All Relations between ddr and chek1
| Christina Pfeiffer, Alexander M Grandits, H\\xc3\\xa9l\\xc3\\xa8ne Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670.
||combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis.
| Ewud Agborbesong, Julie X Zhou, Linda X Li, Peter C Harris, James P Calvet, Xiaogang L. Prdx5 regulates DNA damage response through autophagy-dependent Sirt2-p53 axis. Human molecular genetics. 2022-09-06. PMID:36067023.
||we show that prdx5 regulates ddr through: 1) polo-like kinase 1 (plk1) mediated phosphorylation of ataxia telangiectasia mutated (atm) kinase to further trigger downstream mediators chek1 and chek2; 2) the increase of the acetylation of p53 at lysine 382, stabilizing p53 in the nucleus and enhancing transcription; 3) the induction of autophagy, which regulates the recycling of molecules involved in ddr.