| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Filippo Consonni, Solange Moreno, Blanca Vinuales Colell, Marie-Claude Stolzenberg, Alicia Fernandes, Mélanie Parisot, Cécile Masson, Nathalie Neveux, Jérémie Rosain, Sarah Bamberger, Marie-Gabrielle Vigue, Marion Malphettes, Pierre Quartier, Capucine Picard, Frédéric Rieux-Laucat, Aude Mageru. Study of the potential role of CASPASE-10 mutations in the development of autoimmune lymphoproliferative syndrome. Cell death & disease. vol 15. issue 5. 2024-05-04. PMID:38704374. |
the genetic landscape of alps includes mutations in fas, faslg, and fadd, all associated with apoptosis deficiency, while the role of casp10 defect in the disease remains debated. |
2024-05-04 |
2024-05-07 |
human |
| Sophie I Worsfold, Kristyn Carter, Moeed Akbar, Lisa Hackett, Neal L Millar, George A C Murrel. Rotator Cuff Tendinopathy: Pathways of Apoptosis. Sports medicine and arthroscopy review. vol 32. issue 1. 2024-05-02. PMID:38695498. |
a prospective cohort study was conducted with 28 patients-14 rotator cuff tear patients, 5 instability patients, and 9 anterior cruciate ligament reconstruction patients to determine whether there was any increase in several genes implicated in apoptosis, including fas receptor (fasr), fas ligand, aifm-1, bcl-2, fadd, bax, and caspase-3. |
2024-05-02 |
2024-05-04 |
Not clear |
| Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Keisuke Kohama, Noritomo Fujisaki, Hiromoto Murakami, Taihei Yamada, Junichi Hirat. The role of death receptor signaling pathways in mouse Sertoli cell avoidance of apoptosis during LPS- and IL-18-induced inflammatory conditions. Journal of reproductive immunology. vol 158. 2023-06-01. PMID:37263030. |
we stimulated tm4 cells, a mouse sertoli cell line, with lps (200 or 1000 ng/ml) or ril-18 (0.1-100 ng/ml) at levels that induced leydig cell apoptosis in our previous study and assessed caspase 3 cleavage and the mrna expression of inflammatory cytokines and markers of apoptotic pathways (tnfr1, fasl, fas, fadd) after stimulation. |
2023-06-01 |
2023-08-14 |
mouse |
| Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Keisuke Kohama, Noritomo Fujisaki, Hiromoto Murakami, Taihei Yamada, Junichi Hirat. The role of death receptor signaling pathways in mouse Sertoli cell avoidance of apoptosis during LPS- and IL-18-induced inflammatory conditions. Journal of reproductive immunology. vol 158. 2023-06-01. PMID:37263030. |
treatment with ril-18 increased il18r1 mrna and induced inflammation, but decreased tnfr1 and had little influence on apoptosis, as indicated by tnfα, fasl, fas, fadd and cleaved caspase 3. |
2023-06-01 |
2023-08-14 |
mouse |
| Lulin Wu, Tianhui Jiang, Zhiping Fu, Luqi Wang, Hongjie You, Jingyi Xue, Dali Lu. Connexin 43 dephosphorylation at serine 282 induces spontaneous arrhythmia and increases susceptibility to ischemia/reperfusion injury. Heliyon. vol 9. issue 5. 2023-05-23. PMID:37215881. |
previously we found that deficiency in cx43 s282 phosphorylation could impair intercellular communication and contribute to cardiomyocyte apoptosis by activating p38 mitogen-activated protein kinase (p38 mapk)/factor-associated suicide (fas)/fas-associating protein with a novel death domain (fadd) pathway, which is involved in myocardium injury in ischemia/reperfusion ( |
2023-05-23 |
2023-08-14 |
Not clear |
| Özge Kılınçarslan Aksoy, Mücahit Seçme, Ramazan Mammado. Antioxidant, Cytotoxicity, Apoptotic Properties of Extracts of Andricus sternlichti galls and Their Phenolic Characterisation by HPLC. Chemistry & biodiversity. 2022-12-08. PMID:36478153. |
