| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
we previously found that the pro-apoptotic dna damaging agent, cisplatin, mediated the proteasome-dependent degradation of delta np63 alpha associated with its increased phosphorylated status. |
2008-11-03 |
2023-08-12 |
human |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
since delta np63 alpha usually plays an opposite role to p53 and tap63 in human cancers, we tested the notion that phosphorylation events induced by dna damage would affect the protein degradation of delta np63 alpha in hnscc cells upon cisplatin exposure. |
2008-11-03 |
2023-08-12 |
human |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
we found that delta np63 alpha is phosphorylated in the time-dependent fashion at the following positions: s385, t397 and s466, which were surrounded by recognition motifs for atm, cdk2 and p70s6k kinases, respectively. |
2008-11-03 |
2023-08-12 |
human |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
we showed that chemical agents or sirna inhibiting the activity of atm, cdk2 and p70s6k kinases blocked degradation of delta np63 alpha in hnscc cells after cisplatin exposure. |
2008-11-03 |
2023-08-12 |
human |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
site-specific mutagenesis of delta np63 alpha residues targeted for phosphorylation by atm, cdk2 or p70s6k led to dramatic modulation of delta np63 alpha degradation. |
2008-11-03 |
2023-08-12 |
human |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
finally, we demonstrated that the delta np63 alpha protein is a target for direct in vitro phosphorylation by atm, cdk2 or p70s6k. |
2008-11-03 |
2023-08-12 |
human |
| Yiping Huang, Tanusree Sen, Jatin Nagpal, Sunil Upadhyay, Barry Trink, Edward Ratovitski, David Sidransk. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18769144. |
our results implicate specific kinases, and target phosphorylation sites in the degradation of delta np63 alpha following dna damage. |
2008-11-03 |
2023-08-12 |
human |
| Lisa Y Pang, Ted R Hup. Protein kinases coordinately regulate the p53: Delta Np63 alpha axis after DNA damage. Cell cycle (Georgetown, Tex.). vol 7. issue 18. 2008-11-03. PMID:18797190. |
protein kinases coordinately regulate the p53: delta np63 alpha axis after dna damage. |
2008-11-03 |
2023-08-12 |
Not clear |
| Takashi Akiyama, Takeshi Okino, Hiroshi Konishi, Yoji Wani, Kenji Notohara, Choutatsu Tsukayama, Tsukasa Tsunoda, Taizo Tasaka, Yuji Masaki, Takashi Sugihara, Yoshito Sadahir. CD8+, CD56+ (natural killer-like) T-cell lymphoma involving the small intestine with no evidence of enteropathy: clinicopathology and molecular study of five Japanese patients. Pathology international. vol 58. issue 10. 2008-10-30. PMID:18801082. |
immunohistochemistry and genetics suggested that three cases were of alpha beta t-cell origin and two cases were of gamma delta t-cell origin. |
2008-10-30 |
2023-08-12 |
Not clear |
| Gerald J Obermair, Petronel Tuluc, Bernhard E Fluche. Auxiliary Ca(2+) channel subunits: lessons learned from muscle. Current opinion in pharmacology. vol 8. issue 3. 2008-10-28. PMID:18329337. |
a multitude of studies in heterologous cells demonstrated that coexpression of the pore-forming alpha(1) subunits with auxiliary alpha(2)delta and beta subunits promotes membrane expression and modulates the biophysical channel properties. |
2008-10-28 |
2023-08-12 |
Not clear |
| Gerald J Obermair, Petronel Tuluc, Bernhard E Fluche. Auxiliary Ca(2+) channel subunits: lessons learned from muscle. Current opinion in pharmacology. vol 8. issue 3. 2008-10-28. PMID:18329337. |
whether these specific functions in muscle indicate similar roles of alpha(2)delta and beta subunits as functional modulator and structural organizer, respectively, in neurons is being discussed. |
2008-10-28 |
2023-08-12 |
Not clear |
| G S Coyne, D A Kenny, S Childs, J M Sreenan, S M Water. Dietary n-3 polyunsaturated fatty acids alter the expression of genes involved in prostaglandin biosynthesis in the bovine uterus. Theriogenology. vol 70. issue 5. 2008-10-28. PMID:18582926. |
expression of mrna for prostaglandin e synthase (pges) and peroxisome proliferator-activated receptors, ppar alpha and delta was increased (p<0.05) while mrna expression of phospholipase a(2) (pla(2)) was decreased (p=0.06) in the high pufa endometrial tissues. |
