| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linhe Lu, Yalan Shao, Nisha Wang, Xiang Xiong, Mengen Zhai, Jiayou Tang, Yang Liu, Jian Yang, Lifang Yan. Follistatin-like protein 1 attenuates doxorubicin-induced cardiomyopathy by inhibiting MsrB2-mediated mitophagy. Molecular and cellular biochemistry. 2024-05-02. PMID:38696001. |
fstl1 treatment attenuated dox-induced cardiac dysfunction, cardiac fibrosis, and cellular apoptosis by inhibiting excess mitochondrial matrix protein methionine sulfoxide reductase b2 (msrb2)-mediated mitophagy. |
2024-05-02 |
2024-05-04 |
Not clear |
| Xu Yan, Jing-Yu Ding, Ren-Jie Zhang, Hua-Qing Zhang, Liang Kang, Chong-Yu Jia, Xiao-Ying Liu, Cai-Liang She. FSTL1 Accelerates Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration Through TLR4/NF-κB Pathway. Inflammation. 2024-02-05. PMID:38316670. |
in addition, recombinant human fstl1 (rh-fstl1) was found to upregulate the expression of p16 and p21, increase the number of senescence-associated β-galactosidase (sa-β-gal)-positive cells, induce senescence-related secretory phenotypes (sasp), and downregulate extracellular matrix (ecm) protein expressions, leading to an imbalance in ecm metabolism destructions. |
2024-02-05 |
2024-02-09 |
human |
| Xiaowei Qin, Jinjie Zhang, Mengmeng Wang, Yafei Feng, Yanbo Zhao, Huipeng Zhang, Wei Gu. The effect of thalidomide on the invasive ability of gastric cancer cells by regulating miR-524-5p/FSTL1. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 14. 2024-01-27. PMID:38279459. |
the experiment was divided into a blank control group, thal group (25 μg/ml thal-treated cells), thal+inhibitor nc group, and thal+mir-524-5p inhibitor group (transfected with inhibitor nc and mir-524-5p inhibitor respectively on the basis of thal group), cultivated for 48 h. the level of mir-524-5p in the cells was detected by rt-qpcr; the cell invasion was detected by transwell; the expression of matrix metalloproteinase (mmp)-2, mmp-9, fstl1 protein in the cells was detected by western blot. |
2024-01-27 |
2024-01-29 |
Not clear |
| Yu Zhang, Yang Wang, Guoxun Zheng, Yang Liu, Jinhong Li, Huihui Huang, Chunhua Xu, Yelin Zeng, Xiaoyi Zhang, Jinzhong Qin, Chunsun Dai, Harald O Hambrock, Ursula Hartmann, Bo Feng, Kingston Kinglun Mak, Youhua Liu, Hui-Yao Lan, Yu Huang, Zhi-Hua Zheng, Yin Xi. Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo. The Journal of biological chemistry. 2022-05-07. PMID:35525270. |
follistatin-like 1 (fstl1) is a member of the follistatin-sparc family of secreted and extracellular matrix proteins. |
2022-05-07 |
2023-08-13 |
mouse |
| Jie Shi, Shaoyi Wang, Qiting He, Kaiwen Liu, Wei Zhao, Qing Xie, Lei Chen. TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34190406. |
at the same time, mir27a is up-regulated by tnf-α via the p38 signalling pathway, which ameliorates inflammation, apoptosis and matrix degradation by targeting fstl1. |
2021-10-15 |
2023-08-13 |
human |
| Jie Shi, Shaoyi Wang, Qiting He, Kaiwen Liu, Wei Zhao, Qing Xie, Lei Chen. TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34190406. |
ectopic mir27a expression inhibited apoptosis, suppressed the inflammatory response and attenuated the catabolism of the extracellular matrix by targeting fstl1. |
2021-10-15 |
2023-08-13 |
human |
| Xiaohe Li, Yinshan Fang, Dingyuan Jiang, Yingying Dong, Yingying Liu, Si Zhang, Jiasen Guo, Chao Qi, Chenjing Zhao, Fangxin Jiang, Yueyue Jin, Jing Geng, Cheng Yang, Hongkai Zhang, Bin Wei, Jiurong Liang, Chen Wang, Huaping Dai, Honggang Zhou, Dianhua Jiang, Wen Nin. Targeting FSTL1 for Multiple Fibrotic and Systemic Autoimmune Diseases. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 1. 2021-09-30. PMID:33007201. |
