| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Theresa J Kannanayakal, Jerry R Mendell, Jeff Kure. Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. Neuroscience letters. vol 431. issue 2. 2008-05-02. PMID:18191026. |
results showed that the alpha isoform of casein kinase 1, but not the delta or epsilon isoforms, stained degenerating muscle fibers in all eight inclusion body myositis cases examined. |
2008-05-02 |
2023-08-12 |
Not clear |
| Ryosuke Yazawa, Glenn A Cooper, Peter Hunt, Marianne Beetz-Sargent, Adrienne Robb, Melanie Conrad, Linda McKinnel, Stacy So, Stuart Jantzen, Ruth B Phillips, William S Davidson, Ben F Koo. Striking antigen recognition diversity in the Atlantic salmon T-cell receptor alpha/delta locus. Developmental and comparative immunology. vol 32. issue 3. 2008-04-29. PMID:17604101. |
at least 99 valpha, 13 vdelta 86 jalpha, 1 jdelta, and 2 ddelta segments were used in tcr alpha or delta transcription, and 652 unique genes were identified from a sample of 759 tcralpha cdna clones. |
2008-04-29 |
2023-08-12 |
Not clear |
| Nieves Márquez, Marco A Calzado, Gonzalo Sánchez-Duffhues, Moisés Pérez, Alberto Minassi, Alberto Pagani, Giovanni Appendino, Laura Diaz, Maria Angeles Muñoz-Fernández, Eduardo Muño. Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation. Biochemical pharmacology. vol 75. issue 6. 2008-04-29. PMID:18241838. |
nevertheless, this compound induces a translocation pattern of the pkc isotypes alpha and delta to cellular compartments distinctly different from that elicited by prostratin and pma. |
2008-04-29 |
2023-08-12 |
human |
| Cindy V Ly, Chi-Kuang Yao, Patrik Verstreken, Tomoko Ohyama, Hugo J Belle. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. The Journal of cell biology. vol 181. issue 1. 2008-04-22. PMID:18391075. |
in a screen to identify genes involved in synaptic function, we isolated mutations in drosophila melanogaster straightjacket (stj), an alpha(2)delta subunit of the voltage-gated calcium channel. |
2008-04-22 |
2023-08-12 |
drosophila_melanogaster |
| Cindy V Ly, Chi-Kuang Yao, Patrik Verstreken, Tomoko Ohyama, Hugo J Belle. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. The Journal of cell biology. vol 181. issue 1. 2008-04-22. PMID:18391075. |
interestingly, neuronal overexpression of cac partially rescues the viability and physiological defects in stj mutants, indicating a role for the alpha(2)delta ca(2+) channel subunit in mediating the proper localization of an alpha(1) subunit at synapses. |
2008-04-22 |
2023-08-12 |
drosophila_melanogaster |
| Jan Hendrich, Alexandra Tran Van Minh, Fay Heblich, Manuela Nieto-Rostro, Katrin Watschinger, Jörg Striessnig, Jack Wratten, Anthony Davies, Annette C Dolphi. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 9. 2008-04-18. PMID:18299583. |
we formulated the hypothesis that gbp impairs the ability of alpha(2)delta subunits to enhance voltage-gated ca(2+)channel plasma membrane density by means of an effect on trafficking. |
2008-04-18 |
2023-08-12 |
Not clear |
| Jan Hendrich, Alexandra Tran Van Minh, Fay Heblich, Manuela Nieto-Rostro, Katrin Watschinger, Jörg Striessnig, Jack Wratten, Anthony Davies, Annette C Dolphi. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 9. 2008-04-18. PMID:18299583. |
our results conclusively demonstrate that gbp inhibits calcium currents, mimicking a lack of alpha(2)delta only when applied chronically, but not acutely, both in heterologous expression systems and in dorsal root-ganglion neurons. |
2008-04-18 |
2023-08-12 |
Not clear |
| Jan Hendrich, Alexandra Tran Van Minh, Fay Heblich, Manuela Nieto-Rostro, Katrin Watschinger, Jörg Striessnig, Jack Wratten, Anthony Davies, Annette C Dolphi. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 9. 2008-04-18. PMID:18299583. |
however, it is mediated by alpha(2)delta subunits, being prevented by mutations in either alpha(2)delta-1 or alpha(2)delta-2 that abolish gbp binding, and is not observed for alpha(2)delta-3, which does not bind gbp. |
2008-04-18 |
2023-08-12 |
Not clear |
| Jan Hendrich, Alexandra Tran Van Minh, Fay Heblich, Manuela Nieto-Rostro, Katrin Watschinger, Jörg Striessnig, Jack Wratten, Anthony Davies, Annette C Dolphi. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 9. 2008-04-18. PMID:18299583. |
our evidence indicates that gbp may act chronically by displacing an endogenous ligand that is normally a positive modulator of alpha(2)delta subunit function, thereby impairing the trafficking function of the alpha(2)delta subunits to which it binds. |
2008-04-18 |
2023-08-12 |
Not clear |
| T Thomaides, T Karapanayiotides, E Kerezoudi, T Avramidis, C Haeropoulos, Y Zoukos, A Spantidea. Intravenous valproate aborts glyceryl trinitrate-induced migraine attacks: a clinical and quantitative EEG study. Cephalalgia : an international journal of headache. vol 28. issue 3. 2008-04-08. PMID:18201252. |
