| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
here we show that pyramidal cells (pcs) in the dorsal ca1 region of the hippocampus elicited a larger action potential (ap) number in response to suprathreshold stimulation in juvenile fmr1 knockout (ko) than wild-type (wt) mice. |
2024-07-08 |
2024-07-12 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
because kv7/m channels modulate ca1 pc excitability in rats, we investigated if their dysfunction produces neuronal hyperexcitability in fmr1 ko mice. |
2024-07-08 |
2024-07-12 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
furthermore, a low concentration of retigabine (2.5 μm) normalized ca1 pc excitability of fmr1 ko mice. |
2024-07-08 |
2024-07-12 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
finally, ex vivo seizure-like events evoked by 4-aminopyiridine (200 μm) in the dorsal ca1 region were more frequent in fmr1 ko mice, and were abolished by retigabine (5-10 μm). |
2024-07-08 |
2024-07-12 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
we conclude that ca1 pcs of fmr1 ko mice exhibit hyperexcitability, caused by kv7/m channel dysfunction, and increased epileptiform activity, which were abolished by retigabine. |
2024-07-08 |
2024-07-12 |
mouse |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
ex vivo seizure-like events evoked in the dorsal ca1 region were more frequent in fmr1 ko mice, and such an epileptiform activity was abolished by a kv7/m channel opener depending on drug concentration. |
2024-07-08 |
2024-07-12 |
mouse |
| Nazim Kourdougli, Toshihiro Nomura, Michelle Wu, Anouk Heuvelmans, Zoë Dobler, Anis Contractor, Carlos Portera-Caillia. The NKCC1 inhibitor bumetanide restores cortical feedforward inhibition and lessens sensory hypersensitivity in early postnatal fragile X mice. Biological psychiatry. 2024-07-01. PMID:38950809. |
sensory hypersensitivity is recapitulated in the fmr1 knockout (ko) mouse model of fxs. |
2024-07-01 |
2024-07-04 |
mouse |
| Nazim Kourdougli, Toshihiro Nomura, Michelle Wu, Anouk Heuvelmans, Zoë Dobler, Anis Contractor, Carlos Portera-Caillia. The NKCC1 inhibitor bumetanide restores cortical feedforward inhibition and lessens sensory hypersensitivity in early postnatal fragile X mice. Biological psychiatry. 2024-07-01. PMID:38950809. |
recent studies in fmr1 ko mice have demonstrated differences in activity of cortical interneurons and a delayed switch in the polarity of gaba signaling during development. |
2024-07-01 |
2024-07-04 |
mouse |
| Nazim Kourdougli, Toshihiro Nomura, Michelle Wu, Anouk Heuvelmans, Zoë Dobler, Anis Contractor, Carlos Portera-Caillia. The NKCC1 inhibitor bumetanide restores cortical feedforward inhibition and lessens sensory hypersensitivity in early postnatal fragile X mice. Biological psychiatry. 2024-07-01. PMID:38950809. |
previously, we reported that blocking the chloride transporter nkcc1 with the diuretic bumetanide, could rescue synaptic circuit phenotypes in primary somatosensory cortex (s1) of fmr1 ko mice. |
2024-07-01 |
2024-07-04 |
mouse |
| Nazim Kourdougli, Toshihiro Nomura, Michelle Wu, Anouk Heuvelmans, Zoë Dobler, Anis Contractor, Carlos Portera-Caillia. The NKCC1 inhibitor bumetanide restores cortical feedforward inhibition and lessens sensory hypersensitivity in early postnatal fragile X mice. Biological psychiatry. 2024-07-01. PMID:38950809. |
however, it remains unknown whether bumetanide can rescue earlier circuit phenotypes or sensory hypersensitivity in fmr1 ko mice. |
2024-07-01 |
2024-07-04 |
mouse |
