| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhengda Sun, Jiqing Song, Qijun Song, Lin Li, Xinxin Tian, Lijun Wan. Recombinant human erythropoietin protects against immature brain damage induced by hypoxic/ischemia insult. Neuroreport. vol 34. issue 17. 2023-11-08. PMID:37938927. |
the proportion of tunel positive neurons and the expression of cox-2 and caspase-3 proteins in brain tissue in the hippocampus and cortex was decreased, while the expression of p-akt protein was upregulated (p\xe2\x80\x85<\xe2\x80\x850.05). |
2023-11-08 |
2023-11-20 |
human |
| Katarzyna Stachowic. Deciphering the mechanisms of reciprocal regulation or interdependence at the cannabinoid CB1 receptors and cyclooxygenase-2 level: Effects on mood, cognitive implications, and synaptic signaling. Neuroscience and biobehavioral reviews. 2023-10-28. PMID:37898448. |
in addition, cox-2 regulates the formation of cb1 ligands, which reduce excitatory transmission in the hippocampus (hc). |
2023-10-28 |
2023-11-08 |
Not clear |
| Chidinma P Anyachor, Chinna N Orish, Anthonet N Ezejiofor, Ana Cirovic, Aleksandar Cirovic, Kenneth M Ezealisiji, Orish E Orisakw. Nickel and aluminium mixture elicit memory impairment by activation of oxidative stress, COX-2, and diminution of AChE, BDNF and NGF levels in cerebral cortex and hippocampus of male albino rats. Current research in toxicology. vol 5. 2023-10-16. PMID:37841055. |
nickel and aluminium mixture elicit memory impairment by activation of oxidative stress, cox-2, and diminution of ache, bdnf and ngf levels in cerebral cortex and hippocampus of male albino rats. |
2023-10-16 |
2023-11-08 |
rat |
| Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. |
the mrna expressions and the relative protein expressions of interleukin-1\xce\xb2(il-1\xce\xb2), interleukin-18(il-18), cyclooxyganese-2(cox-2) and glutamyl-prolyl-trna synthetase(eprs) in the hippocampus of mice were determined by quantitative real-time polymerase chain reaction(qrt-pcr) and immunohistochemistry, respectively. |
2023-07-20 |
2023-08-14 |
mouse |
| Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. |
the experimental results indicated that compared with the normal group, the model group had reduced glucose consumption and lowered number of total activities in open field test(p<0.05, p<0.01), prolonged first feeding latency in no-velty-suppressed feeding test(p<0.01), and significant depression-like behavior; the contents of il-1\xce\xb2, il-18, cox-2, and eprs in hippocampus were increased(p<0.05, p<0.01), with hippocampal microglia activation and obvious neuronal damage. |
2023-07-20 |
2023-08-14 |
mouse |
| Ying He, Man-Shu Zou, Ting-Ting Ren, Ping Li, Yang Liu, Yuan-Shan Ha. [Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475079. |
compared with the model group, the positive drug group and the xkjr group presented an improvement in depressive behaviors, a decrease in the contents of il-1\xce\xb2, il-18, cox-2 and eprs in hippocampus, and an alleviation in the activation of hippocampal microglia and neuronal damage; the tumor suppression rates of positive drug and xkjr were 40.32% and 48.83%, respectively, suggesting a lower tumor growth rate than that of the model group. |
2023-07-20 |
2023-08-14 |
mouse |
| Rengasamy Balakrishnan, Yon-Suk Kim, Ga-Won Kim, Woo-Jung Kim, Sun-Mee Hong, Choong-Gon Kim, Dong-Kug Cho. Standardized extract of Glehnia Littoralis abrogates memory impairment and neuroinflammation by regulation of CREB/BDNF and NF-\\xce\\xbaB/MAPK signaling in scopolamine-induced amnesic mice model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-08. PMID:37421783. |
correspondingly, gle treatment significantly decreased the ache level and upregulated the protein expression of neuroprotective markers, such as bdnf and creb, as well as nrf2/ho-1 and decreased the levels of inos and cox-2 in the hippocampus and cortex. |
