| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pippa F Cosper, Maha Paracha, Kathryn M Jones, Laura Hrycyniak, Les Henderson, Ava Bryan, Diego Eyzaguirre, Emily McCunn, Elizabeth Boulanger, Jun Wan, Kwangok P Nickel, Vanessa Horner, Rong Hu, Paul M Harari, Randall J Kimple, Beth A Weave. Chromosomal instability increases radiation sensitivity. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345631. |
docetaxel causes cell death by inducing cin due to abnormal multipolar spindles rather than causing mitotic arrest, as previously assumed. |
2024-09-30 |
2024-10-02 |
Not clear |
| John B Tucker, Caleb L Carlsen, Christina M Scribano, Srishrika M Pattaswamy, Mark E Burkard, Beth A Weave. CENP-E inhibition induces chromosomal instability and synergizes with diverse microtubule-targeting agents in breast cancer. Cancer research. 2024-06-04. PMID:38832939. |
while maintenance of multipolar spindles can generate cytotoxic rates of chromosomal instability (cin), focusing of aberrant multipolar spindles into normal bipolar spindles dramatically reduces cin and confers resistance to microtubule poisons. |
2024-06-04 |
2024-06-06 |
Not clear |
| Andrew R Lynch, Shermineh Bradford, Amber S Zhou, Kim Oxendine, Les Henderson, Vanessa L Horner, Beth A Weaver, Mark E Burkar. A survey of chromosomal instability measures across mechanistic models. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 16. 2024-04-08. PMID:38588415. |
we evaluated measures of cin by comparing quantitative methods using specific, inducible phenotypic cin models of chromosome bridges, pseudobipolar spindles, multipolar spindles, and polar chromosomes. |
2024-04-08 |
2024-04-11 |
human |
| Amber S Zhou, John B Tucker, Christina M Scribano, Andrew R Lynch, Caleb L Carlsen, Sophia T Pop-Vicas, Srishrika M Pattaswamy, Mark E Burkard, Beth A Weave. Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles. PLoS biology. vol 21. issue 10. 2023-10-26. PMID:37883329. |
however, we recently demonstrated that intratumoral paclitaxel concentrations are insufficient to induce mitotic arrest and rather induce chromosomal instability (cin) via multipolar mitotic spindles. |
2023-10-26 |
2023-11-08 |
human |
| Andrew R Lynch, Shermineh Bradford, Amber S Zhou, Kim Oxendine, Les Henderson, Vanessa L Horner, Beth A Weaver, Mark E Burkar. A survey of CIN measures across mechanistic models. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398147. |
we evaluated measures of cin by comparing quantitative methods using specific, inducible phenotypic cin models of chromosome bridges, pseudobipolar spindles, multipolar spindles, and polar chromosomes. |
2023-07-03 |
2023-08-14 |
human |
| Carolyn Marquis, Cindy L Fonseca, Katelyn A Queen, Lisa Wood, Sarah E Vandal, Heidi L H Malaby, Joseph E Clayton, Jason Stumpf. Chromosomally unstable tumor cells specifically require KIF18A for proliferation. Nature communications. vol 12. issue 1. 2021-03-02. PMID:33619254. |
following kif18a inhibition, cin tumor cells exhibit mitotic delays, multipolar spindles, and increased cell death. |
2021-03-02 |
2023-08-13 |
Not clear |
| Lia Mara Gomes Paim, Greg FitzHarri. Tetraploidy causes chromosomal instability in acentriolar mouse embryos. Nature communications. vol 10. issue 1. 2020-02-06. PMID:31645568. |
the current model for how tetraploidy drives cin in mammalian cells is that a doubling of the number of centrioles that accompany the genome doubling event leads to multipolar spindle formation and chromosome segregation errors. |
2020-02-06 |
2023-08-13 |
mouse |
| Therese Wilhelm, Anna-Maria Olziersky, Daniela Harry, Filipe De Sousa, Helène Vassal, Anja Eskat, Patrick Merald. Mild replication stress causes chromosome mis-segregation via premature centriole disengagement. Nature communications. vol 10. issue 1. 2020-01-07. PMID:31395887. |
we postulate that replication stress in cancer cells induces numerical cin via transient multipolar spindles caused by premature centriole disengagement. |
2020-01-07 |
2023-08-13 |
Not clear |
| Ravi Kiran Deevi, Arman Javadi, Jane McClements, Jekaterina Vohhodina, Kienan Savage, Maurice Bernard Loughrey, Emma Evergren, Frederick Charles Campbel. Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring. The Journal of pathology. vol 244. issue 4. 2019-07-15. PMID:29520890. |
