| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyan Hu, Shuang Liu, Zhang Jing, Yuxiao He, Gang Qin, Liang Jian. Immunomodulation in allergic rhinitis: Insights from Th2 cells and NLRP3/IL-18 pathway. Cell biochemistry and function. vol 42. issue 3. 2024-03-31. PMID:38555506. |
following ova stimulation, increased nasal symptoms were observed in the ova group along with augmented gata3 expression and elevated il-4 and il-1b levels, indicative of th2 polarization and cellular pyroptosis involvement. |
2024-03-31 |
2024-04-02 |
mouse |
| Simone Bellavia, Irene Scala, Pier Andrea Rizzo, Valerio Brunetti, Aldobrando Broccolini, Giacomo Della Marca, Paolo Calabresi, Giovanni Frisull. Th1/Th2 polarization of peripheral immune response in atherothrombotic and cardioembolic stroke: a prospective study. Scientific reports. vol 12. issue 1. 2022-09-30. PMID:36180482. |
although the balance between proinflammatory cd4 + t helper (th)-1 lymphocytes, expressing t-bet transcription factor, and anti-inflammatory th2 cells expressing gata3 seems to influence the outcome in experimental stroke, the role of peripheral immune response in acute stroke patients is poorly understood. |
2022-09-30 |
2023-08-14 |
human |
| Shiyao Wu, Yaou Zhou, Sijia Liu, Huali Zhang, Hui Luo, Xiaoxia Zuo, Tong L. Regulatory effect of nicotine on the differentiation of Th1, Th2 and Th17 lymphocyte subsets in patients with rheumatoid arthritis. European journal of pharmacology. vol 831. 2018-10-15. PMID:29715455. |
meanwhile, nicotine increased the levels of il-4 and gata3 during th2 differentiation. |
2018-10-15 |
2023-08-13 |
Not clear |
| Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Ok Hee Cha. Skullcapflavone II attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release. International immunopharmacology. vol 52. 2018-06-12. PMID:28886581. |
ova-induced ar mice increased nasal symptoms, eosinophils and mast cells infiltration into nasal cavity, ova-specific ige/igg1 and histamine in serum, th2 cytokines including il-13 and gata3, and nf-κb signaling in nalf and lung homogenate. |
2018-06-12 |
2023-08-13 |
mouse |
| Zhao Wei Gu, Yun Xiu Wang, Zhi Wei Ca. Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a murine model. Oncotarget. vol 8. issue 9. 2017-10-09. PMID:28187441. |
we measured nasal rubbing motion, sneezing and eosinophils, as well as the th1 (th1 cell percentage, ifn-γ mrna/protein, t-bet mrna), th2 (th2 cell percentage, il-4 mrna/protein, gata3 mrna), th9 (th9 cell percentages il-9 mrna/protein, pu.1 and irf4 mrna), th17 (th17 cell percentage, il-17 mrna/protein, rorγt mrna), and treg (treg cell percentage, foxp3 mrna) responses in the nasal mucosa. |
2017-10-09 |
2023-08-13 |
mouse |
| Sheikh Rayees, Ulaganathan Mabalirajan, Wajid Waheed Bhat, Shafaq Rasool, Rafiq Ahmad Rather, Lipsa Panda, Naresh Kumar Satti, Surrinder Kumar Lattoo, Balaram Ghosh, Gurdarshan Sing. Therapeutic effects of R8, a semi-synthetic analogue of Vasicine, on murine model of allergic airway inflammation via STAT6 inhibition. International immunopharmacology. vol 26. issue 1. 2016-02-16. PMID:25863236. |
also, the r8 treatment in the therapeutic model decreased methacholine induced ahr, th2 cytokine release, serum ige levels, infiltration of inflammatory cells into the airways, phosphorylation of stat6 and expression of gata3. |
2016-02-16 |
2023-08-13 |
mouse |
| Mao-Liang Chen, Tzung-Chieh Tsai, Lu-Kai Wang, Yi-Yin Lin, Ya-Min Tsai, Ming-Cheng Lee, Fu-Ming Tsa. Clozapine inhibits Th1 cell differentiation and causes the suppression of IFN-γ production in peripheral blood mononuclear cells. Immunopharmacology and immunotoxicology. vol 34. issue 4. 2012-11-13. PMID:22268679. |
also, clozapine can enhance the expression of signal transducer and activator of transcription 6 and gata3, which are critical for the differentiation of th2 cells. |
2012-11-13 |
2023-08-12 |
Not clear |
| Atsushi Onodera, Masakatsu Yamashita, Yusuke Endo, Makoto Kuwahara, Soichi Tofukuji, Hiroyuki Hosokawa, Akinori Kanai, Yutaka Suzuki, Toshinori Nakayam. STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. The Journal of experimental medicine. vol 207. issue 11. 2010-11-16. PMID:20956546. |
in this study, we show that activation of stat6 induces displacement of the pcg complex by the trxg complex at the upstream region of the gene encoding gata3, a transcription factor essential for t helper type 2 (th2) cell differentiation. |
2010-11-16 |
2023-08-12 |
Not clear |
| Atsushi Onodera, Masakatsu Yamashita, Yusuke Endo, Makoto Kuwahara, Soichi Tofukuji, Hiroyuki Hosokawa, Akinori Kanai, Yutaka Suzuki, Toshinori Nakayam. STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. The Journal of experimental medicine. vol 207. issue 11. 2010-11-16. PMID:20956546. |
thus, stat6-mediated displacement of pcg by the trxg complex establishes subsequent stat6-independent maintenance of gata3 expression in th2 cells via the recruitment of the menin-trxg complex. |
2010-11-16 |
2023-08-12 |
Not clear |
| Thomas W Klein, Cathy Newton, Kellie Larsen, Joe Chou, Izabella Perkins, Lily Lu, Liang Nong, Herman Friedma. Cannabinoid receptors and T helper cells. Journal of neuroimmunology. vol 147. issue 1-2. 2004-03-15. PMID:14741435. |
these results suggest that thc suppresses th1 biasing activity such as il-12rbeta2 by a cb1 mediated mechanism and enhances the th2 biasing activity, gata3, by a cb2 mechanism. |
2004-03-15 |
2023-08-12 |
mouse |