| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kotaro Haruhara, Yusuke Okabayashi, Takaya Sasaki, Eisuke Kubo, Vivette D D'Agati, John F Bertram, Nobuo Tsuboi, Takashi Yoko. Podocyte density as a predictor of long-term kidney outcome in obesity-related glomerulopathy. Kidney international. 2024-07-24. PMID:39046396. |
patients with lower podocyte density were predominantly male and had larger body surface area, greater proteinuria, fewer non-sclerotic glomeruli, larger glomeruli and higher single-nephron egfr. |
2024-07-24 |
2024-07-26 |
Not clear |
| Pei Zhang, Jun Yao, Chun-Lin Gao, Xiang Fang, Zhi-Qiang Zhang, Zheng-Kun Xi. Validation of a renal risk score in a cohort of children with ANCA-associated glomerulonephritis. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2023-08-24. PMID:37615067. |
each patient was assessed by egfr, normal glomeruli, and tubular atrophy/interstitial fibrosis, and the renal outcome was evaluated using the arrs. |
2023-08-24 |
2023-09-07 |
Not clear |
| Dušan Božić, Bojana Ljubičić, Violeta Knežević, Dejan Ćelić, Vladimir Veselino. Importance of numerical density of tubulointerstitium infiltrates in the prognosis of antineutrophil cytoplasmic antibodies-associated glomerulonephritis. Croatian medical journal. vol 64. issue 1. 2023-03-03. PMID:36864817. |
to examine the association of the numerical density of the tubulointerstitium infiltrate with pathohistological changes in the glomeruli and the estimated glomerular filtration rate (egfr) at kidney biopsy and after 18 months. |
2023-03-03 |
2023-08-14 |
Not clear |
| Pallav Gupta, Satyendra Dharamdasani, Anurag Gupta, A K Bhalla, Ashwani Gupta, Manish Malik, Vinant Bhargava, Vaibhav Tiwari, D S Rana, R L Sapr. Evaluation of Factors Influencing Outcomes in Pauci-Immune Crescentic Glomerulonephritis: Single Centre Experience of 51 Cases. Indian journal of nephrology. vol 31. issue 6. 2022-01-24. PMID:35068754. |
the newly proposed renal risk score of brix takes into account both the histopathological parameters (% of normal glomeruli, tubular atrophy and interstitial fibrosis) and clinical parameter (egfr) which influences outcome. |
2022-01-24 |
2023-08-13 |
Not clear |
| Danyi Yang, Haiyang Liu, Youmin Peng, Ying Fu, Anqun Chen, Xiangqing Xu, Shuguang Yuan, Zheng Dong, Yu Liu, Hong Li. Clinical implication of the circumferential crescents lesions in immunoglobulin A nephropathy: a single-center study of Han Chinese population. Human pathology. vol 118. 2021-11-30. PMID:34592241. |
the circumferential crescents lesion was associated with adverse outcomes in igan, and more than one-fifth of glomeruli circumferential crescents is an independent predictor of 30% egfr decline after adjusting for clinical and histological parameters. |
2021-11-30 |
2023-08-13 |
human |
| Danyi Yang, Haiyang Liu, Youmin Peng, Ying Fu, Anqun Chen, Xiangqing Xu, Shuguang Yuan, Zheng Dong, Yu Liu, Hong Li. Clinical implication of the circumferential crescents lesions in immunoglobulin A nephropathy: a single-center study of Han Chinese population. Human pathology. vol 118. 2021-11-30. PMID:34592241. |
in multivariable cox analyses, having the circumferential crescents in at least one-fifth of glomeruli was independently associated with primary endpoint (hazard ratio:3.60, 95% ci:1.46-8.83), after adjusting for oxford-score, egfr, systolic blood pressure, and proteinuria. |
2021-11-30 |
2023-08-13 |
human |
| Xue Bai, Qiaoyan Guo, Yan Lou, Ping Nie, Yuexin Zhu, Bing Li, Ping Lu. Validation of the renal risk score for antineutrophil cytoplasmic antibody-associated glomerulonephritis in a Chinese population. Clinical rheumatology. vol 40. issue 12. 2021-11-19. PMID:34282511. |
in 2018, a renal risk score of antineutrophil cytoplasmic antibody (anca)-associated glomerulonephritis (aagn) based on estimated glomerular filtration rate (egfr), normal glomeruli, and tubular atrophy/interstitial fibrosis (ta/if) was proposed to predict renal outcomes. |
2021-11-19 |
