| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nurit Papismadov, Naama Levi, Lior Roitman, Amit Agrawal, Yossi Ovadya, Ulysse Cherqui, Reut Yosef, Hagay Akiva, Hilah Gal, Valery Krizhanovsk. p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb. The EMBO journal. 2024-09-30. PMID:39349844. |
here, we show that the cdk inhibitor p21 (cdkn1a), known to regulate the cell cycle and the viability of senescent cells, also controls the expression of extracellular matrix (ecm) components in senescent and proliferating cells of the fibrotic lung, in a manner dependent on cdk4 and rb phosphorylation. |
2024-09-30 |
2024-10-03 |
mouse |
| Majdolin Mohammed Eltayeb, Mohamed M Ali, Saeed M Omar, Nouh Saad Mohamed, Ishag Adam, Hamdan Z Hamda. Gene polymorphisms of cyclin-dependent kinase inhibitor and matrix metalloproteinase-9 in Sudanese patients with esophageal squamous cell carcinoma. Molecular genetics & genomic medicine. 2022-10-19. PMID:36259348. |
the polymorphisms of the cyclin-dependent kinase inhibitor (cdkn1a) gene and matrix metalloproteinase-9 (mmp9) gene may increase one's susceptibility to malignancies. |
2022-10-19 |
2023-08-14 |
Not clear |
| Ji-Gang Yin, Xian-Ying Liu, Bin Wang, Dan-Yang Wang, Man Wei, Hua Fang, Mei Xian. Gene expression profiling analysis of ovarian cancer. Oncology letters. vol 12. issue 1. 2020-09-30. PMID:27347159. |
meanwhile, fos (degree, 15), cd44 (degree, 9), b-cell cll/lymphoma 2 (bcl2; degree, 7), cdkn1a (degree, 7) and matrix metallopeptidase 3 (mmp3; degree, 6) had higher connectivity degrees in the ppi network for the degs. |
2020-09-30 |
2023-08-13 |
Not clear |
| Precious Takondwa Makondi, Chia-Hwa Lee, Chien-Yu Huang, Chi-Ming Chu, Yu-Jia Chang, Po-Li We. Prediction of novel target genes and pathways involved in bevacizumab-resistant colorectal cancer. PloS one. vol 13. issue 1. 2018-01-29. PMID:29342159. |
cyclin-dependent kinase inhibitor 1a(cdkn1a), toll-like receptor 4 (tlr4), cd19 molecule (cd19), breast cancer 1, early onset (brca1), platelet-derived growth factor subunit a (pdgfa), and matrix metallopeptidase 1 (mmp1) were the degs involved in the pathways and the ppis. |
2018-01-29 |
2023-08-13 |
Not clear |
| Mousumi Sahu, Bibekanand Mallic. An integrative approach predicted co-expression sub-networks regulating properties of stem cells and differentiation. Computational biology and chemistry. vol 64. 2017-11-16. PMID:27475236. |
moreover, our study identified three k-clique sub-networks regulating tgf-β signaling pathway thereby promoting ebs to fibs differentiation by: (i) modulating extracellular matrix involving itgb1, tgfb1i1 and gbp1, (ii) regulating cell cycle remodeling involving cdkn1a, junb and dusp1 and (iii) helping in epithelial to mesenchymal transition (emt) involving thbs1, inhba and lox. |
2017-11-16 |
2023-08-13 |
human |
| Sean M Garvey, Daniel S Sinden, Pamela D Schoppee Bortz, Brian R Wamhof. Cyclosporine up-regulates Krüppel-like factor-4 (KLF4) in vascular smooth muscle cells and drives phenotypic modulation in vivo. The Journal of pharmacology and experimental therapeutics. vol 333. issue 1. 2010-04-22. PMID:20089806. |
we show that the vsmc differentiation marker genes smooth muscle alpha-actin (acta2), transgelin (tagln), smoothelin (smtn), and myocardin (myocd) are all down-regulated by csa in vsmc monoculture, whereas cyclin-dependent kinase inhibitor-1a (cdkn1a) and matrix metalloproteinase-3 (mmp3) are up-regulated. |
2010-04-22 |
2023-08-12 |
rat |
| Nica M Borradaile, J Geoffrey Pickerin. Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase. American journal of physiology. Cell physiology. vol 298. issue 1. 2010-01-15. PMID:19846757. |
global gene expression analyses of tetraploid endothelial cells revealed a dysfunctional phenotype characterized by a cell cycle arrest profile (decreased ccne2/a2, rbl1, bub1b; increased cdkn1a) and increased expression of genes involved in inflammation (il32, tnfrsf21/10c, ptgs1) and extracellular matrix remodeling (col5a1, fn1, mmp10/14). |
2010-01-15 |
2023-08-12 |
human |
| Ottavia Barbieri, Simonetta Astigiano, Monica Morini, Sara Tavella, Anna Schito, Alessandro Corsi, Davide Di Martino, Paolo Bianco, Ranieri Cancedda, Silvio Garofal. Depletion of cartilage collagen fibrils in mice carrying a dominant negative Col2a1 transgene affects chondrocyte differentiation. American journal of physiology. Cell physiology. vol 285. issue 6. 2004-01-05. PMID:12917109. |
chondrocytes carrying the mutation showed altered expression of several differentiation markers, like fibroblast growth factor receptor 3 (fgfr3), indian hedgehog (ihh), runx2, cyclin-dependent kinase inhibitor p21cip/waf (cdkn1a), and collagen type x (col10a1), suggesting that a defective extracellular matrix (ecm) depleted of collagen fibrils affects chondrocytes differentiation and that this defect participates in the reduced endochondral bone growth observed in chondrodysplasias caused by mutations in col2a1. |
2004-01-05 |
2023-08-12 |
mouse |