| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongyu Niu, Chao Li, Hexin Zhang, Haokun Liu, Chunmei Shang, Yanni Jia, Wuenjiya, Zuhui Li, Aihua Wang, Yaping Jin, Pengfei Li. Androgen synthesis cell-specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 9. 2024-05-02. PMID:38696238. |
immunohistochemical staining revealed increased expression of star, cyp11a1, and 17β-hsd3 in the adrenal cortex of crebzf-cko mice, while the expression of ar was significantly reduced. |
2024-05-02 |
2024-05-04 |
mouse |
| Ruixue Nie, Haoyu Tian, Wenhui Zhang, Fuwei Li, Bo Zhang, Hao Zhan. NR5A1 and NR5A2 regulate follicle development in chicken (Gallus gallus) by altering proliferation, apoptosis, and steroid hormone synthesis of granulosa cells. Poultry science. vol 103. issue 5. 2024-03-16. PMID:38492249. |
the overexpression of nr5a1 and nr5a2 significantly promoted proliferation and inhibited apoptosis of cultured gc; upregulated star, cyp11a1, and cyp19a1 expression and estradiol (e2) and progesterone (p4) synthesis in gc from preovulatory follicles (po-gc); and increased star, cyp11a1, and cyp19a1 promoter activities. |
2024-03-16 |
2024-03-19 |
chicken |
| Qianhui Zhao, Ying Liu, Xiao Wang, Yixuan Zhu, Yulan Jiao, Yongzhan Bao, Wanyu Sh. Cuscuta chinensis flavonoids reducing oxidative stress of the improve sperm damage in bisphenol A exposed mice offspring. Ecotoxicology and environmental safety. vol 255. 2023-03-26. PMID:36966614. |
our results showed that compared with the bpa group, ccfs could significantly increase the serum contents of luteinizing hormone (lh), follicle-stimulating hormone (fsh), and testosterone (t) in males at pnd 56, as well as the transcription levels of estrogen receptor alpha (erα), steroidogenic acute regulatory protein (star) and cytochrome p450 family 11, subfamily a, and member 1 (cyp11a1). |
2023-03-26 |
2023-08-14 |
mouse |
| Shogo Harashima, Yuto Yamazaki, Naoki Motomura, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hiroyoshi Suzuki, Go Eun Kwon, Man Ho Choi, Hironobu Sasan. Phenotype-genotype Correlation in Aldosterone-producing Adenomas Characterized by Intracellular Cholesterol Metabolism. The Journal of steroid biochemistry and molecular biology. 2022-05-09. PMID:35533918. |
therefore, in order to explore these differences, 52 apa cases (kcnj5 mt: n=33, non-kcnj5 mt: n=19; atp1a1: n=3, atp2b3: n=3, cacna1d: n=5, ctnnb1: n=1, tumors without any mutation above: n=7), zona glomerulosa (zg) tissue adjacent to apa and 10 non-pathological adrenal glands (nas) were examined for quantitative histopathological analysis of tumor morphology and immunohistochemical analysis of cholesterol receptors (sr-b1, ldl-r), cholesterol metabolic enzymes (acat1, acat2, hsl, dhcr24, star), and the enzymes required for steroid synthesis (cyp11a1, cyp17a, 3βhsd, cyp11b1, cyp11b2). |
2022-05-09 |
2023-08-13 |
Not clear |
| Lu-Xi Lin, Qin-Qin Cao, Chao-Dong Zhang, Ting-Ting Xu, Ke Yue, Qinghao Li, Fang Liu, Xuebing Wang, Hai-Ju Dong, Shu-Cheng Huang, Fu-Chun Jia. Aflatoxin B1 causes oxidative stress and apoptosis in sheep testes associated with disrupting rumen microbiota. Ecotoxicology and environmental safety. vol 232. 2022-02-06. PMID:35124419. |
afb1 stimulated the secretion of plasma testosterone level through regulating testosterone synthesis-related genes (star, 3β-hsd, cyp11a1, and cyp17a1), which are accompanied by the increase of oxidative stress and testicular apoptosis that had a close relationship with the regulation of testosterone secretion. |
2022-02-06 |
2023-08-13 |
Not clear |
