| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiangyi Wang, Xiaoyu Lin, Zongshan Shen, Guoqing Li, Lei Hu, Qiong Li, Yang Li, Jinsong Wang, Chunmei Zhang, Songlin Wang, Xiaoshan W. AKT from dental epithelium to papilla promotes odontoblast differentiation. Differentiation; research in biological diversity. vol 134. 2023-10-28. PMID:37898102. |
additionally, we found that de cells secreted collagen type iv alpha 6 chain (col4a6) downstream of epithelial akt signaling to positively regulate mesenchymal akt levels. |
2023-10-28 |
2023-11-08 |
Not clear |
| Mélanie H Thomas, Yujuan Gui, Pierre Garcia, Mona Karout, Borja Gomez Ramos, Christian Jaeger, Alessandro Michelucci, Anthoula Gaigneaux, Heike Kollmus, Arthur Centeno, Klaus Schughart, Rudi Balling, Michel Mittelbronn, Joseph H Nadeau, Thomas Sauter, Robert W Williams, Lasse Sinkkonen, Manuel Buttin. Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain as a novel regulator of striatal axonal branching in mice. Genes, brain, and behavior. vol 20. issue 8. 2021-11-11. PMID:34453370. |
among the five differentially expressed genes within the locus, we found that the gene coding for the collagen iv alpha 6 chain (col4a6) was expressed nine times less in a/j than in c57bl/6j. |
2021-11-11 |
2023-08-13 |
mouse |
| Dongchan Ryu, Chaeyoung Le. Expression quantitative trait loci for PI3K/AKT pathway. Medicine. vol 96. issue 1. 2017-02-15. PMID:28072738. |
they also included eqtls for type iv collagen molecules; 13 eqtls for both collagen type iv alpha 1 (col4a1) and collagen type iv alpha 2 (col4a2) and 18 eqtls for both collagen type iv alpha 5 (col4a5) and collagen type iv alpha 6 (col4a6). |
2017-02-15 |
2023-08-13 |
Not clear |
| Akira Nishimura-Tadaki, Takahito Wada, Gul Bano, Karen Gough, Janet Warner, Tomoki Kosho, Noriko Ando, Haruka Hamanoue, Hideya Sakakibara, Gen Nishimura, Yoshinori Tsurusaki, Hiroshi Doi, Noriko Miyake, Keiko Wakui, Hirotomo Saitsu, Yoshimitsu Fukushima, Fumiki Hirahara, Naomichi Matsumot. Breakpoint determination of X;autosome balanced translocations in four patients with premature ovarian failure. Journal of human genetics. vol 56. issue 2. 2011-06-02. PMID:21150920. |
interestingly, col4a6 at xq22.3 encoding collagen type iv alpha 6 was disrupted by the translocation in one case, but in the remaining three cases, breakpoints did not involve any x-linked genes. |
2011-06-02 |
2023-08-12 |
Not clear |
| R Garcia-Torres, D Cruz, L Orozco, L Heidet, M C Guble. Alport syndrome and diffuse leiomyomatosis. Clinical aspects, pathology, molecular biology and extracellular matrix studies. A synthesis. Nephrologie. vol 21. issue 1. 2000-04-20. PMID:10730274. |
mutations of both the col4a5 and col4a6 genes, located head to head in xq22 encoding the alpha 5 and alpha 6(iv) chains are responsible for the abnormalities. |
2000-04-20 |
2023-08-12 |
Not clear |
| H H Lemmink, C H Schröder, L A Monnens, H J Smeet. The clinical spectrum of type IV collagen mutations. Human mutation. vol 9. issue 6. 1997-08-22. PMID:9195222. |
the predominant form of alport syndrome is x-linked; more than 160 different mutations have yet been identified in the type iv collagen alpha 5 chain (col4a5) gene, located at xq22-24 head to head to the col4a6 gene. |
1997-08-22 |
2023-08-12 |
Not clear |
| L Heidet, Y Cai, Y Sado, Y Ninomiya, P Thorner, L Guicharnaud, E Boye, V Chauvet, L C Solal, A Beziau, R G Torres, C Antignac, M C Guble. Diffuse leiomyomatosis associated with X-linked Alport syndrome: extracellular matrix study using immunohistochemistry and in situ hybridization. Laboratory investigation; a journal of technical methods and pathology. vol 76. issue 2. 1997-03-18. PMID:9042160. |
despite the deletion, a col4a6 transcript including exon 4, but not exon 3, was found in a tumor sample, raising the possibility of the involvement of a truncated alpha 6(iv) chain in the tumorous process. |
1997-03-18 |
2023-08-12 |
Not clear |
