| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuting Shao, Yunhui Li, Dayong Wan. Polylactic acid microplastics cause transgenerational reproductive toxicity associated with activation of insulin and hedgehog ligands in C. elegans. The Science of the total environment. 2024-06-08. PMID:38851356. |
meanwhile, transgenerational increase in germline apoptosis was detected after pla-mp exposure at p0-g, which was associated with transgenerational dysregulation in expressions of genes governing apoptosis (ced-3, ced-4, egl-1, and ced-9) and dna damage related genes (cep-1, mrt-2, hus-1, and clk-2). |
2024-06-08 |
2024-06-11 |
caenorhabditis_elegans |
| Yuting Shao, Xin Hua, Yunhui Li, Dayong Wan. Comparison of reproductive toxicity between pristine and aged polylactic acid microplastics in Caenorhabditis elegans. Journal of hazardous materials. vol 466. 2024-01-20. PMID:38244453. |
meanwhile, aged pla-mps caused more severe enhancement in germline apoptosis and alterations in expressions of ced-9, ced-4, ced-3, and egl-1 governing cell apoptosis. |
2024-01-20 |
2024-01-23 |
caenorhabditis_elegans |
| Zhengying Liu, Xin Hua, Yue Zhao, Qian Bian, Dayong Wan. Polyethylene nanoplastics cause reproductive toxicity associated with activation of both estrogenic hormone receptor NHR-14 and DNA damage checkpoints in C. elegans. The Science of the total environment. 2023-10-01. PMID:37778542. |
accompanied with alteration in expressions of genes (egl-1, ced-9, ced-4, and ced-3) governing cell apoptosis, germline apoptosis was enhanced by pe-np. |
2023-10-01 |
2023-10-07 |
caenorhabditis_elegans |
| Yuting Shao, Yuxing Wang, Xin Hua, Yunhui Li, Dayong Wan. Polylactic acid microparticles in the range of μg/L reduce reproductive capacity by affecting the gonad development and the germline apoptosis in Caenorhabditis elegans. Chemosphere. 2023-06-14. PMID:37315859. |
moreover, the induction of germline apoptosis in pla mp exposed nematodes was suppressed by rnai of ced-3, ced-4, and egl-1, and strengthened by rnai of ced-9. |
2023-06-14 |
2023-08-14 |
caenorhabditis_elegans |
| Yuting Shao, Yuxing Wang, Xin Hua, Yunhui Li, Dayong Wan. Polylactic acid microparticles in the range of μg/L reduce reproductive capacity by affecting the gonad development and the germline apoptosis in Caenorhabditis elegans. Chemosphere. 2023-06-14. PMID:37315859. |
accompanied with the enhancement in germline apoptosis, exposure to 10 and 100 μg/l pla mp decreased expression of ced-9 and increased expressions of ced-3, ced-4, and egl-1. |
2023-06-14 |
2023-08-14 |
caenorhabditis_elegans |
| Xin Hua, Xiao Feng, Geyu Liang, Jie Chao, Dayong Wan. Long-term exposure to 6-PPD quinone reduces reproductive capacity by enhancing germline apoptosis associated with activation of both DNA damage and cell corpse engulfment in Caenorhabditis elegans. Journal of hazardous materials. vol 454. 2023-04-29. PMID:37119572. |
meanwhile, exposure to 1 and 10 μg/l 6-ppdq enhanced the germline apoptosis, which was accompanied by upregulation of ced-3, ced-4, and egl-1 expressions and downregulation of ced-9 expression. |
2023-04-29 |
2023-08-14 |
caenorhabditis_elegans |
| Xin Hua, Xiao Feng, Yingshun Hua, Dayong Wan. Paeoniflorin attenuates polystyrene nanoparticle-induced reduction in reproductive capacity and increase in germline apoptosis through suppressing DNA damage checkpoints in Caenorhabditis elegans. The Science of the total environment. 2023-02-12. PMID:36775158. |
