| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Shen, Wenwen Han, Xiangrong Tan, Kyle J Gu, Danial F Naseem, Guibin Zheng, Guojun Li, Jianlin Lou, Chao Che. Expression of RIPK1 and FADD are associated with chemosensitivity and survival in head and heck squamous cell carcinoma via tanshinone IIA-mediated modulation of the RIPK1-FADD-Caspase 8 complex. Molecular carcinogenesis. 2024-05-02. PMID:38695620. |
moreover, tan iia reduced the expression of ripk1 and fadd in hnscc chemoresistant cell lines, which could increase the chemosensitivity of cisplatin and promote apoptosis. |
2024-05-02 |
2024-05-04 |
Not clear |
| Parisa Ghanavatian, Hossein Salehi-Sedeh, Farangis Ataei, Saman Hosseinkhan. Bioluminescent RIPoptosome Assay for FADD/RIPK1 Interaction Based on Split Luciferase Assay in a Human Neuroblastoma Cell Line SH-SY5Y. Biosensors. vol 13. issue 2. 2023-02-25. PMID:36832063. |
tumor necrosis factor α (tnfα) stimulated assembly of receptor-interacting protein kinase 1 (ripk1)/fas-associated death domain (fadd) interaction forms ripoptosome complex that may cause either apoptosis or necroptosis. |
2023-02-25 |
2023-08-14 |
human |
| Duqiang Gong, Kexin Sun, Kexin Yin, Xu Wan. Selenium mitigates the inhibitory effect of TBBPA on NETs release by regulating ROS/MAPK pathways-induced carp neutrophil apoptosis and necroptosis. Fish & shellfish immunology. 2022-12-25. PMID:36566834. |
the expression of genes related to the mitochondrial apoptosis pathway (bax, cyt-c, bcl-2 and caspase-3) and necroptosis pathway (mlkl, ripk1, ripk3, caspase-8 and fadd) were activated. |
2022-12-25 |
2023-08-14 |
Not clear |
| Lili Liu, Xiangling Liu, Liangyou Zhao, Yuan Li. 1,8-cineole alleviates bisphenol A-induced apoptosis and necroptosis in bursa of Fabricius in chicken through regulating oxidative stress and PI3K/AKT pathway. Ecotoxicology and environmental safety. vol 226. 2021-10-20. PMID:34634738. |
tunel analysis results, histopathological variations, and the overexpression of proapoptosis biomakers (caspase 3, bax, cyt-c, and p53) and necroptosis pathway-related factors (ripk1, ripk3, mlkl, and fadd) indicated that bpa exposure induced the apoptosis and necroptosis in chicken bf. |
2021-10-20 |
2023-08-13 |
cat |
| Dianrong Li, Jie Chen, Jia Guo, Lin Li, Gaihong Cai, She Chen, Jia Huang, Hui Yang, Yinhua Zhuang, Fengchao Wang, Xiaodong Wan. A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin eLife. vol 10. 2021-10-18. PMID:34029184. |
the apoptotic function of ripk3 requires phosphorylation of the serine 165/threonine 166 sites on its kinase activation loop, resulting in inactivation of ripk3 kinase activity while gaining the ability to recruit ripk1, fadd, and caspase-8 to form a cytosolic caspase-activating complex, thereby triggering apoptosis. |
2021-10-18 |
2023-08-13 |
Not clear |
| Kartik Gupta, Bo Li. PLK1-mediated S369 phosphorylation of RIPK3 during G2 and M phases enables its ripoptosome incorporation and activity. iScience. vol 24. issue 4. 2021-04-21. PMID:33870135. |
upon induction of an altered conformation by chemical inhibitors or via mutations in its kinase site, ripk3 associates with a multiprotein complex called the ripoptosome-a signaling platform containing fadd, ripk1, caspase 8, and cflip-and becomes decisive in the execution of apoptosis. |
2021-04-21 |
2023-08-13 |
Not clear |
| Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Lisette Van Hove, Sofie Voet, Jana Roels, Jonathan Maelfait, Laura Bongiovanni, Alain de Bruin, Charlotte L Scott, Yvan Saeys, Manolis Pasparakis, Mathieu J M Bertrand, Geert van Lo. OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis. Cell reports. vol 30. issue 7. 2021-03-09. PMID:32075762. |
genetic ablation of fas-associated death domain (fadd) completely rescues and knockin expression of kinase inactive receptor-interacting protein kinase 1 (ripk1) significantly protects mice from developing liver disease, demonstrating that apoptosis of otulin-deficient hepatocytes triggers disease pathogenesis in this model. |
2021-03-09 |
2023-08-13 |
mouse |
| Mark Lötzerich, Pascal S Roulin, Karin Boucke, Robert Witte, Oleg Georgiev, Urs F Grebe. Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death. Cell death & disease. vol 9. issue 3. 2020-04-06. PMID:29449668. |