during attacks in msp there was an increase of theta [16.6% (14.8-19.3) to 19.4% (17.4-22.1), p = 0.02] and delta activity [3.6% (3.1-4.4) to 5.4% (3.9-6.5), p = 0.009], whereas there was no decrease in alpha [41.4% (36.2-45.1) to 39.7% (34.7-44.8)] or beta activity [37.6% (34.7-40.3) to 35.1% (33.5-38.8)]. |
2008-04-08 |
2023-08-12 |
Not clear |
| Nelson P Barrera, Jill Betts, Haitao You, Robert M Henderson, Ian L Martin, Susan M J Dunn, J Michael Edwardso. Atomic force microscopy reveals the stoichiometry and subunit arrangement of the alpha4beta3delta GABA(A) receptor. Molecular pharmacology. vol 73. issue 3. 2008-04-07. PMID:18079275. |
here we addressed the subunit arrangement within the alpha(4)beta(3)delta form of the receptor. |
2008-04-07 |
2023-08-12 |
Not clear |
| M Dupuis, E Houdeau, S Mhaouty-Kodj. Increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/Gh alpha/phospholipase C delta 1 signaling pathway in term rat myometrium. Reproduction (Cambridge, England). vol 135. issue 1. 2008-04-07. PMID:18159083. |
increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/gh alpha/phospholipase c delta 1 signaling pathway in term rat myometrium. |
2008-04-07 |
2023-08-12 |
rat |
| M Dupuis, E Houdeau, S Mhaouty-Kodj. Increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/Gh alpha/phospholipase C delta 1 signaling pathway in term rat myometrium. Reproduction (Cambridge, England). vol 135. issue 1. 2008-04-07. PMID:18159083. |
in the present study, we studied the potential regulation by rat myometrial alpha1-adrenergic receptors (alpha1-ar) of the newly identified gh alpha protein/phospholipase c delta 1 (plc delta 1) signaling pathway and compared myometrial inositol phosphates (insp) production and activity of the uterine circular muscle in response to alpha1-ar activation between mid-pregnancy and term. |
2008-04-07 |
2023-08-12 |
rat |
| M Dupuis, E Houdeau, S Mhaouty-Kodj. Increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/Gh alpha/phospholipase C delta 1 signaling pathway in term rat myometrium. Reproduction (Cambridge, England). vol 135. issue 1. 2008-04-07. PMID:18159083. |
for this, we quantified the level of rat myometrial alpha1-ar coupling to gh alpha protein by photoaffinity-labeling, the cytosolic amount of plc delta 1 enzyme by immunoblotting, and the expression level of alpha1-ar subtypes by rt-pcr. |
2008-04-07 |
2023-08-12 |
rat |
| M Dupuis, E Houdeau, S Mhaouty-Kodj. Increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/Gh alpha/phospholipase C delta 1 signaling pathway in term rat myometrium. Reproduction (Cambridge, England). vol 135. issue 1. 2008-04-07. PMID:18159083. |
the results showed an increased level of alpha1-ar/gh alpha protein coupling and the amount of plc delta 1 at term (+147 and +65% respectively, versus mid-pregnancy). |
2008-04-07 |
2023-08-12 |
rat |
| M Dupuis, E Houdeau, S Mhaouty-Kodj. Increased potency of alpha 1-adrenergic receptors to induce inositol phosphates production correlates with the up-regulation of alpha 1d/Gh alpha/phospholipase C delta 1 signaling pathway in term rat myometrium. Reproduction (Cambridge, England). vol 135. issue 1. 2008-04-07. PMID:18159083. |
our results show, for the first time, that rat myometrial alpha 1d-ar/gh alpha/plc delta 1 signaling pathway is up-regulated at term. |
2008-04-07 |
2023-08-12 |
rat |
| Victoria L Haller, Marissa A Bernstein, Sandra P Welc. Chronic morphine treatment decreases the Cav1.3 subunit of the L-type calcium channel. European journal of pharmacology. vol 578. issue 2-3. 2008-04-03. PMID:18048029. |
l- and n-type vocs are heteropentamers of alpha(1), alpha(2)delta, beta, and gamma subunits. |
2008-04-03 |
2023-08-12 |
Not clear |
| B Brawek, M Löffler, D J Dooley, A Weyerbrock, T J Feuerstei. Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by gabapentin and pregabalin. Naunyn-Schmiedeberg's archives of pharmacology. vol 376. issue 5. 2008-04-03. PMID:18074120. |
these drugs appear to act by binding to the alpha(2)delta subunit of voltage-sensitive ca(2+) channels (vscc), resulting in the inhibition of neurotransmitter release. |
2008-04-03 |
2023-08-12 |
human |
| B Brawek, M Löffler, D J Dooley, A Weyerbrock, T J Feuerstei. Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by gabapentin and pregabalin. Naunyn-Schmiedeberg's archives of pharmacology. vol 376. issue 5. 2008-04-03. PMID:18074120. |
the alpha(2)delta ligands produced significant inhibitions of k(+)-evoked (3)h-ach, (3)h-na, and (3)h-5-ht release between 22% and 56% without affecting (3)h-da release. |
2008-04-03 |
2023-08-12 |
human |
| B Brawek, M Löffler, D J Dooley, A Weyerbrock, T J Feuerstei. Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by gabapentin and pregabalin. Naunyn-Schmiedeberg's archives of pharmacology. vol 376. issue 5. 2008-04-03. PMID:18074120. |
neither drug reduced (3)h-na release in the presence of l: -isoleucine, a putative alpha(2)delta antagonist. |
2008-04-03 |
2023-08-12 |
human |