| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongyu Niu, Chao Li, Hexin Zhang, Haokun Liu, Chunmei Shang, Yanni Jia, Wuenjiya, Zuhui Li, Aihua Wang, Yaping Jin, Pengfei Li. Androgen synthesis cell-specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 9. 2024-05-02. PMID:38696238. |
immunohistochemical staining revealed increased expression of star, cyp11a1, and 17β-hsd3 in the adrenal cortex of crebzf-cko mice, while the expression of ar was significantly reduced. |
2024-05-02 |
2024-05-04 |
mouse |
| V S Efimova, L V Isaeva, M A Rubtsov, L A Novikov. Analysis of In Vivo Activity of the Bovine Cholesterol Hydroxylase/Lyase System Proteins Expressed in Escherichia coli. Molecular biotechnology. vol 61. issue 4. 2019-07-01. PMID:30729436. |
the cholesterol hydroxylase/lyase (chl) system, located in the mitochondria of the mammalian adrenal cortex cells, consists of cytochrome p450scc (cyp11a1), adrenodoxin (adx), and adrenodoxin reductase (adr) and performs the first stage of the steroidogenesis: adr and adx enable the electron transfer between nadph and cytochrome p450scc, and p450scc catalyzes the conversion of cholesterol into pregnenolone. |
2019-07-01 |
2023-08-13 |
cattle |
| Hsin-Chieh Lan, I-Wen Lin, Zhi-Jie Yang, Jyun-Hong Li. Low-dose Bisphenol A Activates Cyp11a1 Gene Expression and Corticosterone Secretion in Adrenal Gland via the JNK Signaling Pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 148. issue 1. 2016-08-16. PMID:26209791. |
to investigate the influence of bpa on steroidogenesis, we examined the activity of the steroidogenic gene cyp11a1 and its regulatory pathways in mouse y1 adrenal cortex cells. |
2016-08-16 |
2023-08-13 |
mouse |
| L O Sakhno, M S Slyvet. Superoxide dismutase activity in transgenic canola. TSitologiia i genetika. vol 48. issue 3. 2014-09-09. PMID:25016823. |
superoxide dismutase (sod) activity was investigated in leaves of transgenic canola plants which expressed heterologous genes of different origin, namely 1) herbicide resistance genes (bar and simultaneously bar and epsps); 2) desc desaturase gene (desc) of cyanobacterium synechococcus vulcanus; 3) human interferon alpha2b gene (hulfn-alpha2b); 4) esxa::fbpb(deltatmd) fused gene, encoding esat-6 and ag85b mycobacterium tuberculosis proteins, inducing immune response against tuberculosis; 5) cyp11a1 gene of cytochrome p450(scc) from bovine adrenal cortex mitochondria. |
2014-09-09 |
2023-08-13 |
human |
| Charles A Ducsay, Ken Furuta, Vladimir E Vargas, Kanchan M Kaushal, Krista Singleton, Kimberly Hyatt, Dean A Myer. Leptin receptor antagonist treatment ameliorates the effects of long-term maternal hypoxia on adrenal expression of key steroidogenic genes in the ovine fetus. American journal of physiology. Regulatory, integrative and comparative physiology. vol 304. issue 6. 2013-05-08. PMID:23344230. |
fetal adrenal cortex was collected for determination of steriodogenic acute regulatory protein (star), acth, and leptin receptor, cholesterol side-chain cleavage (cyp11a1), cytochrome p-450 11β-hydroxylase (cyp11b1), 17α-hydroxylase (cyp17), 21-hydroxylase (cyp21), signal transducer and activator of transcription 3 (stat3), pstat3, and 17β-hydroxysteroid dehydrogenase (hsd3b) expression. |
2013-05-08 |
2023-08-12 |
Not clear |
| Camila Martinez Calejman, Juan M Di Gruccio, María E Mercau, Esteban M Repetto, Francisco Astort, Rocío Sanchez, Matías Pandolfi, Gabriela Berg, Laura Schreier, Pablo Arias, Cora B Cymeryn. Insulin sensitization with a peroxisome proliferator-activated receptor γ agonist prevents adrenocortical lipid infiltration and secretory changes induced by a high-sucrose diet. The Journal of endocrinology. vol 214. issue 3. 2012-12-10. PMID:22700193. |
