All Relations between depdc5 and hypertrophic

Publication Sentence Publish Date Extraction Date Species
Rosario Maroto, Ted G Graber, Trevor B Romsdahl, Andrzej Kudlicki, William K Russell, Blake B Rasmusse. Metabolomic and Lipidomic Signature of Skeletal Muscle with Constitutively Active mTORC1. The Journal of nutrition. 2023-10-28. PMID:37898335. skeletal muscle specific knockout of dep domain-containing 5 protein (depdc5) results in constitutively active mtorc1 signaling, muscle hypertrophy and an increase in mitochondrial respiratory capacity. 2023-10-28 2023-11-08 Not clear
Ted G Graber, Christopher S Fry, Camille R Brightwell, Tatiana Moro, Rosario Maroto, Nisha Bhattarai, Craig Porter, Maki Wakamiya, Blake B Rasmusse. Skeletal muscle-specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration. The Journal of biological chemistry. vol 294. issue 11. 2019-05-30. PMID:30635399. to study the function of depdc5 in skeletal muscle, we generated a muscle-specific inducible depdc5 knockout mouse, hypothesizing that knocking out depdc5 in muscle would make mtorc1 constitutively active, causing hypertrophy and improving muscle function. 2019-05-30 2023-08-13 mouse