| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Ohshima, J Suzumiya, M Sugihara, M Kanda, K Shimazaki, C Kawasaki, S Haraoka, M Kikuch. Clinical, immunohistochemical and phenotypic features of aggressive nodal cytotoxic lymphomas, including alpha/beta, gamma/delta T-cell and natural killer cell types. Virchows Archiv : an international journal of pathology. vol 435. issue 2. 2000-01-06. PMID:10599306. |
phenotypically and genotypically, four cases showed alpha beta t cell type [cd2+, cd3+, t-cell receptor (tcr)-delta-1-, beta f1+, and tcr gene rearrangement], two cases showed gamma delta cell type [cd2+, cd3+, t-cell receptor (tcr) delta-1+, beta f1-, and tcr gene rearrangement], and one case showed nk cell type [cd2+, cd3-, cd56+, t-cell receptor (tcr) delta-1-, beta f1-, and tcr gene germline]. |
2000-01-06 |
2023-08-12 |
Not clear |
| S Salvadori, R Guerrini, G Balboni, C Bianchi, S D Bryant, P S Cooper, L H Lazaru. Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism. Journal of medicinal chemistry. vol 42. issue 24. 2000-01-04. PMID:10585210. |
h-dmt-betahtic-oh (methylene bridge between c(alpha) of tic and carboxylate function) yielded a biostable peptide with high delta affinity (k(i) = 0.85 nm) and delta antagonism (pa(2) = 8.85) without mu bioactivity. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
dual g1 and g2/m phase inhibition by sc-alpha alpha delta 9, a combinatorially derived cdc25 phosphatase inhibitor. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
one compound, 4-(benzyl-(2-[(2, 5-diphenyl-oxazole-4-carbonyl)-amino]-ethyl)-carbamoyl)-2-decanoylami no butyric acid (sc-alpha alpha delta 9), was previously identified as the most potent reported synthetic inhibitor of cdc25 phosphatases in vitro. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
in the present study, we demonstrate that sc-alpha alpha delta 9 inhibited cdc25-dependent cell cycle progression at both g1 and g2/m phase using tsft210 cells, which express a temperature-sensitive cdc2 mutant. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
sc-alpha alpha delta 9 blocked both g2/m transition and dephosphorylation of cdc2 in a concentration-dependent manner. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
sc-alpha alpha delta 9 also enhanced tyrosine phosphorylation of both cdk2 and cdk4, and decreased cdk4 kinase activity. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
sc-alpha alpha delta 9 did not alter p53, p21 or p16 levels. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
our results support the hypothesis that the disruption in cell cycle transition caused by sc-alpha alpha delta 9 was due to intracellular cdc25 inhibition. |
2000-01-04 |
2023-08-12 |
Not clear |
| K Tamura, R L Rice, P Wipf, J S Laz. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597298. |
we propose that the sc-alpha alpha delta 9 pharmacophore could be useful in further clarifying the role of cdc25 phosphatase-dependent pathways in checkpoint control, oncogenesis, and apoptosis. |
2000-01-04 |
2023-08-12 |
Not clear |
| F Nobili, F Copello, P Vitali, T Prastaro, S Carozzo, G Perego, G Rodrigue. Timing of disease progression by quantitative EEG in Alzheimer' s patients. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. vol 16. issue 6. 2000-01-04. PMID:10600024. |
in the whole group, the loss of activities of daily living was predicted by delta power in either side (p = 0.01), incontinence was predicted by alpha power in the right side (p < 0.01), whereas the statistical significance was not reached for death (p < 0.05). |
2000-01-04 |
2023-08-12 |
Not clear |
| F Nobili, F Copello, P Vitali, T Prastaro, S Carozzo, G Perego, G Rodrigue. Timing of disease progression by quantitative EEG in Alzheimer' s patients. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. vol 16. issue 6. 2000-01-04. PMID:10600024. |
