| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nurit Papismadov, Naama Levi, Lior Roitman, Amit Agrawal, Yossi Ovadya, Ulysse Cherqui, Reut Yosef, Hagay Akiva, Hilah Gal, Valery Krizhanovsk. p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb. The EMBO journal. 2024-09-30. PMID:39349844. |
here, we show that the cdk inhibitor p21 (cdkn1a), known to regulate the cell cycle and the viability of senescent cells, also controls the expression of extracellular matrix (ecm) components in senescent and proliferating cells of the fibrotic lung, in a manner dependent on cdk4 and rb phosphorylation. |
2024-09-30 |
2024-10-03 |
mouse |
| Jiawei Li, Eyleen L K Goh, Ji He, Yan Li, Zhimin Fan, Zhigang Yu, Peng Yuan, Dong-Xu Li. Emerging Intrinsic Therapeutic Targets for Metastatic Breast Cancer. Biology. vol 12. issue 5. 2023-05-27. PMID:37237509. |
in this review, we summarize the emerging intrinsic therapeutic targets for metastatic breast cancer, including cyclin d-dependent kinases cdk4 and cdk6, the pi3k/akt/mtor pathway, the insulin/igf1r pathway, the egfr/her family, the jak/stat pathway, poly(adp-ribose) polymerases (parp), trop-2, src kinases, histone modification enzymes, activated growth factor receptors, androgen receptors, breast cancer stem cells, matrix metalloproteinases, and immune checkpoint proteins. |
2023-05-27 |
2023-08-14 |
Not clear |
| Zongang Liu, Mengnan Zhao, Xizi Jiang, Yao Zhang, Suning Zhang, Yitong Xu, Hongjiu Ren, Hongbo Su, Huanxi Wang, Xueshan Qi. Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway. Laboratory investigation; a journal of technical methods and pathology. vol 102. issue 12. 2023-02-15. PMID:36792299. |
overexpression of klhl17 in the cell lines of nsclc with klhl17-flag plasmid promoted the proliferation and migration of tumor cells, which was associated with elevated activation of rat sarcoma/mitogen-activated protein kinases (ras/mapk) signaling and increased expression of cyclin d1, cyclin d-dependent kinases 4 (cdk4), matrix metalloproteinase 2 (mmp2) and ras homolog gene family member a (rhoa). |
2023-02-15 |
2023-08-14 |
human |
| Jianhua Guan, Bin Guan, Haixia Shang, Jun Peng, Hong Yang, Jiumao Li. Babao Dan inhibits lymphangiogenesis of gastric cancer in vitro and in vivo via lncRNA-ANRIL/VEGF-C/VEGFR-3 signaling axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 154. 2022-09-04. PMID:36058147. |
in addition, wb assay found that bbd decreased the expression levels of vegf-c, vegfr-3, matrix metallopeptidase 2 (mmp2) and matrix metallopeptidase 9 (mmp9), and rt-qpcr assay found that the mrna expression levels of lncrna-anril, vegf-c, vegfr-3, mmp2, mmp9, cdk4, cyclin d1, and bcl-2 were down-regulated, and the expression of p21 and bax were increased. |
2022-09-04 |
2023-08-14 |
Not clear |
| Zongang Liu, Mengnan Zhao, Xizi Jiang, Yao Zhang, Suning Zhang, Yitong Xu, Hongjiu Ren, Hongbo Su, Huanxi Wang, Xueshan Qi. Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway. Laboratory investigation; a journal of technical methods and pathology. 2022-08-17. PMID:35978057. |
overexpression of klhl17 in the cell lines of nsclc with klhl17-flag plasmid promoted the proliferation and migration of tumor cells, which was associated with elevated activation of rat sarcoma/mitogen-activated protein kinases (ras/mapk) signaling and increased expression of cyclin d1, cyclin d-dependent kinases 4 (cdk4), matrix metalloproteinase 2 (mmp2) and ras homolog gene family member a (rhoa). |
2022-08-17 |
2023-08-14 |
human |
| Pengcheng Dou, Yu He, Bo Yu, Juan Dua. Downregulation of microRNA-29b by DNMT3B decelerates chondrocyte apoptosis and the progression of osteoarthritis via PTHLH/CDK4/RUNX2 axis. Aging. vol 13. issue 5. 2021-07-22. PMID:33177241. |