2023-08-13 |
Not clear |
| Yasunori Kitamoto, Takahisa Imamura, Yoshio Taguma, Taisuke Iwaoka, Hoichi Yorinaka, Kenji Arizon. Urinary Thrombin as a Marker of Glomerular Inflammation Associated with Renal Injury in Type 2 Diabetes. The Tohoku journal of experimental medicine. vol 253. issue 1. 2021-11-04. PMID:33441513. |
to investigate the implications of urinary thrombin in the nephropathy, we compared urinary thrombin with expression of tissue factor, the trigger of blood coagulation activation, in glomeruli and with markers of renal injury (estimated glomerular filtration rate (egfr) and proteinuria). |
2021-11-04 |
2023-08-13 |
Not clear |
| Ruiqiang Wang, Yunqi Wu, Xiaofeng Zhang, Dongyue An, Ningning Guo, Yuanyuan Guo, Jin Wang, Lin Tan. Clinicopathological Characteristics and Influencing Factors of Renal Vascular Lesions in Anti-neutrophil Cytoplasmic Autoantibody-Related Renal Vasculitis. Frontiers in medicine. vol 8. 2021-10-16. PMID:34650993. |
it was found that there were significant differences in serum creatinine (scr), estimated glomerular filtration rate (egfr), erythrocyte sedimentation rate (esr), high-density lipoprotein (hdl), systolic blood pressure (sbp), the prevalence rate of hypertension, the proportion of normal glomeruli, and the proportion of sclerotic glomeruli and interstitial fibrosis integral. |
2021-10-16 |
2023-08-13 |
human |
| Ming-Zhi Zhang, Kensuke Sasaki, Yan Li, Zhilian Li, Yu Pan, Guan-Nan Jin, Yinqiu Wang, Aolei Niu, Suwan Wang, Xiaofeng Fan, Jian Chun Chen, Corina Borza, Haichun Yang, Ambra Pozzi, Agnes B Fogo, Raymond C Harri. The Role of the EGF Receptor in Sex Differences in Kidney Injury. Journal of the American Society of Nephrology : JASN. vol 30. issue 9. 2020-05-27. PMID:31292196. |
the egf receptor (egfr) is widely expressed in the kidney in glomeruli and tubules, and persistent and dysregulated egfr activation mediates progressive renal injury. |
2020-05-27 |
2023-08-13 |
Not clear |
| Tang-Chuan Wang, Ta-Yuan Chang, Richard Salvi, Chun-Jung Juan, Yi-Wen Liu, Chia-Hao Chang, Chien-Jen Chiu, Chia-Der Lin, Ming-Hsui Tsa. Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey. Medicine. vol 99. issue 11. 2020-03-26. PMID:32176052. |
this cross-sectional population-based study aimed to examine whether hearing loss in non-diabetic united states (us) adults is independently associated with low-grade albuminuria or reduced estimated glomeruli filtration rate (egfr).a total of 2518 participants aged 20 to 69 years were selected from the us national health and nutritional examination survey database. |
2020-03-26 |
2023-08-13 |
human |
| Go Kanzaki, Victor G Puelles, Luise A Cullen-McEwen, Wendy E Hoy, Yusuke Okabayashi, Nobuo Tsuboi, Akira Shimizu, Kate M Denton, Michael D Hughson, Takashi Yokoo, John F Bertra. New insights on glomerular hyperfiltration: a Japanese autopsy study. JCI insight. vol 2. issue 19. 2019-07-29. PMID:28978800. |
we estimated total nephron (glomerular) number (nglomtotal) as well as numbers of nonsclerosed (nglomnsg) and globally sclerosed glomeruli (nglomgsg), and the mean volume of nonsclerosed glomeruli (vglomnsg) in japanese normotensive, hypertensive, and ckd subjects and investigated associations between these parameters and estimated glomerular filtration rate (egfr). |
2019-07-29 |
2023-08-13 |
human |
| Natallia Shved, Gregor Warsow, Felix Eichinger, David Hoogewijs, Simone Brandt, Peter Wild, Matthias Kretzler, Clemens D Cohen, Maja T Lindenmeye. Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819298. |
in our study, genome-wide expression profiles of more than 200 renal biopsies from patients with different ckd stages revealed significant correlation of hif-target genes with egfr in glomeruli and tubulointerstitium. |
2019-03-25 |
2023-08-13 |
Not clear |
