| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Hui Wu, Jia-Min Du, Peng Liu, Fan-Liang Meng, Yue-Yan Li, Wen-Jing Li, Shuang-Xi Wang, Nai-Li Du, Yan Zheng, Liang Zhang, Hui-Yun Wang, Yi-Ran Liu, Chun-Hong Song, Xi Ni, Ying Li, Guo-Hai S. LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment. International immunopharmacology. vol 136. 2024-06-08. PMID:38850787. |
nicotine treatment impaired autophagy flux by regulating the ampk/mtor signaling pathway, impeding the nuclear translocation of transcription factor eb (tfeb), and reducing the activity of cathepsin b (ctsb). |
2024-06-08 |
2024-06-11 |
rat |
| Shu-Ya Wang, Xi Ni, Ke-Qing Hu, Fan-Liang Meng, Min Li, Xiao-Li Ma, Ting-Ting Meng, Hui-Hui Wu, Di Ge, Jing Zhao, Ying Li, Guo-Hai S. Cilostazol alleviate nicotine induced cardiomyocytes hypertrophy through modulation of autophagy by CTSB/ROS/p38MAPK/JNK feedback loop. International journal of biological sciences. vol 16. issue 11. 2021-11-10. PMID:32398966. |
interestingly, cathepsin b (ctsb) activity decreased dramatically after stimulation with nicotine in nrvms, which was crucial for substrate degradation in the late stage of autophagy process, and cilostazol could reverse this effect dramatically. |
2021-11-10 |
2023-08-13 |
rat |
| Shu-Ya Wang, Xi Ni, Ke-Qing Hu, Fan-Liang Meng, Min Li, Xiao-Li Ma, Ting-Ting Meng, Hui-Hui Wu, Di Ge, Jing Zhao, Ying Li, Guo-Hai S. Cilostazol alleviate nicotine induced cardiomyocytes hypertrophy through modulation of autophagy by CTSB/ROS/p38MAPK/JNK feedback loop. International journal of biological sciences. vol 16. issue 11. 2021-11-10. PMID:32398966. |
this is the first demonstration that cilostazol could alleviate nicotine induced cardiomyocytes hypertrophy through restoration of autophagy flux by activation of ctsb and inhibiting ros/p38/jnk pathway, exhibiting a feedback loop on regulation of autophagy and cardiomyocytes hypertrophy. |
2021-11-10 |
2023-08-13 |
rat |
| Ting-Ting Meng, Wei Wang, Fan-Liang Meng, Shu-Ya Wang, Hui-Hui Wu, Jia-Min Chen, Yan Zheng, Guang-Xin Wang, Mao-Xiu Zhang, Ying Li, Guo-Hai S. Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes. Frontiers in physiology. vol 12. 2021-06-29. PMID:34177609. |
in addition to ctsb, as we previously reported, the enzyme activity of cathepsin l (ctsl) was also decreased in lysosomes after stimulation with nicotine, which may be the main cause of the hindered mitophagic flux induced by nicotine in nrvms. |
2021-06-29 |
2023-08-13 |
rat |