expression of some genes ( bax, bcl-2, fas, bid, caspase-3, caspase-8, caspase-9, caspase-10, fadd, tradd ) in the apoptosis pathway was determined to investigate apoptosis inducing activity. |
2022-12-08 |
2023-08-14 |
Not clear |
| Hao Li, Luqi Li, Xun Qiu, Jing Zhang, Zichun Hu. The interaction of CFLAR with p130Cas promotes cell migration. Biochimica et biophysica acta. Molecular cell research. 2022-11-18. PMID:36400248. |
casp8 and fadd like apoptosis regulator (cflar) is a key anti-apoptotic regulator for resistance to apoptosis mediated by fas and trail. |
2022-11-18 |
2023-08-14 |
human |
| Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhan. Astilbin attenuates apoptosis induced by cadmium through oxidative stress in carp (Cyprinus carpio L.) head kidney lymphocyte. Fish & shellfish immunology. 2022-05-16. PMID:35577320. |
after exposure to cd, the level of oxidative stress in head kidney lymphocytes increased, and the mrna and protein expression of apoptosis-related markers fas, fadd, caspase8 and caspase3 increased significantly (p < 0.05), which led to lymphocytes apoptosis. |
2022-05-16 |
2023-08-13 |
Not clear |
| Hui Wang, Yanbing Liu, Ziyu Guo, Kexin Wu, Yunhao Zhang, Yanan Tian, Baoyu Zhao, Hao L. Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line. Research in veterinary science. vol 143. 2022-01-13. PMID:35026629. |
aconitine treatment induced apoptosis in ht22 cells and we found aconitine induced apoptosis by upregulating the expression of bax, cyto c, apaf-1, caspase9, fas, fas-l, fadd, caspase8, caspase3 with concomitant decreasing of bcl-2 and bid expression. |
2022-01-13 |
2023-08-13 |
Not clear |
| Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Hayato Yamashita, Yuka Koga, Mariko Terashima, Makoto Usami, Joji Kotani, Junichi Hirat. Interleukin-18 levels and mouse Leydig cell apoptosis during lipopolysaccharide-induced acute inflammatory conditions. Journal of reproductive immunology. vol 141. 2021-09-20. PMID:32629316. |
when high-dose ril-18 was administered to the leydig cell line to mimic levels seem after inflammation, ril-18 upregulated tnf-α mrna, fadd mrna, and fas protein, promoted cleavage of caspase-8 and caspase-3, and induced apoptosis. |
2021-09-20 |
2023-08-13 |
mouse |
| Ana Patrícia Bastos Ferreira, Ana Paula Pimentel Cassilhas, Patrícia Moura, Pedro Augusto Sampaio Rocha-Filh. Intrinsic and Extrinsic Cell Apoptotic Pathways in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Systematic Review. Viral immunology. vol 34. issue 6. 2021-08-16. PMID:33470891. |
the descriptors used for this systematic literature review were: tropical paraparesis, proto-oncogenic protein c, bcl-2, bcl-x protein, bax protein, fas ligand (fasl) protein, fas receptor, tnf-related apoptosis-inducing ligand and fas-associated protein with death domain (fadd)-like apoptosis regulating. |
2021-08-16 |
2023-08-13 |
human |
| Wenjie Su, Min Xie, Yao Li, Xinran Gong, Jiacen L. Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway. Neuromolecular medicine. vol 22. issue 2. 2021-07-19. PMID:31758388. |
as results, tpm administration improved the spatial learning and memory ability in pocd rat by decreasing the expression levels of fas, fadd, and inflammatory factors (tumor necrosis factor-α, tnf-α; interleukin-1β, il-1β; interleukin-6, il-6) in pocd rats. |
2021-07-19 |
2023-08-13 |
rat |
| Lei Xiang, Bin He, Qiang Liu, Dongdong Hu, Wenjing Liao, Ruochan Li, Xinyi Peng, Qian Wang, Gang Zha. Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells. Oncology reports. vol 44. issue 5. 2021-07-06. PMID:33000266. |