2008-10-28 |
2023-08-12 |
cattle |
| Tatsuo Yamamot. [Mechanisms of the development of neuropathic pain and its treatment]. Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association. vol 77. issue 3. 2008-10-28. PMID:18800643. |
alpha 2 delta subunit blockers, such as gabapentin and pregabalin, may reduce the release of neurotransmitter and elicit analgesic effect in the treatment of neuropathic pain. |
2008-10-28 |
2023-08-12 |
Not clear |
| Takeshi Tomita, Taketomo Kido, Reiko Kurotani, Shun-Ichiro Iemura, Esta Sterneck, Tohru Natsume, Charles Vinson, Shioko Kimur. CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression. The Journal of biological chemistry. vol 283. issue 37. 2008-10-23. PMID:18632661. |
caatt/enhancer-binding proteins alpha and delta interact with nkx2-1 to synergistically activate mouse secretoglobin 3a2 gene expression. |
2008-10-23 |
2023-08-12 |
mouse |
| Flavio F Contreras-Torres, Vladimir A Basiuk, Elena V Basiu. Regioselectivity in azahydro[60]fullerene derivatives: application of general-purpose reactivity indicators. The journal of physical chemistry. A. vol 112. issue 35. 2008-10-21. PMID:18690673. |
the study objective was to predict the regioselectivity in the reaction of hydrogen addition onto azahydro[60]fullerene c 59h n+1 n ( n = 0-4) systems using a new reactivity indicator termed general-purpose reactivity indicator, xi delta nalpha (kappa), proposed by anderson et al. |
2008-10-21 |
2023-08-12 |
Not clear |
| Flavio F Contreras-Torres, Vladimir A Basiuk, Elena V Basiu. Regioselectivity in azahydro[60]fullerene derivatives: application of general-purpose reactivity indicators. The journal of physical chemistry. A. vol 112. issue 35. 2008-10-21. PMID:18690673. |
because xi delta nalpha (kappa) combines the information from the electrostatic potential and the fukui function, this indicator is a two-parameter model that depends on the atomic charges and fukui values calculated. |
2008-10-21 |
2023-08-12 |
Not clear |
| Flavio F Contreras-Torres, Vladimir A Basiuk, Elena V Basiu. Regioselectivity in azahydro[60]fullerene derivatives: application of general-purpose reactivity indicators. The journal of physical chemistry. A. vol 112. issue 35. 2008-10-21. PMID:18690673. |
comparisons with traditional indicators show that the application of xi delta nalpha (kappa) performs much better for predicting reactivity in the aza[60]fullerene derivatives studied. |
2008-10-21 |
2023-08-12 |
Not clear |
| Yael M Cycowicz, Bruce Luber, Timothy Spellman, Sarah H Lisanb. Differential neurophysiological effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS) in non-human primates. Clinical EEG and neuroscience. vol 39. issue 3. 2008-10-21. PMID:18751564. |
eeg power within four frequencies (delta, theta, alpha and beta) was calculated. |
2008-10-21 |
2023-08-12 |
monkey |
| Yoko Araya, Jun-Ichi Kasuga, Kenji Toyota, Yuko Hirakawa, Takuji Oyama, Makoto Makishima, Kosuke Morikawa, Yuichi Hashimoto, Hiroyuki Miyach. Structure-based design and synthesis of fluorescent PPARalpha/delta co-agonist and its application as a probe for fluorescent polarization assay of PPARdelta ligands. Chemical & pharmaceutical bulletin. vol 56. issue 9. 2008-10-21. PMID:18758120. |
based on the result of x-ray crystallographic analysis of our peroxisome proliferator-activated receptor alpha and delta (pparalpha/delta) co-agonist complexed with human ppar ligand binding domain (lbd), we designed and synthesized an optically active fluorescent pparalpha/delta co-agonist, which has a pyrene unit incorporated directly at the hydrophobic tail part of the structure as a fluorophore. |
2008-10-21 |
2023-08-12 |
human |
| Jennifer A Hunt, Stephen R Petteway, Philip Scuderi, Valery Novokhatn. Simplified recombinant plasmin: production and functional comparison of a novel thrombolytic molecule with plasma-derived plasmin. Thrombosis and haemostasis. vol 100. issue 3. 2008-10-17. PMID:18766256. |
additionally, delta[k2-k5]pm was rapidly inhibited by alpha(2)-antiplasmin (1.1+/-0.1 x 10(7) m(-1) s(-1)) and alpha(2)-macroglobulin (7.6+/-0.6 x 10(5) m(-1) s(-1)). |
2008-10-17 |
2023-08-12 |
human |