| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Basiru Olaitan Ajiboye, Toluwase Hezekiah Fatoki, Olamilekan Ganiu Akinola, Kazeem Olasunkanmi Ajeigbe, Abraham Fisayo Bamisaye, Eva-María Domínguez-Martín, Patricia Rijo, Babatunji Emmanuel Oyinloy. In silico exploration of anti-prostate cancer compounds from differential expressed genes. BMC urology. vol 24. issue 1. 2024-07-03. PMID:38956591. |
the findings revealed a total of 79 upregulated degs and 110 downregulated degs in pca, which were used to identify drug compounds capable of reversing the dysregulated conditions (dexverapamil, emetine, parthenolide, dobutamine, terfenadine, pimozide, mefloquine, ellipticine, and trifluoperazine) at a threshold probability of 20% on several molecular targets, such as serotonin receptors 2a/2b/2c, herg protein, adrenergic receptors alpha-1a/2a, dopamine d3 receptor, inducible nitric oxide synthase (inos), epidermal growth factor receptor erbb1 (egfr), tyrosine-protein kinases, and c-c chemokine receptor type 5 (ccr5). |
2024-07-03 |
2024-07-06 |
Not clear |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Unveiling the therapeutic prospects of EGFR inhibition in rotenone-mediated parkinsonism in rats: Modulation of dopamine D3 receptor. Brain research. 2024-03-30. PMID:38554797. |
therefore, we investigated the impact of modulating the egfr, a member of the rtks family, and the dopamine d3r, a member of the gpcr family. |
2024-03-30 |
2024-04-02 |
rat |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Unveiling the therapeutic prospects of EGFR inhibition in rotenone-mediated parkinsonism in rats: Modulation of dopamine D3 receptor. Brain research. 2024-03-30. PMID:38554797. |
unveiling the therapeutic prospects of egfr inhibition in rotenone-mediated parkinsonism in rats: modulation of dopamine d3 receptor. |
2024-03-30 |
2024-04-02 |
rat |
| Xiaoke Di, Meiyu Wan, Ya-Nan Bai, Fengjuan Lu, Minghui Zhao, Zhifei Zhang, Yang L. Exploring the mechanism of Icariin in the treatment of depression through BDNF-TrkB pathway based on network pharmacology. Naunyn-Schmiedeberg's archives of pharmacology. 2023-07-20. PMID:37470804. |
in a cums-induced depression model, we found that icariin could effectively improve depression-like behavior of mice, increase the expression of monoamine neurotransmitters 5-hydroxytryptamine, dopamine, and norepinephrine, decrease the secretion of inflammatory factors tumor necrosis factor-α, interleukin-6, and interleukin-1β, and upregulate the relative expression levels of bdnf, p-trkb/trkb, p-akt/akt, p-creb/creb, mapk3, mapk1, bcl-2, egfr, and mtor. |
2023-07-20 |
2023-08-14 |
mouse |
| Hui Liu, Zhiwei Deng, Jiaqi Bu, Yunshan Zhang, Zhuomin Zhang, Yao He, Tianhao Li, Peiru Gao, Yanjing Yang, Shian Zhon. Capsule-like molecular imprinted polymer nanoparticles for targeted and chemophotothermal synergistic cancer therapy. Colloids and surfaces. B, Biointerfaces. vol 208. 2021-11-16. PMID:34600360. |
using dopamine (da) as functional monomer, cross-linking agent as well as photo-thermal agent, zif-8 (zeoliticimidazolate framework-8) as drug carrier, epitope of egfr (epidermal growth factor receptor) as template molecules, molecular imprinted polymer (mip) drug carrier was constructed. |
2021-11-16 |
2023-08-13 |
Not clear |
| Sk Kayum Alam, Yongchang Zhang, Li Wang, Zhu Zhu, Christina E Hernandez, Yuling Zhou, Nong Yang, Jian Lei, Xiaoyan Chen, Liang Zeng, Mark A Klein, Luke H Hoeppne. DARPP-32 promotes ERBB3-mediated resistance to molecular targeted therapy in EGFR-mutated lung adenocarcinoma. Oncogene. 2021-10-26. PMID:34675407. |
here, we show that dopamine and cyclic amp-regulated phosphoprotein, mr 32000 (darpp-32) physically recruits erbb3 (her3) to egfr to mediate switching from egfr homodimers to egfr:erbb3 heterodimers to bypass egfr tki-mediated inhibition by potentiating erbb3-dependent activation of oncogenic signaling. |
2021-10-26 |
2023-08-13 |
mouse |
| Ningning Sun, Xiaowei Zhang, Shuohan Guo, Hang Thi Le, Xiaohan Zhang, Kyeong-Man Ki. Molecular mechanisms involved in epidermal growth factor receptor-mediated inhibition of dopamine D Biochimica et biophysica acta. Molecular cell research. vol 1865. issue 9. 2018-12-11. PMID:29885323. |
the present study used the epidermal growth factor receptor (egfr) and dopamine d |
2018-12-11 |
2023-08-13 |
Not clear |
| G Somlo, C L Martel, S K Lau, P Frankel, C Ruel, L Gu, A Hurria, C Chung, T Luu, R Morgan, L Leong, M Koczywas, M McNamara, C A Russell, S E Kan. A phase I/II prospective, single arm trial of gefitinib, trastuzumab, and docetaxel in patients with stage IV HER-2 positive metastatic breast cancer. Breast cancer research and treatment. vol 131. issue 3. 2012-05-15. PMID:22042372. |
immunohistochemical analysis of biomarker expression of the pka-related proteins camp response element-binding protein (creb), phospho-creb and darpp-32 (dopamine and camp-regulated phosphoprotein of 32 kda) plus t-darpp (the truncated isoform of darpp-32); pten; p-p70 s6k; and egfr was conducted on tissue from metastatic sites. |
2012-05-15 |
2023-08-12 |
Not clear |
| Sehyoun Yoon, Mi-hyun Choi, Min Seok Chang, Ja-Hyun Bai. Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activation. The Journal of biological chemistry. vol 286. issue 18. 2011-07-01. PMID:21454669. |
these results suggest that the interaction between d2r and wnt5a has an important role in dopamine neuron development in association with egfr and the erk pathway. |
2011-07-01 |
2023-08-12 |
mouse |
| Gráinne C O'Keeffe, Pam Tyers, Dag Aarsland, Jeffrey W Dalley, Roger A Barker, Maeve A Caldwel. Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 21. 2009-06-23. PMID:19433789. |
in particular, we demonstrate that dopamine increases the proliferation of svz-derived cells by releasing egf in a pkc-dependent manner in vitro and that activation of the egf receptor (egfr) is required for this effect. |
2009-06-23 |
2023-08-12 |
human |
| Thomas v O Hansen, Rehannah Borup, Troels Marstrand, Jens F Rehfeld, Finn C Nielse. Cholecystokinin-2 receptor mediated gene expression in neuronal PC12 cells. Journal of neurochemistry. vol 104. issue 6. 2008-03-26. PMID:18028338. |
but transcripts encoding proteins involved in dopamine signaling, ornithine decarboxylase (odc) regulation, memory and epidermal growth factor receptor (egfr) signaling were also found. |
2008-03-26 |
2023-08-12 |
Not clear |