP-1) analog. Bioorganic & medicinal chemistry. vol 85. 2023-04-25. PMID:37098289. |
by binding to its receptor, glucagon-like peptide-1 (glp-1) plays various physiological roles, including activating glucose-dependent insulin secretion, inhibiting gastric emptying, and reducing appetite. |
2023-04-25 |
2023-08-14 |
mouse |
| G Pugliese, G de Alteriis, G Muscogiuri, L Barrea, L Verde, F Zumbolo, A Colao, S Savastan. Liraglutide and polycystic ovary syndrome: is it only a matter of body weight? Journal of endocrinological investigation. 2023-04-24. PMID:37093453. |
obesity and insulin resistance, which commonly characterized this syndrome, prompted the design of studies investigating the effects of glucagon-like peptide 1 (glp-1) receptor agonists (glp-1ra) in pcos. |
2023-04-24 |
2023-08-14 |
human |
| Jia Liu, Kevin W Aylor, Zhenqi Li. Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-induced Obesity. Diabetes. 2023-04-19. PMID:37074396. |
to examine whether exercise and glucagon-like peptide 1 (glp-1) receptor agonism, alone or in combination, modulate vascular and metabolic insulin actions during obesity development, we performed a euglycemic insulin clamp in adult male rats after 2 weeks of high-fat diet feeding with either access to running wheel (exercise), liraglutide, or both. |
2023-04-19 |
2023-08-14 |
rat |
| Jia Liu, Kevin W Aylor, Zhenqi Li. Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-induced Obesity. Diabetes. 2023-04-19. PMID:37074396. |
our data suggest that early combination use of exercise and glp-1 receptor agonism might be an effective strategy in preventing vascular and metabolic insulin resistance and associated complications during the development of obesity. |
2023-04-19 |
2023-08-14 |
rat |
| Elisabet Jerlha. The therapeutic potential of glucagon-like peptide-1 for persons with addictions based on findings from preclinical and clinical studies. Frontiers in pharmacology. vol 14. 2023-04-17. PMID:37063267. |
the physiological complexity of glp-1 entails glucose homeostasis, gastrointestinal motility, and the release of insulin and glucagon. |
2023-04-17 |
2023-08-14 |
Not clear |
| Yue Wang, Fengyi Deng, Xing Zhong, Yijun Du, Xingyu Fan, Hong Su, Tianrong Pa. Dulaglutide provides protection against sepsis-induced lung injury in mice by inhibiting inflammation and apoptosis. European journal of pharmacology. 2023-04-16. PMID:37062504. |
in addition to promoting insulin secretion in a glucose-dependent manner, glucagon-like peptide-1 (glp-1) also exhibits anti-inflammatory properties. |
2023-04-16 |
2023-08-14 |
mouse |
| Johan Jendle, Yves Rezni. Insulin Pump and Closed Loop Systems' Use in People Living with Diabetes: A Narrative Review of Clinical and Cost-Effectiveness to Enable Access to Technology and Meet the Need of Payers. Diabetes, obesity & metabolism. 2023-04-12. PMID:37046364. |
hcl systems are to be evaluated in future trials performed in t2d to compare their incremental efficacy and cost effectiveness in comparison with available intensification tools which include multiple daily insulin injections, metformin, sglt-2 inhibitors and glp-1 receptor agonists. |
2023-04-12 |
2023-08-14 |
Not clear |
| Elizabeth A Jurica, Ximao Wu, Kristin N Williams, Lauren E Haque, Richard A Rampulla, Arvind Mathur, Min Zhou, Gary Cao, Hong Cai, Tao Wang, Heng Liu, Carrie Xu, Lori K Kunselman, Thomas M Antrilli, Michael B Hicks, Qin Sun, Elizabeth A Dierks, Atsu Apedo, Douglas B Moore, Kimberly A Foster, Mary Ellen Cvijic, Reshma Panemangalore, Purnima Khandelwal, Jason J Wilkes, Bradley A Zinker, Donald G Robertson, Evan B Janovitz, Michael Galella, Yi-Xin Li, Julia Li, Thangeswaran Ramar, Prasada Rao Jalagam, Ramya Jayaram, Jean M Whaley, Joel C Barrish, Jeffrey A Robl, William R Ewing, Bruce A Ellswort. Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities. Bioorganic & medicinal chemistry. vol 85. 2023-04-08. PMID:37030194. |
gpr40 agopams are highly effective antidiabetic agents that have a dual mechanism of action, stimulating both glucose-dependent insulin and glp-1 secretion. |
2023-04-08 |
2023-08-14 |
rat |
| Takafumi Osaka, Masahide Hamaguchi, Michiaki Fuku. Favorable Appendicular Skeletal Muscle Mass Changes in Older Patients With Type 2 Diabetes Receiving GLP-1 Receptor Agonist and Basal Insulin Co-Therapy. Clinical medicine insights. Endocrinology and diabetes. vol 16. 2023-04-07. PMID:37025567. |
