All Relations between fmr1 and ko

Publication Sentence Publish Date Extraction Date Species
Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. to explore the mechanism by which fmrp deficiency inhibits autophagy, we examined the akt/mtor signaling pathway in the hippocampus of fmr1 ko mice, found that fmrp deficiency caused overactivation of the akt/mtor pathway. 2024-06-08 2024-06-11 mouse
Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. the fmr1 ko mice exhibited stereotypical behavior, impaired social ability, and learning and memory impairment, while rapamycin treatment improved behavioral disorders in fmr1 ko mice. 2024-06-08 2024-06-11 mouse
Kathryn E Reynolds, Eileen Huang, Monica Sabbineni, Eliza Wiseman, Nadeem Murtaza, Desmond Ahuja, Matt Napier, Kathryn M Murphy, Karun K Singh, Angela L Scot. Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model. Molecular neurobiology. 2024-04-23. PMID:38652351. in this study, we examined whether elevated astrocyte purinergic signalling also impacts neuronal morphology and connectivity of fmr1 ko cortical neurons. 2024-04-23 2024-04-26 mouse
Kathryn E Reynolds, Eileen Huang, Monica Sabbineni, Eliza Wiseman, Nadeem Murtaza, Desmond Ahuja, Matt Napier, Kathryn M Murphy, Karun K Singh, Angela L Scot. Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model. Molecular neurobiology. 2024-04-23. PMID:38652351. here, we found that conditioned media from primary fmr1 ko astrocytes was sufficient to enhance neurite extension and complexity of both wildtype and fmr1 ko neurons to a similar degree as utp-mediated outgrowth. 2024-04-23 2024-04-26 mouse
Carrie R Jonak, Samantha A Assad, Manbir S Sandhu, Terese A Garcia, Jeffrey A Rumschlag, Khaleel A Razak, Devin K Binde. Phenotypic analysis of multielectrode array EEG biomarkers in developing and adult male Fmr1 KO mice. Neurobiology of disease. 2024-04-06. PMID:38582333. third, we found hemispheric asymmetry of fast temporal processing in the mouse auditory cortex in wt but not fmr1 ko mice. 2024-04-06 2024-04-10 mouse
George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. multi-level profiling of the fmr1 ko rat unveils altered behavioral traits along with aberrant glutamatergic function. 2024-02-20 2024-02-23 mouse
George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. therefore, we employed a multi-level approach to study the behavioral profile and the glutamatergic and gabaergic neurotransmission status in pathophysiology-associated brain structures of fmr1 ko rats, including the recordings of evoked and spontaneous field potentials from hippocampal slices, paralleled with next-generation rna sequencing (rna-seq). 2024-02-20 2024-02-23 mouse
Vipendra Kumar, Kwan Young Lee, Anirudh Acharya, Matthew S Babik, Catherine A Christian-Hinman, Justin S Rhodes, Nien-Pei Tsa. mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS. EMBO molecular medicine. 2024-02-20. PMID:38374465. when evaluating the animals' behavior, we showed that treatment of amn082 reduces repetitive behavior and improves learning and memory in fmr1 ko mice. 2024-02-20 2024-02-22 mouse
Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. septotemporal variation of information processing in the hippocampus of fmr1 ko rat. 2024-02-18 2024-02-21 rat
Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. method we used a fmr1 knock-out (ko) rat model of fxs and recordings of evoked field potentials from the ca1 field of transverse slices from both the dorsal and the ventral hippocampus of adult rats. 2024-02-18 2024-02-21 rat
Heleen M Van't Spijker, Joel D Richte. FMRP regulation of aggrecan mRNA translation controls perineuronal net development. Journal of neurochemistry. 2024-01-15. PMID:38225196. examination of pnns by wfa staining at p14 and p42 in the hippocampus, somatosensory cortex, and retrosplenial cortex shows that they were reduced in these brain regions at p14 but mostly less so at p42 in fmr1 ko mice. 2024-01-15 2024-01-18 mouse
Xiaotong Wu, Yali Liu, Xiaomeng Wang, Lu Zheng, Libiao Pan, Hao Wan. Developmental Impairments of Synaptic Refinement in the Thalamus of a Mouse Model of Fragile X Syndrome. Neuroscience bulletin. 2023-11-28. PMID:38015349. here, we found that the developmental elimination of synapses formed between the principal nucleus of v (prv) and the ventral posterior medial nucleus (vpm) of the somatosensory system was delayed in fragile x mental retardation 1 gene knockout (fmr1 ko) mice, while the developmental strengthening of these synapses was disrupted. 2023-11-28 2023-11-29 mouse
