| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jordan Siu Fung Chan, Tanin Shafaati, John R Usshe. Incretin-mediated control of cardiac energy metabolism. The Journal of endocrinology. 2024-07-16. PMID:39013412. |
glucose-dependent insulinotropic polypeptide (gip) and glucagon-like-peptide-1 (glp-1) are incretin hormones that stimulate insulin secretion and improve glycemic control in individuals with type 2 diabetes (t2d). |
2024-07-16 |
2024-07-19 |
Not clear |
| Jordan Siu Fung Chan, Tanin Shafaati, John R Usshe. Incretin-mediated control of cardiac energy metabolism. The Journal of endocrinology. 2024-07-16. PMID:39013412. |
not only do gip and glp-1 increase the secretion of insulin, they may also modify glucagon secretion, both of which have potent actions on cardiac substrate utilization. |
2024-07-16 |
2024-07-19 |
Not clear |
| Shaobin Yang, Xiaoqian Zhao, Yimeng Zhang, Qi Tang, Yanhong Li, Yaqin Du, Peng Y. Tirzepatide shows neuroprotective effects via regulating brain glucose metabolism in APP/PS1 mice. Peptides. 2024-07-13. PMID:39002758. |
tirzepatide (ly3298176), a glp-1 and gip receptor agonist, is fatty-acid-modified and 39-amino acid linear peptide, which ameliorates learning and memory impairment in diabetic rats. |
2024-07-13 |
2024-07-16 |
mouse |
| Ferenc Sztanek, László Imre Tóth, Attila Pető, Marcell Hernyák, Ágnes Diószegi, Mariann Harang. New Developments in Pharmacological Treatment of Obesity and Type 2 Diabetes-Beyond and within GLP-1 Receptor Agonists. Biomedicines. vol 12. issue 6. 2024-06-27. PMID:38927527. |
incretin-based peptides exert their effect through g-protein-coupled receptors, the receptors for glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), and glucagon peptide hormones are important regulators of insulin secretion and energy metabolism. |
2024-06-27 |
2024-06-29 |
Not clear |
| Hussain Sohail Rangwala, Hareer Fatima, Mirha Ali, Muhammad Saqlain Mustafa, Muhammad Ashir Shafique, Burhanuddin Sohail Rangwala, Syed Raza Abba. Evaluating the effectiveness and safety of various Tirzepatide dosages in the management of Type 2 diabetes mellitus: a network meta-analysis of randomized controlled trials. Journal of diabetes and metabolic disorders. vol 23. issue 1. 2024-06-27. PMID:38932909. |
titrzepatide (tzp), a dual gip and glp-1 receptor agonist, proves highly effective in controlling hyperglycemia, stimulating insulin secretion, and promoting weight loss. |
2024-06-27 |
2024-06-29 |
Not clear |
| Tingyu Huang, Aoyun Li, Shanshan Zhang, Jiayan Fan, Zeao Hua, Xuebing Wang, Cong Zhang, Xu Yan. The role of gut microbiota in anorexia induced by T-2 toxin. Ecotoxicology and environmental safety. vol 281. 2024-06-19. PMID:38896898. |
this data proved that t-2 toxin was able to induce an anorexia in mice by increased the contents of gastrointestinal hormones (cck, gip, glp-1 and pyy), neurotransmitters (5-ht and sp), as well as pro-inflammatory cytokines (il-1β, il-6 and tnf-α) in serum of mice. |
2024-06-19 |
2024-06-22 |
mouse |
| Anca Moțățăianu, Ion Bogdan Mănescu, Georgiana Șerban, Laura Bărcuțean, Valentin Ion, Rodica Bălașa, Sebastian Andon. Exploring the Role of Metabolic Hormones in Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 25. issue 10. 2024-05-25. PMID:38791099. |
serum levels of insulin, total amylin, c-peptide, active ghrelin, gip (gastric inhibitory peptide), glp-1 active (glucagon-like peptide-1), glucagon, pyy (peptide yy), pp (pancreatic polypeptide), leptin, interleukin-6, mcp-1 (monocyte chemoattractant protein-1), and tnfα (tumor necrosis factor alpha) were measured, and correlations with alsfrs-r, evolution scores, and biomarkers were analyzed using spearman correlation coefficients. |
2024-05-25 |
2024-05-27 |
Not clear |
