| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samyah T Alanazi, Samir A Salama, Musaad M Althobaiti, Rana A Alotaibi, Ammar A AlAbdullatif, Arafa Musa, Gamaleldin I Haris. Alleviation of Copper-Induced Hepatotoxicity by Bergenin: Diminution of Oxidative Stress, Inflammation, and Apoptosis via Targeting SIRT1/FOXO3a/NF-κB Axes and p38 MAPK Signaling. Biological trace element research. 2024-09-30. PMID:39347884. |
collectively, these findings highlight the alleviating activity of bergenin against the copper-induced hepatotoxicity via controlling oxidative stress, inflammation, and apoptosis potentially through upregulation of sirt1, activation of foxo3a along with suppression of nf-κb and p38 mapk signaling. |
2024-09-30 |
2024-10-02 |
rat |
| Sugandh Saxena, Sumit Kumar Anand, Ankita Sharma, Poonam Kakka. Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine. Toxicology in vitro : an international journal published in association with BIBRA. 2024-08-10. PMID:39127087. |
treatment with srt-1720 (sirt1 activator) enhanced autophagy, decreased apoptosis, upregulated expression of downstream moieties (foxo3a and bnip3) and ameliorated mitochondria related anomalies while nicotinamide (sirt1 inhibitor) treatment exhibited reversal of the same. |
2024-08-10 |
2024-08-13 |
Not clear |
| Zhao-Bo Yan, Xian-Ming Wu, Ning Zhang, Zhi-Hong Yang, Zhou Zhu, Hua-Mei Yu, Xiao-Qi Jia, Xiao-Fang Yan. Effect of moxibustion on the SIRT1/FOXO3a signaling pathway in ApoE Zhen ci yan jiu = Acupuncture research. vol 49. issue 4. 2024-04-22. PMID:38649205. |
effect of moxibustion on the sirt1/foxo3a signaling pathway in apoe to observe the effects of moxibustion on blood lipid metabolism, pathological morphology of thoracic aorta, and the expression of silent information regulator 1 (sirt1) and forkhead box transcription factor o3a (foxo3a) in apoe |
2024-04-22 |
2024-04-26 |
Not clear |
| Saba Ubaid, Shivani Pandey, Mohd Sohail Akhtar, Mohammad Rumman, Babita Singh, Abbas Ali Mahd. SIRT1 Mediates Neuroprotective and Neurorescue Effects of Camel α-Lactalbumin and Oleic Acid Complex on Rotenone-Induced Parkinson's Disease. ACS chemical neuroscience. 2022-04-06. PMID:35385250. |
sirt1 upregulates the expression of foxo3a and hsf-1, thus inhibiting apoptosis and maintaining the homeostasis of cellular proteins. |
2022-04-06 |
2023-08-13 |
Not clear |
| Yu Wang, Runhong Mei, Shimin Hao, Peng Luo, Penghao Wang, Yaser Almatari, Lei Guo, Lan Gu. Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts. Aging. vol 13. issue 20. 2021-11-17. PMID:34711685. |
this study aimed to assess whether the up-regulation of sirt1 induced by 17beta-estradiol (17β-e2) could promote autophagy and inhibit apoptosis in osteoblasts via the ampk-mtor and foxo3a pathways, respectively. |
2021-11-17 |
2023-08-13 |
Not clear |
| Lingli Chen, Santie Li, Jianyu Zhu, Anfu You, Xingzhou Huang, Xinchu Yi, Mei Xu. Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway. Journal of cellular and molecular medicine. vol 25. issue 6. 2021-09-23. PMID:33523605. |
further studies revealed that mangiferin increased foxo3a deacetylation by up-regulating sirt1, thus preventing apoptosis, and adenovirus-mediated constitutive acetylation of foxo3a restricted the anti-apoptotic effects of mangiferin in vivo and in vitro. |
2021-09-23 |
2023-08-13 |
mouse |
| Mahrokh Samadi, Shiva Gholizadeh-Ghaleh Aziz, Roya Nader. The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats. Cell stress & chaperones. vol 26. issue 1. 2021-07-06. PMID:33047279. |