moreover, the pthlh upregulation induced by mir-29b methylation led to the enhancement of chondrocyte growth and suppression of their apoptosis and extracellular matrix degradation, which was achieved by the upregulation cyclin-dependent kinase 4 (cdk4) expression. |
2021-07-22 |
2023-08-13 |
mouse |
| Pei-Fei Li, Zhi-Xin Zhang, Xin Yuan, Hao-Jun Song, Xiao-Yun Ding, Lei X. Hsa_circ_0001696 modulates cell proliferation and migration in colorectal cancer. Oncology letters. vol 21. issue 2. 2021-02-10. PMID:33552272. |
in addition, western blot analysis demonstrated that the protein expression levels of cyclin-dependent kinase 4 (cdk4), cyclin d, cyclin e and matrix metalloproteinase 9 (mmp9) increased. |
2021-02-10 |
2023-08-13 |
human |
| Xianglu Ji, Liping Shan, Peng Shen, Ming H. Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. Cell death & disease. vol 11. issue 1. 2021-01-15. PMID:31907361. |
results indicated circ_001621-promoted osteosarcoma proliferation and migration via attenuating the inhibition of cyclin-dependent kinase 4 (cdk4) and matrix metallopeptidase 9 (mmp9) by mir-578, respectively. |
2021-01-15 |
2023-08-13 |
mouse |
| Zhongzheng Sun, Hao Xue, Yan Wei, Chaochao Wang, Rui Yu, Chengwei Wang, Shaobo Wang, Jianye Xu, Mingyu Qian, Qinghu Meng, Gang L. Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis. Clinical science (London, England : 1979). vol 133. issue 10. 2020-03-03. PMID:31076460. |
western blot analysis and lectin pull-down assays indicated that galnt2 knockdown decreased the level of phosphorylated epidermal growth factor receptor (egfr) and the expression of the tn antigen on egfr and affected the expression levels of p21, cyclin-dependent kinase 4 (cdk4), cyclind1, matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 9 (mmp9) through the egfr/pi3k/akt/mtor pathway. |
2020-03-03 |
2023-08-13 |
human |
| Hanlet Camacho-Rodríguez, Isabel A Guillen-Pérez, Juan Roca-Campaña, Julio E Baldomero-Hernández, Ángela D Tuero-Iglesias, José A Galván-Cabrera, Maciel Rodriguez-Cordero, Daniel O Palenzuela-Gardón, Jorge Berlanga-Acosta, Lidia I Novoa-Pére. Heberprot-P's Effect on Gene Expression in Healing Diabetic Foot Ulcers. MEDICC review. vol 20. issue 3. 2019-12-06. PMID:31242156. |
results after treatment, there was a statistically significant increase in expression of genes related to cell proliferation, angiogenesis and formation of extracellular matrix (pdgfb, cdk4, p21, tp53, angpt1, col1a1, mmp2 and timp2). |
2019-12-06 |
2023-08-13 |
Not clear |
| Wang Jiashi, Qiu Chuang, Zhang Zhenjun, Wang Guangbin, Li Bin, He Min. MicroRNA-506-3p inhibits osteosarcoma cell proliferation and metastasis by suppressing RAB3D expression. Aging. vol 10. issue 6. 2019-09-30. PMID:29905536. |
suppression of mir-506-3p in osteosarcoma led to increased expression of rab3d, which in turn led to increased cdk4 (cyclin-dependent kinase 4) and mmp9 (matrix metalloprotein 9) activities. |
2019-09-30 |
2023-08-13 |
Not clear |
| Yu Wang, Ting Zhang, Hongyi Zhang, Haixia Yang, Yanju Li, Yiqun Jian. Bovine Hemoglobin Derived Peptide Asn-Phe-Gly-Lys Inhibits Pancreatic Cancer Cells Metastasis by Targeting Secreted Hsp90α. Journal of food science. vol 82. issue 12. 2018-04-12. PMID:29083493. |
western blotting results further proved that nfgk inhibited secreted hsp90α and downstream matrix metalloproteinase-9 (mmp-9) level dose dependently, while it did not inhibit intracellular hsp90 and cyclin-dependent-kinase 4 (cdk4). |
2018-04-12 |
2023-08-13 |
human |
| Li-Juan Zhao, Hong-Li Yang, Ke-Yi Li, Yue-Hua Gao, Kai Dong, Zhong-Hao Liu, Le-Xin Wang, Bin Zhan. Knockdown of SKA1 gene inhibits cell proliferation and metastasis in human adenoid cystic carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-20. PMID:28340379. |
furthermore, knockdown of ska1 reduced the ndc80, cdk4, cyclin d1, cyclin e1, cyclin b1 and matrix metalloproteinase-9 (mmp-9) protein expression, but increased the p27 protein expression. |