| Ana M Salmerón, Cristian Pérez-Fernández, Ana C Abreu, Silvia Fernández, Ana I Tristán, Diego Ruiz-Sobremazas, María Cabré, Laia Guardia-Escote, Ignacio Fernández, Fernando Sánchez-Sante. Exploring Microbiota-Gut-Brain Axis Biomarkers Linked to Autism Spectrum Disorder in Prenatally Chlorpyrifos-Exposed Fmr1 Knock-Out and Wild-Type Male Rats. Toxicology. 2024-06-26. PMID:38925359. |
fmr1 (fragile x messenger ribonucleoprotein 1)-knockout (ko) rats, modeling the human fragile x syndrome (fxs), are of particular interest for exploring the asd-like phenotype in preclinical studies. |
2024-06-26 |
2024-06-29 |
human |
| Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. |
to explore the mechanism by which fmrp deficiency inhibits autophagy, we examined the akt/mtor signaling pathway in the hippocampus of fmr1 ko mice, found that fmrp deficiency caused overactivation of the akt/mtor pathway. |
2024-06-08 |
2024-06-11 |
mouse |
| Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. |
the fmr1 ko mice exhibited stereotypical behavior, impaired social ability, and learning and memory impairment, while rapamycin treatment improved behavioral disorders in fmr1 ko mice. |
2024-06-08 |
2024-06-11 |
mouse |
| Kathryn E Reynolds, Eileen Huang, Monica Sabbineni, Eliza Wiseman, Nadeem Murtaza, Desmond Ahuja, Matt Napier, Kathryn M Murphy, Karun K Singh, Angela L Scot. Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model. Molecular neurobiology. 2024-04-23. PMID:38652351. |
in this study, we examined whether elevated astrocyte purinergic signalling also impacts neuronal morphology and connectivity of fmr1 ko cortical neurons. |
2024-04-23 |
2024-04-26 |
mouse |
| Kathryn E Reynolds, Eileen Huang, Monica Sabbineni, Eliza Wiseman, Nadeem Murtaza, Desmond Ahuja, Matt Napier, Kathryn M Murphy, Karun K Singh, Angela L Scot. Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model. Molecular neurobiology. 2024-04-23. PMID:38652351. |
here, we found that conditioned media from primary fmr1 ko astrocytes was sufficient to enhance neurite extension and complexity of both wildtype and fmr1 ko neurons to a similar degree as utp-mediated outgrowth. |
2024-04-23 |
2024-04-26 |
mouse |
| Carrie R Jonak, Samantha A Assad, Manbir S Sandhu, Terese A Garcia, Jeffrey A Rumschlag, Khaleel A Razak, Devin K Binde. Phenotypic analysis of multielectrode array EEG biomarkers in developing and adult male Fmr1 KO mice. Neurobiology of disease. 2024-04-06. PMID:38582333. |
third, we found hemispheric asymmetry of fast temporal processing in the mouse auditory cortex in wt but not fmr1 ko mice. |
2024-04-06 |
2024-04-10 |
mouse |
| George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. |
multi-level profiling of the fmr1 ko rat unveils altered behavioral traits along with aberrant glutamatergic function. |
2024-02-20 |
2024-02-23 |
mouse |
| George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. |
therefore, we employed a multi-level approach to study the behavioral profile and the glutamatergic and gabaergic neurotransmission status in pathophysiology-associated brain structures of fmr1 ko rats, including the recordings of evoked and spontaneous field potentials from hippocampal slices, paralleled with next-generation rna sequencing (rna-seq). |
2024-02-20 |
2024-02-23 |
mouse |
| Vipendra Kumar, Kwan Young Lee, Anirudh Acharya, Matthew S Babik, Catherine A Christian-Hinman, Justin S Rhodes, Nien-Pei Tsa. mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS. EMBO molecular medicine. 2024-02-20. PMID:38374465. |
when evaluating the animals' behavior, we showed that treatment of amn082 reduces repetitive behavior and improves learning and memory in fmr1 ko mice. |
2024-02-20 |
2024-02-22 |
mouse |
| Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. |
septotemporal variation of information processing in the hippocampus of fmr1 ko rat. |
2024-02-18 |
2024-02-21 |
rat |