All Relations between ced-9 and egl-1

Publication Sentence Publish Date Extraction Date Species
Shun-Chang Wang, Zhi-Zhong Geng, Yun Wang, Zhong-Hua Tong, Han-Qing Y. Essential roles of p53 and MAPK cascades in microcystin-LR-induced germline apoptosis in Caenorhabditis elegans. Environmental science & technology. vol 46. issue 6. 2012-09-13. PMID:22353034. mc-lr-induced apoptosis was blocked in bcl-2 gain-of-function strain ced-9(n1950), whereas it showed a slight increase in bh3-only protein egl-1 mutated strain. 2012-09-13 2023-08-12 caenorhabditis_elegans
E Pourkarimi, S Greiss, A Gartne. Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction. Cell death and differentiation. vol 19. issue 3. 2012-06-08. PMID:21886181. in c. elegans, the bh3-only domain protein egl-1, the apaf-1 homolog ced-4 and the ced-3 caspase are required for apoptosis induction, whereas the bcl-2 homolog ced-9 prevents apoptosis. 2012-06-08 2023-08-12 caenorhabditis_elegans
David G Breckenridge, Byung-Ho Kang, Ding Xu. Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans. Current biology : CB. vol 19. issue 9. 2009-08-11. PMID:19327994. to better understand the potential roles of bcl-2 family proteins in regulating mitochondrial dynamics, we carried out a detailed analysis of mitochondria in animals that either lose or have increased activity of egl-1 and ced-9, two bcl-2 family genes that induce and inhibit apoptosis in c. elegans, respectively. 2009-08-11 2023-08-12 caenorhabditis_elegans
Qinfang Shen, Fengsong Qin, Zhiyang Gao, Jie Cui, Hui Xiao, Zhiheng Xu, Chonglin Yan. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Molecular and cellular biology. vol 29. issue 14. 2009-07-13. PMID:19414600. in cells destined to die, egl-1 binds to ced-9 and results in the release of ced-4 from the mitochondrion-tethered ced-9-ced-4 complex to the perinucleus, which facilitates processing of the ced-3 caspase to cause apoptosis. 2009-07-13 2023-08-12 caenorhabditis_elegans
Shunchang Wang, Lijun Wu, Yun Wang, Xun Luo, Yun L. Copper-induced germline apoptosis in Caenorhabditis elegans: the independent roles of DNA damage response signaling and the dependent roles of MAPK cascades. Chemico-biological interactions. vol 180. issue 2. 2009-06-26. PMID:19497412. the knockout of checkpoint genes hus-1, clk-2, the bcl-2 homolog ced-9, and the bh3-only domain egl-1 did not prevent cells of the germline from copper-induced apoptosis. 2009-06-26 2023-08-12 caenorhabditis_elegans
E S Blum, M Driscoll, S Shaha. Noncanonical cell death programs in the nematode Caenorhabditis elegans. Cell death and differentiation. vol 15. issue 7. 2008-08-28. PMID:18437162. genetic studies of the nematode caenorhabditis elegans have uncovered four genes, egl-1 (bh3 only), ced-9 (bcl-2 related), ced-4 (apoptosis protease activating factor-1), and ced-3 (caspase), which function in a linear pathway to promote developmental cell death in this organism. 2008-08-28 2023-08-12 caenorhabditis_elegans
Sebastian Greiss, Björn Schumacher, Kaj Grandien, Jonathan Rothblatt, Anton Gartne. Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. BMC genomics. vol 9. 2008-08-20. PMID:18627611. egl-1 and ced-13 proteins inactivate bcl-2 like ced-9 to trigger ced-4 and ced-3 caspase dependent germ cell apoptosis. 2008-08-20 2023-08-12 caenorhabditis_elegans
Hillel T Schwartz, H Robert Horvit. The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes & development. vol 21. issue 23. 2008-01-04. PMID:18056428. the established mechanism for the regulation of specific programmed cell deaths in c. elegans is the transcriptional control of the bh3-only gene egl-1, which inhibits the bcl-2 homolog ced-9; similarly, most regulation of vertebrate apoptosis involves the bcl-2 superfamily. 2008-01-04 2023-08-12 mouse
Yonatan B Tzur, Ayelet Margalit, Naomi Melamed-Book, Yosef Gruenbau. Matefin/SUN-1 is a nuclear envelope receptor for CED-4 during Caenorhabditis elegans apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 36. 2006-10-19. PMID:16938876. induction of apoptosis begins when the proapoptotic protein egl-1 is expressed and binds ced-9. 2006-10-19 2023-08-12 caenorhabditis_elegans
W D Fairlie, M A Perugini, M Kvansakul, L Chen, D C S Huang, P M Colma. CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13. Cell death and differentiation. vol 13. issue 3. 2006-04-20. PMID:16167070. in cells undergoing apoptosis, the bcl-2 homology domain 3 (bh3)-only protein egl-1 binds to ced-9 at the mitochondrial membrane to cause the release of ced-4, which oligomerises and facilitates the activation of the caspase ced-3. 2006-04-20 2023-08-12 caenorhabditis_elegans
G V Putcha, E M Johnso. Men are but worms: neuronal cell death in C elegans and vertebrates. Cell death and differentiation. vol 11. issue 1. 2004-08-25. PMID:14647239. their studies of lineage determination in worms established the 'central dogma' of apoptosis: the bh3-only protein egl-1 is induced in cells destined to die, interacts with the bcl-2-like inhibitor ced-9, displacing the adaptor ced-4, which then promotes activation of the caspase ced-3. 2004-08-25 2023-08-12 human
J Parrish, H Metters, L Chen, D Xu. Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 22. 2000-11-28. PMID:11027303. we show here that an unusual gain-of-function mutation in ced-9 (substitution of glycine 169 to glutamate) that results in potent inhibition of most nematode cell deaths impairs the binding of egl-1 to ced-9 and egl-1-induced release of ced-4 from ced-4/ced-9 complexes. 2000-11-28 2023-08-12 caenorhabditis_elegans
L del Peso, V M Gonzalez, N Inohara, R E Ellis, G Núñe. Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. The Journal of biological chemistry. vol 275. issue 35. 2000-10-03. PMID:10846174. finally, the ability of egl-1 to promote apoptosis is impaired by the replacement of wild-type ced-9 with ced-9g169e, and this effect is correlated with the inability of egl-1 to induce the displacement of ced-4 from the ced-9.ced-4 complex. 2000-10-03 2023-08-12 caenorhabditis_elegans
Q A Liu, M O Hengartne. The molecular mechanism of programmed cell death in C. elegans. Annals of the New York Academy of Sciences. vol 887. 2000-02-25. PMID:10668467. these 15 genes have been divided into four groups based on the order of their activity during the process of programmed cell death: (1) those involved in the decision making (ces-1 and ces-2); (2) in the process of execution (ced-3, ced-4, ced-9 and egl-1); (3) in the engulfment of dying cells by engulfing cells (ced-1, ced-2, ced-5, ced-6, ced-7, ced-10, ced-12); and (4) those in the degradation of cell corpses within engulfing cells (nuc-1). 2000-02-25 2023-08-12 caenorhabditis_elegans