| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie A Barnes, Aurore Thomazeau, Peter S B Finnie, Maxwell J Heinrich, Arnold J Heynen, Noburu H Komiyama, Seth G N Grant, Frank S Menniti, Emily K Osterweil, Mark F Bea. Non-ionotropic signaling through the NMDA receptor GluN2B carboxy-terminal domain drives dendritic spine plasticity and reverses fragile X phenotypes. Cell reports. 2025-02-21. PMID:39983718. |
disruption of non-ionotropic signaling by replacing the glun2b ctd with the glun2a ctd leads to an increase in spine density, dysregulated basal protein synthesis, exaggerated long-term depression mediated by g-protein-coupled metabotropic glutamate receptors (mglur-ltd), and epileptiform activity reminiscent of phenotypes observed in the fmr1 knockout (ko) model of fragile x syndrome. |
2025-02-21 |
2025-02-24 |
mouse |
| Alishah Lakhani, Washington Huang, Chris C Rodgers, Peter Wenne. Impairment in the homeostatic recruitment of layer 5/6 neurons following whisker stimulation in Fmr1 KO mice. Neurobiology of disease. 2025-02-12. PMID:39938578. |
here, we aimed to examine how sensory integration changes in vivo following a homeostatic perturbation, unilateral whisker deprivation (wd), in an fmr1 knock out (ko) mouse model. |
2025-02-12 |
2025-02-15 |
mouse |
| Jan Tuma, Amtul-Noor Rana, Teena Philip, Jeong Ben Park, Hye Young Le. Altered olfactory responses in Fmr1 KO mice. Scientific reports. vol 15. issue 1. 2025-01-23. PMID:39848954. |
altered olfactory responses in fmr1 ko mice. |
2025-01-23 |
2025-01-26 |
mouse |
| Jan Tuma, Amtul-Noor Rana, Teena Philip, Jeong Ben Park, Hye Young Le. Altered olfactory responses in Fmr1 KO mice. Scientific reports. vol 15. issue 1. 2025-01-23. PMID:39848954. |
moreover, we found an increased volume of the olfactory bulb in fmr1 ko males. |
2025-01-23 |
2025-01-26 |
mouse |
| Jan Tuma, Amtul-Noor Rana, Teena Philip, Jeong Ben Park, Hye Young Le. Altered olfactory responses in Fmr1 KO mice. Scientific reports. vol 15. issue 1. 2025-01-23. PMID:39848954. |
overall, our findings suggest that the fmr1 ko mice demonstrate atypical olfactory behaviors as well as structural changes in the olfactory bulb. |
2025-01-23 |
2025-01-26 |
mouse |
| Chen Wang, Jia-Yu Liu, Li-Da Su, Xin-Tai Wang, Yu-Peng Bian, Zhao-Xiang Wang, Lu-Yu Ye, Xin-Jiang Lu, Lin Zhou, Wei Chen, Wei Yang, Jun Liu, Luxi Wang, Ying She. GABAergic Progenitor Cell Graft Rescues Cognitive Deficits in Fragile X Syndrome Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025-01-17. PMID:39823534. |
here, transplantation of gabaergic precursor cells from the medial ganglionic eminence (mge) is demonstrated to significantly improve cognitive performance in fmr1 knockout (ko) mice. |
2025-01-17 |
2025-01-20 |
mouse |
| Adam E Fox, Abbie R Cooper, Amelia L Pape, Hannah M Tobias-Wallingford, William E DeCotea. Time perception and delay discounting in the FMR1 knockout rat. Journal of the experimental analysis of behavior. 2024-11-08. PMID:39513510. |
we also discovered significantly increased smaller, sooner reward choice in the fmr1 ko rats. |
2024-11-08 |
2024-11-16 |
human |
| Matthew Napier, Ashish Kumar, Natasha Szulist, Dale Martin, Angela L Scot. P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus. Hippocampus. 2024-09-13. PMID:39269925. |
using the fmr1 ko mouse model of fxs, much work has been done to understand fxs hippocampus dysfunction. |
2024-09-13 |
2024-09-16 |
mouse |
| Matthew Napier, Ashish Kumar, Natasha Szulist, Dale Martin, Angela L Scot. P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus. Hippocampus. 2024-09-13. PMID:39269925. |
purinergic signaling, where atp and its metabolites are used as signaling molecules, participates in hippocampus development, but it is unknown if purinergic signaling is affected in the developing fmr1 ko hippocampus. |
2024-09-13 |
2024-09-16 |
mouse |
| Matthew Napier, Ashish Kumar, Natasha Szulist, Dale Martin, Angela L Scot. P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus. Hippocampus. 2024-09-13. PMID:39269925. |
