| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mikhail Melnik, Tina Bilousova, Ricky Ma, Yuriko Matsuo, Swetha Atluri, Achyutha Kodavatikanti, Nina Knitowski, Karen H Gyly. Basic Science and Pathogenesis - Part 2. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 19 Suppl 13. 2024-08-09. PMID:39120864. |
we probed microglia with markers against amyloid-associated (clec7a, axl), inflammatory m1 (cd86), alternatively activated m2 (cd206, cd163), and homeostatic (p2ry12, tmem119) phenotypes in low plaque/tangle pathology controls (a-t-), high plaque/low tangle pathology controls (a+,t-), high plaque/high tangle pathology controls (hpcs) and late ad samples. |
2024-08-09 |
2024-08-12 |
Not clear |
| Walaa Bayoumie El Gazzar, Amina A Farag, Mohamed Samir, Heba Bayoumi, Heba S Youssef, Yasmin Mohammed Marei, Shimaa K Mohamed, Azza M Marei, Reham M Abdelfatah, Manal Moustafa Mahmoud, Elshaimaa Ahmed Fahmy Aboelkomsan, Eman Kamel M Khalfallah, Hala Magdy Anwe. Berberine chloride loaded nano-PEGylated liposomes attenuates imidacloprid-induced neurotoxicity by inhibiting NLRP3/Caspase-1/GSDMD-mediated pyroptosis. BioFactors (Oxford, England). 2024-07-29. PMID:39074847. |
the histopathological changes, anti-oxidant and oxidative stress markers (gsh, sod, and mda), proinflammatory cytokines (il1β and tnf-α), microglia phenotype markers (cd86 and inos for m1; cd163 for m2), the canonical pyroptotic pathway markers (nlrp3, caspase-1, gsdmd, and il-18) and alzheimer's disease markers (neprilysin and beta amyloid [aβ] deposits) were assessed. |
2024-07-29 |
2024-08-02 |
rat |
| Sanjive Qazi, Zahra Talebi, Vuong Trie. Transforming Growth Factor Beta 2 (TGFB2) and Interferon Gamma Receptor 2 (IFNGR2) mRNA Levels in the Brainstem Tumor Microenvironment (TME) Significantly Impact Overall Survival in Pediatric DMG Patients. Biomedicines. vol 12. issue 1. 2024-01-23. PMID:38255296. |
this hypothesis-generating study characterized the mrna expression profiles and prognostic impacts of antigen-presenting cell (apc) markers (cd14, cd163, cd86, and itgax/cd11c) in pediatric brainstem diffuse midline glioma (pbdmg) tumors. |
2024-01-23 |
2024-01-25 |
Not clear |
| Roxana-Olimpia Gheorghe, Andreea Violeta Grosu, Melania Magercu, Mihail-Sebastian Ghenghea, Cristina Elena Zbarcea, Alexandra Tanase, Simona Negres, Alexandru Filippi, Gabriela Chiritoiu, Mihaela Gherghiceanu, Sorina Dinescu, Gisela Gaina, Damir Sapunar, Violeta Ristoi. Switching Rat Resident Macrophages from M1 to M2 Phenotype by Iba1 Silencing Has Analgesic Effects in SNL-Induced Neuropathic Pain. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958812. |
the results show that 5 days after iba1 silencing, iba1 (+) resident macrophages are switched from an m1 (pro-inflammatory) phenotype to an m2 (anti-inflammatory) phenotype, which was confirmed by a significant decrease of m1 markers (cd32 and cd86), a significant increase of m2 markers (cd163 and arginase-1), a reduced secretion of pro-inflammatory cytokines (il-6, tnf-α and il-1β) and an increased release of pro-regenerative factors (bdnf, ngf and nt-3) which initiated the regrowth of adult drg neurites and reduced snl-induced neuropathic pain. |
2023-11-14 |
2023-11-20 |
rat |
| Shirabe Matsumoto, Mohammed E Choudhury, Haruna Takeda, Arisa Sato, Nanako Kihara, Kanta Mikami, Akihiro Inoue, Hajime Yano, Hideaki Watanabe, Yoshiaki Kumon, Takeharu Kunieda, Junya Tanak. Microglial re-modeling contributes to recovery from ischemic injury of rat brain: A study using a cytokine mixture containing granulocyte-macrophage colony-stimulating factor and interleukin-3. Frontiers in neuroscience. vol 16. 2022-08-15. PMID:35968363. |