by contrast, defective anchoring of extra centrosomes promoted multipolar spindle formation, chromosomal instability (cin), disruption of glandular morphology, and cell outgrowth across the extracellular matrix interface characteristic of aggressive, high-grade crc. |
2019-07-15 |
2023-08-13 |
human |
| Alka Bhatia, Yashwant Kuma. Relevance of microscopic indicators of chromosomal instability in routine reporting of malignancies. Diagnostic cytopathology. vol 42. issue 2. 2014-07-17. PMID:23754835. |
therefore, this article tries to revisit the already described morphological indicators of cin like multipolar mitoses, chromatin bridges, chromatin strings, nuclear heterogeneity, laggards, nuclear buds, micronuclei, and multinucleated micronucleated cells. |
2014-07-17 |
2023-08-12 |
human |
| Corinna Herz, Fabienne Schlürmann, Daniela Batarello, Christiane D Fichter, Anja Schöpflin, Claudia Münch, Dieter Hauschke, Martin Werner, Silke Lassman. Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition. Molecular carcinogenesis. vol 51. issue 9. 2012-09-27. PMID:21739483. |
in situ, three-dimensional immunofluorescence (3d-if) revealed aurora a positive multipolar mitoses in both cin- (n = 8) and min- (n = 10) type primary crcs with similar frequencies (cin: 27 ± 14%; min: 34 ± 14%, p = 0.224). |
2012-09-27 |
2023-08-12 |
Not clear |
| Corentin Laulier, Anita Cheng, Jeremy M Star. The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation. Nucleic acids research. vol 39. issue 14. 2011-10-17. PMID:21459848. |
we suggest that mild hdr disruption favors the proliferation of cells that are prone to cin due to defective chromosome separation during anaphase, whereas, severe hdr deficiency leads to multipolar divisions that are prohibitive for cell proliferation. |
2011-10-17 |
2023-08-12 |
Not clear |
| William T Silkworth, Isaac K Nardi, Lindsey M Scholl, Daniela Cimin. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PloS one. vol 4. issue 8. 2010-01-19. PMID:19668340. |
finally, we found that multipolar cin prometaphases typically possessed gamma-tubulin at all spindle poles, and that a significant fraction of bipolar metaphase/early anaphase cin cells possessed more than one centrosome at a single spindle pole. |
2010-01-19 |
2023-08-12 |
Not clear |
| William T Silkworth, Isaac K Nardi, Lindsey M Scholl, Daniela Cimin. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PloS one. vol 4. issue 8. 2010-01-19. PMID:19668340. |
however, multipolar anaphase cells were very rare, and live-cell experiments showed that almost all cin cells divided in a bipolar fashion. |
2010-01-19 |
2023-08-12 |
Not clear |
| William T Silkworth, Isaac K Nardi, Lindsey M Scholl, Daniela Cimin. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PloS one. vol 4. issue 8. 2010-01-19. PMID:19668340. |
we found that cin cells frequently assembled multipolar spindles in early mitosis. |
2010-01-19 |
2023-08-12 |
Not clear |
| William T Silkworth, Isaac K Nardi, Lindsey M Scholl, Daniela Cimin. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PloS one. vol 4. issue 8. 2010-01-19. PMID:19668340. |
moreover, fixed-cell analysis showed high frequencies of merotelically attached lagging chromosomes in bipolar anaphase cin cells, and higher frequencies of merotelic attachments in multipolar vs. bipolar prometaphases. |
2010-01-19 |
2023-08-12 |
Not clear |
| Neil J Ganem, Susana A Godinho, David Pellma. A mechanism linking extra centrosomes to chromosomal instability. Nature. vol 460. issue 7252. 2009-09-02. PMID:19506557. |
thus, multipolar divisions cannot explain observed rates of cin. |
2009-09-02 |
2023-08-12 |
human |
| Neil J Ganem, Susana A Godinho, David Pellma. A mechanism linking extra centrosomes to chromosomal instability. Nature. vol 460. issue 7252. 2009-09-02. PMID:19506557. |
it has been proposed that extra centrosomes generate cin by promoting multipolar anaphase, a highly abnormal division that produces three or more aneuploid daughter cells. |
2009-09-02 |
2023-08-12 |
human |