| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liu-Yan Chen, Chuan-Mei Wu, Pan Liang, Jin-Feng Wei, Ting-Ting Lan, Min Guo, Yong-Hua Li, Mei R. [Anti-inflammatory effect and its mechanism of Saracae Cortex based on zebrafish model and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 11. 2024-07-23. PMID:39041167. |
protein-protein interaction(ppi) analysis showed that saracae cortex mainly acted on signal transducer and activator of transcription 3(stat3), vascular endothelial growth factor a( vegfa), epidermal growth factor( egf), tumor necrosis factor( tnf),tumor protein p53(tp53), matrix metalloprotein 9(mmp9), c-fos proto-oncogene protein(fos), estrogen receptor 1(esr1), cx-c motif chemokine ligand 8(cxcl8), cluster of differentiation 8(cd8), and other targets. |
2024-07-23 |
2024-07-25 |
zebrafish |
| Jiangang Zheng, Abdul Haseeb, Ziyang Wang, Hejie Wan. Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555283. |
the results of network pharmacological analysis showed that there were 35 intersection proteins, among which interleukin-1β (il-1β), albumin (alb), nuclear factor kappa-b1 (nf-κb1), toll-like receptor 4 (tlr4), tumor necrosis factor alpha (tnf-α), tumor protein p53 (tp53), recombinant smad family member 3 (samd3), epidermal growth factor (egf) and interleukin-4 (il-4) were potential core targets of ea anti-rv. |
2024-03-30 |
2024-04-02 |
Not clear |
| Peng Zheng, Xue Qin, Rui Feng, Qi Li, Fushuo Huang, Yulong Li, Qian Zhao, He Huan. Alleviative effect of melatonin on the decrease of uterine receptivity caused by blood ammonia through ROS/NF-κB pathway in dairy cow. Ecotoxicology and environmental safety. vol 231. 2022-01-14. PMID:35030520. |
cell viability, apoptosis, oxidative stress and mitochondrial membrane potential were measured and the expression of apoptosis-related genes (p53, cyt-c, bax, bcl-2, caspase-8, caspase-9 and caspase-3), uterus receptivity related genes (vegf, lif and egf) and inflammatory factors (tlr-4, il-6 and nf-κb) were detected. |
2022-01-14 |
2023-08-13 |
cattle |
| Peng Zheng, Xue Qin, Rui Feng, Qi Li, Fushuo Huang, Yulong Li, Qian Zhao, He Huan. Alleviative effect of melatonin on the decrease of uterine receptivity caused by blood ammonia through ROS/NF-κB pathway in dairy cow. Ecotoxicology and environmental safety. vol 231. 2022-01-14. PMID:35030520. |
the results showed that ammonia significantly increased intracellular ros level, mrna and protein expression of bax, p53, cyt-c, caspase-9, caspase-8, caspase-3, tlr-4, nf-κb and il-6, promoted cell apoptosis, while decreased mitochondrial membrane potential, the mrna and protein expression of vegf and egf. |
2022-01-14 |
2023-08-13 |
cattle |
| AmirReza Hesari, Faezeh Ghasemi, Arrigo F G Cicero, Mohammad Mohajeri, Omid Rezaei, Seyed Mohammad Gheibi Hayat, Amirhossein Sahebka. Berberine: A potential adjunct for the treatment of gastrointestinal cancers? Journal of cellular biochemistry. vol 119. issue 12. 2019-12-02. PMID:30125974. |
several mechanisms of action have been hypothesized and demonstrated: immunomodulation, inhibition of topoisomerase enzymes, suppression of the egf receptor, her2/neu, and the vegf receptor, induction of p53, cip1/p21, kip1/p27, rb expression, induction of apoptosis (by regulation of mmps pathway, caspases, bax, and smac/diablo), inhibition of arylamin n-acetyltransferase activity, and regulation of micrornas expression. |
2019-12-02 |
2023-08-13 |
human |
| Svetlana Demyanenko, Anatoly Uzdensk. Profiling of Signaling Proteins in Penumbra After Focal Photothrombotic Infarct in the Rat Brain Cortex. Molecular neurobiology. vol 54. issue 9. 2019-05-23. PMID:27771897. |
these included over-expression of proteins initiating, regulating, or executing various apoptosis stages (caspases, smac/diablo, bcl-10, phosphatidylserine receptor (psr), prostate apoptosis response 4 (par4), e2f1, p75, p38, jnk, p53, growth arrest and dna damage inducible protein 153 (gadd153), glutamate decarboxylases (gad65/67), nmdar2a, c-myc) and antiapoptotic proteins (bcl-x, p63, mdm2, p21waf-1, erk1/2, erk5, map kinase-activated protein kinase-2 (makapk2), pkcα, pkcβ, pkcμ, raf1, protein phosphatases 1α and map kinase phosphatase-1 (mkp-1), neural precursor cell expressed, developmentally down-regulated 8 (nedd8), estrogen and egf receptors, calmodulin, camkiiα, camkiv, amyloid precursor protein (app), nicastrin). |