2023-07-08 |
2023-08-14 |
mouse |
| Katarzyna Stachowicz, Patrycja Pa\\xc5\\x84czyszyn-Trzewik, Magdalena Sowa-Ku\\xc4\\x87ma, Paulina Miszta. Changes in working memory induced by lipopolysaccharide administration in mice are associated with metabotropic glutamate receptors 5 and contrast with changes induced by cyclooxygenase-2: Involvement of postsynaptic density protein 95 and down syndrome cell adhesion molecule. Neuropeptides. vol 100. 2023-05-14. PMID:37182274. |
here, the effects of treatment with an antagonist of mglur5 (mtep) and ns398 (cyclooxygenase-2, cox-2 inhibitor) on psd95, mtor, and dscam in the hippocampus (hc) of c57b1/6\xc2\xa0j mice using western blots in the context of learning were examined. |
2023-05-14 |
2023-08-14 |
mouse |
| Amira E El-Nahas, Heba M Elbedaiwy, Inas M Masoud, Rania G Aly, Maged W Helmy, Amal H El-Kame. Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023-04-17. PMID:37068561. |
the hippocampal tissue of rats receiving b2 showed signs of reduced neuro-degeneration, remarkably lower expression levels of cox-2 and tnf-\xce\xb1, and enhanced antioxidant activity. |
2023-04-17 |
2023-08-14 |
rat |
| In-Seo Lee, Ga-Young Choi, Inturu Sreelatha, Ji-Won Yoon, Suk-Hee Youn, Sungho Maeng, Ji-Ho Par. Effect of Sinapic Acid on Scopolamine-Induced Learning and Memory Impairment in SD Rats. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979237. |
in addition, sinapic acid weakened the inhibition of the brain-derived neurotrophic factor (bdnf), tropomyosin receptor kinase b (trkb) and the activation of prostaglandin-endoperoxide synthase 2 (cox-2) and interleukin 1 beta (il-1\xce\xb2) induced by scopolamine in the hippocampus. |
2023-03-29 |
2023-08-14 |
rat |
| Varun Rawat, Clifford L Eastman, Radhika Amaradhi, Avijit Banik, Jason S Fender, Raymond J Dingledine, Raimondo D'Ambrosio, Thota Ganes. Temporal Expression of Neuroinflammatory and Oxidative Stress Markers and Prostaglandin E2 Receptor EP2 Antagonist Effect in a Rat Model of Epileptogenesis. ACS pharmacology & translational science. vol 6. issue 1. 2023-01-19. PMID:36654746. |
fpi results in increased mrna expression of inflammatory mediators including cyclooxygenase-2 (cox-2) and prostanoid receptor ep2, marker of oxidative stress (nox2), astrogliosis (gfap), and microgliosis (cd11b) in ipsilateral cortex and hippocampus. |
2023-01-19 |
2023-08-14 |
rat |
| Varun Rawat, Clifford L Eastman, Radhika Amaradhi, Avijit Banik, Jason S Fender, Raymond J Dingledine, Raimondo D'Ambrosio, Thota Ganes. Temporal Expression of Neuroinflammatory and Oxidative Stress Markers and Prostaglandin E2 Receptor EP2 Antagonist Effect in a Rat Model of Epileptogenesis. ACS pharmacology & translational science. vol 6. issue 1. 2023-01-19. PMID:36654746. |
the analysis of protein levels indicated a significant increase in the expression of cox-2 in ipsilateral hippocampus and cortex post-fpi. |
2023-01-19 |
2023-08-14 |
rat |
| Ying He, Yuanshan Han, Xiaolin Liao, Manshu Zou, Yuhong Wan. Biology of cyclooxygenase-2: An application in depression therapeutics. Frontiers in psychiatry. vol 13. 2022-11-28. PMID:36440427. |
this paper summarizes the relationship between cox-2 and depression in terms of neuroinflammation, intestinal flora, neurotransmitters, hpa axis, mitochondrial dysfunction and hippocampal neuronal damage, which can provide a reference for further preventive control, clinical treatment and scientific research on depression. |
2022-11-28 |
2023-08-14 |
Not clear |