to investigate the possible underlying molecular mechanisms, the gene and protein levels of fas, fas‑associated via death domain (fadd), caspase‑8, caspase‑3, matrix metalloproteinase (mmp)‑9, nuclear factor (nf)‑κb, e‑cadherin and claudin‑3 were detected using quantitative pcr analysis, zymography and western blotting. |
2021-07-06 |
2023-08-13 |
mouse |
| Takehiko Doi, Satoshi Okad. [Lymphoproliferative disorders and inborn errors of immunity]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 61. issue 9. 2021-01-18. PMID:33162537. |
autoimmune lymphoproliferative syndrome (alps), a typical lpd disease, is caused by germline mutations in fas, fasl, casp10, casp8 and fadd, which are involved in the apoptosis pathway. |
2021-01-18 |
2023-08-13 |
Not clear |
| Shasha Yu, Haiyu Ji, Xiaodan Dong, Anjun Liu, Juan Y. FAS/FAS-L-mediated apoptosis and autophagy of SPC-A-1 cells induced by water-soluble polysaccharide from Polygala tenuifolia. International journal of biological macromolecules. vol 150. 2020-12-28. PMID:32027895. |
the death receptor pathway demonstrated the up-regulated expression of fas, ligand fas-l, and fadd, which led to a cascade reaction of the caspase family that induced cell apoptosis. |
2020-12-28 |
2023-08-13 |
Not clear |
| Mingliang Zhang, Xiao Lin, Jinping Zhang, Lin Su, Mingming Ma, Vicki L Ea, Xun Liu, Liming Wang, Jin Chang, Xiaorong Li, Xiaomin Zhan. Blue light-triggered optogenetic system for treating uveal melanoma. Oncogene. vol 39. issue 10. 2020-11-25. PMID:31811271. |
we found that blue light irradiation dynamically controlled the translocation of fadd to fas on the plasma membrane and induced the apoptosis of b16 cells transfected with the optogenetic nanosystem in vitro. |
2020-11-25 |
2023-08-13 |
Not clear |
| Meng-Meng Li, Xiao-Hui Liu, Yi-Chen Zhao, Xiao-Ye Ma, Yu-Chen Zhou, Yan-Xin Zhao, Xue-Yuan Li. Long noncoding RNA KCNQ1OT1 promotes apoptosis in neuroblastoma cells by regulating miR-296-5p/Bax axis. The FEBS journal. vol 287. issue 3. 2020-10-15. PMID:31433907. |
previously, we found that the target genes of several mirnas, including fadd, fas, casp and bax, are related to neuronal apoptosis and form a regulatory network. |
2020-10-15 |
2023-08-13 |
Not clear |
| Sorah Yoon, Xiwei Wu, Brian Armstrong, Nagy Habib, John J Ross. An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma. Molecular therapy. Nucleic acids. vol 14. 2020-09-28. PMID:30594071. |
pdr3 also upregulated serine phosphorylation of p53, which subsequently mediated apoptosis through the death receptors: tumor necrosis factor (tnf)-related apoptosis-inducing ligand receptors 1/2 (trail-r1/r2), fas-associated via death domain (fadd), and fas. |
2020-09-28 |
2023-08-13 |
human |
| Yuting Jiang, Yanmei Yang, Chengzhi Zhang, Wei Huang, Liaowei Wu, Jian Wang, Mengyao Su, Dianjun Sun, Yanhui Ga. Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway. Environmental pollution (Barking, Essex : 1987). vol 266. issue Pt 1. 2020-09-15. PMID:32629210. |
this resulted in activation of fas-associated extrinsic apoptosis via interaction with increased fas, fadd, cleaved caspase-8 and cleaved caspase-3. |
2020-09-15 |
2023-08-13 |
human |
| E D Bazhanova, V N Anisimo. [FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.] Advances in gerontology = Uspekhi gerontologii. vol 33. issue 1. 2020-08-18. PMID:32362081. |
the apoptosis level of neurons in hypothalamic sections (supraoptic and paraventricular nuclei) (tunel) and expression of caspase-8, cd178 (fasl), fas, fadd, tradd (western blotting) was determined. |
2020-08-18 |
2023-08-13 |
mouse |