All Relations between fak and src

Publication Sentence Publish Date Extraction Date Species
Piman Pocasap, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunpra. Network pharmacology- and cell-based assessments identify the FAK/Src pathway as a molecular target for the antimetastatic effect of momordin Ic against cholangiocarcinoma. Heliyon. vol 10. issue 11. 2024-07-04. PMID:38961933. the results unveiled the potential involvement of mic in apoptosis and cell migration, pinpointing src and fak as key targets. 2024-07-04 2024-07-10 Not clear
William George Warren, Myles Osborn, Andy Yates, Saoirse E O'Sulliva. The emerging role of fatty acid binding protein 7 (FABP7) in cancers. Drug discovery today. 2024-04-13. PMID:38614160. the molecular mechanisms involve promotion of fa uptake, lipid droplets, signalling [focal adhesion kinase (fak), proto-oncogene tyrosine-protein kinase src (src), mitogen-activated protein kinase kinase/p-extracellular signal-regulated kinase (mek/erk), and wnt/β-catenin], hypoxia-inducible factor 1-alpha (hif1α), vascular endothelial growth factor a/prolyl 4-hydroxylase subunit alpha-1 (vegfa/p4ha1), snail family zinc finger 1 (snail1), and twist-related protein 1 (twist1). 2024-04-13 2024-04-16 Not clear
Hsien-Ming Wu, Liang-Hsuan Chen, Wei-Jung Chiu, Chia-Lung Tsa. Kisspeptin Regulates Cell Invasion and Migration in Endometrial Cancer. Journal of the Endocrine Society. vol 8. issue 3. 2024-01-24. PMID:38264268. in conclusion, we suggest that kisspeptin regulates endometrial cancer cell motility via fak and src expression and the erk1/2, n-cadherin, e-cadherin, beta-catenin, twist, and matrix metalloproteinase signaling pathways. 2024-01-24 2024-01-26 Not clear
Tsung-Teng Huang, Chuan-Mu Chen, Song-Shu Lin, Ying-Wei Lan, Hsu-Chen Cheng, Kong-Bung Choo, Ching-Chiung Wang, Tse-Hung Huang, Kowit-Yu Chon. E7050 Suppresses the Growth of Multidrug-Resistant Human Uterine Sarcoma by Inhibiting Angiogenesis via Targeting of VEGFR2-Mediated Signaling Pathways. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298555. moreover, e7050 suppressed the phosphorylation of vegfr2, fak, src, akt, jnk, and p38 mapk in huvecs exposed to mes-sa/dx5 cells-derived conditioned medium (cm). 2023-06-11 2023-08-14 human
Sheng Chen, Tailin He, Yiming Zhong, Mingjue Chen, Qing Yao, Di Chen, Zengwu Shao, Guozhi Xia. Roles of focal adhesion proteins in skeleton and diseases. Acta pharmaceutica Sinica. B. vol 13. issue 3. 2023-03-27. PMID:36970189. focal adhesions (fas) are macromolecular assemblies that are composed of the extracellular matrix (ecm), integrins, intracellular cytoskeleton and other proteins, including kindlin, talin, vinculin, paxillin, pinch, src, focal adhesion kinase (fak) and integrin-linked protein kinase (ilk) and other proteins. 2023-03-27 2023-08-14 Not clear
Sina Ahandoust, Kexin Li, Xun Sun, Bai-Yan Li, Hiroki Yokota, Sungsoo N. Intracellular and extracellular moesins differentially regulate Src activity and β-catenin translocation to the nucleus in breast cancer cells. Biochemical and biophysical research communications. vol 639. 2022-12-05. PMID:36470073. conditioned medium derived from msn-overexpressing mesenchymal stem cells or osteocytes showed the anti-tumor effects by inhibiting the src activity and β-catenin translocation to the nucleus as well as the activities of fak and rhoa and mtt-based cell viability. 2022-12-05 2023-08-14 Not clear
Sina Ahandoust, Kexin Li, Xun Sun, Bai-Yan Li, Hiroki Yokota, Sungsoo N. Intracellular and extracellular moesins differentially regulate Src activity and β-catenin translocation to the nucleus in breast cancer cells. Biochemical and biophysical research communications. vol 639. 2022-12-05. PMID:36470073. conditioned medium derived from msn-inhibited cells increased the src activity, but it did not affect the activities of fak and rhoa. 2022-12-05 2023-08-14 Not clear
