| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyeryeong Cho, Jaechul Li. The emerging role of gut hormones. Molecules and cells. 2024-10-19. PMID:39426686. |
the gut is traditionally recognized as the central organ for the digestion and absorption of nutrients, however it also functions as a significant endocrine organ, secreting a variety of hormones such as glucagon-like peptide 1 (glp-1), serotonin, somatostatin, and glucocorticoids. |
2024-10-19 |
2024-10-22 |
Not clear |
| Ananyaa Sridhar, Dawood Khan, Mahmoud Abdelaal, Jessie A Elliott, Violetta Naughton, Peter R Flatt, Carel W Le Roux, Neil G Docherty, Charlotte R Moffet. Differential effects of RYGB surgery and best medical treatment for obesity-diabetes on intestinal and islet adaptations in obese-diabetic ZDSD rats. PloS one. vol 17. issue 9. 2022-09-22. PMID:36137097. |
insulin, glucagon, somatostatin, pyy, glp-1 and gip expression patterns were assessed using immunocytochemistry and analyzed using imagej. |
2022-09-22 |
2023-08-14 |
rat |
| Hongjun Deng, Fengying Yang, Xiaoyi Ma, Ying Wang, Qi Chen, Li Yua. Long-Term Liraglutide Administration Induces Pancreas Neogenesis in Adult T2DM Mice. Cell transplantation. vol 29. 2021-06-25. PMID:32584149. |
the primitive bud was characterized by scattered single monohormonal cells expressing insulin, glp-1, somatostatin, or pancreatic polypeptide, and four-hormonal cells, but no acinar cells and ductal epithelial cells. |
2021-06-25 |
2023-08-13 |
mouse |
| Hale M Tasyurek, Hasan Ali Altunbas, Mustafa Kemal Balci, Thomas S Griffith, Salih Sanliogl. Therapeutic Potential of Lentivirus-Mediated Glucagon-Like Peptide-1 Gene Therapy for Diabetes. Human gene therapy. vol 29. issue 7. 2019-06-24. PMID:29409356. |
among the variety of effects it mediates, glp-1 induces delta cell secretion of somatostatin, inhibits alpha cell release of glucagon, reduces gastric emptying, and slows food intake. |
2019-06-24 |
2023-08-13 |
human |
| Giovanna Muscogiuri, Giancarlo Balercia, Luigi Barrea, Angelo Cignarelli, Francesco Giorgino, Jens J Holst, Daniela Laudisio, Francesco Orio, Giacomo Tirabassi, Annamaria Cola. Gut: A key player in the pathogenesis of type 2 diabetes? Critical reviews in food science and nutrition. vol 58. issue 8. 2018-09-28. PMID:27892685. |
at the same time, intestinal milieu regulates the secretion of hormones such as glp-1, gip, ghrelin, gastrin, somatostatin, cck, serotonin, peptide yy, glp-2, all of which importantly influence metabolism in general and in particular glucose metabolism. |
2018-09-28 |
2023-08-13 |
Not clear |
| Sangeeta P Bhat, Arun Sharm. Current Drug Targets in Obesity Pharmacotherapy - A Review. Current drug targets. vol 18. issue 8. 2018-04-25. PMID:28245771. |
several promising new targets are currently being evaluated, such as amylin analogues (pramlintide, davalintide), leptin analogues (metreleptin), glp-1 analogues (exenatide, liraglutide, ttp-054), mc4r agonists (rm-493), oxyntomodulin analogues, neuropeptide y antagonists (velneperit), cannabinoid type-1 receptor blockers (am-6545), metap2 inhibitors (beloranib), lipase inhibitors (cetilistat) and anti-obesity vaccines (ghrelin, somatostatin, ad36). |
2018-04-25 |
2023-08-13 |
Not clear |
| Thomas B Farb, Marta Adeva, Thomas J Beauchamp, Over Cabrera, David A Coates, Tamika DeShea Meredith, Brian A Droz, Alexander Efanov, James V Ficorilli, Susan L Gackenheimer, Maria A Martinez-Grau, Victoriano Molero, Gema Ruano, Michael A Statnick, Todd M Suter, Samreen K Syed, Miguel A Toledo, Francis S Willard, Xin Zhou, Krister B Bokvist, David G Barret. Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5. Endocrinology. vol 158. issue 11. 2017-12-12. PMID:28938487. |