| Shanthi Ganesan, Bailey C McGuire, Aileen F Keatin. Absence of glyphosate-induced effects on ovarian folliculogenesis and steroidogenesis. Reproductive toxicology (Elmsford, N.Y.). vol 96. 2021-12-06. PMID:32592754. |
ovarian mrna or protein abundance of star, 3β-hydroxysteroid dehydrogenase (hsd3b1), cyp11a1 or cyp19a were also not altered by gly. |
2021-12-06 |
2023-08-13 |
mouse |
| Qigang Fan, Zhongying Zhao, Qing Meng, Ruifeng He, Hongli Li, Meigui Zhang, Pu Gao, Xinlong Li, Yi Li, Qinying Zhu, Fengqin Shen, Lihui Zhao, Xiaolei Lian. Improvement of Astragalin on Spermatogenesis in Oligoasthenozoospermia Mouse Induced by Cyclophosphamide. Reproductive sciences (Thousand Oaks, Calif.). 2021-11-30. PMID:34846706. |
rna-seq analysis highlighted astragalin upregulated gene expression of anti-apoptosis (akt1and bcl2-xl), cell proliferation (etv1, mapkapk2, and rps6ka5) and synthesis of testosterone (star, cyp11a1, and prkacb), but downregulated gene expression of cell apoptosis (bad, bcl-2, caspase9, and caspase3) in mouse testis. |
2021-11-30 |
2023-08-13 |
mouse |
| Michał M Hryciuk, Katarina Jewgenow, Beate C Brau. Cloprostenol, a synthetic analog of prostaglandin F2α induces functional regression in cultured luteal cells of felids†. Biology of reproduction. vol 105. issue 1. 2021-11-17. PMID:33864060. |
gene-expression analysis by real-time pcr revealed that treatment with cloprostenol did not have an influence on expression of selected genes coding for enzymes of steroidogenesis (star, hsd3b, cyp11a1) or prostaglandin synthesis (ptgs2, pges), nor did it effect hormone receptors (ar, esr1, pgr, ptger2), an anti-oxidative enzyme (sod1) or factors of cell apoptosis (fas, casp3, tnfrsf1b, bcl2) over the studied period. |
2021-11-17 |
2023-08-13 |
cat |
| Adam J Ziecik, Jan Klos, Katarzyna Gromadzka-Hliwa, Mariola A Dietrich, Mariola Slowinska, Pawel Likszo, Katarzyna Knapczyk-Stwora, Zdzislaw Gajewski, Monika M Kaczmare. Endocrine and molecular milieus of ovarian follicles are diversely affected by human chorionic gonadotropin and gonadotropin-releasing hormone in prepubertal and mature gilts. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34188064. |
trigger- and/or maturity-dependent changes in the abundance of hormone receptors (fshr and lhcgr) and proteins associated with lipid metabolism and steroidogenesis (e.g., star, hsd3b1, and cyp11a1), prostaglandin synthesis (ptgs2 and ptgfs), extracellular matrix remodeling (mmp1 and timp1), protein folding (hsps), molecular transport (tf), and cell function and survival (e.g., vim) were observed. |
2021-11-08 |
2023-08-13 |
human |
| Jing Li, Xue-Jie Ma, Xing Wu, Su-Jin Si, Chong Li, Peng-Kun Yang, Guo-Xi Li, Xiao-Jun Liu, Ya-Dong Tian, Xiang-Tao Kan. Adiponectin modulates steroid hormone secretion, granulosa cell proliferation and apoptosis via binding its receptors during hens' high laying period. Poultry science. vol 100. issue 7. 2021-07-05. PMID:34089930. |
our results revealed that adiponectin and its receptors wildly exist in follicles and granulosa cells, and adiporon (5 and 10 µg/ml) had no effect on granulosa cell proliferation and apoptosis but significantly stimulated the secretion of adiponectin and its receptors in granulosa cells after incubation for 24 h. furthermore, adiporon could significantly stimulate the secretion of p4 and inhibit e2 level compared to those of the control group through modulating the key genes expression of steroidogenesis (cyp19a1, star, cyp11a1, fshr, and lhr). |
2021-07-05 |
2023-08-13 |
Not clear |