fstl1 nabs exerted their potent antifibrotic effects via reduced tgf-β1 responsiveness and subsequent myofibroblast activation and extracellular matrix production. |
2021-09-30 |
2023-08-13 |
mouse |
| Qiong Wang, Junfang Wang, Xiaofeng Gu, Dehong Feng, Ding Li, Tao Jian. MicroRNA-124-3p inhibits the differentiation of precartilaginous stem cells into nucleus pulposus-like cells via targeting FSTL1. Experimental and therapeutic medicine. vol 22. issue 1. 2021-05-20. PMID:34007334. |
subsequent experiments revealed that mir-124-3p overexpression significantly decreased the expression of the extracellular matrix proteins, aggrecan and collagen type ii, which was accompanied by a significant decrease in follistatin-related protein 1 (fstl1) expression levels. |
2021-05-20 |
2023-08-13 |
rat |
| Peng-Fei Hu, Chi-Yuan Ma, Fang-Fang Sun, Wei-Ping Chen, Li-Dong W. Follistatin-like protein 1 (FSTL1) promotes chondrocyte expression of matrix metalloproteinase and inflammatory factors via the NF-κB pathway. Journal of cellular and molecular medicine. vol 23. issue 3. 2020-07-07. PMID:30644158. |
follistatin-like protein 1 (fstl1) promotes chondrocyte expression of matrix metalloproteinase and inflammatory factors via the nf-κb pathway. |
2020-07-07 |
2023-08-13 |
rat |
| Yuan Qu, Yi Liu, Rui L. FSTL1 Promotes Inflammatory Reaction and Cartilage Catabolism through Interplay with NFκB Signaling Pathways in an In Vitro ONFH Model. Inflammation. vol 42. issue 4. 2020-01-13. PMID:31011927. |
additionally, administration of an nfκb inhibitor (jsh-23) significantly reduced the overexpression of inflammatory cytokines and protein degradation enzymes induced by fstl1 and maintained the level of major cartilage matrix components (aggrecan and collagen ii). |
2020-01-13 |
2023-08-13 |
human |
| Shinnosuke Yamada, Norimichi Itoh, Taku Nagai, Tsuyoshi Nakai, Daisuke Ibi, Akira Nakajima, Toshitaka Nabeshima, Kiyofumi Yamad. Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3. Journal of neuroinflammation. vol 15. issue 1. 2018-12-18. PMID:30348171. |
through a quantitative proteomic screen, we previously identified candidate astroglial factors, such as matrix metalloproteinase-3 (mmp3) and follistatin-like 1 (fstl1), in polyl:c-induced neurodevelopmental impairment. |
2018-12-18 |
2023-08-13 |
Not clear |
| Gopinath M Sundaram, Hisyam M Ismail, Mohsin Bashir, Manish Muhuri, Candida Vaz, Srikanth Nama, Ghim Siong Ow, Ivshina Anna Vladimirovna, Rajkumar Ramalingam, Brian Burke, Vivek Tanavde, Vladimir Kuznetsov, E Birgitte Lane, Prabha Sampat. EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis. The Journal of experimental medicine. vol 214. issue 10. 2017-10-24. PMID:28827448. |
fstl1 blocks wnt7a-mediated repression of extracellular signal-regulated kinase phosphorylation, enabling production of mmp9, which degrades the extracellular matrix and facilitates metastasis. |
2017-10-24 |
2023-08-13 |
Not clear |
| Muhammad Fawwaz Abdullah, Siti Fadilah Abdullah, Nor Shamsuria Omar, Zuliani Mahmood, Siti Noor Fazliah Mohd Noor, Thirumulu Ponnuraj Kannan, Khairani Idah Mokhta. Proliferation rate of stem cells derived from human dental pulp and identification of differentially expressed genes. Cell biology international. vol 38. issue 5. 2015-06-15. PMID:24375868. |
timp1 is involved in degradation of the extracellular matrix, cell proliferation and anti-apoptotic function and rps8 is involved as a rate-limiting factor in translational regulation; col1a1 is involved in the resistance and elasticity of the tissues; fstl1 is an autoantigen associated with rheumatoid arthritis; lgals1 is involved in cell growth, differentiation, adhesion, rna processing, apoptosis and malignant transformation. |
2015-06-15 |
2023-08-12 |
human |