in addition, in 100 μg/l ps-np exposed nematodes, treatment with 100 mg/l paeoniflorin modulated the expressions of genes governing germline apoptosis as indicated by the decrease in ced-3, ced-4, an egl-1 expressions and the increase in ced-9 expression. |
2023-02-12 |
2023-08-14 |
caenorhabditis_elegans |
| Yunjiang Yu, Xin Hua, Haibo Chen, Yue Yang, Yao Dang, Mingdeng Xian. Tetrachlorobisphenol A mediates reproductive toxicity in Caenorhabditis elegans via DNA damage-induced apoptosis. Chemosphere. 2022-04-15. PMID:35427672. |
apoptosis was nearly abolished in ced-4 and ced-3 mutants and blocked in hus-1, egl-1, cep-1, and ced-9 mutants. |
2022-04-15 |
2023-08-13 |
caenorhabditis_elegans |
| Chi-Wei Huang, Zhi-Ying Kung, Chia-Cheng We. UV-filter octyl methoxycinnamate causes reproductive toxicity associated with germline apoptosis and vitellogenin decrease in Caenorhabditis elegans. Aquatic toxicology (Amsterdam, Netherlands). vol 247. 2022-04-09. PMID:35397382. |
decreased mrna levels of vitellogenin-related genes (vit-2 and vit-6) and increased mrna levels of apoptosis-related genes (egl-1 and ced-3) were observed in 10 μm omc-treated c. elegans (experimental concentrations = 0, 10 μm), suggesting that reproductive toxicity was associated with decreased vitellogenin levels and germline apoptosis. |
2022-04-09 |
2023-08-13 |
caenorhabditis_elegans |
| Haibo Chen, Yue Yang, Chen Wang, Xin Hua, Hui Li, Dongli Xie, Mingdeng Xiang, Yunjiang Y. Reproductive toxicity of UV-photodegraded polystyrene microplastics induced by DNA damage-dependent cell apoptosis in Caenorhabditis elegans. The Science of the total environment. 2021-12-17. PMID:34919931. |
germline apoptosis induced by aged ps-mps was altered in egl-1, hus-1, cep-1, ced-3, ced-4, and ced-9 mutants. |
2021-12-17 |
2023-08-13 |
caenorhabditis_elegans |
| Ling Jin, Ting-Ting Dou, Jing-Ya Chen, Ming-Xiu Duan, Quan Zhen, Hua-Zhang Wu, Yun-Li Zha. Sublethal toxicity of graphene oxide in Caenorhabditis elegans under multi-generational exposure. Ecotoxicology and environmental safety. vol 229. 2021-12-11. PMID:34890989. |
simultaneously, the fertility function of the nematode was impaired under consecutive exposure as reduced brood sizes and oocytes numbers, increased apoptosis of germline, and aberrant expression of reproductive related genes ced-3, ced-4, ced-9, egl-1 and ced-13 were detected in exposed worms. |
2021-12-11 |
2023-08-13 |
human |
| Hongdan Zhang, Tongtong Liu, Xuelong Song, Qinyu Zhou, Jielin Tang, Qianyu Sun, Yuepu Pu, Lihong Yin, Juan Zhan. Study on the reproductive toxicity and mechanism of tri-n-butyl phosphate (TnBP) in Caenorhabditis elegans. Ecotoxicology and environmental safety. vol 227. 2021-11-10. PMID:34673412. |
furthermore, tnbp exposure caused abnormal gene expressions of cell apoptosis (ced-9, ced-4 and ced-3), dna damage (hus-1, clk-2, cep-1 and egl-1) and oxidative stress (mev-1 and gas-1). |
2021-11-10 |
2023-08-13 |
caenorhabditis_elegans |
| Joseph Ryan Polli, Mary Farwell, Xiaoping Pa. Detection of Caenorhabditis elegans Germ Cell Apoptosis Following Exposure to Environmental Contaminant Mixtures: A Crude Oil-Dispersant Mixture Example. Methods in molecular biology (Clifton, N.J.). vol 2326. 2021-08-13. PMID:34097257. |
in addition, qrt-pcr was utilized to demonstrate the aberrant expression of apoptosis (ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1) and cytochrome p450 (cyp14a3, cyp35a1, cyp35a2, cyp35a5, and cyp35c1) protein-coding genes following exposure to dispersed crude oil. |
2021-08-13 |
2023-08-13 |
caenorhabditis_elegans |
| N Mukherjee, N Joardar, S P Sinha Bab. Antifilarial activity of azadirachtin fuelled through reactive oxygen species induced apoptosis: a thorough molecular study on Setaria cervi. Journal of helminthology. vol 93. issue 5. 2019-08-07. PMID:30032733. |
