| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Rohde, A Sabri, R Kamasamudran, S F Steinber. The alpha(1)-adrenoceptor subtype- and protein kinase C isoform-dependence of Norepinephrine's actions in cardiomyocytes. Journal of molecular and cellular cardiology. vol 32. issue 7. 2000-08-09. PMID:10860763. |
norepinephrine (ne) induces a rise in diacylglycerol levels which is sustained for 24 h and is associated with the translocation (at 5 min) and down-regulation (at 24 h) of pkc delta and pkc xi (but not pkc alpha). |
2000-08-09 |
2023-08-12 |
Not clear |
| S Rohde, A Sabri, R Kamasamudran, S F Steinber. The alpha(1)-adrenoceptor subtype- and protein kinase C isoform-dependence of Norepinephrine's actions in cardiomyocytes. Journal of molecular and cellular cardiology. vol 32. issue 7. 2000-08-09. PMID:10860763. |
wb-4101 (alpha(1a/c)- and alpha(1d)-receptor antagonist) and 5-methylurapidil (alpha(1a/c)-receptor antagonist) inhibit norepinephrine-dependent accumulation of inositol phosphate and diacylglycerol, down-regulation of pkc delta and pkc xi, and activation of erk. |
2000-08-09 |
2023-08-12 |
Not clear |
| H Rochlitz, A Voigt, B Lankat-Buttgereit, B Göke, H Heimberg, M A Nauck, U Schiemann, H Schatz, A F Pfeiffe. Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells. Diabetologia. vol 43. issue 4. 2000-08-03. PMID:10819240. |
there are four isoforms of camk ii, alpha to delta, that are expressed from different genes in mammals. |
2000-08-03 |
2023-08-12 |
human |
| D B Winter, Q H Phung, R D Wood, P J Gearhar. Differential expression of DNA polymerase epsilon in resting and activated B lymphocytes is consistent with an in vivo role in replication and not repair. Molecular immunology. vol 37. issue 3-4. 2000-07-28. PMID:10865111. |
the resting b cells did not express polymerases alpha or epsilon at detectable levels, although they did express polymerases beta, delta, and zeta. |
2000-07-28 |
2023-08-12 |
Not clear |
| S D Dunn, D T McLachlin, M Revingto. The second stalk of Escherichia coli ATP synthase. Biochimica et biophysica acta. vol 1458. issue 2-3. 2000-07-27. PMID:10838050. |
the two b subunits and the delta subunit associate to form b(2)delta, a second, peripheral stalk extending from the membrane up the side of alpha(3)beta(3) and binding to the n-terminal regions of the alpha subunits, which are approx. |
2000-07-27 |
2023-08-12 |
Not clear |
| D T McLachlin, A M Coveny, S M Clark, S D Dun. Site-directed cross-linking of b to the alpha, beta, and a subunits of the Escherichia coli ATP synthase. The Journal of biological chemistry. vol 275. issue 23. 2000-07-20. PMID:10747904. |
the b subunit dimer of the escherichia coli atp synthase, along with the delta subunit, is thought to act as a stator to hold the alpha(3)beta(3) hexamer stationary relative to the a subunit as the gammaepsilonc(9-12) complex rotates. |
2000-07-20 |
2023-08-12 |
Not clear |
| P Dinçer, Z Akçören, E Demir, I Richard, O Sancak, G Kale, S Ozme, A Karaduman, E Tan, J A Urtizberea, J S Beckmann, H Topaloğl. A cross section of autosomal recessive limb-girdle muscular dystrophies in 38 families. Journal of medical genetics. vol 37. issue 5. 2000-07-17. PMID:10807695. |
the classification of families was as follows: calpainopathy 7, dysferlinopathy 3, alpha sarcoglycan deficiency 2, beta sarcoglycan deficiency 7, gamma sarcoglycan deficiency 5, delta sarcoglycan deficiency 1, and merosinopathy 2. |
2000-07-17 |
2023-08-12 |
Not clear |
| G Dekomien, J T Epple. Exclusion of the PDE6A gene for generalised progressive retinal atrophy in 11 breeds of dog. Animal genetics. vol 31. issue 2. 2000-07-13. PMID:10782214. |
this enzyme consists of two catalytic alpha and beta subunits, two identical inhibitory gamma subunits as well as a delta subunit. |
2000-07-13 |
2023-08-12 |
human |
| S Han, R J Hickey, T D Tom, P W Wills, J E Syväoja, L H Malka. Differential inhibition of the human cell DNA replication complex-associated DNA polymerases by the antimetabolite 1-beta-D-arabinofuranosylcytosine triphosphate (ara-CTP). Biochemical pharmacology. vol 60. issue 3. 2000-07-13. PMID:10856436. |
inhibition of the dna synthesome-associated dna polymerase alpha increased in a concentration-dependent manner, and was correlated closely with the inhibition of simian virus 40 (sv40) origin-dependent in vitro dna replication, whereas dna synthesome-associated dna polymerase delta activity was not inhibited significantly by ara-ctp at 100 microm. |