James Sinnet-Smith, Tarique Anwar, Elaine F Reed, Yaroslav Teper, Guido Eibl, Enrique Rozengur. Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy. Molecular cancer therapeutics. 2022-08-24. PMID:35999654. here, we show that a combination of insulin and the gpcr agonist neurotensin induced rapid activation of src family of tyrosine kinases (sfks) within panc-1 cells, as shown by fak phosphorylation at tyr576/577 and tyr861, sensitive biomarkers of sfk activity within intact cells and src419 autophosphorylation. 2022-08-24 2023-08-14 mouse
Chien-Chung Huang, Tzu-Ting Tseng, Shan-Chi Liu, Yen-You Lin, Yat-Yin Law, Sung-Lin Hu, Shih-Wei Wang, Chun-Hao Tsai, Chih-Hsin Tan. S1P Increases VEGF Production in Osteoblasts and Facilitates Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-16-5p Expression via the c-Src/FAK Signaling Pathway in Rheumatoid Arthritis. Cells. vol 10. issue 8. 2021-11-29. PMID:34440937. conditioned medium from s1p-treated osteoblasts significantly increased epc tube formation and migration by inhibiting mir-16-5p synthesis via proto-oncogene tyrosine-protein kinase src (c-src) and fak signaling in chick chorioallantoic membrane (cam) and matrigel plug assays. 2021-11-29 2023-08-13 mouse
Caihua Dong, Xinying Li, Jiao Yang, Detian Yuan, Yuanshuai Zhou, Yina Zhang, Guohua Shi, Ruobing Zhang, Jianping Liu, Peng Fu, Minxuan Su. PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway. Cell death & disease. vol 12. issue 9. 2021-10-11. PMID:34480020. furthermore, we demonstrate that ppfibp1 activates focal adhesion kinase (fak), src, c-jun n-terminal kinase (jnk), and c-jun, thereby enhancing matrix metalloproteinase (mmp)-2 expression probably through interacting with srcin1 (p140cap). 2021-10-11 2023-08-13 Not clear
Yen-Ru Chou, Wen-Cheng Lo, Navneet Kumar Dubey, Jui-Hua Lu, Hen-Yu Liu, Ching-Yu Tsai, Yue-Hua Deng, Chi-Ming Wu, Mao-Suan Huang, Win-Ping Den. Platelet-derived biomaterials-mediated improvement of bone injury through migratory ability of embryonic fibroblasts: Aging. vol 13. issue 3. 2021-08-16. PMID:33461165. osteogenic lineage, matrix mineralization and cell migration were determined by gene markers (runx2, opn and ocn), alizarin red s staining, and migration markers (fak, pfak and src) and emt markers, respectively. 2021-08-16 2023-08-13 mouse
Nehal Gupta, Sanjay K Srivastav. Atovaquone Suppresses the Growth of Metastatic Triple-Negative Breast Tumors in Lungs and Brain by Inhibiting Integrin/FAK Signaling Axis. Pharmaceuticals (Basel, Switzerland). vol 14. issue 6. 2021-07-14. PMID:34071408. we showed that atovaquone induced apoptosis and reduced the survival of several aggressive metastatic tnbc cell lines including metastatic patient-derived cells by reducing the expression of integrin α6, integrin β4, fak, src, and vimentin. 2021-07-14 2023-08-13 mouse
Neha R Dhoke, Komal Kaushik, Amitava Da. Cxcr6-Based Mesenchymal Stem Cell Gene Therapy Potentiates Skin Regeneration in Murine Diabetic Wounds. Molecular therapy : the journal of the American Society of Gene Therapy. vol 28. issue 5. 2021-06-07. PMID:32112713. induction of the cxcl16-cxcr6 axis led to activation of focal adhesion kinase (fak), src, and extracellular signal-regulated kinases 1/2 (erk1/2)-mediated matrix metalloproteinases (mmp)-2 promoter regulation and expression, the migratory signaling pathways in msc. 2021-06-07 2023-08-13 mouse