ripk1 binds to adaptor proteins, such as trif (toll-il-1 receptor-domain-containing-adaptor-inducing interferon-beta factor), fadd (fas-associated-protein with death domain), nemo (nf-κb regulatory subunit ikkγ), sqstm1 (sequestosome 1/p62), or ripk3 (receptor-interacting protein kinase 3), which are involved in rna sensing, nf-κb signaling, autophagosome formation, apoptosis, and necroptosis. |
2020-04-06 |
2023-08-13 |
Not clear |
| Christopher McCann, Nyree Crawford, Joanna Majkut, Caitriona Holohan, Chris W D Armstrong, Pamela J Maxwell, Chee Wee Ong, Melissa J LaBonte, Simon S McDade, David J Waugh, Daniel B Longle. Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists. Cell death & disease. vol 9. issue 11. 2019-11-13. PMID:30349042. |
in the presence of recombinant or macrophage-derived tnfα, we found that iap antagonists triggered degradation of ciap1 and induced formation of complex-iib, consisting of caspase-8, fadd and ripk1 in crpc models; however, no, or modest levels of apoptosis were induced. |
2019-11-13 |
2023-08-13 |
Not clear |
| Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira, Junying Yua. Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nature communications. vol 8. issue 1. 2017-12-21. PMID:28842570. |
on the other hand, blocking ser321 phosphorylation promotes ripk1 activation and its interaction with fadd to mediate ripk1-dependent apoptosis (rda). |
2017-12-21 |
2023-08-13 |
Not clear |
| Roshan J Thapa, Justin P Ingram, Katherine B Ragan, Shoko Nogusa, David F Boyd, Asiel A Benitez, Haripriya Sridharan, Rachelle Kosoff, Maria Shubina, Vanessa J Landsteiner, Mark Andrake, Peter Vogel, Luis J Sigal, Benjamin R tenOever, Paul G Thomas, Jason W Upton, Siddharth Balachandra. DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death. Cell host & microbe. vol 20. issue 5. 2017-09-06. PMID:27746097. |
iav activates the host kinase ripk3, which induces cell death via parallel pathways of necroptosis, driven by the pseudokinase mlkl, and apoptosis, dependent on the adaptor proteins ripk1 and fadd. |
2017-09-06 |
2023-08-13 |
mouse |
| Maria Feoktistova, Peter Geserick, Martin Leverku. Ripoptosome Analysis by Caspase-8 Coimmunoprecipitation. Cold Spring Harbor protocols. vol 2016. issue 3. 2016-12-13. PMID:26933246. |
however, the method cannot discriminate whether this complex triggers apoptosis (through the ripk1 → fadd → caspase-8 activation pathway), necroptosis (through the ripk1 → ripk3 → mlkl activation pathway) or nondeath signaling. |
2016-12-13 |
2023-08-13 |
Not clear |
| Kenta Moriwaki, Nivea Farias Luz, Sakthi Balaji, Maria Jose De Rosa, Carey L O'Donnell, Peter J Gough, John Bertin, Raymond M Welsh, Francis Ka-Ming Cha. The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. Journal of immunology (Baltimore, Md. : 1950). vol 196. issue 1. 2016-05-18. PMID:26582950. |
these include the apoptosis inducers fadd and caspase 8, and the necroptosis kinases receptor interacting protein kinase 1 (ripk1) and ripk3. |
2016-05-18 |
2023-08-13 |
mouse |
| Marius Dannappel, Katerina Vlantis, Snehlata Kumari, Apostolos Polykratis, Chun Kim, Laurens Wachsmuth, Christina Eftychi, Juan Lin, Teresa Corona, Nicole Hermance, Matija Zelic, Petra Kirsch, Marijana Basic, Andre Bleich, Michelle Kelliher, Manolis Pasparaki. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. vol 513. issue 7516. 2014-09-24. PMID:25132550. |
epithelial fadd ablation inhibited iec apoptosis and prevented the premature death of mice with iec-specific ripk1 knockout. |
2014-09-24 |
2023-08-13 |
mouse |
| Marius Dannappel, Katerina Vlantis, Snehlata Kumari, Apostolos Polykratis, Chun Kim, Laurens Wachsmuth, Christina Eftychi, Juan Lin, Teresa Corona, Nicole Hermance, Matija Zelic, Petra Kirsch, Marijana Basic, Andre Bleich, Michelle Kelliher, Manolis Pasparaki. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. vol 513. issue 7516. 2014-09-24. PMID:25132550. |
epidermis-specific ripk1 knockout triggered keratinocyte apoptosis and necroptosis and caused severe skin inflammation that was prevented by ripk3 but not fadd deficiency. |
2014-09-24 |
2023-08-13 |
mouse |
| Linde Duprez, Mathieu J M Bertrand, Tom Vanden Berghe, Yves Dondelinger, Nele Festjens, Peter Vandenabeel. Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22362767. |
addition of the ripk1 kinase inhibitor necrostatin-1 strongly reduced recruitment of ripk1 and caspase-8 to fadd and subsequent apoptosis, indicating a role for ripk1 kinase activity in apoptotic complex formation. |
2012-07-02 |
2023-08-12 |
Not clear |