| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongyu Niu, Chao Li, Hexin Zhang, Haokun Liu, Chunmei Shang, Yanni Jia, Wuenjiya, Zuhui Li, Aihua Wang, Yaping Jin, Pengfei Li. Androgen synthesis cell-specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 9. 2024-05-02. PMID:38696238. |
immunohistochemical staining revealed increased expression of star, cyp11a1, and 17β-hsd3 in the adrenal cortex of crebzf-cko mice, while the expression of ar was significantly reduced. |
2024-05-02 |
2024-05-04 |
mouse |
| Hien Thi My Ong, Eda Ates, Oh-Seung Kwon, Min-Jung Kan. Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma. Biological procedures online. vol 25. issue 1. 2023-11-30. PMID:38036976. |
the cholesterol side-chain cleavage enzyme (cyp11a1) is closely associated with steroidogenesis, and its downregulation is linked to adrenal dysfunction and several types of carcinoma. |
2023-11-30 |
2023-12-10 |
Not clear |
| Hien Thi My Ong, Tae-Hun Kim, Eda Ates, Jae-Chul Pyun, Min-Jung Kan. Overexpression of CYP11A1 recovers cell cycle distribution in renal cell carcinoma Caki-1. Cancer cell international. vol 22. issue 1. 2022-10-01. PMID:36182900. |
recent studies have shown that deficiencies in cyp11a1 expression can lead to fatal adrenal failure if left untreated and are associated with downstream regulation in various cancer types. |
2022-10-01 |
2023-08-14 |
Not clear |
| Yiqi Christina Lin, Garett Cheung, Edith Porter, Vassilios Papadopoulo. The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells. The Journal of biological chemistry. 2022-06-10. PMID:35688208. |
unlike testicular and adrenal cortical cells, pregnenolone production in glial cells was not inhibited by cyp11a1 inhibitors dl-aminoglutethimide and ketoconazole. |
2022-06-10 |
2023-08-14 |
human |
| Shogo Harashima, Yuto Yamazaki, Naoki Motomura, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hiroyoshi Suzuki, Go Eun Kwon, Man Ho Choi, Hironobu Sasan. Phenotype-genotype Correlation in Aldosterone-producing Adenomas Characterized by Intracellular Cholesterol Metabolism. The Journal of steroid biochemistry and molecular biology. 2022-05-09. PMID:35533918. |
therefore, in order to explore these differences, 52 apa cases (kcnj5 mt: n=33, non-kcnj5 mt: n=19; atp1a1: n=3, atp2b3: n=3, cacna1d: n=5, ctnnb1: n=1, tumors without any mutation above: n=7), zona glomerulosa (zg) tissue adjacent to apa and 10 non-pathological adrenal glands (nas) were examined for quantitative histopathological analysis of tumor morphology and immunohistochemical analysis of cholesterol receptors (sr-b1, ldl-r), cholesterol metabolic enzymes (acat1, acat2, hsl, dhcr24, star), and the enzymes required for steroid synthesis (cyp11a1, cyp17a, 3βhsd, cyp11b1, cyp11b2). |
2022-05-09 |
2023-08-13 |
Not clear |
| Ozlem Kara, Orhan Gorukmez, Arzu Ekici, Fatih Celi. A Novel Homozygous Mutation in Fetal and pediatric pathology. vol 40. issue 5. 2021-10-07. PMID:32000563. |
a novel homozygous mutation in one of the causes of congenital adrenal insufficiency, a genetically heterogeneous disorder is a mutation in the cyp11a1 gene, which is responsible for the initiation of steriodogenesis by converting cholesterol to pregnenolone. |
2021-10-07 |
2023-08-13 |
Not clear |
| Francesca Spiga, Zidong Zhao, Stafford L Lightma. Prolonged treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:32156515. |
we have found that 5-days treatment with methylprednisolone suppresses basal acth and corticosterone secretion, as well as corticosterone secretion in response to a high dose of acth, and down-regulates key genes in the adrenal steroidogenic pathway, including star, mrap, cyp11a1 and cyp11b1. |
2021-04-27 |
2023-08-13 |
rat |