2018-02-20 |
2023-08-13 |
human |
| Bo Liang, Wenjuan Zheng, Lu Fang, Linquan Wu, Fan Zhou, Xiangbao Yin, Xin Yu, Zhenhong Zo. Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancer. Cancer biology & therapy. vol 17. issue 8. 2017-09-27. PMID:27314162. |
at the gene level, knockdown of tpx2 expression upregulated the levels of cyclin b1, cdk4, p53, bax, caspase-3, and e-cadherin, but downregulated the levels of cyclin d1, cdk2, n-cadherin, slug, matrix metalloprotease (mmp)-2, and mmp-9, suggesting that knockdown of tpx2 expression suppressed tumor cell epithelial-mesenchymal transition (emt). |
2017-09-27 |
2023-08-13 |
human |
| Sanaz Koosha, Mohammed A Alshawsh, Chung Yeng Looi, Atefehalsadat Seyedan, Zahurin Mohame. An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer. International journal of medical sciences. vol 13. issue 5. 2017-04-17. PMID:27226778. |
the main targets for the inhibitory effect of flavonoids on crc signaling pathways are caspase; nuclear factor kappa b; mitogen-activated protein kinase/p38; matrix metalloproteinase (mmp)-2, mmp-7, and mmp-9; p53; β-catenin; cyclin-dependent kinase (cdk)2 and cdk4; and cyclins a, b, d, and e. in this review article, we summarize the in vitro and in vivo studies that have been performed since 2000 on the anti-crc properties of flavonoids. |
2017-04-17 |
2023-08-13 |
Not clear |
| Yu-hua Chow, Li Liu, Barbara Schwartz, John M Harlan, Lynn M Schnap. Short communication: adhesion pathways utilized by HIV-infected lymphocytes. AIDS research and human retroviruses. vol 28. issue 12. 2013-04-23. PMID:22394260. |
we now demonstrate that hiv-infected lymphocytes also use cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. |
2013-04-23 |
2023-08-12 |
Not clear |
| Kwang-Il Park, Hyeon-Soo Park, Sang-Rim Kang, Arulkumar Nagappan, Do-Hoon Lee, Jin-A Kim, Dae-Yong Han, Gon-Sup Ki. Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells. Journal of ethnopharmacology. vol 133. issue 2. 2011-05-26. PMID:21073943. |
the present study investigated the cytotoxicity of scutellaria baicalensis water extract (sbwe) on a549 non-small-cell-lung cancer cells and the a549 expression of cyclin d1, cyclin-dependent kinase 4 (cdk4) and matrix metalloproteinase-2 (mmp-2), and the effects of sbwe on cell cycle progression, especially the g1/s phase, and on cell motility. |
2011-05-26 |
2023-08-12 |
human |
| Yu-Hua Chow, Xiao Dong Zhu, Li Liu, Barbara R Schwartz, Xiao Zhu Huang, John M Harlan, Lynn M Schnap. Role of Cdk4 in lymphocyte function and allergen response. Cell cycle (Georgetown, Tex.). vol 9. issue 24. 2011-05-02. PMID:21150327. |
however cdk4(-/-) thymocytes had decreased adhesion to both endothelial cell matrix and fibronectin compared to wildtype (wt) controls, whereas cdk4(-/-) and wt splenocytes had similar adhesion. |
2011-05-02 |
2023-08-12 |
mouse |
| Ning Zu, Ping Li, Ning Li, Patrick Choy, Yuewen Gon. Mechanism of saikosaponin-d in the regulation of rat mesangial cell proliferation and synthesis of extracellular matrix proteins. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 85. issue 2. 2007-08-02. PMID:17534396. |
we conclude that ssd inhibited mc proliferation and synthesis of extracullular matrix proteins through the downregulation of the cdk4, c-jun, and c-fos genes. |
2007-08-02 |
2023-08-12 |
rat |
| Aki Okamoto, Yasuhiko Iwamoto, Yoshiro Mar. Oxidative stress-responsive transcription factor ATF3 potentially mediates diabetic angiopathy. Molecular and cellular biology. vol 26. issue 3. 2006-02-28. PMID:16428460. |
while atf3 failed to induce expressions of vegf and vegfr, it regulated those of cdk2, cdk4, p8, plasminogen activator inhibitor 1, integrin alpha1, subunit and matrix metalloprotease mmp13. |
2006-02-28 |
2023-08-12 |
rat |