All Relations between dat and sert

Publication Sentence Publish Date Extraction Date Species
Arnav Paul, Diwakar Shukl. Oligomerization of Monoamine Transporters. Sub-cellular biochemistry. vol 104. 2024-07-04. PMID:38963486. the mat family functions using the electrochemical gradient of ions across the membrane and comprises three transporters, dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). 2024-07-04 2024-07-10 Not clear
Hoang Nguyen, Mary Hongying Cheng, Ji Young Lee, Shaili Aggarwal, Ole Valente Mortensen, Ivet Baha. Allosteric modulation of serotonin and dopamine transporters: New insights from computations and experiments. Current research in physiology. vol 7. 2024-06-05. PMID:38836245. we present here a comparative study of the structural dynamics and ligand-binding properties of two mats, dopamine transporter (dat) and serotonin transporter (sert), with focus on the allosteric modulation of their transport function by drugs or substrates that consistently bind a secondary site s2, proposed to serve as an allosteric site. 2024-06-05 2024-06-07 human
Sixiang Chen, Xingyu Huang, Xintong Zhang, Chan Li, Yuan-Wei Zhan. A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612840. the monoamine transporters, including the serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net), are the therapeutic targets for the treatment of many neuropsychiatric disorders. 2024-04-13 2024-04-15 Not clear
Samantha Alvarez-Herrera, Mauricio Rosel Vales, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Yvonne Flores-Medina, José Luis Maldonado-García, Ricardo Saracco-Alvarez, Raúl Escamilla, Lenin Pavó. Risperidone Decreases Expression of Serotonin Receptor-2A (5-HT2A) and Serotonin Transporter (SERT) but Not Dopamine Receptors and Dopamine Transporter (DAT) in PBMCs from Patients with Schizophrenia. Pharmaceuticals (Basel, Switzerland). vol 17. issue 2. 2024-02-24. PMID:38399382. risperidone decreases expression of serotonin receptor-2a (5-ht2a) and serotonin transporter (sert) but not dopamine receptors and dopamine transporter (dat) in pbmcs from patients with schizophrenia. 2024-02-24 2024-02-26 Not clear
Lauren R Fitzgerald, Brenda M Gannon, Donna Walther, Antonio Landavazo, Takato Hiranita, Bruce E Blough, Michael H Baumann, William E Fantegross. Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones. Neuropharmacology. 2023-12-28. PMID:38154512. automated photobeam analysis was used to evaluate effects of drugs on ambulatory activity in mice, whereas in vitro assays were used to determine activities at transporters for dopamine (dat), norepinephrine (net), and 5-ht (sert) in rat brain synaptosomes. 2023-12-28 2023-12-31 mouse
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. furthermore, compared to the control group, the metal mixture exposure group showed a significantly lower expression level of tyrosine hydroxylase (th) and significantly higher expression levels of dopamine transporter (dat), tryptophan hydroxylase 1 (tph1), and serotonin reuptake transporter (sert). 2023-12-01 2023-12-10 mouse
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. these findings suggest that the key proteins involved in the synthesis and reuptake of dopamine (th and dat, respectively), as well as in the synthesis and reuptake of serotonin (tph1 and sert, respectively), play crucial roles in the neurotoxic effects associated with exposure to metal mixtures. 2023-12-01 2023-12-10 mouse
Hyomin Ahn, Kichul Park, Dongyoung Kim, Sung-Gil Chi, Kee-Hyun Choi, Seo-Jung Han, Chiman Son. Implications for Combination Therapy of Selective Monoamine Reuptake Inhibitors on Dopamine Transporters. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893219. monoamine transporters, including dopamine, norepinephrine, and serotonin transporters (dat, net, and sert, respectively), are important therapeutic targets due to their essential roles in the brain. 2023-10-30 2023-11-08 Not clear
Felix P Mayer, Marco Niello, Simon Bulling, Yuan-Wei Zhang, Yang Li, Oliver Kudlacek, Marion Holy, Fatemeh Kooti, Walter Sandtner, Gary Rudnick, Diethart Schmid, Harald H Sitt. Mephedrone induces partial release at human dopamine transporters but full release at human serotonin transporters. Neuropharmacology. 2023-09-13. PMID:37703919. the stimulating properties are believed to arise from the ability of mephedrone to interact with the high-affinity transporters for dopamine (da) (dat) and norepinephrine (net), whereas the entactogenic effect presumably relies on its activity at the serotonin (5-ht) transporter (sert). 2023-09-13 2023-10-07 human
