| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giulio Sartori, Chiara Tarantelli, Filippo Spriano, Eugenio Gaudio, Luciano Cascione, Michele Mascia, Marilia Barreca, Alberto J Arribas, Luca Licenziato, Gaetanina Golino, Adele Ferragamo, Stefano Pileri, Giovanna Damia, Emanuele Zucca, Anastasios Stathis, Oliver Politz, Antje M Wengner, Francesco Berton. The ATR inhibitor elimusertib exhibits anti-lymphoma activity and synergizes with the PI3K inhibitor copanlisib. British journal of haematology. 2023-11-27. PMID:38011941. |
the ataxia telangiectasia and rad3-related (atr) kinase is a crucial factor of ddr in the response to dna single-strand breaks. |
2023-11-27 |
2023-11-29 |
Not clear |
| Christina Pfeiffer, Alexander M Grandits, H\\xc3\\xa9l\\xc3\\xa8ne Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis. |
2023-10-29 |
2023-11-08 |
Not clear |
| Kang Ning, Xiujuan Zhang, Zehua Feng, Siyuan Hao, Cagla Aksu Kuz, Fang Cheng, Soo Yuen Park, Shane McFarlin, John F Engelhardt, Ziying Yan, Jianming Qi. Inhibition of DNA-dependent protein kinase catalytic subunit boosts rAAV transduction of polarized human airway epithelium. Molecular therapy. Methods & clinical development. vol 31. 2023-10-16. PMID:37841417. |
this study found that recombinant aav2.5t (raav2.5t) transduction of well-differentiated primary human airway epithelia induced a dna damage response (ddr) characterized by the phosphorylation of replication protein a32 (rpa32), histone variant h2ax (h2a histone family member x), and all three phosphatidylinositol 3-kinase-related kinases: ataxia telangiectasia mutated kinase, ataxia telangiectasia and rad3-related kinase (atr), and dna-dependent protein kinase catalytic subunit (dna-pk |
2023-10-16 |
2023-11-08 |
human |
| Valerie M Tesmer, Kirsten A Brenner, Jayakrishnan Nandakuma. Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome. Science (New York, N.Y.). vol 381. issue 6659. 2023-08-17. PMID:37590346. |
protection of telomeres 1 (pot1) is the 3' single-stranded overhang-binding telomeric protein that prevents an ataxia telangiectasia and rad3-related (atr) dna damage response (ddr) at chromosome ends. |
2023-08-17 |
2023-09-07 |
mouse |
| Himadri Biswas, Yetunde Makinwa, Yue Zo. Novel Cellular Functions of ATR for Therapeutic Targeting: Embryogenesis to Tumorigenesis. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511442. |
atr (ataxia telangiectasia mutated and rad3-related) kinase, a major regulator of ddr, has shown significant therapeutic potential in cancer treatment. |
2023-07-29 |
2023-08-14 |
Not clear |
| Yujin Kang, Ye Gi Han, Keon Woo Khim, Woo Gyun Choi, Min Kyung Ju, Kibeom Park, Kyeong Jin Shin, Young Chan Chae, Jang Hyun Choi, Hongtae Kim, Ja Yil Le. Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase. Nucleic acids research. 2023-06-28. PMID:37378431. |
rpa accumulation on ssdna due to replication stress triggers the dna damage response (ddr) by activating the ataxia telangiectasia and rad3-related (atr) kinase, which phosphorylates itself and downstream ddr factors, including rpa. |
2023-06-28 |
2023-08-14 |
Not clear |
| Jialu Shao, Lei Huang, Wenwen Lai, Yi Zou, Qihua Zh. Design, Synthesis, and Biological Evaluation of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase for the Efficient Treatment of Cancer. Molecules (Basel, Switzerland). vol 28. issue 11. 2023-06-11. PMID:37298997. |
ataxia telangiectasia mutated and rad3-related (atr), a vital member of the phosphatidylinositol 3-kinase-related kinase (pikk) family, plays a critical role in the dna damage response (ddr). |
2023-06-11 |
2023-08-14 |
Not clear |