the effect of tropisetron on oxidative stress, sirt1, foxo3a, and claudin-1 in the renal tissue of stz-induced diabetic rats. |
2021-07-06 |
2023-08-13 |
rat |
| Mahrokh Samadi, Shiva Gholizadeh-Ghaleh Aziz, Roya Nader. The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats. Cell stress & chaperones. vol 26. issue 1. 2021-07-06. PMID:33047279. |
hence, tropisetron ameliorated renal damage due to diabetic nephropathy possibly by suppressing oxidative stress and alteration of sirt1, foxo3a, and claudin-1 levels. |
2021-07-06 |
2023-08-13 |
rat |
| Saba Ubaid, Mohammad Rumman, Babita Singh, Mohd Sohail Akhtar, Abbas A Mahdi, Shivani Pande. Elucidating the Neuroprotective Role of Formulated Camel α-Lactalbumin-Oleic Acid Complex by Curating the SIRT1 Pathway in Parkinson's Disease Model. ACS chemical neuroscience. vol 11. issue 24. 2021-06-18. PMID:33253528. |
moreover, cloa complex treatment reduced the oxidative stress and increased the cell viability by enhancing the level of dopamine and the expression of sirt1, foxo3a, hif-1α, and hsf-1. |
2021-06-18 |
2023-08-13 |
Not clear |
| L-N Zheng, F-Q Guo, Z-S Li, Z Wang, J-H Ma, T Wang, J-F Wei, W-W Zhan. Dexmedetomidine protects against lidocaine-induced neurotoxicity through SIRT1 downregulation-mediated activation of FOXO3a. Human & experimental toxicology. vol 39. issue 9. 2021-03-16. PMID:32228195. |
in the present study, we designed in vitro and in vivo models to investigate the potential effects of lidocaine and dex on sirt1 and foxo3a and to verify whether sirt1/foxo3a-mediated regulation of apoptosis is involved in dex-induced neuroprotective effects against lidocaine. |
2021-03-16 |
2023-08-13 |
mouse |
| L-N Zheng, F-Q Guo, Z-S Li, Z Wang, J-H Ma, T Wang, J-F Wei, W-W Zhan. Dexmedetomidine protects against lidocaine-induced neurotoxicity through SIRT1 downregulation-mediated activation of FOXO3a. Human & experimental toxicology. vol 39. issue 9. 2021-03-16. PMID:32228195. |
upregulation of sirt1 or downregulation of foxo3a significantly inhibited lidocaine-induced changes in both cell viability and apoptosis. |
2021-03-16 |
2023-08-13 |
mouse |
| L-N Zheng, F-Q Guo, Z-S Li, Z Wang, J-H Ma, T Wang, J-F Wei, W-W Zhan. Dexmedetomidine protects against lidocaine-induced neurotoxicity through SIRT1 downregulation-mediated activation of FOXO3a. Human & experimental toxicology. vol 39. issue 9. 2021-03-16. PMID:32228195. |
dexmedetomidine protects against lidocaine-induced neurotoxicity through sirt1 downregulation-mediated activation of foxo3a. |
2021-03-16 |
2023-08-13 |
mouse |
| Hunian Li, Ping Chou, Fang Du, Liang Sun, Jie Liu, Wei Wan. Depleting microRNA-183-3p improves renal tubulointerstitial fibrosis after acute kidney injury via SIRT1/PUMA/FOXO3a deacetylation. Life sciences. vol 269. 2021-02-16. PMID:33450262. |
therefore, this study is started to explore the potential role of mir-183-3p from the perspective of sirtuin (sirt1)/forkhead box o3a (foxo3a)/p53 up-regulated modulator of apoptosis (puma) in aki. |
2021-02-16 |
2023-08-13 |
Not clear |
| Ronghui Wang, Yongxiang Xie, Jiwei Qiu, Jueying Che. The Effects of Dexmedetomidine in a Rat Model of Sepsis-Induced Lung Injury are Mediated Through the Adenosine Monophosphate-Activated Protein Kinase (AMPK)/Silent Information Regulator 1 (SIRT1) Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-11-24. PMID:32034118. |