Zhenfeng Hao, Jing Qian, Jishi Yan. Shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of Src and FAK. Oncology letters. vol 9. issue 2. 2020-10-01. PMID:25621031. shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of src and fak. 2020-10-01 2023-08-13 Not clear
Raúl Isaías-Tizapa, Erika Acosta, Arvey Tacuba-Saavedra, Miguel Mendoza-Catalán, Napoleón Navarro-Tit. The Leptin induced Hic-5 expression and actin puncta formation by the FAK/Src-dependent pathway in MCF10A mammary epithelial cells Biomedica : revista del Instituto Nacional de Salud. vol 39. issue 3. 2020-03-17. PMID:31584768. recently, overexpression and activation of hic-5 during the emt have been shown to induce the formation of actin puncta; these structures are indicative of the formation and functionality of invadopodia, which promote the local degradation of extracellular matrix components and cancer metastasis.objective: to evaluate the role of fak and src kinases in the expression of hic-5 during the epithelial-mesenchymal transition induced by leptin in mcf10a cells.materials and methods: we used specific inhibitors of fak (pf-573228) and src (pp2) to evaluate hic-5 expression and subcellular localization by western blot and immunofluorescence assays and to investigate the formation of actin puncta by epifluorescence in mcf10a cells stimulated with leptin.results: leptin induced an increase in hic-5 expression and the formation of actin puncta. 2020-03-17 2023-08-13 Not clear
Jia-Sin Yang, Chiao-Wen Lin, Yi-Hsien Hsieh, Ming-Hsien Chien, Chun-Yi Chuang, Shun-Fa Yan. Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells. Oncotarget. vol 8. issue 47. 2019-11-20. PMID:29137326. in addition, caix overexpression increased the mrna and protein expression of matrix metalloproteinase-9 (mmp-9) and the phosphorylation of focal adhesion kinase (fak), steroid receptor coactivator (src), and extracellular signal-regulated kinase 1/2 signaling proteins. 2019-11-20 2023-08-13 human
Carmen Ruggiero, Mauro Grossi, Giorgia Fragassi, Antonella Di Campli, Carmine Di Ilio, Alberto Luini, Michele Salles. The KDEL receptor signalling cascade targets focal adhesion kinase on focal adhesions and invadopodia. Oncotarget. vol 9. issue 12. 2019-11-20. PMID:29535802. by acting on src and fak, kdel receptor increases invadopodia-mediated matrix degradation. 2019-11-20 2023-08-13 Not clear
Wenjun Wang, Emmanuel M Lollis, François Bordeleau, Cynthia A Reinhart-Kin. Matrix stiffness regulates vascular integrity through focal adhesion kinase activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 1. 2019-09-17. PMID:30102569. matrix stiffness-mediated fak activation determines src localization to cell-cell junctions, which then induces increased vascular endothelial cadherin phosphorylation both in vitro and in vivo. 2019-09-17 2023-08-13 mouse
Xi Hong, Jian-Jun Y. Silencing of lysyl oxidase‑like 2 inhibits the migration, invasion and epithelial‑to‑mesenchymal transition of renal cell carcinoma cells through the Src/FAK signaling pathway. International journal of oncology. vol 54. issue 5. 2019-08-13. PMID:30816490. rt‑qpcr and western blot analysis were applied to determine the expression of loxl2, fak, src, matrix metalloproteinase (mmp)‑9, epithelial (e)‑cadherin, neuronal (n)‑cadherin and vimentin. 2019-08-13 2023-08-13 Not clear
Dionéia Araldi, Luiz F Ferrari, Jon D Levin. Role of GPCR (mu-opioid)-receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II). Pain. vol 159. issue 5. 2019-06-04. PMID:29447132. a phosphopeptide, which blocks the interaction of src, focal adhesion kinase (fak), and egfr, also prevented damgo-induced prolongation of pge2 hyperalgesia, but only partially attenuated the induction of oih. 2019-06-04 2023-08-13 Not clear