| L Heidet, Y Cai, Y Sado, Y Ninomiya, P Thorner, L Guicharnaud, E Boye, V Chauvet, L C Solal, A Beziau, R G Torres, C Antignac, M C Guble. Diffuse leiomyomatosis associated with X-linked Alport syndrome: extracellular matrix study using immunohistochemistry and in situ hybridization. Laboratory investigation; a journal of technical methods and pathology. vol 76. issue 2. 1997-03-18. PMID:9042160. |
families with this condition are consistently found to have deletions encompassing the 5' ends of both the alpha 5 chain of type iv collagen (col4a5) and the alpha 6 chain of type iv collagen (col4a6) genes, always limited in col4a6 to exons 1', 1, and 2. |
1997-03-18 |
2023-08-12 |
Not clear |
| K Dahan, L Heidet, J Zhou, G Mettler, K A Leppig, W Proesmans, A David, B Roussel, J G Mongeau, J M Goul. Smooth muscle tumors associated with X-linked Alport syndrome: carrier detection in females. Kidney international. vol 48. issue 6. 1996-03-27. PMID:8587250. |
x-linked alport syndrome (as) associated with diffuse esophageal leiomyomatosis (dl) has been reported to be due to deletions removing the 5' ends of both the col4a5 and col4a6 genes, encoding the alpha 5 and alpha 6 chains of type iv collagen, respectively, whereas a variety of mutations in col4a5 has been identified in patients with as alone. |
1996-03-27 |
2023-08-12 |
Not clear |
| T Oohashi, Y Ueki, M Sugimoto, Y Ninomiy. Isolation and structure of the COL4A6 gene encoding the human alpha 6(IV) collagen chain and comparison with other type IV collagen genes. The Journal of biological chemistry. vol 270. issue 45. 1995-12-26. PMID:7592929. |
the genes col4a5 and col4a6, coding for the basement membrane collagen chains, alpha 5(iv) and alpha 6(iv), respectively, are located head-to-head in close proximity on human chromosome xq22, and col4a6 is transcribed from two alternative promoters in a tissue-specific fashion (sugimoto m., oohashi t., and ninomiya y. |
1995-12-26 |
2023-08-12 |
human |
| T Oohashi, Y Ueki, M Sugimoto, Y Ninomiy. Isolation and structure of the COL4A6 gene encoding the human alpha 6(IV) collagen chain and comparison with other type IV collagen genes. The Journal of biological chemistry. vol 270. issue 45. 1995-12-26. PMID:7592929. |
isolation and structure of the col4a6 gene encoding the human alpha 6(iv) collagen chain and comparison with other type iv collagen genes. |
1995-12-26 |
2023-08-12 |
human |
| M Sugimoto, T Oohashi, Y Ninomiy. The genes COL4A5 and COL4A6, coding for basement membrane collagen chains alpha 5(IV) and alpha 6(IV), are located head-to-head in close proximity on human chromosome Xq22 and COL4A6 is transcribed from two alternative promoters. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 24. 1994-12-27. PMID:7972123. |
the genes col4a5 and col4a6, coding for basement membrane collagen chains alpha 5(iv) and alpha 6(iv), are located head-to-head in close proximity on human chromosome xq22 and col4a6 is transcribed from two alternative promoters. |
1994-12-27 |
2023-08-12 |
human |
| J Zhou, M Ding, Z Zhao, S T Reeder. Complete primary structure of the sixth chain of human basement membrane collagen, alpha 6(IV). Isolation of the cDNAs for alpha 6(IV) and comparison with five other type IV collagen chains. The Journal of biological chemistry. vol 269. issue 18. 1994-06-09. PMID:8175748. |
we have recently isolated part of the cdna for a novel type iv collagen, alpha 6(iv), and shown that col4a6, the gene encoding this new chain, is deleted in alport syndrome-associated leiomyomatosis (zhou, j., mochizuki, t., smeets, h., antignac, c., laurila, p., de paepe, a., tryggvason, k., and reeders, s. t. (1993) science 261, 1167-1169). |
1994-06-09 |
2023-08-12 |
human |
| J Zhou, T Mochizuki, H Smeets, C Antignac, P Laurila, A de Paepe, K Tryggvason, S T Reeder. Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors. Science (New York, N.Y.). vol 261. issue 5125. 1993-09-21. PMID:8356449. |
the gene encoding alpha 6(iv) collagen, col4a6, was identified on the human x chromosome in a head-to-head arrangement and within 452 base pairs of the alpha 5(iv) collagen gene, col4a5. |
1993-09-21 |
2023-08-12 |
human |