the downregulation of anti-apoptotic ced-9 and upregulation of proapoptotic egl-1, ced-4 and ced-3 at both the transcription and translation levels confirmed apoptosis execution at the molecular level. |
2019-08-07 |
2023-08-13 |
Not clear |
| Brittany O'Donnell, Lily Huo, Joseph R Polli, Li Qiu, David N Collier, Baohong Zhang, Xiaoping Pa. From the Cover: ZnO Nanoparticles Enhanced Germ Cell Apoptosis in Caenorhabditis elegans, in Comparison with ZnCl2. Toxicological sciences : an official journal of the Society of Toxicology. vol 156. issue 2. 2018-02-15. PMID:28003440. |
genes involved in the apoptosis pathway (ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1) were in general upregulated in response to zno np exposure. |
2018-02-15 |
2023-08-13 |
caenorhabditis_elegans |
| Jerome Teuliere, Gian Garrig. Size Matters: How C. elegans Asymmetric Divisions Regulate Apoptosis. Results and problems in cell differentiation. vol 61. 2017-07-26. PMID:28409303. |
pioneering work defined a conserved apoptosis pathway that is initiated in c. elegans by the bh3-only protein egl-1 and that leads to the activation of the caspase ced-3. |
2017-07-26 |
2023-08-13 |
caenorhabditis_elegans |
| Niladri Mukherjee, Pravat Kumar Parida, Abhishek Santra, Tamashree Ghosh, Ananya Dutta, Kuladip Jana, Anup Kumar Misra, Santi P Sinha Bab. Oxidative stress plays major role in mediating apoptosis in filarial nematode Setaria cervi in the presence of trans-stilbene derivatives. Free radical biology & medicine. vol 93. 2016-12-13. PMID:26849945. |
along with the ros generation and oxidative stress, the decreased expression of anti-apoptotic ced-9 gene and increased expression of nematode specific pro-apoptotic genes, egl-1, ced-4 and ced-3 at the level of transcription and translation level; the up-regulation of caspase-3 activity and involvement of caspase-8,9,3, cytochrome-c and parp were also observed and which denotes the probable existence of both extrinsic and intrinsic pathways apoptosis in parasitic nematodes. |
2016-12-13 |
2023-08-13 |
Not clear |
| Joseph Ryan Polli, Yanqiong Zhang, Xiaoping Pa. Dispersed crude oil amplifies germ cell apoptosis in Caenorhabditis elegans, followed a CEP-1-dependent pathway. Archives of toxicology. vol 88. issue 3. 2015-05-12. PMID:24496467. |
genes involved in the apoptosis pathway were dysregulated, which include ced-13, ced-3, ced-4, ced-9, cep-1, dpl-1, efl-1, efl-2, egl-1, egl-38, lin-35, pax-2, and sir-2.1. |
2015-05-12 |
2023-08-12 |
human |
| Takashi Hirose, H Robert Horvit. An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways. Nature. vol 500. issue 7462. 2013-09-24. PMID:23851392. |
sptf-3 directly drives the transcription of the gene egl-1, which encodes a bh3-only protein that promotes apoptosis through the activation of the ced-3 caspase. |
2013-09-24 |
2023-08-12 |
caenorhabditis_elegans |
| Berangere Pinan-Lucarre, Christopher V Gabel, Christopher P Reina, S Elizabeth Hulme, Sergey S Shevkoplyas, R Daniel Slone, Jian Xue, Yujie Qiao, Sarah Weisberg, Kevin Roodhouse, Lin Sun, George M Whitesides, Aravinthan Samuel, Monica Driscol. The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans. PLoS biology. vol 10. issue 5. 2012-08-24. PMID:22629231. |
the ced-3 activator, ced-4/apaf-1, similarly promotes regeneration, but the upstream regulators of apoptosis ced-9/bcl2 and bh3-domain proteins egl-1 and ced-13 are not essential. |
2012-08-24 |
2023-08-12 |
caenorhabditis_elegans |