| Mark Haas, Jacobien C Verhave, Zhi-Hong Liu, Charles E Alpers, Jonathan Barratt, Jan U Becker, Daniel Cattran, H Terence Cook, Rosanna Coppo, John Feehally, Antonello Pani, Agnieszka Perkowska-Ptasinska, Ian S D Roberts, Maria Fernanda Soares, Hernan Trimarchi, Suxia Wang, Yukio Yuzawa, Hong Zhang, Stéphan Troyanov, Ritsuko Katafuch. A Multicenter Study of the Predictive Value of Crescents in IgA Nephropathy. Journal of the American Society of Nephrology : JASN. vol 28. issue 2. 2017-05-24. PMID:27612994. |
in a large iga nephropathy cohort pooled from four retrospective studies, we addressed crescents as a predictor of renal outcomes and determined whether the fraction of crescent-containing glomeruli associates with survival from either a ≥50% decline in egfr or esrd (combined event) adjusting for covariates used in the original oxford study. |
2017-05-24 |
2023-08-13 |
human |
| Bertha M Córdova-Sánchez, Juan M Mejía-Vilet, Luis E Morales-Buenrostro, Georgina Loyola-Rodríguez, Norma O Uribe-Uribe, Ricardo Correa-Rotte. Clinical presentation and outcome prediction of clinical, serological, and histopathological classification schemes in ANCA-associated vasculitis with renal involvement. Clinical rheumatology. vol 35. issue 7. 2017-02-10. PMID:26852317. |
histopathological classification predicted response to therapy, with a poorer renal remission rate for sclerosing group and those with less than 25 % normal glomeruli; in addition, it adequately delimited 24-month glomerular filtration rate (egfr) evolution, but it did not predict renal nor patient survival. |
2017-02-10 |
2023-08-13 |
Not clear |
| Shivani Shah, John Havill, M Hafizur Rahman, Duvuru Geeth. A historical study of American patients with anti-neutrophil cytoplasmic antibody negative pauci-immune glomerulonephritis. Clinical rheumatology. vol 35. issue 4. 2017-01-16. PMID:26445939. |
baseline egfr, percentage of normal glomeruli, glomerular sclerosis, and tubulointerstitial scarring predicted egfr at 1 year in both groups similarly. |
2017-01-16 |
2023-08-13 |
Not clear |
| Nora Ledo, Yi-An Ko, Ae-Seo Deok Park, Hyun-Mi Kang, Sang-Youb Han, Peter Choi, Katalin Suszta. Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD. Journal of the American Society of Nephrology : JASN. vol 26. issue 3. 2015-04-28. PMID:25231882. |
92 transcripts in the tubule compartment and 34 transcripts in glomeruli showed statistically significant correlation with egfr. |
2015-04-28 |
2023-08-13 |
human |
| Li Zhu, Qingxian Zhang, Sufang Shi, Lijun Liu, Jicheng Lv, Hong Zhan. Synergistic effect of mesangial cell-induced CXCL1 and TGF-β1 in promoting podocyte loss in IgA nephropathy. PloS one. vol 8. issue 8. 2014-04-15. PMID:24023680. |
moreover, igan patients with higher urinary cxcl1 and tgf-β1 presented with severe clinical and pathological manifestations, including higher 24-hour urine protein excretion, lower egfr and higher cresentic glomeruli proportion. |
2014-04-15 |
2023-08-12 |
Not clear |
| Guillaume Bollée, Martin Flamant, Sandra Schordan, Cécile Fligny, Elisabeth Rumpel, Marine Milon, Eric Schordan, Nathalie Sabaa, Sophie Vandermeersch, Ariane Galaup, Anita Rodenas, Ibrahim Casal, Susan W Sunnarborg, David J Salant, Jeffrey B Kopp, David W Threadgill, Susan E Quaggin, Jean-Claude Dussaule, Stéphane Germain, Laurent Mesnard, Karlhans Endlich, Claude Boucheix, Xavier Belenfant, Patrice Callard, Nicole Endlich, Pierre-Louis Tharau. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nature medicine. vol 17. issue 10. 2011-12-07. PMID:21946538. |
in hb-egf-deficient mice, egfr activation in glomeruli is absent and the course of rpgn is improved. |
2011-12-07 |
2023-08-12 |
mouse |
| Xiwu Chen, Carrie Whiting, Corina Borza, Wen Hu, Stacey Mont, Nada Bulus, Ming-Zhi Zhang, Raymond C Harris, Roy Zent, Ambra Pozz. Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Molecular and cellular biology. vol 30. issue 12. 2010-06-17. PMID:20368353. |
finally, we show that glomeruli of integrin alpha1-null mice have reduced levels of cav-1 and activated ppargamma but increased levels of phosphorylated egfr both at baseline and following injury. |
2010-06-17 |
2023-08-12 |
mouse |