| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiunn-Min Shieh, Yih-Jeng Tsai, Ming-Chieh Ma, Chih-Li Chen, Wen-Bin W. The cyclooxygenase-2 upregulation mediates production of PGE2 autacoid to positively regulate interleukin-6 secretion in chronic rhinosinusitis with nasal polyps and polyp-derived fibroblasts. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555391. |
the cox-2 protein and mrna expression was found higher in nps than that in the control and crssnp patients' nasal tissues, mainly located at the epithelium and subepithelial stroma. |
2024-03-30 |
2024-04-02 |
human |
| Jialong Fan, Bin Liu, Ying Long, Zhou Wang, Chunyi Tong, Wei Wang, Peidong You, Xuanming Li. Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition. Acta biomaterialia. vol 113. 2021-05-14. PMID:32569637. |
in vivo assay indicated that the accumulation of gtdc@m-r nps in tumor sites increased about 2-fold compared to naked gtdc nps, which was accompanied by high tumor apoptosis rates through blocking chemotherapy-activated cyclooxygenase-2 (cox-2) and enhancing dox's anti-tumor activity of chemical drugs (85%). |
2021-05-14 |
2023-08-13 |
mouse |
| Hong Joon Choi, Somang Choi, Jae Gyoon Kim, Mi Hyun Song, Kyu-Sik Shim, Youn-Mook Lim, Hak-Jun Kim, Kyeongsoon Park, Sung Eun Ki. Enhanced tendon restoration effects of anti-inflammatory, lactoferrin-immobilized, heparin-polymeric nanoparticles in an Achilles tendinitis rat model. Carbohydrate polymers. vol 241. 2021-01-20. PMID:32507170. |
long-term lf-deliverable nps (lf/hep-plga nps) remarkably decreased mrna levels of pro-inflammatory factors [cyclooxygenase-2 (cox-2), il-1β, matrix metalloproteinase-3 (mmp-3), mmp-13, il-6, and tumor necrosis factor-α (tnf-α)] and increased mrna levels of anti-inflammatory cytokines (il-4 and il-10) in both il-1β-treated tenocytes and the achilles tendons of a collagenase-induced achilles tendinitis rat model. |
2021-01-20 |
2023-08-13 |
rat |
| Dong-Yung Kim, Jun-Hyung Kim, Jae-Chul Lee, Moo-Ho Won, Se-Ran Yang, Hyoung-Chun Kim, Myung-Bok Wi. Zinc Oxide Nanoparticles Exhibit Both Cyclooxygenase- and Lipoxygenase-Mediated Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells. Toxicological research. vol 35. issue 1. 2020-09-29. PMID:30766660. |
previously, we found that zinc oxide (zno) nps that are neurotoxic to human dopaminergic neuroblastoma sh-sy5y cells are mediated by lipoxygenase (lox), not cyclooxygenase-2 (cox-2). |
2020-09-29 |
2023-08-13 |
human |
| Jordi Roca-Ferrer, Francesc J Garcia-Garcia, Javier Pereda, Maria Perez-Gonzalez, Laura Pujols, Isam Alobid, Joaquim Mullol, Cesar Picad. Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma. The Journal of allergy and clinical immunology. vol 128. issue 1. 2011-09-12. PMID:21397936. |
researchers have debated whether regulation of the cox enzymes (cox-1 and cox-2), which mediate production of prostaglandins (pgs), affects the pathogenesis of nasal polyps (nps) and aspirin-intolerant asthma (aia). |
2011-09-12 |
2023-08-12 |
Not clear |