on flow cytometric analysis, the expression of cd86, a marker of pro-inflammatory type microglia, was suppressed, and the expression of cd163, a marker of tissue-repairing type microglia, was increased by the cytokine treatment. |
2022-08-15 |
2023-08-14 |
rat |
| Sanjay, Jae-Ho Shin, Miey Park, Hae-Jeung Le. Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model. Molecular neurobiology. 2022-06-07. PMID:35670898. |
the in vitro data revealed that c3g could shift the m1 phenotype of microglia to m2 by reducing the expression of m1-specific markers (cd86 and cd80), inflammatory cytokines (il-iβ, il-6, tnf-α), reactive oxygen species, and enhancing the expression of m2-specific markers (cd206 and cd163). |
2022-06-07 |
2023-08-14 |
mouse |
| Assaf Gottlieb, Naama Toledano-Furman, Karthik S Prabhakara, Akshita Kumar, Henry W Caplan, Supinder Bedi, Charles S Cox, Scott D Olso. Time dependent analysis of rat microglial surface markers in traumatic brain injury reveals dynamics of distinct cell subpopulations. Scientific reports. vol 12. issue 1. 2022-04-16. PMID:35428862. |
we conducted a temporal analysis of the response to controlled cortical impact (cci) in rat microglia between ipsilateral and contralateral hemispheres across seven time points, identified microglia through expression of activation markers including cd45, cd11b/c, and p2y12 receptor and evaluated their activation state using additional markers of cd32, cd86, rt1b, cd200r, and cd163. |
2022-04-16 |
2023-08-13 |
rat |
| Uwe Klinge, Axel Dievernich, Rene Tolba, Bernd Klosterhalfen, Luke Davie. CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining. Journal of biomedical materials research. Part B, Applied biomaterials. vol 108. issue 8. 2021-11-08. PMID:32475069. |
the list of second markers includes lymphocytes (cd3, cd4, cd8, cd16, cd56, foxp3, and cd11b) stem cells (cd34), leucocytes (cd45, cd15), macrophages (cd86, cd105, cd163, and cd206); deposition of ec matrix (collagen-i, collagen-iii, mmp2, and mmp8); ki67 as a marker for proliferation; and the tyrosine-protein kinase receptor axl. |
2021-11-08 |
2023-08-13 |
Not clear |
| Naama Toledano Furman, Assaf Gottlieb, Karthik S Prabhakara, Supinder Bedi, Henry W Caplan, Katherine A Ruppert, Amit K Srivastava, Scott D Olson, Charles S Co. High-resolution and differential analysis of rat microglial markers in traumatic brain injury: conventional flow cytometric and bioinformatics analysis. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32686718. |
we use cd45, cd11b/c, and p2y12 receptor to identify microglia and evaluate their activation state using cd32, cd86, rt1b, cd200r, and cd163. |
2020-12-10 |
2023-08-13 |
rat |
| Fang Xu, Xiaojuan Zhang, Xiaoqin Liu, Wei Zhang, Xiaolan She, Xiuhua Xue, Jiang Bian, Minfang Guo, Jiezhong Yu, Cungen Ma, Yanhua L. [Dihydrotanshinone I (DHTS1) attenuates cuprizone-induced demyelination via regulating microglia polarization]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 5. 2020-10-30. PMID:32696752. |
microglia polarization was evaluated by iba-1, cd86 and cd163 immunohistochemical staining in vivo. |
2020-10-30 |
2023-08-13 |
mouse |
| Olga Manzhulo, Anna Tyrtyshnaia, Yulia Kipryushina, Inessa Dyuizen, Igor Manzhul. Docosahexaenoic acid induces changes in microglia/macrophage polarization after spinal cord injury in rats. Acta histochemica. vol 120. issue 8. 2019-02-08. PMID:30170694. |
in present study, we characterized the expression of iba-1, cd86, cd163 in microglia/macrophages, to assess activation state and m1 (pro-inflammatory)/m2 (anti-inflammatory) phenotypes respectively, in the rostral, central and caudal segment of the spinal cord on 7 and 35 days after sci. |
2019-02-08 |
2023-08-13 |
rat |