| Jialu Shao, Lei Huang, Wenwen Lai, Yi Zou, Qihua Zh. Design, Synthesis, and Biological Evaluation of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase for the Efficient Treatment of Cancer. Molecules (Basel, Switzerland). vol 28. issue 11. 2023-06-11. PMID:37298997. |
tumor cells with a loss of ddr function or defects in the ataxia telangiectasia mutated (atm) gene are generally more dependent on atr for survival, suggesting that atr is an attractive anticancer drug target based on its synthetic lethality. |
2023-06-11 |
2023-08-14 |
Not clear |
| Yunxin Duan, Haodong Cheng, Lili Zhuang, Jiawei Xia, Yerong Xu, Ruyue Zhang, Rui Sun, Tao Lu, Yadong Che. Discovery of Thieno[3,2-d]pyrimidine derivatives as potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) kinase. European journal of medicinal chemistry. vol 255. 2023-05-02. PMID:37130473. |
the ataxia telangiectasia mutated and rad3-related (atr) kinase regulates the dna damage response (ddr), which plays a critical role in the atr-chk1 signaling pathway. |
2023-05-02 |
2023-08-14 |
Not clear |
| Rui Zhao, Ke Cai, Jing-Jing Yang, Qian Zhou, Wei Cao, Jie Xiang, Yi-Hui Shen, Lei-Lei Cheng, Wei-Dong Zang, Yan Lin, Yi-Yuan Yuan, Wei Xu, Hui Tao, Shi-Min Zhao, Jian-Yuan Zha. Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response. Cell reports. vol 42. issue 4. 2023-04-18. PMID:37071536. |
mechanistically, tyrosyl-trna synthetase (yars) binds to ataxia telangiectasia and rad3-related gene (atr), catalyzes lysine tyrosylation (k-tyr) of atr, and activates the dna damage response (ddr) in the nucleus. |
2023-04-18 |
2023-08-14 |
mouse |
| Katharigatta N Venugopal. Targeting the DNA Damage Response Machinery for Lung Cancer Treatment. Pharmaceuticals (Basel, Switzerland). vol 15. issue 12. 2022-12-23. PMID:36558926. |
this review article sheds light on the different dna repair pathways and some of the inhibitors targeting the proteins involved in the dna damage response (ddr) machinery, such as ataxia telangiectasia and rad3-related protein (atr), dna-dependent protein kinase (dna-pk), and poly-adp-ribose polymerase (parp). |
2022-12-23 |
2023-08-14 |
human |
| Wenjing Liu, Min Zheng, Rou Zhang, Qiuyun Jiang, Guangshi Du, Yingying Wu, Chuanyu Yang, Fubing Li, Wei Li, Luzhen Wang, Jiao Wu, Lei Shi, Wenhui Li, Kai Zhang, Zhongmei Zhou, Rong Liu, Yingzheng Gao, Xinwei Huang, Songqing Fan, Xu Zhi, Dewei Jiang, Ceshi Che. RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022-12-23. PMID:36563124. |
mechanistically, rnf126 physically associates with the mre11-rad50-nbs1 (mrn) complex and ubiquitinates mre11 at k339 and k480 to increase its dna exonuclease activity, subsequent rpa binding, and atr phosphorylation, promoting sustained ddr in a homologous recombination repair-prone manner. |
2022-12-23 |
2023-08-14 |
mouse |
| Hao Xiong, Fuzhou Hua, Yao Dong, Yue Lin, Jun Ying, Jie Liu, Xifeng Wang, Lieliang Zhang, Jing Zhan. DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology. Frontiers in aging neuroscience. vol 14. 2022-09-30. PMID:36177479. |
dna damage response (ddr) can activate ataxia telangiectasia-mutated serine/threonine kinase (atm) and rad3-related serine/threonine kinase (atr), after which p53 activates p21, stopping the cell cycle and inducing cell senescence. |
2022-09-30 |
2023-08-14 |
Not clear |
| Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuan. Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury. Cell death & disease. vol 13. issue 9. 2022-09-06. PMID:36068197. |
further studies showed that mm102 effectively inhibited cisplatin-triggered dna damage response (ddr), as indicated by dephosphorylation of ataxia telangiectasia mutated (atm) and atm and rad-3 related (atr) proteins, dephosphorylation of checkpoint kinase 1 and 2 (chk1 and chk2); depression of \xce\xb3-h2ax; and restrained cell cycle arrest, as evidenced by decreased expression of p21 and phospho-histone h3 at serine 10 in vitro and in vivo. |