dexmedetomidine significantly reduced the expression of caspase-3 in the rat lung tissue (p<0.01), and significantly increased the expression of bcl-2/bax and the phosphorylation levels of ampk, sirt1, nuclear factor-kappab (nf-kappab), and forkhead box class o 3a (foxo3a). |
2020-11-24 |
2023-08-13 |
rat |
| Hanan Abdelmawgoud, Rehab Refaat El Awad. Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells. Genes & diseases. vol 4. issue 4. 2020-10-01. PMID:30258927. |
sirt1 regulates forkhead box o3a (foxo3a) by both inhibiting foxo3-induced apoptosis and potentiating the ability of foxo3a to resist oxidative stress. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yingji Jin, Yoshito Takeda, Yasushi Kondo, Lokesh P Tripathi, Sujin Kang, Hikari Takeshita, Hanako Kuhara, Yohei Maeda, Masayoshi Higashiguchi, Kotaro Miyake, Osamu Morimura, Taro Koba, Yoshitomo Hayama, Shohei Koyama, Kaori Nakanishi, Takeo Iwasaki, Satoshi Tetsumoto, Kazuyuki Tsujino, Muneyoshi Kuroyama, Kota Iwahori, Haruhiko Hirata, Takayuki Takimoto, Mayumi Suzuki, Izumi Nagatomo, Ken Sugimoto, Yuta Fujii, Hiroshi Kida, Kenji Mizuguchi, Mari Ito, Takashi Kijima, Hiromi Rakugi, Eisuke Mekada, Isao Tachibana, Atsushi Kumanogo. Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging. Scientific reports. vol 8. issue 1. 2019-09-25. PMID:29572511. |
importantly, sirna knockdown of cd9 and cd81 in lung epithelial cells additively decreased sirt1 and foxo3a expression, but reciprocally upregulated the expression of p21 and p53, leading to reduced cell proliferation and elevated apoptosis. |
2019-09-25 |
2023-08-13 |
mouse |
| Xinyuan Zhao, Yiming Liu, Ganlin Zhu, Yuanyuan Liang, Bo Liu, Yifan Wu, Muxi Han, Wenxing Sun, Yu Han, Gang Chen, Junkang Jian. SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis. The Science of the total environment. vol 646. 2019-04-03. PMID:30235590. |
sirt1 activation by resveratrol clearly attenuated mn-triggered apoptosis and foxo3a activation. |
2019-04-03 |
2023-08-13 |
mouse |
| Anorut Jenwitheesuk, Seongjoon Park, Prapimpun Wongchitrat, Jiraporn Tocharus, Sujira Mukda, Isao Shimokawa, Piyarat Govitrapon. Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. Neurochemical research. vol 43. issue 1. 2018-08-16. PMID:28770437. |
mel treatment upregulated the mrna expression of sirt1, foxos (foxo1 and foxo3a) target genes that regulated the cell cycle [e.g., cyclin-dependent kinase inhibitor 1b (p27)], wingless and int-1 (wnt1) and inducible signaling pathway protein 1 (wisp1) in the aged mouse hippocampus. |
2018-08-16 |
2023-08-13 |
mouse |
| Anorut Jenwitheesuk, Seongjoon Park, Prapimpun Wongchitrat, Jiraporn Tocharus, Sujira Mukda, Isao Shimokawa, Piyarat Govitrapon. Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. Neurochemical research. vol 43. issue 1. 2018-08-16. PMID:28770437. |
this study aimed to compare the effects of melatonin (mel) and caloric restriction (cr) on the expression of sirt1, foxo1, foxo3a and foxos target genes in the aging mouse hippocampus. |
2018-08-16 |
2023-08-13 |
mouse |
| Bin Wang, Wayne Yuk-Wai Lee, Biao Huang, Jin-Fang Zhang, TianYi Wu, Xiaohua Jiang, Chi Chiu Wang, Gang L. Secretome of Human Fetal Mesenchymal Stem Cell Ameliorates Replicative Senescen. Stem cells and development. vol 25. issue 22. 2017-09-18. PMID:27539404. |
cellular studies revealed concomitant activation of sirt1 and foxo3a in hamsc after hfs treatment, which was associated with upregulation of p21 and downregulation of bax and p53. |
2017-09-18 |
2023-08-13 |
mouse |