| Yating Li, Jiongjie Jing, Wenqing Dang, Qi Han, Xiangyu Guo, Kaiqi Jia, Ying Cheng, Kai Wang, Ermias Kebreab, Lihua Ly. Effects of Notch2 on proliferation, apoptosis and steroidogenesis in bovine luteinized granulosa cells. Theriogenology. vol 171. 2021-06-21. PMID:34023619. |
quantitative reverse transcription polymerase chain reaction (qrt-pcr) showed that the mrna expression of apoptosis related gene bcl-2/bax decreased (p < 0.01) and caspase3 increased (p < 0.05), cell cycle related gene cyclind2/cdk4 complex decreased (p < 0.01) and p21 increased (p < 0.05), steroidogenesis gene star and 3β-hsd decreased (p < 0.01) while cyp19a1 and cyp11a1 had no significant difference (p > 0.05). |
2021-06-21 |
2023-08-13 |
cattle |
| Francesca Spiga, Zidong Zhao, Stafford L Lightma. Prolonged treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:32156515. |
we have found that 5-days treatment with methylprednisolone suppresses basal acth and corticosterone secretion, as well as corticosterone secretion in response to a high dose of acth, and down-regulates key genes in the adrenal steroidogenic pathway, including star, mrap, cyp11a1 and cyp11b1. |
2021-04-27 |
2023-08-13 |
rat |
| Shanthi Ganesan, Aileen F Keatin. Ovarian mitochondrial and oxidative stress proteins are altered by glyphosate exposure in mice. Toxicology and applied pharmacology. vol 402. 2021-01-06. PMID:32634520. |
there were no detectable effects of gly on ovarian protein abundance of pakt, akt, pakt:akt, γh2ax, star, cyp11a1, hsd3b, cyp19a, era or erb. |
2021-01-06 |
2023-08-13 |
mouse |
| Ashley L Gehrand, Jonathan Phillips, Kevin Malott, Hershel Raf. Corticosterone, Adrenal, and the Pituitary-Gonadal Axis in Neonatal Rats: Effect of Maternal Separation and Hypoxia. Endocrinology. vol 161. issue 7. 2020-12-14. PMID:32459830. |
our findings were (a) hypoxic separation led to a large increase in plasma corticosterone from 4h-pd4, (b) neither normoxic nor hypoxic separation affected critical adrenal steroidogenic pathway genes; however, a significant decrease in baseline cyp11a1, mc2r, mrap, and star adrenal expression during the first week of neonatal life confirmed the start of the adrenal stress hyporesponsive period, (c) a luteinizing hormone/follicle-stimulating hormone-independent increase in plasma testosterone occurred in normoxic and hypoxic separated male pups at birth, (d) testicular cyp11a1, lhcgr, and star expression was high at birth and decreased thereafter suggesting a hyporesponsive period in the testes, and (e) elevated estrogen in the early neonatal period occurred independently of gonadotropin stimulation. |
2020-12-14 |
2023-08-13 |
rat |
| Ronald J van der Sluis, Marie A C Depuydt, Miranda Van Eck, Menno Hoekstr. VLDL/LDL serves as the primary source of cholesterol in the adrenal glucocorticoid response to food deprivation. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1865. issue 7. 2020-10-22. PMID:32169652. |
a parallel 19-29% decrease in adrenal relative mrna expression levels of acth-responsive genes sr-bi (p < 0.01), star (p < 0.05), and cyp11a1 (p < 0.05) was detected. |
2020-10-22 |
2023-08-13 |
mouse |
| M Vodička, P Ergang, T Hrnčíř, A Mikulecká, P Kvapilová, K Vagnerová, B Šestáková, A Fajstová, P Hermanová, T Hudcovic, H Kozáková, J Pách. Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress. Brain, behavior, and immunity. vol 73. 2019-07-31. PMID:29990567. |
in the pituitary gland, microbiota attenuated the expression of fkbp5, a gene regulating glucocorticoid receptor sensitivity, while in the adrenal gland, it attenuated the expression of genes encoding steroidogenesis (mc2r, star, cyp11a1) and catecholamine synthesis (th, pnmt). |