regulation of endogenous (male) rodent glp-1 secretion and human islet insulin secretion by antagonism of somatostatin receptor 5. |
2017-12-12 |
2023-08-13 |
mouse |
| Patricia Martins, Josiane Fakhry, Enio Chaves de Oliveira, Billie Hunne, Linda J Fothergill, Mitchell Ringuet, Débora d'Ávila Reis, Jens F Rehfeld, Brid Callaghan, John B Furnes. Analysis of enteroendocrine cell populations in the human colon. Cell and tissue research. vol 367. issue 2. 2017-05-31. PMID:27844204. |
only four hormones, 5-hydroxytryptamine (5-ht), glucagon-like peptide 1 (glp-1), peptide yy (pyy) and somatostatin, were common in enteroendocrine cells of the human colon. |
2017-05-31 |
2023-08-13 |
human |
| Patricia Martins, Josiane Fakhry, Enio Chaves de Oliveira, Billie Hunne, Linda J Fothergill, Mitchell Ringuet, Débora d'Ávila Reis, Jens F Rehfeld, Brid Callaghan, John B Furnes. Analysis of enteroendocrine cell populations in the human colon. Cell and tissue research. vol 367. issue 2. 2017-05-31. PMID:27844204. |
the most numerous cells were 5-ht cells, some of which also contained pyy or somatostatin and very rarely glp-1. |
2017-05-31 |
2023-08-13 |
human |
| Yohan Reynaud, Josiane Fakhry, Linda Fothergill, Brid Callaghan, Mitchell Ringuet, Billie Hunne, David M Bravo, John B Furnes. The chemical coding of 5-hydroxytryptamine containing enteroendocrine cells in the mouse gastrointestinal tract. Cell and tissue research. vol 364. issue 3. 2017-03-06. PMID:26803512. |
small proportions of 5-ht cells contained gastrin or somatostatin in the stomach, pyy or glp-1 in the small intestine and glp-1 or somatostatin in the large intestine. |
2017-03-06 |
2023-08-13 |
mouse |
| Claire L Meek, Hannah B Lewis, Frank Reimann, Fiona M Gribble, Adrian J Par. The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones. Peptides. vol 77. 2016-12-13. PMID:26344355. |
the aim of this review is to summarise the effects of different bariatric surgery procedures upon gastrointestinal and pancreatic peptides, including ghrelin, gastrin, cholecystokinin (cck), glucose-dependent insulinotropic hormone (gip), glucagon-like peptide 1 (glp-1), peptide yy (pyy), oxyntomodulin, insulin, glucagon and somatostatin. |
2016-12-13 |
2023-08-13 |
Not clear |
| P Ritz, C Vaurs, M Barigou, H Hanair. Hypoglycaemia after gastric bypass: mechanisms and treatment. Diabetes, obesity & metabolism. vol 18. issue 3. 2016-11-04. PMID:26508374. |
pharmacological treatment with acarbose is efficient, but other drugs still need to be validated in a greater number of subjects (insulin, glucagon, calcium channel blockers, somatostatin analogues and glp-1 analogues). |
2016-11-04 |
2023-08-13 |
human |
| Daniel J Drucke. Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls. Diabetes. vol 62. issue 10. 2013-12-10. PMID:23818527. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are incretin hormones that control the secretion of insulin, glucagon, and somatostatin to facilitate glucose disposal. |
2013-12-10 |
2023-08-12 |
human |
| Daisy Mohanasundaram, Chris Drogemuller, John Brealey, Claire F Jessup, Clyde Milner, Chiara Murgia, Carol J Lang, Austin Milton, Peter D Zalewski, Graeme R Russ, Patrick T Coate. Ultrastructural analysis, zinc transporters, glucose transporters and hormones expression in New world primate (Callithrix jacchus) and human pancreatic islets. General and comparative endocrinology. vol 174. issue 2. 2012-05-15. PMID:21821034. |