Xiaotong Wu, Yali Liu, Xiaomeng Wang, Lu Zheng, Libiao Pan, Hao Wan. Developmental Impairments of Synaptic Refinement in the Thalamus of a Mouse Model of Fragile X Syndrome. Neuroscience bulletin. 2023-11-28. PMID:38015349. our results uncovered the developmental impairment of thalamic relay synapses in fmr1 ko mice and suggest that a thalamic contribution to the somatosensory over-reactivity in fxs should be considered. 2023-11-28 2023-11-29 mouse
Leonidas J Leontiadis, George Trompoukis, Panagiotis Felemegkas, Giota Tsotsokou, Athina Miliou, Costas Papatheodoropoulo. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Brain sciences. vol 13. issue 11. 2023-11-25. PMID:38002556. using a fmr1 knock-out (ko) rat model of fxs, we found increased neuronal excitability in both the dorsal and ventral ko hippocampus and increased excitatory synaptic transmission in the dorsal hippocampus. 2023-11-25 2023-11-28 rat
Caroline Zeitouny, Martin Korte, Kristin Michaelsen-Preuss. Prolonged and specific spatial training during adolescence reverses adult hippocampal network impairments in a mouse model of fragile X syndrome. Neurobiology of disease. 2023-07-29. PMID:37516137. a hallmark of fxs patients and the fxs mouse model (fmr1 ko) is an overabundance of immature appearing dendritic spines in the cortex and hippocampus which is associated with behavioral deficits. 2023-07-29 2023-08-14 mouse
Caroline Zeitouny, Martin Korte, Kristin Michaelsen-Preuss. Prolonged and specific spatial training during adolescence reverses adult hippocampal network impairments in a mouse model of fragile X syndrome. Neurobiology of disease. 2023-07-29. PMID:37516137. intriguingly, only specific spatial training alleviated the cognitive symptoms and the spine phenotype shown in adult fmr1 ko mice suggesting that specific stimulation of hippocampal networks during development might be used in the future as a therapeutic strategy. 2023-07-29 2023-08-14 mouse
Yu-Jiao Li, Kun Zhang, Ting Sun, Yan-Yan Guo, Qi Yang, Shui-Bing Liu, Yu-Mei Wu, Ming-Gao Zha. Improvement of Learning and Memory by Elevating Brain D-Aspartate in a Mouse Model of Fragile X Syndrome. Molecular neurobiology. 2023-07-15. PMID:37453994. it is reported that n-methyl-d-aspartate receptor (nmdar)-mediated facilitation of long-term potentiation (ltp) and fear memory are impaired in fmr1 knockout (ko) mice. 2023-07-15 2023-08-14 mouse
Yu-Jiao Li, Kun Zhang, Ting Sun, Yan-Yan Guo, Qi Yang, Shui-Bing Liu, Yu-Mei Wu, Ming-Gao Zha. Improvement of Learning and Memory by Elevating Brain D-Aspartate in a Mouse Model of Fragile X Syndrome. Molecular neurobiology. 2023-07-15. PMID:37453994. in conclusion, supplement of d-asp may benefit for synaptic plasticity and behaviors in fmr1 ko mice and offer a potential therapeutic strategy for fxs. 2023-07-15 2023-08-14 mouse
Nazim Kourdougli, Anand Suresh, Benjamin Liu, Pablo Juarez, Ashley Lin, David T Chung, Anette Graven Sams, Michael J Gandal, Verónica Martínez-Cerdeño, Dean V Buonomano, Benjamin J Hall, Cédric Mombereau, Carlos Portera-Caillia. Improvement of sensory deficits in fragile X mice by increasing cortical interneuron activity after the critical period. Neuron. 2023-07-14. PMID:37451263. using all-optical in vivo approaches, we find that parvalbumin (pv) ins and their immature precursors are hypoactive and transiently decoupled from excitatory neurons in postnatal mouse somatosensory cortex (s1) of fmr1 ko mice, a model of fragile x syndrome (fxs). 2023-07-14 2023-08-14 mouse
Ernest V Pedapati, John A Sweeney, Lauren M Schmitt, Lauren E Ethridge, Makoto Miyakoshi, Rui Liu, Elizabeth Smith, Rebecca C Shaffer, Steve W Wu, Donald L Gilbert, Paul S Horn, Craig Erickso. Empirical Frequency Bound Derivation Reveals Prominent Mid-Frontal Alpha Associated with Neurosensory Dysfunction in Fragile X Syndrome. Research square. 2023-05-10. PMID:37162907. the fmr1 gene is inactive in fragile x syndrome (fxs), resulting in low levels of fmrp and consequent neurochemical, synaptic, and local circuit neurophysiological alterations in the fmr1 ko mouse. 2023-05-10 2023-08-14 mouse