| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Kaplinsky, Reut Halperin, Gadi Shlomai, Amit Tiros. Role of epigenetic regulation on catecholamine synthesis in pheochromocytoma and paraganglioma. Cancer. 2024-06-14. PMID:38872410. |
catecholamines are synthesized by several enzymes: phenylalanine hydroxylase (encoded by pah), tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (ddc), dopamine β-hydroxylase (dbh), and phenylethanolamine n-methyltransferase (pnmt). |
2024-06-14 |
2024-06-16 |
Not clear |
| Yoshiaki Soejima, Nahoko Iwata, Koichiro Yamamoto, Atsuhito Suyama, Yasuhiro Nakano, Fumio Otsuk. Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338864. |
orexin a treatment reduced the mrna levels of key enzymes for catecholamine synthesis, including tyrosine hydroxylase (th), 3,4-dihydroxyphenylalanie decarboxylase (ddc) and dopamine β-hydroxylase (dbh), in a concentration-dependent manner. |
2024-02-10 |
2024-02-12 |
rat |
| Yunxiao Li, Yongsheng Zhu, Jianghua Lai, Xugang Shi, Yuanyuan Chen, Jinyu Zhang, Shuguang We. Association studies of dopamine synthesis and metabolism genes with multiple phenotypes of heroin dependence. BMC medical genetics. vol 21. issue 1. 2020-10-28. PMID:32736537. |
this study aimed to identify the association between genetic polymorphisms of da synthesis and metabolism genes, including tyrosine hydroxylase (th), dopa decarboxylase (ddc), solute carrier family 6 member 3 (slc6a3) and da beta-hydroxylase (dbh), with six important phenotypes of heroin dependence. |
2020-10-28 |
2023-08-13 |
Not clear |
| Anna Vavřínová, Michal Behuliak, Michal Bencze, Ivana Vaněčková, Josef Zich. Which sympathoadrenal abnormalities of adult spontaneously hypertensive rats can be traced to a prehypertensive stage? Hypertension research : official journal of the Japanese Society of Hypertension. vol 42. issue 7. 2020-09-08. PMID:30651588. |
in the adrenal glands of adult shr, the expression of catecholamine biosynthetic enzymes th, ddc, dbh and pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001). |
2020-09-08 |
2023-08-13 |
rat |
| Anna Vavřínová, Michal Behuliak, Michal Bencze, Ivana Vaněčková, Josef Zich. Which sympathoadrenal abnormalities of adult spontaneously hypertensive rats can be traced to a prehypertensive stage? Hypertension research : official journal of the Japanese Society of Hypertension. vol 42. issue 7. 2020-09-08. PMID:30651588. |
in the adrenal glands of prehypertensive shr, the expression of catecholamine biosynthetic enzymes ddc, dbh and pnmt was lower than in aged-matched wistar-kyoto rats. |
2020-09-08 |
2023-08-13 |
rat |
| Venkataramaiah Chintha, Rajendra Wudayagir. Bioavailability and Neuroprotectivity of 3-(3, 4-dimethoxy phenyl)-1-4 (methoxy phenyl) prop-2-en-1-one against Schizophrenia: an Journal of receptor and signal transduction research. vol 39. issue 5-6. 2020-06-17. PMID:31829066. |
mutated amino acid sequences in genes of dopa such as th, ddc, dbh, vmat2, and nmda (set-1) have been implicated as major factors causing schizophrenia. |
2020-06-17 |
2023-08-13 |
Not clear |
| A G Galyamina, I L Kovalenko, D A Smagin, N N Kudryavtsev. [Altered Expression of Neurotransmitters Systems' Genes in the Ventral Tegmental Area of Depressive Male Mice: Data of RNA-Seq]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 67. issue 1. 2019-02-19. PMID:30695556. |
besides, upregulation of dopaminergic th, ddc, slc6a3, sic18a2, drd2, and maob genes was found while noradrenergic dbh, slc6a2, adra2c, and adra2a genes were downregulated. |
2019-02-19 |
2023-08-13 |
mouse |
| Esfandiar Azadmarzabadi, Arvin Haghighatfard, Alireza Mohammad. Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 18. issue 3. 2018-08-01. PMID:29423959. |