antibody staining for insulin, glucagon, somatostatin and glucagon-like peptide-1 (glp-1) showed that the distribution pattern of the different cell types within islets was comparable to pig and human islets. |
2012-05-15 |
2023-08-12 |
human |
| Hisamitsu Ishihar. [Cross-talk among pancreatic alpha, beta and delta cells stimulated by incretin hormones]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 5. 2011-07-08. PMID:21595261. |
incretin hormones, glp-1 and gip, contribute to whole body glucose homeostasis by modulating secretion of islet hormones, insulin, glucagon and somatostatin. |
2011-07-08 |
2023-08-12 |
Not clear |
| Hisamitsu Ishihar. [Cross-talk among pancreatic alpha, beta and delta cells stimulated by incretin hormones]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 5. 2011-07-08. PMID:21595261. |
both glp-1 and gip stimulate insulin and somatostatin secretion. |
2011-07-08 |
2023-08-12 |
Not clear |
| Yu-Cheng Wang, Emerick Gallego-Arteche, Gioia Iezza, Xiaochen Yuan, Mary R Matli, Su-Pin Choo, Marlene B Zuraek, Ravi Gogia, Francis C Lynn, Michael S German, Emily K Bergsland, David B Donner, Robert S Warren, Eric K Nakakur. Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors. Endocrine-related cancer. vol 16. issue 1. 2009-05-11. PMID:18987169. |
in the intestine of nkx2.2 (-/-) mice, we found a dramatic reduction in the number of cells producing numerous hormones, such as serotonin, gastrin, cholecystokinin, somatostatin, glucagon-like peptide 1 (glp-1), and secretin, but an increase in cells producing ghrelin. |
2009-05-11 |
2023-08-12 |
mouse |
| Maria Sörhede Winzell, Bo Ahré. G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes. Pharmacology & therapeutics. vol 116. issue 3. 2008-02-15. PMID:17900700. |
examples of islet gpcr are gpr40 and gpr119, which are gpcr with fatty acids as ligands, the receptors for the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), the receptors for the islet hormones glucagon and somatostatin, the receptors for the classical neurotransmittors acetylcholine (ach; m(3) muscarinic receptors) and noradrenaline (beta(2)- and alpha(2)-adrenoceptors) and for the neuropeptides pituitary adenylate cyclase-activating polypeptide (pacap) and vasoactive intestinal polypeptide (vip; pac(1) and vpac(2) receptors), cholecystokinin (cck(a) receptors) and neuropeptide y (npy y1 receptors). |
2008-02-15 |
2023-08-12 |
Not clear |
| P H L M Geelhoed-Duijvestij. Incretins: a new treatment option for type 2 diabetes? The Netherlands journal of medicine. vol 65. issue 2. 2007-05-01. PMID:17379930. |
glp-1 stimulates the production and secretion of insulin, the release of somatostatin, glucose utilisation by increasing insulin sensitivity and in animal studies also beta-cell function and expansion (proliferation). |
2007-05-01 |
2023-08-12 |
Not clear |
| Naciye Isbil-Buyukcoskun, Guldal Gule. Investigation of the mechanisms involved in the central effects of glucagon-like peptide-1 on ethanol-induced gastric mucosal lesions. Regulatory peptides. vol 128. issue 1. 2005-09-26. PMID:15721488. |
cysteamine, a somatostatin depletor (280 mg/kg, s.c.), did not affect the protective activity of glp-1, while inhibition of nitric oxide (no) synthesis by l-name (3 mg/kg, i.v.) |
2005-09-26 |
2023-08-12 |
rat |