| João Carlos Locatelli, Juliene Gonçalves Costa, Andrew Haynes, Louise H Naylor, P Gerry Fegan, Bu B Yeap, Daniel J Gree. Incretin-Based Weight Loss Pharmacotherapy: Can Resistance Exercise Optimize Changes in Body Composition? Diabetes care. 2024-04-30. PMID:38687506. |
liraglutide and semaglutide (glp-1ra), tirzepatide (glp-1 and gip receptor dual agonist), and retatrutide (glp-1, gip, and glucagon receptor triple agonist) are peptides with incretin agonist activity that induce ∼15-24% weight loss in adults with overweight and obesity, alongside beneficial impacts on blood pressure, cholesterol, blood glucose, and insulin. |
2024-04-30 |
2024-05-03 |
Not clear |
| Giulia Angelini, Sara Russo, Geltrude Mingron. Incretin hormones, obesity and gut microbiota. Peptides. 2024-04-18. PMID:38636809. |
gip (glucose-dependent insulinotropic polypeptide) and glp-1 (glucagon-like peptide-1), which are secreted from the intestine after nutrient intake and stimulate insulin secretion from pancreatic β cells, influence lipid metabolism, gastric empting, appetite and body weight. |
2024-04-18 |
2024-04-21 |
Not clear |
| Anne-Sofie H Jensen, Henriette Ytting, Mikkel P Werge, Elias B Rashu, Liv E Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Kirstine N Bojsen-Møller, Anders E Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza R Serizawa, Lise L Gluud, Nicolai J Wewer Albrechtse. Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease. American journal of physiology. Gastrointestinal and liver physiology. 2024-04-16. PMID:38625142. |
we measured the concentrations of glucose, c-peptide, insulin, glucagon, the two incretin hormones glucose insulinotropic peptide (gip) and glucagon-like peptide-1 (glp-1). |
2024-04-16 |
2024-04-18 |
Not clear |
| Lampros G Chrysavgis, Spyridon Kazanas, Konstantina Bafa, Sophia Rozani, Maria-Evangelia Koloutsou, Evangelos Cholongita. Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide, and Glucagon Receptor Agonists in Metabolic Dysfunction-Associated Steatotic Liver Disease: Novel Medication in New Liver Disease Nomenclature. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612640. |
glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are incretins that regulate postprandial glucose regulation, stimulating insulin secretion from pancreatic β-cells in response to food ingestion. |
2024-04-13 |
2024-04-15 |
human |
| Samrin Kagdi, Sulayman Lyons, Jacqueline L Beaudr. The interplay of glucose-dependent insulinotropic polypeptide in adipose tissue. The Journal of endocrinology. 2024-04-05. PMID:38579777. |
glucose-dependent insulinotropic polypeptide (gip) is an incretin hormone secreted from the small intestinal k-cells, responsible for augmenting insulin release, and has gained attention for its independent and amicable effects with glucagon-like peptide-1 (glp-1), another incretin hormone secreted from the small intestinal l-cells. |
2024-04-05 |
2024-04-10 |
human |
| Samrin Kagdi, Sulayman Lyons, Jacqueline L Beaudr. The interplay of glucose-dependent insulinotropic polypeptide in adipose tissue. The Journal of endocrinology. 2024-04-05. PMID:38579777. |
the gip receptor (gipr) is found in whole adipose tissue, whereas the glp-1 receptor (glp-1r) is not, and some studies suggest that gipr action lowers body weight and plays a role in lipolysis, glucose/lipid uptake/disposal, adipose tissue blood flow, lipid oxidation, and free-fatty acid (ffa) re-esterification that may or may not be influenced by other hormones such as insulin. |
2024-04-05 |
2024-04-10 |
human |
| Kayoko Kamemoto, Yusei Tataka, Ayano Hiratsu, Chihiro Nagayama, Yuka Hamada, Koji Kurata, Michiko Chiyoda, Machi Ito, Masashi Miyashit. Effect of vegetable consumption with chewing on postprandial glucose metabolism in healthy young men: a randomised controlled study. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555375. |