2022-09-06 |
2023-08-14 |
mouse |
| Chloe Gulliver, Ralf Hoffmann, George S Bailli. Ataxia-telangiectasia mutated & ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer. The international journal of biochemistry & cell biology. 2022-05-24. PMID:35609768. |
an alternative approach is selectively targeting atm and ataxia telangiectasia and rad3-related (atr) which, due to their position at the forefront of the ddr, represent attractive pharmacological targets. |
2022-05-24 |
2023-08-13 |
Not clear |
| Yu Ma, Siwen Li, Shuzi Ye, Die Hu, Lai Wei, Fang Xia. Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF-\\xce\\xbaB signaling pathway mediated by the DNA damage response. Ecotoxicology and environmental safety. vol 239. 2022-05-19. PMID:35588622. |
continuous cr(vi) stimulation led to dna damaged in hepatocytes, and dna damage response (ddr) signals were transmitted by ataxia telangiectasia-mutated gene (atm)/ataxia telangiectasia and rad-3-related protein (atr), resulting in zinc finger transcription factor gata4 escaping p62-mediated selective autophagy, thereby regulating nuclear factor kappa-b (nf-\xce\xbab) to induce premature senescence in hepatocytes. |
2022-05-19 |
2023-08-13 |
Not clear |
| Fangfang Wang, Sora Jin, Franklin Mayca Pozo, Danmei Tian, Xiyang Tang, Yi Dai, Xinsheng Yao, Jinshan Tang, Youwei Zhan. Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR. Acta pharmaceutica Sinica. B. vol 12. issue 3. 2022-05-09. PMID:35530159. |
mechanistically, shikonin inhibited the activation of ataxia telangiectasia mutated (atm), and to a lesser degree atm and rad3-related (atr), two master upstream regulators of the ddr signal, through inducing degradation of atm and atr-interacting protein (atrip), an obligate associating protein of atr, respectively. |
2022-05-09 |
2023-08-13 |
mouse |
| Li-Wei Wang, Songwei Jiang, Ying-Hui Yuan, Jilong Duan, Nian-Dong Mao, Zi Hui, Renren Bai, Tian Xie, Xiang-Yang Y. Recent Advances in Synergistic Antitumor Effects Exploited from the Inhibition of Ataxia Telangiectasia and RAD3-Related Protein Kinase (ATR). Molecules (Basel, Switzerland). vol 27. issue 8. 2022-04-23. PMID:35458687. |
as one of the key phosphatidylinositol 3-kinase-related kinases (pikks) family members, ataxia telangiectasia and rad3-related protein kinase (atr) is crucial in maintaining mammalian cell genomic integrity in dna damage response (ddr) and repair pathways. |
2022-04-23 |
2023-08-13 |
Not clear |
| Ying Su, Ting Wu, Xiao-Yan Yu, Wen-Bo Huo, Shao-Hua Wang, Chen Huan, Yu-Meng Liu, Jin-Ming Liu, Min-Na Cui, Xin-Hua Li, Jing-Hua Y. Inhibitory effect of tanshinone IIA, resveratrol and silibinin on enterovirus 68 production through inhibiting ATM and DNA-PK pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 99. 2022-03-19. PMID:35305353. |
three ddr pathways includes ataxia telangiectasia mutated (atm), atm and rad3-related (atr), and dna-dependent protein kinase (dna-pk). |
2022-03-19 |
2023-08-13 |
human |
| Pei Chen, Huachao Bin, Yan Jiao, Guifeng Lin, Yun Zhang, Anjie Xia, Zhilin Pan, Jingxin Qiao, Yinping Guo, Jingming Liu, Yangli Zhou, Linli L. Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors. Bioorganic & medicinal chemistry letters. 2022-03-04. PMID:35245663. |
ataxia telangiectasia and rad3-related (atr) kinase is a key regulating protein within the dna damage response (ddr), responsible for sensing replication stress (rs), and has been considered as a potential target for cancer therapy. |
2022-03-04 |
2023-08-13 |
Not clear |