2019-05-23 |
2023-08-13 |
rat |
| Kausik Bishayee, Debrup Chakraborty, Samrat Ghosh, Naoual Boujedaini, Anisur Rahman Khuda-Bukhs. Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23142370. |
administration of lycopodine down-regulated the expression of 5-lipoxygenase and the 5-oxo-ete receptor (oxe receptor1) and egf receptor, and caused up-regulation of cytochrome c with depolarization of mitochondrial inner membrane potential, without palpable change in p53 activity, resulting in apoptosis, cell arrest at g0/g1 stage and ultimately reduced proliferation of cancer cells; concomitantly, there was externalization of phosphotidyl serine residues. |
2013-06-10 |
2023-08-12 |
Not clear |
| E O Kutumova, I N Kiselev, R N Sharipov, I N Lavrik, Fedor A Kolpako. A modular model of the apoptosis machinery. Advances in experimental medicine and biology. vol 736. 2013-01-30. PMID:22161332. |
using this approach, we created the apoptosis model including 13 modules: death stimuli (trail, cd95l, and tnf-α)-induced activation of caspase-8; survival stimuli (p53, egf, and nf-κb) regulation; the mitochondria level; cytochrome c- and smac-induced activation of caspase-3; direct activation of effector caspases by caspase-8 and - 12; parp and apoptosis execution phase modules. |
2013-01-30 |
2023-08-12 |
Not clear |
| Y Murayam. High-concentration of epidermal growth-factor induces apoptosis in breast and esophageal cancer-cells transplanted into nude-mice. Oncology reports. vol 1. issue 6. 2012-10-02. PMID:21607490. |
two mu g of egf induced apoptosis in es-4 esophageal cancer cells and mx-1 breast cancer cells after increased accumulation of p53 induced by 2 mu g of egf. |
2012-10-02 |
2023-08-12 |
mouse |
| S M Mense, A Sengupta, M Zhou, C Lan, G Bentsman, D J Volsky, L Zhan. Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiological genomics. vol 25. issue 3. 2007-11-08. PMID:16507782. |
furthermore, gene ontology and computational algorithms revealed that many target genes of the egf and insulin signaling pathways and the transcriptional regulators myc, jun, and p53 were selectively altered by hypoxia in astrocytes. |
2007-11-08 |
2023-08-12 |
human |
| Alain Beliveau, Paul Yaswe. Soothing the watchman: telomerase reduces the p53-dependent cellular stress response. Cell cycle (Georgetown, Tex.). vol 6. issue 11. 2007-08-09. PMID:17534147. |
this heightened activity of the p53 pathway enhanced the efficiency with which cells arrested growth in response to tgfbeta or to egf or insulin withdrawal, and was abolished by ectopic expression of htert, the catalytic subunit of telomerase. |
2007-08-09 |
2023-08-12 |
human |
| Silvia Lăcrămioara Roznovanu, Cornelia Amălinci, Doiniţa Rădulesc. Molecular mechanisms in hormone-resistant prostate cancer. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. vol 109. issue 3. 2006-06-27. PMID:16607754. |
the mechanism that determines tumoral progression during the endocrine treatment is driven by genomic instability, characterized by activating mutations of androgen receptor gene (ar), progression of some cellular clones possible of neuroendocrine origin that become adapted to low concentrations of residual adrenal androgens, suppression of apoptosis, by bcl-2 oncogene overexpression and p53 mutations, and growth factors (igf-1--insulin-like growth factor, kgf--keratinocyte growth factor, egf--epidermal growth factor, tgf a, b- transforming growth factor a and b, bfgf--fibroblastic growth factor type b) regulatory effect through either a paracrine or an autocrine mechanism. |
2006-06-27 |
2023-08-12 |
Not clear |
| Ai Shih, Shenli Zhang, H James Cao, Sarah Boswell, Yun-Hsuan Wu, Heng-Yuan Tang, Michelle R Lennartz, Faith B Davis, Paul J Davis, Hung-Yun Li. Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha. Molecular cancer therapeutics. vol 3. issue 11. 2005-05-02. PMID:15542774. |
exposure of these cells to epidermal growth factor (egf) for up to 4 hours resulted in brief activation of mapk followed by inhibition of resveratrol-induced signal transduction, p53 phosphorylation, and apoptosis. |
2005-05-02 |
2023-08-12 |
Not clear |
| Hakan Akca, Selma Yenisoy Akan, Atila Yanikoglu, Osman Nidai Oze. Suppression of TNF-alpha mediated apoptosis by EGF in TNF-alpha sensitive human cervical carcinoma cell line. Growth factors (Chur, Switzerland). vol 21. issue 1. 2004-01-08. PMID:12795334. |