favorable appendicular skeletal muscle mass changes in older patients with type 2 diabetes receiving glp-1 receptor agonist and basal insulin co-therapy. |
2023-04-07 |
2023-08-14 |
Not clear |
| Samantha Ouellette, Giulia Frias, Radhika Shah, Mahin Alamgir, Cindy Wasse. Dermal Hypersensitivity Reaction to Semaglutide: Two Case Reports. Journal of drugs in dermatology : JDD. vol 22. issue 4. 2023-04-07. PMID:37026881. |
glucagon-like peptide-1 (glp-1) receptor agonists are a class of antidiabetic agents that work by inducing insulin secretion and inhibiting release of glucagon in a glucose-dependent manner. |
2023-04-07 |
2023-08-14 |
Not clear |
| Jerad H Dumolt, Fredrick J Rosario, Avery C Kramer, Stacee Horwitz, Theresa L Powell, Thomas Jansso. Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity. Clinical science (London, England : 1979). 2023-04-04. PMID:37014924. |
umbilical cord plasma insulin, c-peptide, and glp-1 were increased in ob-lga infants. |
2023-04-04 |
2023-08-14 |
human |
| Giacomo Gastaldi, Barbara Lucchini, Sebastien Thalmann, Stephanie Alder, Markus Laimer, Michael Brändle, Peter Wiesli, Roger Lehman. Swiss recommendations of the Society for Endocrinology and Diabetes (SGED/SSED) for the treatment of type 2 diabetes mellitus (2023). Swiss medical weekly. vol 153. 2023-04-03. PMID:37011604. |
if insulin deficiency is the predominant factor at the outset of type 2 diabetes, the order of medications has to be reversed: insulin first and then cardio-renal protective medications (sglt-2 inhibitors, glp-1 receptor agonists). |
2023-04-03 |
2023-08-14 |
Not clear |
| Chiara Lopez, Chiara Bima, Martina Bollati, Fabio Bioletto, Matteo Procopio, Stefano Arata, Daniele Giuseppe Candela, Guglielmo Beccuti, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprin. Pathophysiology and Management of Glycemic Alterations before and after Surgery for Pheochromocytoma and Paraganglioma. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982228. |
the main pathophysiological mechanisms of glucose homeostasis alterations in ppgl, related to catecholamine hypersecretion, are impaired insulin and glucagon-like peptide type 1 (glp-1) secretion and increased insulin resistance. |
2023-03-29 |
2023-08-14 |
Not clear |
| Akiko Miyashita, Masaki Kobayashi, Takanori Yokota, Douglas W Zochodn. Diabetic Polyneuropathy: New Strategies to Target Sensory Neurons in Dorsal Root Ganglia. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36983051. |
molecules including insulin, glp-1, pten, hsp27, rage, cwc22, and dusp1 that impact neurotrophic signal transduction (for example, phosphatidylinositol-3 kinase/phosphorylated protein kinase b [pi3/pakt] signaling) and other cellular networks may promote regeneration. |
2023-03-29 |
2023-08-14 |
Not clear |
| Bhawna Puri, Sunita Meena, Sathish Kumar M H, Prashant Ashok Shelke, Latha Sabikhi, Ashutos. Encapsulation and Assessment of Antidiabetic Potential of α-Lactalbumin-Derived Hydrolysates. Journal of agricultural and food chemistry. 2023-03-29. PMID:36989115. |
glp-1 binds to the glp-1 receptors of pancreatic β-cells and leads to β-cell proliferation and increases insulin secretion through associated gene expression. |
2023-03-29 |
2023-08-14 |
rat |
| Bhawna Puri, Sunita Meena, Sathish Kumar M H, Prashant Ashok Shelke, Latha Sabikhi, Ashutos. Encapsulation and Assessment of Antidiabetic Potential of α-Lactalbumin-Derived Hydrolysates. Journal of agricultural and food chemistry. 2023-03-29. PMID:36989115. |
rats in the diabetic control group showed an increase in the blood glucose level and liver function enzymes and a decrease in glp-1, insulin, and antioxidative enzymes. |
2023-03-29 |
2023-08-14 |
rat |
| Bhawna Puri, Sunita Meena, Sathish Kumar M H, Prashant Ashok Shelke, Latha Sabikhi, Ashutos. Encapsulation and Assessment of Antidiabetic Potential of α-Lactalbumin-Derived Hydrolysates. Journal of agricultural and food chemistry. 2023-03-29. PMID:36989115. |
administration of hydrolysates reversed the parameters by lowering the blood glucose level and increasing glp-1 and insulin levels in plasma. |
2023-03-29 |
2023-08-14 |
rat |