| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fuping Sun, Zhening Liu, Jun Yang, Zebin Fan, Feiwen Wang, Jie Yan. Aberrant brain dynamics in major depressive disorder during working memory task. European archives of psychiatry and clinical neuroscience. 2024-07-08. PMID:38976050. |
compared with controls, under '2back vs. 0back' contrast, patients showed an elevated ddc variability in wide range of brain regions, including the middle frontal gyrus, orbital part of inferior frontal gyrus (ifgorb), hippocampus, and middle temporal gyrus. |
2024-07-08 |
2024-07-11 |
Not clear |
| Fuping Sun, Zhening Liu, Jun Yang, Zebin Fan, Feiwen Wang, Jie Yan. Aberrant brain dynamics in major depressive disorder during working memory task. European archives of psychiatry and clinical neuroscience. 2024-07-08. PMID:38976050. |
furthermore, the increased ddc variability in the hippocampus and ifgorb correlated with worse wm performance. |
2024-07-08 |
2024-07-11 |
Not clear |
| Qi Wang, Ya-Nan Sun, Chun-Ming Zou, Te-Li Zhang, Zhu Li, Min Liu, Bi-Ying Shi, Shan-Shan Shi, Chun-Yue Yu, Tai-Ming We. Regulation of the kynurenine/serotonin pathway by berberine and the underlying effect in the hippocampus of the chronic unpredictable mild stress mice. Behavioural brain research. 2022-01-20. PMID:35051489. |
this study was to investigate the hypothesis that bbr treats depressive-like behavior by shifting the balance of the kynurenine (kyn)/serotonin (5-ht) pathway toward the 5-ht pathway through downregulated indoleamine 2,3-dioxygenase 1 (ido1), monoamine oxidase a (maoa) and upregulated dopamine decarboxylase (ddc) in hippocampus. |
2022-01-20 |
2023-08-13 |
mouse |
| I L Kovalenko, D A Smagin, A G Galyamina, Yu L Orlov, N N Kudryavtsev. [Changes in the Expression of Dopaminergic Genes in Brain Structures of Male Mice Exposed to Chronic Social Defeat Stress: An RNA-seq Study]. Molekuliarnaia biologiia. vol 50. issue 1. 2019-04-11. PMID:27028825. |
the expression of th, ddc, and slc6a3 (dat1) was upregulated, while that of ppp1r1b and sncg was downregulated in the ventral tegmental area; the expression of th, ddc, drd2, and sncg was downregulated in the raphe nuclei of midbrain; the expression of th, aldh2, and ppp1r1b was upregulated, while that of Маоа was downregulated in the hypothalamus; drd1 and snca expression was downregulated and that of sncb was upregulated in the striatum, and sncb expression was upregulated in the hippocampus. |
2019-04-11 |
2023-08-13 |
mouse |
| Hong-Mei Jia, Yu-Fei Feng, Yue-Tao Liu, Xing Chang, Lin Chen, Hong-Wu Zhang, Gang Ding, Zhong-Mei Zo. Integration of ¹H NMR and UPLC-Q-TOF/MS for a comprehensive urinary metabonomics study on a rat model of depression induced by chronic unpredictable mild stress. PloS one. vol 8. issue 5. 2014-02-18. PMID:23696839. |
moreover, the results of western blot analysis of aromatic l-amino acid decarboxylase (ddc) and indoleamine 2, 3-dioxygenase (ido) in the hippocampus of cums-treated rats indicated that depletion of 5-ht and tryptophan, production of 5-mt and altered expression of ddc and ido together played a key role in the initiation and progression of depression. |
2014-02-18 |
2023-08-12 |
rat |
| S Y Cheng, L D Trombett. The induction of amyloid precursor protein and alpha-synuclein in rat hippocampal astrocytes by diethyldithiocarbamate and copper with or without glutathione. Toxicology letters. vol 146. issue 2. 2004-01-06. PMID:14643966. |
in this study, rat hippocampal astrocytes were treated with ddc (75 microm), cucl(2) (0.2 microm), or ddc (75 microm) plus cucl(2) (0.2 microm) for 1h. |
2004-01-06 |
2023-08-12 |
rat |
| Grégory Stupien, Cédrick Florian, Pascal Roulle. Involvement of the hippocampal CA3-region in acquisition and in memory consolidation of spatial but not in object information in mice. Neurobiology of learning and memory. vol 80. issue 1. 2003-08-21. PMID:12737932. |
for that purpose, we performed focal injections of diethyldithiocarbamate (ddc) into the ca3-region of the dorsal hippocampus. |
2003-08-21 |
2023-08-12 |
mouse |
| D Hardej, L D Trombett. The effects of ebselen on cisplatin and diethyldithiocarbamate (DDC) cytotoxicity in rat hippocampal astrocytes. Toxicology letters. vol 131. issue 3. 2002-07-10. PMID:11992741. |
the effects of ebselen on cisplatin and diethyldithiocarbamate (ddc) cytotoxicity in rat hippocampal astrocytes. |
2002-07-10 |
2023-08-12 |
rat |
| M F McManus, L D Trombett. The effects of diethyldithiocarbamate (DDC) on the astrocytic cytoskeleton. Scanning microscopy. vol 9. issue 1. 1996-02-20. PMID:8553021. |
cultured rat hippocampal astroglia treated with 35 micrograms/ml diethyldithiocarbamate (ddc) in media were studied for alterations to the cytoskeleton. |
1996-02-20 |
2023-08-12 |
rat |
| P Cumming, H Kuwabara, A Ase, A Gjedd. Regulation of DOPA decarboxylase activity in brain of living rat. Journal of neurochemistry. vol 65. issue 3. 1995-09-18. PMID:7643116. |
the relative ddc activity (k3d) was 0.26 min-1 in striatum, 0.04 min-1 in hypothalamus, and 0.02 min-1 in hippocampus. |
1995-09-18 |
2023-08-12 |
rat |
| D B Miller, J F Reinhard, A J Daniels, J P O'Callagha. Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium. Journal of neurochemistry. vol 57. issue 2. 1991-08-21. PMID:1649252. |
in hippocampus, the levels of norepinephrine and gfap were not different from controls in mice receiving only mptp, but pretreatment with ddc resulted in a sustained depletion of norepinephrine and an elevation of gfap, suggesting that damage was extended to this brain area by the combined treatment. |
1991-08-21 |
2023-08-11 |
mouse |
| J W Haycock, R van Buskirk, P E Gold, J L McGaug. Effects of diethyldithiocarbamate and fusaric acid upon memory storage processes in rats. European journal of pharmacology. vol 51. issue 3. 1979-01-26. PMID:213292. |
amnestic doses of ddc influence brain and adrenal catecholamine levels, brain electrographic activity and hippocampal timm's staining. |
1979-01-26 |
2023-08-11 |
rat |