expression levels of star, cyp11a1, mc2r, pparγ (pparg), and cd36 were evaluated by real-time pcr, histochemical analysis of the adrenal cortex was performed using masson's trichrome and sudan iii staining, and corticosterone levels were measured by ria. |
2012-12-10 |
2023-08-12 |
rat |
| Takashi Miyashita, Migiwa Okubo, Takashi Shinomiya, Kan-Ichi Nakagawa, Mitsuru Kawaguch. Pregnenolone biosynthesis in the rat salivary gland and its inhibitory effect on secretion. Journal of pharmacological sciences. vol 115. issue 1. 2011-06-24. PMID:21178317. |
however, in response to methamphetamine withdrawal-induced stress, cyp11a1 production in each type of the salivary gland was highly upregulated to levels similar to those seen in the cerebral cortex. |
2011-06-24 |
2023-08-12 |
rat |
| Takashi Miyashita, Migiwa Okubo, Takashi Shinomiya, Kan-Ichi Nakagawa, Mitsuru Kawaguch. Pregnenolone biosynthesis in the rat salivary gland and its inhibitory effect on secretion. Journal of pharmacological sciences. vol 115. issue 1. 2011-06-24. PMID:21178317. |
quantitative rt-pcr and western blotting revealed lesser expression of the prg synthetase cyp11a1 protein and mrna in the parotid, submandibular, and sublingual gland than in the cerebral cortex or adrenal gland as positive control organs. |
2011-06-24 |
2023-08-12 |
rat |
| Melina A Pagotto, María L Roldán, Romina M Pagotto, María C Lugano, Gerardo B Pisani, Gastón Rogic, Sara M Molinas, Laura Trumper, Omar P Pignataro, Liliana Alicia Monasterol. Localization and functional activity of cytochrome P450 side chain cleavage enzyme (CYP11A1) in the adult rat kidney. Molecular and cellular endocrinology. vol 332. issue 1-2. 2011-04-29. PMID:21075169. |
immunohistochemical labeling for cyp11a1 was observed in renal cortex and medulla, on structures identified as distal convoluted tubule and thick ascending limb of henle's loop, respectively. |
2011-04-29 |
2023-08-12 |
rat |
| Melina A Pagotto, María L Roldán, Romina M Pagotto, María C Lugano, Gerardo B Pisani, Gastón Rogic, Sara M Molinas, Laura Trumper, Omar P Pignataro, Liliana Alicia Monasterol. Localization and functional activity of cytochrome P450 side chain cleavage enzyme (CYP11A1) in the adult rat kidney. Molecular and cellular endocrinology. vol 332. issue 1-2. 2011-04-29. PMID:21075169. |
the expression of star and cyp11a1 was found to be higher in medulla than in cortex. |
2011-04-29 |
2023-08-12 |
rat |
| b' S G Spivak, I N Berdichevets, R P Litvinovskaia, S V Drach, N A Kartel\', G V Shpakovski\\xc4\\xa. [Characteristics of steroid metabolism in transgenic Nicotiana tabacum plants bearing the CYP11A1 cDNA of cytochrome P450(SCC) from the bovine adrenal cortex]. Bioorganicheskaia khimiia. vol 36. issue 2. 2010-07-26. PMID:20531483.' |
[characteristics of steroid metabolism in transgenic nicotiana tabacum plants bearing the cyp11a1 cdna of cytochrome p450(scc) from the bovine adrenal cortex]. |
2010-07-26 |
2023-08-12 |
cattle |
| b' S G Spivak, I N Berdichevets, R P Litvinovskaia, S V Drach, N A Kartel\', G V Shpakovski\\xc4\\xa. [Characteristics of steroid metabolism in transgenic Nicotiana tabacum plants bearing the CYP11A1 cDNA of cytochrome P450(SCC) from the bovine adrenal cortex]. Bioorganicheskaia khimiia. vol 36. issue 2. 2010-07-26. PMID:20531483.' |
in this work, we study the steroid metabolism in transgenic tobacco plants carrying the cyp11a1 cdna cytochrome p450(scc)from the bovine adrenal cortex. |
2010-07-26 |
2023-08-12 |