here, we aimed to describe the association between comprehensive psychological characteristics and messenger rna levels of dopamine receptor d1 (drd1), dopamine receptor d2 (drd2), dopamine receptor d3 (drd3), dopamine receptor d4 (drd4), dopamine receptor d5 (drd5), comt, dopamine beta-hydroxylase (dbh), tyrosine hydroxylase (th), monoamine oxidase a (maom), dopa decarboxylase (ddc), dopamine transporter (dat), serotonin transporter (5-htt), brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf) genes based on peripheral blood samples from 400 subjects who react differently to major life event stressors. |
2018-08-01 |
2023-08-13 |
human |
| C Bonvicini, S V Faraone, C Scassellat. Attention-deficit hyperactivity disorder in adults: A systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies. Molecular psychiatry. vol 21. issue 7. 2017-09-25. PMID:27217152. |
genes linked to dopaminergic, serotoninergic and noradrenergic signaling, metabolism (dbh, tph1, tph2, ddc, maoa, maob, bche and th), neurodevelopment (bdnf and others), the snare system and other forty genes/proteins related to different pathways were not meta-analyzed due to insufficient data. |
2017-09-25 |
2023-08-13 |
Not clear |
| Hortensia Alonso-Navarro, Felix Javier Jimenez-Jimenez, Elena Garcia-Martin, Jose A G Agunde. Genomic and pharmacogenomic biomarkers of Parkinson's disease. Current drug metabolism. vol 15. issue 2. 2014-11-24. PMID:24694231. |
nor did polymorphisms in genes related to dopamine or serotonin drd, dat, th, ddc, dbh, mao, comt, slc6a4, mtr, mthfr, oxidative stress noq1, noq2, mephx, hfe, gpx, cat, mnsod, hfe, ho-1, ho-2, nfe2l2, keap1, inflammatory processes, ils, tnf, act, nos, hnmt, abp1, hrhs, trophic and growth factors bdnf, fgf, or mitochondrial metabolism and function. |
2014-11-24 |
2023-08-13 |
cat |
| Hong-Bin Zhao, Hui Ma, Xiao-Qin Ha, Ping Zheng, Xiao-Yun Li, Ming Zhang, Ju-Zi Dong, Yin-Shu Yan. Salidroside induces rat mesenchymal stem cells to differentiate into dopaminergic neurons. Cell biology international. vol 38. issue 4. 2014-10-30. PMID:24323403. |
the expression of dopamine neurons markers, such as dopamine-beta-hydroxy (dbh), dopa decarboxylase (ddc) and tyrosine hydroxylase (th), was significantly upregulated after treatment with salidroside for 1-12 days. |
2014-10-30 |
2023-08-12 |
rat |
| Tri Budi Hartomo, Aiko Kozaki, Daiichiro Hasegawa, Thi Van Huyen Pham, Nobuyuki Yamamoto, Atsuro Saitoh, Toshiaki Ishida, Keiichiro Kawasaki, Yoshiyuki Kosaka, Hiroki Ohashi, Tomoto Yamamoto, Satoru Morikawa, Satoshi Hirase, Ikuko Kubokawa, Takeshi Mori, Tomoko Yanai, Akira Hayakawa, Yasuhiro Takeshima, Kazumoto Iijima, Masafumi Matsuo, Hisahide Nishio, Noriyuki Nishimur. Minimal residual disease monitoring in neuroblastoma patients based on the expression of a set of real-time RT-PCR markers in tumor-initiating cells. Oncology reports. vol 29. issue 4. 2013-09-12. PMID:23417100. |
in the present study, we validated the ability of 14 commonly used real-time rt-pcr markers to detect mrd based on their expression in neuroblastoma tics, and we developed a novel mrd detection protocol, which scored the samples as mrd-positive when the expression of one of the 11 real-time rt-pcr markers (chrna3, crmp1, dbh, dcx, ddc, gabrb3, gap43, isl1, kif1a, phox2b and th) exceeded the normal range. |
2013-09-12 |
2023-08-12 |
Not clear |
| Daniel P Czech, Joohyung Lee, Helena Sim, Clare L Parish, Eric Vilain, Vincent R Harle. The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22568433. |
conversely, sry over-expression increased th, ddc, dbh, d2 r and mao-a levels, accompanied by increased extracellular dopamine levels. |
2013-08-14 |
2023-08-12 |
human |
| Daniel P Czech, Joohyung Lee, Helena Sim, Clare L Parish, Eric Vilain, Vincent R Harle. The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22568433. |
in the human neuroblastoma cell line, m17, sry knockdown resulted in a reduction in th, ddc, dbh and mao-a expression; enzymes which control dopamine synthesis and metabolism. |