| Ashley L Gehrand, Jonathan Phillips, Kevin Malott, Hershel Raf. Corticosterone, Adrenal, and the Pituitary-Gonadal Axis in Neonatal Rats: Effect of Maternal Separation and Hypoxia. Endocrinology. vol 161. issue 7. 2020-12-14. PMID:32459830. |
our findings were (a) hypoxic separation led to a large increase in plasma corticosterone from 4h-pd4, (b) neither normoxic nor hypoxic separation affected critical adrenal steroidogenic pathway genes; however, a significant decrease in baseline cyp11a1, mc2r, mrap, and star adrenal expression during the first week of neonatal life confirmed the start of the adrenal stress hyporesponsive period, (c) a luteinizing hormone/follicle-stimulating hormone-independent increase in plasma testosterone occurred in normoxic and hypoxic separated male pups at birth, (d) testicular cyp11a1, lhcgr, and star expression was high at birth and decreased thereafter suggesting a hyporesponsive period in the testes, and (e) elevated estrogen in the early neonatal period occurred independently of gonadotropin stimulation. |
2020-12-14 |
2023-08-13 |
rat |
| Ronald J van der Sluis, Marie A C Depuydt, Miranda Van Eck, Menno Hoekstr. VLDL/LDL serves as the primary source of cholesterol in the adrenal glucocorticoid response to food deprivation. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1865. issue 7. 2020-10-22. PMID:32169652. |
a parallel 19-29% decrease in adrenal relative mrna expression levels of acth-responsive genes sr-bi (p < 0.01), star (p < 0.05), and cyp11a1 (p < 0.05) was detected. |
2020-10-22 |
2023-08-13 |
mouse |
| Jasmeet Kaur, Alan M Rice, Elizabeth O'Connor, Anil Piya, Bradley Buckler, Himangshu S Bos. Novel SCC mutation in a patient of Mexican descent with sex reversal, salt-losing crisis and adrenal failure. Endocrinology, diabetes & metabolism case reports. vol 2016. 2020-09-30. PMID:27855232. |
congenital adrenal hyperplasia (cah) is caused by mutations in cytochrome p450 side chain cleavage enzyme (cyp11a1 and old name, scc). |
2020-09-30 |
2023-08-13 |
Not clear |
| Himangshu S Bose, Alan M Rice, Brendan Marshall, Fadi Gebrail, David Kupshik, Elizabeth W Perr. Deficient pregnenolone synthesis associated with congenital adrenal hyperplasia and organelle dysfunction. Endocrinology, diabetes & metabolism case reports. vol 2019. 2020-09-28. PMID:31051467. |
in adrenal glands and gonads, cytochrome p450 side chain cleavage enzyme (scc or cyp11a1), catalyzes conversion of cholesterol to pregnenolone. |
2020-09-28 |
2023-08-13 |
Not clear |
| Danielle J Burgess, Emily S Dorey, Emelie M Gardebjer, Helle Bielefeldt-Ohmann, Karen M Moritz, James S M Cuff. Periconceptional ethanol exposure alters the stress axis in adult female but not male rat offspring. Stress (Amsterdam, Netherlands). vol 22. issue 3. 2020-02-18. PMID:30741061. |
expression of adrenal steroidogenesis genes (mc2r, cyp11a1, cyp21a1, 11bhsd2, and nr3c1) and hypothalamic genes (crh, crh-r1, nr3c1, and hsp90a1) was not affected by pc:etoh. |
2020-02-18 |
2023-08-13 |
rat |
| Florence Roucher-Boulez, Claire Goursaud, Delphine Mallet, Yves More. Letter to the Editor: "Characterization of the CYP11A1 Nonsynonymous Variant p.E314K in Children Presenting With Adrenal Insufficiency". The Journal of clinical endocrinology and metabolism. vol 104. issue 5. 2020-02-17. PMID:30500894. |
letter to the editor: "characterization of the cyp11a1 nonsynonymous variant p.e314k in children presenting with adrenal insufficiency". |
2020-02-17 |
2023-08-13 |
Not clear |
| Vipula Kolli, Qizong Lao, Deborah P Merk. Response to Letter to the Editor: "Characterization of the CYP11A1 Nonsynonymous Variant p.E314K in Children Presenting With Adrenal Insufficiency". The Journal of clinical endocrinology and metabolism. vol 104. issue 5. 2020-02-17. PMID:30500909. |