we first found that p2x7 was reduced in fmr1 ko whole hippocampus tissue at p14 and p21, corresponding to the periods of neurite outgrowth and synaptic refinement in the hippocampus. |
2024-09-13 |
2024-09-16 |
mouse |
| Matthew Napier, Ashish Kumar, Natasha Szulist, Dale Martin, Angela L Scot. P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus. Hippocampus. 2024-09-13. PMID:39269925. |
we then evaluated the cell-specific expression of p2x7 with immunofluorescence and found differences between wt and fmr1 ko mice in p2x7 colocalization with hippocampal microglia and neurons. |
2024-09-13 |
2024-09-16 |
mouse |
| Kathryn E Reynolds, Matthew Napier, Fan Fei, Kirk Green, Angela L Scot. Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes. Neuromolecular medicine. vol 26. issue 1. 2024-09-10. PMID:39254908. |
glycosylation of the astrocyte membrane-bound cd39 ectonucleotidase, which facilitates ligand breakdown following synaptic release, was also elevated in fmr1 ko astrocyte cultures. |
2024-09-10 |
2024-09-13 |
mouse |
| Xi Cheng, Sanghamitra Nareddula, Hao-Cheng Gao, Yueyi Chen, Tiange Xiao, Yididiya Y Nadew, Fan Xu, Paige Alyssa Edens, Christopher J Quinn, Adam Kimbrough, Fang Huang, Alexander A Chubyki. Impaired Experience-Dependent Theta Oscillation Synchronization and Inter-Areal Synaptic Connectivity in the Visual Cortex of Fmr1 KO Mice. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211264. |
impaired experience-dependent theta oscillation synchronization and inter-areal synaptic connectivity in the visual cortex of fmr1 ko mice. |
2024-08-30 |
2024-09-04 |
mouse |
| Xi Cheng, Sanghamitra Nareddula, Hao-Cheng Gao, Yueyi Chen, Tiange Xiao, Yididiya Y Nadew, Fan Xu, Paige Alyssa Edens, Christopher J Quinn, Adam Kimbrough, Fang Huang, Alexander A Chubyki. Impaired Experience-Dependent Theta Oscillation Synchronization and Inter-Areal Synaptic Connectivity in the Visual Cortex of Fmr1 KO Mice. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211264. |
we performed simultaneous in vivo recordings with silicon probes in v1 and lm of awake mice and channelrhodopsin-2-assisted circuit mapping (cracm) in acute brain slices to examine the neural activity and strength of long-range synaptic connections between v1 and lm in both wildtype (wt) and fmr1 knockout (ko) mice, the model of fx, before and after visual experience. |
2024-08-30 |
2024-09-04 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
here we show that pyramidal cells (pcs) in the dorsal ca1 region of the hippocampus elicited a larger action potential (ap) number in response to suprathreshold stimulation in juvenile fmr1 knockout (ko) than wild-type (wt) mice. |
2024-07-08 |
2024-07-12 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
because kv7/m channels modulate ca1 pc excitability in rats, we investigated if their dysfunction produces neuronal hyperexcitability in fmr1 ko mice. |
2024-07-08 |
2024-07-12 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
furthermore, a low concentration of retigabine (2.5 μm) normalized ca1 pc excitability of fmr1 ko mice. |
2024-07-08 |
2024-07-12 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
finally, ex vivo seizure-like events evoked by 4-aminopyiridine (200 μm) in the dorsal ca1 region were more frequent in fmr1 ko mice, and were abolished by retigabine (5-10 μm). |
2024-07-08 |
2024-07-12 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
we conclude that ca1 pcs of fmr1 ko mice exhibit hyperexcitability, caused by kv7/m channel dysfunction, and increased epileptiform activity, which were abolished by retigabine. |
2024-07-08 |
2024-07-12 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
ex vivo seizure-like events evoked in the dorsal ca1 region were more frequent in fmr1 ko mice, and such an epileptiform activity was abolished by a kv7/m channel opener depending on drug concentration. |
2024-07-08 |
2024-07-12 |
mouse |