2013-08-14 |
2023-08-12 |
human |
| Zhi Zhou, Lingling Wang, Xiaowei Shi, Feng Yue, Mengqiang Wang, Huan Zhang, Linsheng Son. The expression of dopa decarboxylase and dopamine beta hydroxylase and their responding to bacterial challenge during the ontogenesis of scallop Chlamys farreri. Fish & shellfish immunology. vol 33. issue 1. 2012-10-05. PMID:22521420. |
dopa decarboxylase (ddc) and dopamine beta hydroxylase (dbh) is responsible for the synthesis of dopamine and norepinephrine, respectively. |
2012-10-05 |
2023-08-12 |
Not clear |
| Michail Pavlidis, Maria Sundvik, Yu-Chia Chen, Pertti Panul. Adaptive changes in zebrafish brain in dominant-subordinate behavioral context. Behavioural brain research. vol 225. issue 2. 2012-01-24. PMID:21875623. |
expression of genes encoding proteins involved in the functioning of the hypothalamus-hypophysis-interrenal axis (corticotropin releasing factor, crf; glucocorticoid receptor, gr; mineralocorticoid receptor, mr); arginine vasotocin, avt), in the biosynthesis and catabolism of catecholamines (tyrosine hydroxylase, th1 and th2; dopa decarboxylase, ddc), dopamine β-hydroxylase, dbh; catechol-o-methyl transferase, comt), in the biosynthesis of histamine (histidine decarboxylase, hdc) and in the general stress response (galanin, gal; hypocretin/orexin, hcrt) was examined. |
2012-01-24 |
2023-08-12 |
zebrafish |
| Tobias Banaschewski, Katja Becker, Susann Scherag, Barbara Franke, David Coghil. Molecular genetics of attention-deficit/hyperactivity disorder: an overview. European child & adolescent psychiatry. vol 19. issue 3. 2010-06-14. PMID:20145962. |
in recent years a large number of studies on different candidate genes for adhd have been published, most have focused on genes involved in the dopaminergic neurotransmission system, such as drd4, drd5, dat1/slc6a3, dbh, ddc. |
2010-06-14 |
2023-08-12 |
Not clear |
| W J Chang, C R Barb, R R Kraeling, G B Rampacek, J T Wrigh. Biogenic amines in the hypothalamus of rats after diethyldithiocarbamate or AIMAX treatment, an alternative for norepinephrine depletion. Journal of animal science. vol 73. issue 4. 1995-09-07. PMID:7628959. |
therefore, the effect of aimax (n = 6) on concentrations of biogenic amines in the medial basal hypothalamus (mbh) and anterior hypothalamic area (aha) of ovariectomized (ovx) rats primed with ovarian steroids was compared to that of diethyldithiocarbamate (ddc; n = 5), a potent dopamine-beta-hydroxylase (dbh) inhibitor, which is chemically similar to aimax. |
1995-09-07 |
2023-08-12 |
rat |
| T Nagats. Genes for human catecholamine-synthesizing enzymes. Neuroscience research. vol 12. issue 2. 1992-02-06. PMID:1684650. |
four enzymes are involved in the biosynthesis of adrenaline: (1) tyrosine 3-mono-oxygenase (tyrosine hydroxylase, th); (2) aromatic l-amino acid decarboxylase (aadc, or dopa decarboxylase, ddc); (3) dopamine beta-mono-oxygenase (dopamine beta-hydroxylase, dbh); and (4) noradrenaline n-methyltransferase (phenylethanolamine n-methyltransferase, pnmt). |
1992-02-06 |
2023-08-11 |
mouse |
| M Mogi, M Harada, K Kojima, K Kiuchi, T Nagats. Effects of systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to mice on tyrosine hydroxylase, L-3,4-dihydroxyphenylalanine decarboxylase, dopamine beta-hydroxylase, and monoamine oxidase activities in the striatum and hypothalamus. Journal of neurochemistry. vol 50. issue 4. 1988-04-21. PMID:2894407. |
the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) (30 mg/kg subcutaneously per day for 8 days) to c57bl/6n mice were studied on tyrosine hydroxylase (th), l-3,4-dihydroxyphenylalanine decarboxylase (ddc), and monoamine oxidase (mao) activities in the striatum, and th, ddc, dopamine-beta-hydroxylase (dbh), and mao activities in the hypothalamus. |
1988-04-21 |
2023-08-11 |
mouse |