2000-07-13 |
2023-08-12 |
human |
| S Han, R J Hickey, T D Tom, P W Wills, J E Syväoja, L H Malka. Differential inhibition of the human cell DNA replication complex-associated DNA polymerases by the antimetabolite 1-beta-D-arabinofuranosylcytosine triphosphate (ara-CTP). Biochemical pharmacology. vol 60. issue 3. 2000-07-13. PMID:10856436. |
recent work has shown that the synthesome-associated dna polymerase epsilon does not function in in vitro sv40 dna replication, suggesting that only polymerases alpha and delta drive the dna replication fork. |
2000-07-13 |
2023-08-12 |
human |
| J Yordanova, M Devrim, V Kolev, A Ademoglu, T Demiral. Multiple time-frequency components account for the complex functional reactivity of P300. Neuroreport. vol 11. issue 5. 2000-07-10. PMID:10790889. |
the results demonstrated that several partly or fully simultaneous delta, theta, and alpha tf components significantly depend on the factors eliciting p300, and also manifest distinct patterns of task reactivity and scalp distribution. |
2000-07-10 |
2023-08-12 |
human |
| D Platano, N Qin, F Noceti, L Birnbaumer, E Stefani, R Olces. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophysical journal. vol 78. issue 6. 2000-07-10. PMID:10827975. |
expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac l-type calcium channels. |
2000-07-10 |
2023-08-12 |
xenopus_laevis |
| D Platano, N Qin, F Noceti, L Birnbaumer, E Stefani, R Olces. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophysical journal. vol 78. issue 6. 2000-07-10. PMID:10827975. |
we investigated the role of the accessory alpha(2)delta subunit on the voltage-dependent facilitation of cardiac l-type ca(2+) channels (alpha(1c)). |
2000-07-10 |
2023-08-12 |
xenopus_laevis |
| D Platano, N Qin, F Noceti, L Birnbaumer, E Stefani, R Olces. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophysical journal. vol 78. issue 6. 2000-07-10. PMID:10827975. |
alpha(1c) channels were coexpressed in xenopus oocytes with beta(3) and alpha(2)delta calcium channel subunits. |
2000-07-10 |
2023-08-12 |
xenopus_laevis |
| D Platano, N Qin, F Noceti, L Birnbaumer, E Stefani, R Olces. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophysical journal. vol 78. issue 6. 2000-07-10. PMID:10827975. |
this phenomenon, commonly referred to as voltage-dependent facilitation, was not observed when alpha(2)delta was coexpressed with alpha(1c) + beta(3). |
2000-07-10 |
2023-08-12 |
xenopus_laevis |
| D Platano, N Qin, F Noceti, L Birnbaumer, E Stefani, R Olces. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophysical journal. vol 78. issue 6. 2000-07-10. PMID:10827975. |
instead, the activation curve for alpha(1c) + beta(3) + alpha(2)delta was minimally affected by the prepulse and had a voltage dependence very similar to the g-v curve of the alpha(1c) + beta(3) channel facilitated by the prepulse. |
2000-07-10 |
2023-08-12 |
xenopus_laevis |
| D Platano, N Qin, F Noceti, L Birnbaumer, E Stefani, R Olces. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophysical journal. vol 78. issue 6. 2000-07-10. PMID:10827975. |
coexpression of alpha(2)delta with alpha(1c) + beta(3) seems to mimic the prepulse effect by shifting the activation curve toward more negative potentials, leaving little room for facilitation. |
2000-07-10 |
2023-08-12 |
xenopus_laevis |
| D Platano, N Qin, F Noceti, L Birnbaumer, E Stefani, R Olces. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophysical journal. vol 78. issue 6. 2000-07-10. PMID:10827975. |
in the presence of alpha(2)delta, the charge remained unaffected after the prepulse. |
2000-07-10 |
2023-08-12 |
xenopus_laevis |
| D Platano, N Qin, F Noceti, L Birnbaumer, E Stefani, R Olces. Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophysical journal. vol 78. issue 6. 2000-07-10. PMID:10827975. |
coexpression of alpha(2)delta seems to set all the channels in a conformational state from where the open state can be easily reached, even without prepulse. |
2000-07-10 |
2023-08-12 |
xenopus_laevis |
| K Gyires, K Müllner, A Z Róna. Functional evidence that gastroprotection can be induced by activation of central alpha(2B)-adrenoceptor subtypes in the rat. European journal of pharmacology. vol 396. issue 2-3. 2000-07-06. PMID:10822066. |
the results suggest that central alpha(2b/2c)-adrenoceptor subtypes and opioid--particularly delta--receptors are likely to be involved in the gastric mucosal protective effect of clonidine. |
2000-07-06 |
2023-08-12 |
rat |