| Benneth Ben-Azu, Olusegun G Adebayo, Thiophilus Aghogho Jarikre, Mega O Oyovwi, Kesiena Emmanuel Edje, Itivere Adrian Omogbiya, Anthony T Eduviere, Emuesiri Goodies Moke, Bienose S Chijioke, Onyebuchi S Odili, Osemudiame P Omondiabge, Aghogho Oyovbaire, Daniel T Esuku, Esther O Ozah, Kelvin Japhe. Taurine, an essential \\xce\\xb2-amino acid insulates against ketamine-induced experimental psychosis by enhancement of cholinergic neurotransmission, inhibition of oxidative/nitrergic imbalances, and suppression of COX-2/iNOS immunoreactions in mice. Metabolic brain disease. 2022-09-03. PMID:36057735. |
brain oxidative/nitrergic imbalance, immunoreactivity (cox-2 and inos), and cholinergic markers were determined in the striatum, prefrontal-cortex, and hippocampus. |
2022-09-03 |
2023-08-14 |
mouse |
| Mohammad Rumman, Shivani Pandey, Babita Singh, Mrinal Gupta, Abbas Ali Mahd. Genistein suppresses microglial activation and inhibits apoptosis in different brain regions of hypoxia-exposed mice model of amnesia. Metabolic brain disease. 2022-07-27. PMID:35895244. |
we assessed microglial activation in the hippocampus, amygdala, and pre-frontal cortex (pfc) regions by evaluating the iba-1 and gfap transcript levels, and mip-1\xce\xb2, cox-2, and il6 protein levels. |
2022-07-27 |
2023-08-14 |
mouse |
| Riaz Ahmad, Amjad Khan, Inayat Ur Rehman, Hyeon Jin Lee, Ibrahim Khan, Myeong Ok Ki. Lupeol Treatment Attenuates Activation of Glial Cells and Oxidative-Stress-Mediated Neuropathology in Mouse Model of Traumatic Brain Injury. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682768. |
similarly, our results indicated that lupeol treatment inhibited glial cell activation, p-nf-\xce\xbab, and downstream signaling molecules, such as tnf-\xce\xb1, cox-2, and il-1\xce\xb2, in the mouse cortex and hippocampus. |
2022-06-10 |
2023-08-14 |
mouse |
| Yoon Ah Jeong, Ji Hyeong Chae, Chan Ho Jang, Yoonsu Kim, Jinkyung Lee, Min Jeong Kwon, Eun Jeong Kwon, Hyo Jung Kim, Jisun Oh, Jong-Sang Ki. Wasp Venom Relieves Alzheimer's Phenotypes in 5xFAD Transgenic Mice through Inhibition of A\\xce\\xb2 Aggregation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554152. |
in particular, wv treatment increased expression of antioxidant-associated proteins, a nuclear factor erythroid-derived 2-related factor 2 (nrf2) and heme oxygenase-1 (ho-1), in the cerebral cortex and decreased inflammation-associated protein, cyclooxygenase-2 (cox-2), amyloid beta (a\xce\xb2) plaque-associated proteins, c-terminal fragment (c99), and beta-site amyloid precursor protein cleaving enzyme 1 (bace1, \xce\xb2-secretase) in the hippocampal tissue homogenates. |
2022-05-13 |
2023-08-13 |
mouse |
| Mai Abul, Maie Dawoud Al-Bader, Abdeslam Mouihat. Prenatal Activation of Glucocorticoid Receptors Induces Memory Impairment in a Sex-Dependent Manner: Role of Cyclooxygenase-2. Molecular neurobiology. 2022-04-09. PMID:35396693. |
prenatal dex enhanced the expression of cox-2 protein and cox-2 mrna in the dorsal hippocampus of adult female but not male rats. |
2022-04-09 |
2023-08-13 |
rat |
| Yasmin A Ebedy, Eman I Hassanen, Ahmed M Hussien, Marwa A Ibrahim, M O Elshazl. Neurobehavioral Toxicity Induced by Carbendazim in Rats and the Role of iNOS, Cox-2, and NF-\\xce\\xbaB Signalling Pathway. Neurochemical research. 2022-03-21. PMID:35312909. |
there were extensive neuropathological alterations in the cerebrum, hippocampus, and cerebellum with strong caspase-3, inos, cox-2 protein expressions mainly in rats receiving 600\xc2\xa0mg/kg cbz at each time point. |
2022-03-21 |
2023-08-13 |
human |
| Ali Jaafari Suha, Seyed Shahabeddin Sadr, Mehrdad Roghani, Saeed Mohammadian Haftcheshmeh, Safoura Khamse, Amir Abbas Momtazi-Borojen. Ferulic acid attenuates kainate-induced neurodegeneration in a rat post-status epilepticus model. Current molecular pharmacology. 2022-03-02. PMID:35232370. |
histopathological evaluations including nissl staining and immunohistochemical staining of cyclooxygenase-2 (cox-2), and neural nitric oxide synthases (nnos) were performed for the ca3 region of the hippocampus. |
2022-03-02 |
2023-08-13 |
human |