2019-07-31 |
2023-08-13 |
mouse |
| K Kranthi Kumar, B Uma Devi, P Neeraj. Elucidation of endocrine-disrupting polychlorinated biphenyls binding potency with steroidogenic genes: Integration of in silico methods and ensemble docking approaches. Ecotoxicology and environmental safety. vol 165. 2018-12-11. PMID:30196001. |
in this examination, the combinations of quantitative structure-activity relationship (qsar) modeling and ensemble docking approaches was performed to envisage structural properties of pcbs that influence the developmental toxicity, estrogen receptor-mediated impacts, and to provide a better comprehension of binding levels between pcbs, steroidogenic acute regulatory protein (star) and cholesterol side-chain cleavage enzyme (cyp11a1). |
2018-12-11 |
2023-08-13 |
Not clear |
| Vladimir E Vargas, Dean A Myers, Kanchan M Kaushal, Charles A Ducsa. Expression of StAR and Key Genes Regulating Cortisol Biosynthesis in Near Term Ovine Fetal Adrenocortical Cells: Effects of Long-Term Hypoxia. Reproductive sciences (Thousand Oaks, Calif.). vol 25. issue 2. 2018-11-14. PMID:28468567. |
this study was designed to determine whether the previously observed decrease in lth cytochrome p45011a1/cytochrome p450c17 (cyp11a1/cyp17) in adrenal glands was maintained in vitro, and whether acth alone with or without uo126 treatment had altered the expression of cyp11a1, cyp17, and steroidogenic acute regulatory protein (star) in control versus lth facs. |
2018-11-14 |
2023-08-13 |
Not clear |
| Patricia G Tremblay, Marc-André Sirar. Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28383663. |
gene associations with seven major ovarian functions were identified: prostaglandin- endoperoxide synthase 2 (ptgs2), interleukin 8 (il8), and interleukin 6 (il6) with inflammation; steroidogenic acute regulatory protein (star), cytochrome p450scc (cyp11a1), and cytochrome p450 family 19 subfamily a member 1 (cyp19a1) with steroidogenesis; vascular endothelial growth factor c (vegfc), vascular endothelial growth factor a (vegfa), and c-x-c chemokine receptor type 4 (cxcr4) with angiogenesis; amphiregulin (areg), epidermal growth factor receptor (egfr), and sprouty rtk signaling antagonist 2 (spry2) with differentiation, bcl2 associated x (bax), bcl2 like 12 (bcl2l12), and caspase 1(casp1) with apoptosis, cyclin d1 (ccnd1), cyclin b1 (ccnb1), and cyclin b2 (ccnb2) with division; and matrix metalloproteinase-1 (mmp1), matrix metallopeptidase 9 (mmp9), and timp metallopeptidase inhibitor 1 (timp1) with ovulation. |
2018-03-12 |
2023-08-13 |
human |
| Xiao-Hong Liu, Zhi-Jian Wang, Li Jin, Jing Huang, De-Yong Pu, De-Shou Wang, Yao-Guang Zhan. Effects of subchronic exposure to waterborne cadmium on H-P-I axis hormones and related genes in rare minnows (Gobiocypris rarus). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 202. 2018-01-09. PMID:28743461. |
correspondingly, low dose (5-50μg/l) waterborne cd disrupted the endocrine system of h-p-i axis just at the secretion level, while high dose cd disrupted both the secretion and synthesis of cortisol and its downstream signals in rare minnows, revealed by the significantly upregulation and positive correlation of corticosteroidogenic genes including mc2r, star, cyp11a1, and cyp11b1 in the kidney (including the interrenal tissue) (p<0.05), and the significant alteration of glcci1, hsp90aa and hsp90ab in the hepatopancreas, gill and intestine as well (p<0.05). |
2018-01-09 |
2023-08-13 |
Not clear |