circulating concentrations of glucose, insulin, total glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip) concentrations were measured from the plasma. |
2024-03-30 |
2024-04-02 |
Not clear |
| Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C Schriever, Michael Sterr, Siegfried Ussar, Qian Zhang, Richard DiMarchi, Matthias H Tschöp, Paul T Pfluger, Jonathan D Douros, Timo D Mülle. Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice. Molecular metabolism. 2024-03-16. PMID:38492844. |
loss of gipr in lepr cells impairs glucose control by gip and gip:glp-1 co-agonism without affecting body weight and food intake in mice. |
2024-03-16 |
2024-03-19 |
mouse |
| Christopher Bannon, Claire Meek, Frank Reimann, Fiona M Gribbl. Fasting and Post Prandial Pancreatic and Enteroendocrine Hormone Levels in Obese and Non-Obese Participants. Peptides. 2024-03-15. PMID:38490484. |
participants: with healthy bmi (n=15), overweight bmi (n=29) and obesity (n=161) had samples taken fasting and 30min post mixed liquid meal for analysis of glucagon-like peptide-1 (glp-1), pyy, glucose-dependent insulinotropic polypeptide (gip), insulin and glucagon. |
2024-03-15 |
2024-03-18 |
human |
| Dorte B Zilstorff, Michael M Richter, Jens Hannibal, Henrik L Jørgensen, Henriette P Sennels, Nicolai J Wewer Albrechtse. Secretion of glucagon, GLP-1 and GIP may be affected by circadian rhythm in healthy males. BMC endocrine disorders. vol 24. issue 1. 2024-03-14. PMID:38481208. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are secreted from gut endocrine cells during meals and control glucose homeostasis by potentiating insulin secretion and inhibiting food intake. |
2024-03-14 |
2024-03-16 |
Not clear |
| Xin Jiang, Ji Li, Xiaohui Yao, Hao Ding, Aihong Gu, Zhen Zho. Neuroprotective effects of dipeptidyl peptidase 4 inhibitor on Alzheimer's disease: a narrative review. Frontiers in pharmacology. vol 15. 2024-02-26. PMID:38405664. |
beyond dpp4i's benefits in alleviating insulin resistance and glucose-lowering, underlying mechanisms for the potential neuroprotection with dpp4i medications were categorized into the following sections: (ferrari et al., physiol rev, 2021, 101, 1,047-1,081): the benefits of dpp4is on directly ameliorating the burden of β-amyloid plaques and reducing the formation of neurofibrillary tangles; dpp4i increasing the bioactivity of neuroprotective dpp4 substrates including glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic peptide (gip), and stromal-derived factor-1α (sdf-1α) etc. |
2024-02-26 |
2024-02-28 |
Not clear |
| Rolien Bosch, Marcella Petrone, Rosalin Arends, Paolo Vicini, Eric J G Sijbrands, Sven Hoefman, Nelleke Snelde. Characterisation of cotadutide's dual GLP-1/glucagon receptor agonistic effects on glycaemic control using an in vivo human glucose regulation quantitative systems pharmacology model. British journal of pharmacology. 2024-02-25. PMID:38403793. |
we characterised the effects of cotadutide on glucose, insulin, glp-1, gip, and glucagon over time in a quantitative manner using our glucose dynamics systems model (4gi systems model), in combination with clinical data from a multiple ascending dose/phase 2a (mad/ph2a) study in overweight and obese subjects with a history of type 2 diabetes mellitus (nct02548585). |
2024-02-25 |
2024-02-28 |
human |
| Snehasish Nag, Samanwita Mandal, Oindrila Mukherjee, Tanmay Majumdar, Satinath Mukhopadhyay, Rakesh Kund. Vildagliptin inhibits high fat and fetuin-A mediated DPP-4 expression, intracellular lipid accumulation and improves insulin secretory defects in pancreatic beta cells. Biochimica et biophysica acta. Molecular basis of disease. vol 1870. issue 3. 2024-02-03. PMID:38296116. |
dipeptidyl peptidase-4 (dpp-4), a ubiquitous proteolytic enzyme, inhibits insulin secretion from pancreatic beta cells by inactivating circulating incretin hormones glp-1 and gip. |
2024-02-03 |
2024-02-06 |
mouse |