response to letter to the editor: "characterization of the cyp11a1 nonsynonymous variant p.e314k in children presenting with adrenal insufficiency". |
2020-02-17 |
2023-08-13 |
Not clear |
| Wafa Kallali, Ewan Gray, Muhammad Zain Mehdi, Robert Lindsay, Louise A Metherell, Federica Buonocore, Jenifer P Suntharalingham, John C Achermann, Malcolm Donaldso. Long-term outcome of partial P450 side-chain cleavage enzyme deficiency in three brothers: the importance of early diagnosis. European journal of endocrinology. vol 182. issue 3. 2020-02-17. PMID:31917682. |
cyp11a1 mutations cause p450 side-chain cleavage (scc) deficiency, a rare form of congenital adrenal hyperplasia with a wide clinical spectrum. |
2020-02-17 |
2023-08-13 |
Not clear |
| Vipula Kolli, Hannah Kim, Ahmed Torky, Qizong Lao, Christina Tatsi, Ashwini Mallappa, Deborah P Merk. Characterization of the CYP11A1 Nonsynonymous Variant p.E314K in Children Presenting With Adrenal Insufficiency. The Journal of clinical endocrinology and metabolism. vol 104. issue 2. 2019-12-06. PMID:30299480. |
characterization of the cyp11a1 nonsynonymous variant p.e314k in children presenting with adrenal insufficiency. |
2019-12-06 |
2023-08-13 |
Not clear |
| V S Efimova, L V Isaeva, M A Rubtsov, L A Novikov. Analysis of In Vivo Activity of the Bovine Cholesterol Hydroxylase/Lyase System Proteins Expressed in Escherichia coli. Molecular biotechnology. vol 61. issue 4. 2019-07-01. PMID:30729436. |
the cholesterol hydroxylase/lyase (chl) system, located in the mitochondria of the mammalian adrenal cortex cells, consists of cytochrome p450scc (cyp11a1), adrenodoxin (adx), and adrenodoxin reductase (adr) and performs the first stage of the steroidogenesis: adr and adx enable the electron transfer between nadph and cytochrome p450scc, and p450scc catalyzes the conversion of cholesterol into pregnenolone. |
2019-07-01 |
2023-08-13 |
cattle |
| Dimitrios T Papadimitriou, Christina Bothou, Diagoras Zarganis, Maria Karantza, Anastasios Papadimitrio. Heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A1) can cause transient adrenal insufficiency and life-threatening failure to thrive. Hormones (Athens, Greece). vol 17. issue 3. 2019-05-14. PMID:29995203. |
heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (cyp11a1) can cause transient adrenal insufficiency and life-threatening failure to thrive. |
2019-05-14 |
2023-08-13 |
Not clear |
| Dimitrios T Papadimitriou, Christina Bothou, Diagoras Zarganis, Maria Karantza, Anastasios Papadimitrio. Heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A1) can cause transient adrenal insufficiency and life-threatening failure to thrive. Hormones (Athens, Greece). vol 17. issue 3. 2019-05-14. PMID:29995203. |
this report of severe early adrenal insufficiency caused by a heterozygous mutation of the cyp11a1 gene clearly demonstrates that scc deficiency may be inherited as an autosomal dominant trait in humans. |
2019-05-14 |
2023-08-13 |
Not clear |
| Vladimir E Vargas, Dean A Myers, Kanchan M Kaushal, Charles A Ducsa. Expression of StAR and Key Genes Regulating Cortisol Biosynthesis in Near Term Ovine Fetal Adrenocortical Cells: Effects of Long-Term Hypoxia. Reproductive sciences (Thousand Oaks, Calif.). vol 25. issue 2. 2018-11-14. PMID:28468567. |
this study was designed to determine whether the previously observed decrease in lth cytochrome p45011a1/cytochrome p450c17 (cyp11a1/cyp17) in adrenal glands was maintained in vitro, and whether acth alone with or without uo126 treatment had altered the expression of cyp11a1, cyp17, and steroidogenic acute regulatory protein (star) in control versus lth facs. |
2018-11-14 |
2023-08-13 |
Not clear |