Felix P Mayer, Marco Niello, Simon Bulling, Yuan-Wei Zhang, Yang Li, Oliver Kudlacek, Marion Holy, Fatemeh Kooti, Walter Sandtner, Gary Rudnick, Diethart Schmid, Harald H Sitt. Mephedrone induces partial release at human dopamine transporters but full release at human serotonin transporters. Neuropharmacology. 2023-09-13. PMID:37703919. evidence linked drug-induced reverse transport of 5-ht via sert to prosocial effects, whereas activity at dat is strongly correlated with abuse liability. 2023-09-13 2023-10-07 human
Florian Koban, Michael Freissmut. The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma. EMBO reports. 2023-08-02. PMID:37530743. monoamine transporters retrieve serotonin (sert), dopamine (dat), and norepinephrine (net) from the synaptic cleft. 2023-08-02 2023-08-14 Not clear
Mattias Persson, Svante Vikingsson, Robert Kronstrand, Henrik Gree. Characterization of neurotransmitter inhibition for seven cathinones by a proprietary fluorescent dye method. Drug testing and analysis. 2023-07-25. PMID:37489044. to start addressing this need, a method measuring the inhibition of the dopamine, serotonin, and norepinephrine transporters (dat, sert, and net) by stimulant drugs was developed. 2023-07-25 2023-08-14 Not clear
Cecilia E Villanueva, Bruno Hagenbuc. Palmitoylation of Solute Carriers. Biochemical pharmacology. 2023-07-22. PMID:37481134. among the best-characterized transporters are the glucose transporters glut1 (slc2a1) and glut4 (slc2a4), the three monoamine transporters norepinephrine transporter (net; slc6a2), dopamine transporter (dat; slc6a3), and serotonin transporter (sert; slc6a4), and the sodium-calcium exchanger ncx1 (slc8a1). 2023-07-22 2023-08-14 Not clear
Rachel A Davies, Vy T Nguyen, Jose M Eltit, Richard A Glenno. Structure-Activity Relationships for a Recently Controlled Synthetic Cathinone Dopamine Transporter Reuptake Inhibitor: α-Pyrrolidinohexiophenone (α-PHP). ACS chemical neuroscience. 2023-07-05. PMID:37406364. here, we examined a series of 4-substituted α-php analogues and found that, with one exception, all behaved as relatively (28- to >300-fold) selective dat versus serotonin transporter (sert) reuptake inhibitors with dat inhibition potencies of most falling within a very narrow (i.e., <3-fold) range. 2023-07-05 2023-08-14 Not clear
Carla Carratalá-Ros, Andrea Martínez-Verdú, Regulo Olivares-García, John D Salamone, Mercè Corre. Effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice: sex-dependent response to antidepressant drugs with SERT and DAT blocker profiles. Psychopharmacology. 2023-07-05. PMID:37407727. effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice: sex-dependent response to antidepressant drugs with sert and dat blocker profiles. 2023-07-05 2023-08-14 mouse
Elena Missir, Patrick Begley, Maryam Jessop, Nitasha Singh, Mark Aplin, Helena McMeekin, Puja Parekh, Malgorzata Raczek, Sabina Dizdarevi. Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism. Nuclear medicine communications. 2023-07-03. PMID:37395542. [123]i-ioflupane (datscan) binds to the presynaptic dopamine transporter (dat) and with a lower affinity to the serotonin transporter (sert). 2023-07-03 2023-08-14 Not clear
N J Clauss, F P Mayer, W A Owens, M Vitela, K M Clarke, M A Bowman, R E Horton, D Gründemann, D Schmid, M Holy, G G Gould, W Koek, H H Sitte, L C Daw. Ethanol inhibits dopamine uptake via organic cation transporter 3: Implications for ethanol and cocaine co-abuse. Molecular psychiatry. 2023-06-12. PMID:37308680. cocaine increases extracellular monoamines by blocking dopamine (da), norepinephrine (ne) and serotonin (5-ht) transporters (dat, net and sert, respectively). 2023-06-12 2023-08-14 mouse
N J Clauss, F P Mayer, W A Owens, M Vitela, K M Clarke, M A Bowman, R E Horton, D Gründemann, D Schmid, M Holy, G G Gould, W Koek, H H Sitte, L C Daw. Ethanol inhibits dopamine uptake via organic cation transporter 3: Implications for ethanol and cocaine co-abuse. Molecular psychiatry. 2023-06-12. PMID:37308680. likewise, ethanol also increases extracellular monoamines, however evidence suggests that ethanol does so independently of dat, net and sert. 2023-06-12 2023-08-14 mouse
Melissa M Conti Mazza, Ashley Centner, David F Werner, Christopher Bisho. Striatal serotonin transporter gain-of-function in L-DOPA-treated, hemi-parkinsonian rats. Brain research. 2023-05-01. PMID:37127174. since serotonin transporters (sert) have some affinity for da uptake, they may serve as a functional compensatory mechanism when da transporters (dat) are scant. 2023-05-01 2023-08-14 rat
Melissa M Conti Mazza, Ashley Centner, David F Werner, Christopher Bisho. Striatal serotonin transporter gain-of-function in L-DOPA-treated, hemi-parkinsonian rats. Brain research. 2023-05-01. PMID:37127174. at the end of treatment, the substantia nigra was processed for tyrosine hydroxylase (th) and dat gene expression and dorsal raphe was processed for sert gene expression. 2023-05-01 2023-08-14 rat