in the subgroup of mild demented patients, the loss of activities of daily living was predicted by delta power in the left side (p = 0.01), incontinence by both delta (p < 0.01) and alpha (p < 0.001) power in the right side, and death was not significantly predicted (p = 0.08). |
2000-01-04 |
2023-08-12 |
Not clear |
| T W Spahn, S Issazadah, A J Salvin, H L Weine. Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 - 35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene. European journal of immunology. vol 29. issue 12. 2000-01-04. PMID:10602017. |
furthermore, when eae was induced by adoptive transfer of an anti-mog p35 - 55 alpha beta t cell line, there was a striking reduction of disease incidence (0 %) and severity in delta(- / -) as compared to wild-type mice (83 % incidence). |
2000-01-04 |
2023-08-12 |
mouse |
| T W Spahn, S Issazadah, A J Salvin, H L Weine. Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 - 35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene. European journal of immunology. vol 29. issue 12. 2000-01-04. PMID:10602017. |
delta(- / -) mice showed no cellular infiltration in the spinal cord whereas wild-type animals had infiltration of macrophages, b cells, alpha beta- and gamma delta t cells. |
2000-01-04 |
2023-08-12 |
mouse |
| H Konishi, H Matsuzaki, H Takaishi, T Yamamoto, M Fukunaga, Y Ono, U Kikkaw. Opposing effects of protein kinase C delta and protein kinase B alpha on H(2)O(2)-induced apoptosis in CHO cells. Biochemical and biophysical research communications. vol 264. issue 3. 1999-12-22. PMID:10544018. |
opposing effects of protein kinase c delta and protein kinase b alpha on h(2)o(2)-induced apoptosis in cho cells. |
1999-12-22 |
2023-08-12 |
Not clear |
| S Strack, D Chang, J A Zaucha, R J Colbran, B E Wadzinsk. Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A. FEBS letters. vol 460. issue 3. 1999-12-22. PMID:10556517. |
we have cloned a novel member of the b type regulatory subunit family, b delta, which is most highly related to b alpha. |
1999-12-22 |
2023-08-12 |
Not clear |
| S Strack, D Chang, J A Zaucha, R J Colbran, B E Wadzinsk. Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A. FEBS letters. vol 460. issue 3. 1999-12-22. PMID:10556517. |
b delta shares with b alpha epitopes previously used to generate subunit-specific antibodies. |
1999-12-22 |
2023-08-12 |
Not clear |
| S Strack, D Chang, J A Zaucha, R J Colbran, B E Wadzinsk. Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A. FEBS letters. vol 460. issue 3. 1999-12-22. PMID:10556517. |
b delta is a cytosolic subunit of pp2a with a subcellular localization different from b alpha and may therefore target a pool of pp2a holoenzymes to specific substrates. |
1999-12-22 |
2023-08-12 |
Not clear |
| R H Winger, K R Liedl, A Pichler, A Hallbrucker, E Maye. Helix morphology changes in B-DNA induced by spontaneous B(I)<==>B(II) substrate interconversion. Journal of biomolecular structure & dynamics. vol 17. issue 2. 1999-12-21. PMID:10563572. |
for alpha and delta inside the interconverting base step, a change is seen in short lived b(ii) conformers. |
1999-12-21 |
2023-08-12 |
Not clear |
| H Taniyama, S Oka, H Yokota, K Hirayama, Y Kagawa, T Kurosawa, H Furuoka, T On. Immunohistochemical detection of the enzyme glutamic acid decarboxylase and hormones of the islets of Langerhans in spontaneous insulin-dependent diabetes mellitus in cattle. Veterinary pathology. vol 36. issue 6. 1999-12-20. PMID:10568450. |
these findings suggest that islet cells in cattle with iddm lose their insulin synthesis function and their ability to regulate hormonal secretion of alpha and delta cells. |
1999-12-20 |
2023-08-12 |
cattle |