cattle |
| S G Spivak, I N Berdichevets, D G Iarmolinskiĭ, T V Maneshina, G V Shpakovskiĭ, N A Kartel\. [Construction and characteristics of transgenic tobacco Nicotiana tabacum L. plants expressing CYP11A1 cDNA encoding cytochrome P450scc]. Genetika. vol 45. issue 9. 2009-11-09. PMID:19824542. |
to study the possibility of functioning of mammalian cytochrome p450scc in plants and the mechanism of its integration in the plant steroidogenic system, transgenic plants of tobacco nicotiana tabacum l. were developed carrying cdna of cyp11a1 encoding cytochrome p450scc of bovine adrenal cortex. |
2009-11-09 |
2023-08-12 |
cattle |
| Holly A Lavoie, Steven R Kin. Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1 and HSD3B. Experimental biology and medicine (Maywood, N.J.). vol 234. issue 8. 2009-09-10. PMID:19491374. |
expression of the genes that mediate the first steps in steroidogenesis, the steroidogenic acute regulatory protein (stard1), the cholesterol side-chain cleavage enzyme, cytochrome p450scc (cyp11a1) and 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase (hsd3b), is tightly controlled by a battery of transcription factors in the adrenal cortex, the gonads and the placenta. |
2009-09-10 |
2023-08-12 |
Not clear |
| Hsu-Shui Wu, Hui-Ting Lin, Chi-Kuang Leo Wang, Yen-Feng Chiang, Hsueh-Ping Chu, Meng-Chun H. Human CYP11A1 promoter drives Cre recombinase expression in the brain in addition to adrenals and gonads. Genesis (New York, N.Y. : 2000). vol 45. issue 2. 2007-04-18. PMID:17216615. |
the resulting scc-cre mice express high levels of cre in the adrenal cortex and gonads at the same sites as that for the endogenous cyp11a1 expression. |
2007-04-18 |
2023-08-12 |
mouse |
| M Watzka, F Bidlingmaier, J Schramm, D Klingmüller, B Stoffel-Wagne. Sex- and age-specific differences in human brain CYP11A1 mRNA expression. Journal of neuroendocrinology. vol 11. issue 12. 2000-01-18. PMID:10583724. |
cyp11a1 mrna is significantly higher in the temporal and frontal lobe cortex of women than in that of men. |
2000-01-18 |
2023-08-12 |
human |
| M C Hu, S J Chou, Y Y Huang, N C Hsu, H Li, B C Chun. Tissue-specific, hormonal, and developmental regulation of SCC-LacZ expression in transgenic mice leads to adrenocortical zone characterization. Endocrinology. vol 140. issue 12. 1999-12-20. PMID:10579324. |
its expression continued throughout all stages of adrenal development in a pattern similar to that of the endogenous cyp11a1, which was expressed in all zones of the adrenal cortex, but was strongest in the x zone. |
1999-12-20 |
2023-08-12 |
mouse |
| N Watanabe, H Inoue, Y Fujii-Kuriyam. Regulatory mechanisms of cAMP-dependent and cell-specific expression of human steroidogenic cytochrome P450scc (CYP11A1) gene. European journal of biochemistry. vol 222. issue 3. 1994-08-11. PMID:8026494. |
cytochrome p450scc (cyp11a1) is the enzyme that catalyzes the side-chain cleavage reaction of cholesterol, the first and rate-limiting reaction in the biosynthesis of steroid hormones in the adrenal cortex. |
1994-08-11 |
2023-08-12 |
human |
| N Watanabe, H Inoue, Y Fujii-Kuriyam. Regulatory mechanisms of cAMP-dependent and cell-specific expression of human steroidogenic cytochrome P450scc (CYP11A1) gene. European journal of biochemistry. vol 222. issue 3. 1994-08-11. PMID:8026494. |
dnase-i-footprinting analysis using nuclear extracts from the bovine adrenal cortex and the 5' upstream regulatory region (nucleotides -1697 to -1523) of the cyp11a1 gene, which is mainly required for response to camp [inoue, h., watanabe, n., higashi, y. |
1994-08-11 |
2023-08-12 |
human |