since many tumors secrete growth factor(s) that inhibit apoptosis and support the growth of cancer cells, we investigated the effects of human epidermal growth factor (egf) on human tnf-alpha-mediated induction of p53 and its transcriptional target, p21 in tnf-alpha sensitive human cervical carcinoma cell line, me180s. |
2004-01-08 |
2023-08-12 |
human |
| Jin-Woo Park, Michael W Yeh, Mariwil G Wong, Margaret Lobo, William C Hyun, Quan-Yang Duh, Orlo H Clar. The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines. The Journal of clinical endocrinology and metabolism. vol 88. issue 7. 2003-08-08. PMID:12843186. |
in the ftc-133 cell line, geldanamycin treatment decreased clonogenicity by 21% at a concentration of 50 nm; geldanamycin induced apoptosis and down-regulated c-raf-1, mutant p53, and epidermal growth factor (egf) receptor expression; geldanamycin inhibited egf-stimulated invasion. |
2003-08-08 |
2023-08-12 |
human |
| F P Jori, U Galderisi, E Piegari, M Cipollaro, A Cascino, G Peluso, R Cotrufo, A Giordano, M A B Melon. EGF-responsive rat neural stem cells: molecular follow-up of neuron and astrocyte differentiation in vitro. Journal of cellular physiology. vol 195. issue 2. 2003-05-30. PMID:12652649. |
furthermore, in the absence of mitogens, apoptosis, which appeared to proceed through the "p53 network," was significantly lower than in the presence of egf. |
2003-05-30 |
2023-08-12 |
rat |
| A Slinskey, D Barnes, J M Pipa. Simian virus 40 large T antigen J domain and Rb-binding motif are sufficient to block apoptosis induced by growth factor withdrawal in a neural stem cell line. Journal of virology. vol 73. issue 8. 1999-08-24. PMID:10400777. |
the steady-state levels of p53, p21, and mdm-2 do not increase as sfme cells undergo apoptosis upon egf withdrawal. |
1999-08-24 |
2023-08-12 |
mouse |
| M C Dugan, F H Sarka. Current concepts in pancreatic cancer: symposium summary. Pancreas. vol 17. issue 4. 1999-01-19. PMID:9821173. |
among the findings: peptic ulcer disease is a significant predisposing risk factor (odds ratio = 3.9) for pancreatic cancer; as many as 50% of all intraductal papillary mucinous neoplasms are associated with invasive adenocarcinomas; alteration of gene expression via methylation of a gene promotor region constitutes a potentially reversible method of tumor suppressor gene inactivation; > 400 transcriptional alterations of gene expression have been identified for pancreatic cancer; some common molecular markers such as p53 and her-2/neu may be related to morphologic alterations of in situ neoplasia and to transcriptional alterations of gene expression rather than mutational events; epidermal growth factor (egf), transforming growth factor beta (tgf-beta), and related molecules may modulate gene transcription via "autocrine" or "paracrine" mechanisms; several cytokines, amylin (islet amyloid polypeptide), and other cachexia factors are responsible for paraneoplastic peripheral insulin resistance, ineffective utilization of glucose, and profound cachexia. |
1999-01-19 |
2023-08-12 |
Not clear |
| H Pu, T Tsuji, A Kondo, K Fushimi, R Ohashi, Y Inoue, T Mimura, K Hamazaki, M Miyazaki, M Namb. Comparison of cellular characteristics between human hepatoma cell lines with wild-type p53 and those with mutant-type p53 gene. Acta medica Okayama. vol 51. issue 6. 1998-02-12. PMID:9439773. |
although there was no significant difference in effects of tgf-beta 1, egf, cholera toxin, and db-camp on cell growth between the two types of cells, all three cell lines with the wild-type p53 were resistant to cytotoxicity of tnf-alpha, while two of the three with the mutant p53 were very sensitive to its cytotoxic effects. |
1998-02-12 |
2023-08-12 |
human |
| Y Ikematsu, G Liu, M A Fienhold, M Cano, T E Adrian, M A Hollingsworth, J E Williamson, W Sanger, T Tomioka, P M Pou. In vitro pancreatic ductal cell carcinogenesis. International journal of cancer. vol 72. issue 6. 1997-11-10. PMID:9378545. |
the resulting tumor from taka-1 + bop was re-cultured in vitro and designated taka-1 + bop-t. mutation of c-k-ras and p53 oncogenes, chromosomal changes, expression of transforming growth factor alpha (tgf-alpha) and epidermal growth factor (egf) receptor and several biochemical markers were examined in all cell lines. |
1997-11-10 |
2023-08-12 |
Not clear |